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52 results about "Human thyroid" patented technology
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The thyroid gland is an integral part of the endocrine system in the human body. The thyroid gland secretes the thyroid hormone, which plays an important role in the growth of the body. The thyroid is butterfly shaped, and located at the bottom of the neck. Two important hormones produced by the thyroid gland are thyroxine and triidothyronine.
Quinoline multi-target kinase inhibitor with antitumor activity and preparation method thereof
InactiveCN105541798AStrong in vitro inhibitory activityStrong inhibitory activityOrganic chemistryAntineoplastic agentsPositive controlHuman gastric carcinoma
The invention relates to a quinoline multi-target kinase inhibitor with antitumor activity and a preparation method thereof. A general structural formula of the compound is shown in a formula (I) described in the specification. In vitro cell experiments verify that the compound provided by the invention has strong in vitro inhibitory activity on five common tumor cell lines, namely human thyroid carcinoma SW579, human hepatic carcinoma HepG2, human lung adenocarcinoma A549, human colorectal adenocarcinoma HCT116 and human gastric carcinoma MKN45, antitumor activities of most of target compounds are better than or equivalent to that of a positive control drug Cabozantinib, and the in vitro cell experiments verify that the compound provided by the invention has strong inhibitory activity on two kinases KDR and MET, so that the compound provided by the invention has a broad application prospect in preparation of a new antitumor drug.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Serum-free culture medium for efficiently expressing recombinant human thyroid-stimulating hormone in CHO cells and application thereof
InactiveCN105002242AIncrease cell densityIncrease productionMicrobiological testing/measurementMicroorganism based processesBioreactorHormone
Owner:SUZHOU KANGJU BIOTECHNOLOGY CO LTD
Enzyme-linked immunosorbent assay kit for quantitatively detecting human-serum thyrotrophin receptor antibodies and detecting method
InactiveCN102735850AImprove positive detection rateRealize quantitative determinationBiological testingPhosphateThyroid disorder
The invention discloses an enzyme-linked immunosorbent assay kit for quantitatively detecting a human-serum thyrotrophin receptor antibody and a detecting method. The kit contains a 96 ferment plate precoated with segment fusion protein at the carboxyl terminal of the extracellular domain of a recombinant human thyroid stimulating hormone receptor and the following bottled reagents: phosphate bleaching liquid, confining liquid, sample diluents, thyrotrophin receptor antibody standard liquid, goat-anti-human IgG second antibody labeled with horse radish peroxidase, chromogenic substrate (tetramethyl benzidine), reaction stopping solution and quality-control serum. The invention has the advantages that the detected human-serum thyrotrophin receptor antibodies give priority to a thyroid stimulation blocking antibody, the positive detection rate to patients with hashimoto thyroiditis is high, the detected result is accurate and objective, the method is simple and convenient, and the promotion and the application are easy. The invention has an important significance in diagnosis, guide therapy and curative effect evaluation of the autoimmune thyroid disorders, and has an important clinic reference value in plan making and method selection for treating Graves disease.
Owner:GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
Bacterial ligand-binding sensor
InactiveUS20060211046A1BacteriaFusion with post-translational modification motifInteinEstrogen receptor
The invention relates to fusion proteins and bacteria encoding them. The fusion proteins include a ligand-binding domain interposed between the splicing domains of an intein. An auxotroph-relieving protein domain is fused to one of the splicing domains so that the auxotroph-relieving function of the domain is activated upon ligand binding. The fusion proteins can be expressed in bacterial cells and used as sensors of binding of compounds with the ligand-binding domain of proteins such as the human estrogen receptors or the human thyroid hormone receptor. The bacterially expressed fusion proteins can detect and report agonist and antagonist activity characteristic of the naturally-occurring hormone with the ability to modulate the function of the protein from which the ligand-binding domain of the fusion protein is derived.
