The invention belongs to the technical field of fertilizer, and more specifically relates to a tobacco special-purpose charcoal-based compound fertilizer, and a preparation method and an application method thereof. The tobacco special-purpose charcoal-based compound fertilizer comprises, by weight, tobacco straw, waste tobacco, pig manure, earthworm manure, vegetable waste, domestic garbage, nitrogen fertilizer, phosphate fertilizer, potassium fertilizer, trace element liquid fertilizer, a compound microbial agent, and an adhesive, and is prepared through a plurality of technologies. The tobacco special-purpose charcoal-based compound fertilizer is high in granulation rate, is capable of obviously improving fertilizer utilization rate, and is capable of improving soil acidifying and hardening after being applied to tobacco field, and increasing soil available nutrient content; the quality of the harvested tobacco leaves is improved obviously, the proportion of middle and upper-grade tobacco leaves is increased, the yield per mu and the output value per mu are obviously increased; and the tobacco special-purpose charcoal-based compound fertilizer is taken as a base fertilizer, onlyone time of application is capable of satisfying all the requirements of tobacco on nutrients in the tobacco growth period, reducing the using amount and the application frequency of traditional fertilizers; using is convenient; and labor is saved.