Owner:THE TRUSTEES FOR PRINCETON UNIV
Thyroid stimulating hormone test paper and preparation method thereof
The invention discloses a thyroid-stimulating hormone detection test paper, which comprises a plastic substrate, a sample pad and a water-absorbing pad are arranged on the plastic substrate, a protective film is arranged on the sample-loading pad and the water-absorbing pad, and the bottom between the sample-loading pad and the water-absorbing pad is A nitrocellulose membrane is provided, and the connection end of the sample pad is provided with solid-phase colloidal gold, and one end of the solid-phase colloidal gold is overlapped with one end of the nitrocellulose membrane, and the nitrocellulose membrane is sequentially coated with detection Line and quality control line; the manufacturing method steps include: preparation of nitrocellulose membrane; marking and solid phase of polyester fiber strip; assembly and cutting. The present invention applies the principle of double-antibody sandwich method and immunochromatography to qualitatively detect human thyroid-stimulating hormone (TSH) in urine. The detection steps are relatively simple, and the results can be observed within 10 minutes. General users can perform the detection by themselves. The present invention judges whether there is a risk of hypothyroidism by comparing the color depth of the detection line with the matched color card.
Owner:NANTONG EGENS BIOTECH
Human thyroid cancer gene fusion kit and detection method
InactiveCN112011615AImprove detection accuracyReduced open tube/pipetting riskMicrobiological testing/measurementFresh TissueOncology
The invention discloses a human thyroid cancer gene fusion kit and a detection method in the technical field of molecular biology. According to the kit, a multiple PCR capture technology and an NGS sequencing technology are adopted; the kit is used for qualitatively detecting various variants of CCC6-RET, NCOA4-RET, PAX8 / PPARG and ETV6-NTRK3 fusion genes in a thyroid nodule needle biopsy cytological uncertainty fresh tissue sample, and detection threshold values are determined according to molecular tags. Assistance can be provided for auxiliary diagnosis and treatment of thyroid cancer through detection of fusion sites of the kit in combination with clinical pathological analysis results.
Owner:上海睿璟生物科技有限公司
Preparation method of iron modified cow dung-based biochar for adsorbing and removing perchlorates in water
InactiveCN109012585AImprove protectionWide variety of sourcesOther chemical processesWater contaminantsIron saltsFiltration
The invention relates to a preparation method of iron-modified cow dung-based biochar for adsorbing and removing perchlorates in water, and belongs to the field of applications of water treatment technologies. Perchlorates are toxic inorganic anions. The perchlorates in water can inhibit the ability of the human thyroid to absorb iodine and interfere the normal physiological functions of the thyroid, and are novel noteworthy pollutants in the water environment. Cow dung-based biochar prepared by pyrolysis in a nitrogen atmosphere is used as a matrix, and metal iron salts are coprecipitated onthe surface of the matrix to form iron-based biochar containg a large amount of hydroxyl groups. The material can efficiently remove the perchlorates in water by ion exchange in a solution, and solid-liquid separation can be quickly carried out by reduced pressure filtration or filtration. The raw material in the method is cow dung, and has the advantages of wide range of sources, low cost, and facilitation of environmental protection, and the regeneration process is simple, so the purpose of treating wastes with wastes is achieved.
Owner:HENAN UNIVERSITY OF TECHNOLOGY
Thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof
InactiveUS7230031B2Improve glucose toleranceImprove obesityBiocideSenses disorderArylThyroid hormone receptor beta
Owner:KISSEI PHARMA
Peptides
Owner:WORG PHARM (ZHEJIANG) CO LTD
Peptides
ActiveUS20180327463A1Peptide/protein ingredientsVertebrate antigen ingredientsDiseaseMolecular binding
The present invention provides a peptide at least partially derivable from human Thyroid Stimulating Hormone Receptor (TSHR) which peptide is capable of binding to an MHC molecule in vitro and being presented to a T cell without further antigen processing. The present invention also relates to the use of such peptides for the prevention or suppression of activating autoantibody formation in Graves' Disease.
Owner:WORG PHARM (ZHEJIANG) CO LTD
Sequences encoding novel human thyroid peroxidase proteins and polypeptides
InactiveUS7196181B1Inhibition of secretionPeptide/protein ingredientsMicroorganism based processesPeroxidaseThyroid peroxidase
Disclosed are DNA sequences encoding novel human thyroid peroxidase proteins and polypeptides capable of being secreted from cells, vectors comprising the sequences, and cells transformed with the vectors.
Owner:QUEST DIAGNOSTICS
Vector and preparation for knocking down human CBS gene as well as preparation method and application thereof
PendingCN112980845AInhibit expressionInhibit growthOrganic active ingredientsGenetic material ingredientsCancer cellNeomycin
The invention discloses a vector and a preparation for knocking down a human CBS gene as well as a preparation method and application thereof, and relates to the technical field of biological pharmacy. The preparation method of the vector comprises the following steps: designing a primer for PCR amplification of a target gene according to a human CBS gene sequence, and the specific sequence is as shown in SEQ ID NO.1; restriction sites BamH I and Hind III in the GV102 vector are digested to form a linearized GV102 vector, and the sequence of the GV102 vector is hU6-MCS-CMV-GFP-SV40-Neomycin; and connecting the products obtained in the previous two steps to construct a GV102-CBS vector. The vector prepared by the invention can obviously inhibit the expression of human CBS genes, achieve the purposes of inhibiting the growth of human thyroid cancer cells and reducing the migration rate of the cancer cells, and can be used for preparing a preparation for treating the human thyroid cancer.
Owner:HENAN UNIVERSITY
Application of succinylation-related preparations for regulation of mitochondrion OCR
PendingCN110403940AOrganic active ingredientsEndocrine system disorderPhysiologyThyroid Epithelial Cells
The invention discloses application of succinylation-related preparations for the regulation of mitochondrion OCR. According to the application of the succinylation-related preparations for the regulation of the mitochondrion OCR, mitochondrion oxygen consumption (p<average>is less than 0.05) is significantly reduced after treatment of human thyroid epithelial cells with palmitic acid, while the change of the mitochondrion oxygen consumption(p<average>is less than 0.05) is on the contrary after treatment of the human thyroid epithelial cells with palmitic acid and a desuccinylation inhibitor.The result of further detection of succinylation IDH2 (isocitrate dehydrogenase 2) shows that the result is achieved by regulating the succinylation of IDH2, that is, the succinylation of the IDH2 isreduced, mitochondrion OCR is reduced, and the desuccinylation inhibitor is involved in increasing or restoring succinylation of the IDH2, and the mitochondrion OCR is enabled to be increased or restored. The application of the succinylation-related preparations for the regulation of the mitochondria OCR provides a novel drug target for the treatment of congenital hypothyroidism.
Owner:SHANDONG PROVINCIAL HOSPITAL
Traditional Chinese medicine composition for treating thyroid adenoma due to phlegm-damp stagnation and preparation method thereof
InactiveCN104623152AReduce volumeLittle side effectsAntineoplastic agentsPlant ingredientsSide effectArtemisia anomala
The invention provides a traditional Chinese medicine composition for treating thyroid adenoma due to phlegm-damp stagnation and a preparation method thereof, and belongs to the field of traditional Chinese medicines. The composition is prepared from pinellia ternata, semen brassicae, kamuning, pericarpium citri reticulatae, codonopsis pilosula, rhizoma atractylodis macrocephalae, divaricate knotweed herb, Chinese lobelia, artemisia anomala and licorice root. The composition has the effects of invigorating spleen, replenishing qi, regulating flow of qi and middle jiao, drying dampness, removing phlegm, promoting blood circulation to remove stasis and resolving hard lump, can be used for effectively reducing the size of adenoma, has a remarkable curative effect against the thyroid adenoma due to phlegm-damp stagnation and limited influence on functions of human thyroid, and has small side effect.
Owner:陈红
Extraction-free detection kit and detection method for oncogene mutation in human thyroid glands
InactiveCN111979327ARapid expansionReduce distractionsMicrobiological testing/measurementMultiplexGenes mutation
The invention discloses an extraction-free detection kit and detection method for oncogene mutation in human thyroid glands, belonging to the technical field of molecular biology. According to the kit, a specific nucleic acid releasing agent and PCR reaction liquid matched with the specific nucleic acid releasing agent are adopted, a multiplex PCR capture technology and an NGS sequencing technology are cooperatively used, and the kit is used for qualitatively detecting various variations of BRAF, TERT, RET, TP53, NRAS, HRAS, KRAS and PIK3CA genes in a fresh tissue sample with uncertainty according to results of thyroid nodule needle biopsy cytology; and through detection of multiple genes and multiple sites and consideration of clinical pathological analysis results, assistance is providedfor auxiliary diagnosis and treatment of thyroid cancer.
Owner:上海睿璟生物科技有限公司
Composition comprising recombinant human thyroid stimulating hormone and method for producing recombinant human thyroid stimulating hormone
ActiveUS20190062396A1Efficient productionHigh purification yieldPeptide/protein ingredientsRadioactive preparation carriersRecurrent thyroid cancerHormones regulation
The present invention relates to a composition for the diagnosis and treatment of recurrent thyroid cancer comprising recombinant human thyroid stimulating hormone (rhTSH) and a method for producing the recombinant human thyroid hormone. The method for producing recombinant human thyroid hormone according to the present invention can effectively produce rhTSH despite being cultured through fed-batch culture, and has a high purification yield and purity. Therefore, the recombinant thyroid stimulating hormone produced by the method can be usefully used for the diagnosis or treatment of recurrent thyroid cancer.
Owner:PROGEN CO LTD
Plate-type fluorometric enzyme immunoassay for peroxidase antibody and use thereof
InactiveCN101430332ABuild Quantitative AssaysConvenient sourceFluorescence/phosphorescenceAntigenAutoimmune responses
The invention relates to a peroxydase antibody plate type fluorescence enzyme lmmunoassay and the application thereof. The method is characterized in that human thyroid peroxydase (hTPO) protein is taken as antigens to cover a perforated plate, and PBST containing 1-5 percent BSA is used for sealing the perforated plate; the perforated plate is then taken as a carrier and is added with an anti-hTPO first antibody or a standard, an enzyme-labeled second antibody, fluorogenic substrate and stop solution in sequence; and finally, the fluorogenic strength is detected on a fluorogenic / chemical luminescent analyzer. The method can be used to clinically distinguish autoimmunity thyropathy from non-autoimmunity thyropathy and diagnosis lymphocytic thyroiditis. The invention has the advantages that the perforated plastic plate is taken as a solidoid carrier to carry out the fluorescence enzyme lmmunoassay, the plate material has easy sources, low cost and easy popularization; the method is special, sensitive and stable; the detection value is calibrated according to national standard with favorable accuracy and the method is applicable to clinically requirement and popularization.
Owner:GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
Traditional Chinese medicine composition for treating thyroid cancer and preparation method thereof
ActiveCN114177244AExact therapeutic effectGrowth inhibitionPharmaceutical delivery mechanismAntineoplastic agentsMedicinal herbsCancer cell
The invention belongs to the field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition for treating thyroid cancer and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following nine raw medicinal materials: astragalus membranaceus, bighead atractylodes rhizome, poria cocos, white paeony root, prepared arisaema consanguineum schott, thunberg fritillary bulb, pinellia ternate, oroxylum indicum and selfheal, and has the effects of invigorating spleen and replenishing qi, eliminating dampness and phlegm, and softening hardness to dissipate stagnation. Pharmacodynamic experiment results show that the traditional Chinese medicine composition disclosed by the invention can obviously inhibit the growth of human thyroid cancer tumors in nude mice bearing tumors and obviously inhibit the proliferation of thyroid cancer cells in vitro, has an exact treatment effect on thyroid cancer, and provides a new clinical medication choice for patients.
Owner:ZHEJIANG PROVINCIAL PEOPLES HOSPITAL
Application of antineoplastic polypeptide TT-1 in preparing antineoplastic medicines
InactiveCN104258373AImprove anti-tumor activityPeptide/protein ingredientsAntineoplastic agentsChemical synthesisHigh activity
The invention belongs to the technical field of biomedicine, and in particular relates to immune regulation polypeptide and application thereof. By modifying melittin, original instable amino acid and proline are replaced into positively charged lysine, thus enhancing stability; meanwhile, an active central part at N terminal is retained; antineoplastic polypeptide TT-1 with relatively high activity is obtained through a solid-phase chemical synthesis method. Result of a pharmacodynamic experiment proves that the TT-1 can inhibit growth of human thyroid carcinoma TT and tumor of mice with tumor, and the antineoplastic polypeptide is relatively low in toxicity, showing that the TT-1 can serve as a medicine for antineoplastic therapy.
Owner:JILIN UNIV
Secretory thyroid stimulating hormone receptor, and method for assaying anti-thyroid stimulating hormone receptor antibody using the same
InactiveUS6933364B1Polypeptide with localisation/targeting motifSugar derivativesInfected cellAutoantibody production
A recombinant soluble human thyroid hormone receptor, comprising an extracellular domain moiety of a human thyroid hormone receptor, or a mutant thereof, being secretory, and having reactivity with an anti-human thyroid stimulating hormone receptor autoantibody; a composition for assaying an anti-human thyroid stimulating hormone receptor antibody, comprising the receptor and a carrier or diluent; a method for assaying an anti-human thyroid stimulating hormone receptor antibody, comprising reacting an anti-human thyroid stimulating hormone receptor antibody with the receptor; and a process for producing a recombinant soluble human thyroid hormone receptor which is secretory and has reactivity with an anti-human thyroid stimulating hormone receptor autoantibody, comprising infecting an insect cell with a recombinant baculovirus introduced with an extracellular domain moiety of a gene encoding a human thyroid hormone receptor or a mutant thereof, and culturing the infected cell.
Owner:TOSOH CORP
A positioning mechanism of an infrared thermal imager for examining human parathyroid glands
InactiveCN110115564BReduce shakingImproved imaging stabilityDiagnostics using lightSurgical furnitureHuman bodyMedicine
The invention provides a positioning mechanism of an infrared thermal imager for inspecting human parathyroid glands, and relates to the field of medical infrared thermal imagers. The positioning mechanism of the infrared thermal imager for inspecting human parathyroid glands includes a gravity base, and the bottom of the gravity base is fixedly connected with universal wheels for rolling. The positioning mechanism of the infrared thermal imager used to examine the parathyroid glands of the human body, through the electric telescopic rod installed inside the cylindrical shell, the expansion and contraction of the electric telescopic rod can push the circular block to move, and the circular block can drive the stable contact tube The snapping bump 1 and the snapping bump 2 on the second move and engage with the snapping groove 1 and the snapping groove 2, which can effectively connect the snapping bump 1 and the snapping groove 2 after the drive linear motor stops working. The meshing between the two connecting bumps reduces the problem of shaking of the thermal imager caused by the meshing gap between the transmission gear and the inner ring teeth, and greatly improves the imaging stability of the thermal imager.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY
Thyroid stimulating hormone receptor antigen reagent and thyroid stimulating hormone receptor antibody quantitative detection kit
PendingCN114113637AAvoid interferenceReduce labeling stepsBiological testingAntiendomysial antibodiesCompetitive binding
The invention provides a human thyroid stimulating hormone receptor antibody quantitative detection kit. The human thyroid stimulating hormone receptor antibody quantitative detection kit comprises a solid phase carrier coated with an anti-TSHR monoclonal antibody A; an antigen reagent, wherein the antigen reagent is an immune complex of an anti-TSHR monoclonal antibody B and a TSHR; a human stimulated thyroid stimulating hormone receptor antibody marked by a marker is contained; the anti-TSHR monoclonal antibody A and the anti-TSHR monoclonal antibody B do not generate competitive binding. The kit provided by the invention adopts a competition method reaction principle to detect the concentration of the thyroid stimulating hormone receptor antibody in serum or plasma, the kit is relatively stable, the interference of biotin or fluorescein sodium can be avoided, the preparation process is simpler and more stable, the repeatability is good, and the cost is greatly reduced while the product performance is improved.
Owner:AUTOBIO DIAGNOSTICS CO LTD
Kit for detecting thyroid peroxidase antibody and subtype thereof
ActiveCN114236131AHigh sensitivityStrong specificityBiological material analysisBiological testingPeroxidaseProtein G
The invention discloses a kit for detecting thyroid peroxidase antibodies and subtypes thereof, and belongs to the technical field of biological medicines. The kit comprises < 125 > I labeled human thyroid peroxidase, a streptavidin agarose gel reagent, a biotinylated anti-human IgG subtype monoclonal antibody, protein A agarose and protein G agarose. On the basis of an existing radioactive ligand detection method, core steps are replaced by combining upstream and downstream principles, the streptavidin agarose gel reagent and the biotinylated anti-human IgG subtype monoclonal antibody are introduced for the first time, a core technical platform is created again for subtype typing of the antibody, and the method has the advantages of high specificity, high sensitivity and high sensitivity. And then the biotinylated anti-human IgG subtype monoclonal antibody is combined with the subtype of the thyroid peroxidase antibody, so that the detection of the thyroid peroxidase antibody subtype is realized, and the upgrading of a technical platform and the breakthrough of a thyroid peroxidase antibody subtype detection technology are successfully realized.
Owner:JIANGSU PROVINCE HOSPITAL THE FIRST AFFILIATED HOSPITAL WITH NANJING MEDICAL UNIV
Kit for quantitatively detecting thyroid peroxidase and non-diagnostic purpose detection method
PendingCN112051402AAccurate detectionWide detection rangeBiological material analysisAssayPeroxidase
The invention relates to the technical field of biology, in particular to a kit for quantitatively detecting thyroid peroxidase and a non-diagnostic purpose detection method. The kit comprises a microwell plate, a buffer solution, a confining liquid, a sample diluent, an enzyme diluent, a thyroid peroxidase standard substance, a thyroid peroxidase antibody, a biological enzyme labeled thyroid peroxidase antibody and a luminous substrate, the sample diluent comprises a thyroid peroxidase antibody, PBST, newborn calf serum, a preservative and water. According to the invention, a double-antibodysandwich two-step method is established through an ELISA (Enzyme Linked Immuno Sorbent Assay) method, so that the content of human thyroid peroxidase can be conveniently, timely and accurately detected when the human thyroid peroxidase is researched, developed, recombined and naturally extracted, and the detection range is wide.
Owner:ZHENGZHOU IMMUNO BIOTECH
Composition comprising recombinant human thyroid stimulating hormone and method for producing recombinant human thyroid stimulating hormone
ActiveUS11001620B2Efficient productionEasy to usePeptide/protein ingredientsRadioactive preparation carriersRecurrent thyroid cancerAbnormal thyroid
Owner:PROGEN CO LTD
Method for establishing hypothyroidism Wistar rat eye socket model
ActiveCN102872449AEasy to makeLow costIn-vivo radioactive preparationsPeptide/protein ingredientsIntraperitoneal routeDisease
The invention relates to a method for establishing a hypothyroidism Wistar rat eye socket model. The method comprises the following steps of: (a) performing intraperitoneal injection on a Wistar rat by using human thyroid stimulating hormone to form hyperthyroidism; and (b) performing internal irradiation on the Wistar rat through radioactive 131I. The method has the advantages that an animal model is easy to manufacture, low in cost and easy to repeat; the method is high in success rate, hypothyroidism exists in 85 percent of models, and thyroid tissues have universal characteristics of the hypothyroidism; 100 percent of models have the characteristics of thyroid-associated ophthalmopathy; actual natural courses and states of diseases are simulated, the hyperthyroidism appears, and then the internal irradiation is performed through the 131I to form the hypothyroidism; and in the testing process, the method is low in animal death rate.
Owner:SHANGHAI PUTUO DISTRICT LIQUN HOSPITAL
Application of pyrimidine derivatives to treatment of thyroid cancer
ActiveCN109364081AEnhanced inhibitory effectAffect the efficacyOrganic active ingredientsOrganic chemistryEffective treatmentInhibitory effect
The invention discloses an application of pyrimidine derivatives to treatment of thyroid cancer. Thyroid cancer is an endocrine malignant tumor with high incidence. Cancer incidence and mortality datareleased by Chinese center for cancer control and prevention in 2018 show that about 170,000 new cases of thyroid cancer and about 8,000 deaths of thyroid cancer occurred in China in 2014. At present, drugs for effective treatment of thyroid cancer are few and cannot meet clinical needs. It is found that partial pyrimidine derivatives have significant inhibitory effect on human thyroid cancer B-CPAP cells and can be used for preparing drugs for treating the thyroid cancer. Parent nuclei and substituents of the pyrimidine derivatives significantly affect effect of the derivatives on thyroid cancer.
Owner:SHANGHAI RUOTUO BIOSCIENCES CO LTD
Artificially cultivated phellinus igniarius extract for treating thyroid cancer and preparation method thereof
InactiveCN112189507AInhibition of value addedRelieve painCultivating equipmentsMushroom cultivationTumor reductionCancer cell
The invention belongs to the technical field of artificial cultivation of edible fungi, particularly relates to an artificially cultivated phellinus igniarius sporocarp extract for treating thyroid cancer, and further discloses a preparation method of the artificially cultivated phellinus igniarius sporocarp extract. The artificially cultivated phellinus igniarius sporocarp extract for treating the thyroid cancer is obtained by taking phellinus igniarius sporocarp as a raw material for carrying out water body and alcohol precipitation extraction, the obtained extract has the effects of supporting body resistance and promoting immune functions, has an obvious inhibiting effect on in-vivo transplantation of nude mice with human thyroid cancer, can obviously inhibit proliferation of thyroid cancer cells in vitro at the same time, has a good thyroid cancer treatment effect, can relieve the pain of a tumor patient, prolongs the lifetime, improves the life quality of the patient, and bringsa new candidate medicine for treating the thyroid cancer to clinical application, and the extract is a natural extract, and has the advantages of being high in medication safety and low in toxic and side effects.
Owner:XUZHOU UNIV OF TECH
Human thyroid stimulating hormone receptor fusion protein as well as preparation method and application thereof
ActiveCN111548422AIncrease productionImprove stabilityAntibody mimetics/scaffoldsOxidoreductasesThyrotropin receptorAbnormal thyroid
The invention relates to the technical field of biology, in particular to a human thyroid stimulating hormone receptor fusion protein and a preparation method and application thereof. The fusion protein is composed of a HER2 protein and a TSHR protein, and the HER2 protein and the TSHR protein are connected through a connecting peptide. The HER2 and the low-expression TSHR are subjected to fusionexpression, the yield and stability of the TSHR can be improved under the condition that the structure and function of the TSHR are not affected, the TSHR protein can be secreted into supernate, and purification is facilitated.
Owner:ZHENGZHOU IMMUNO BIOTECH
Human Thyroid Weight Measurement Method Based on Spectrum Imaging
ActiveCN106447650BAccurate extractionIntegrity guaranteedImage enhancementImage analysisDiseaseComputer science
A human thyroid weight measurement method based on SPECT planar imaging mainly solves the problem of large error and low efficiency in manual delineation of the region of interest in the existing thyroid weight measurement method. The implementation steps are: (1) Input the thyroid planar imaging image; (2) Grayscale the thyroid planar imaging image; (3) Binarize the thyroid planar imaging image; (4) Extract the region of interest ; (5) Calculate the area of the region of interest; (6) Calculate the longest diameter of the left and right half lobes of the region of interest; (7) Calculate the mass of the thyroid gland. The invention has the advantages of ensuring the integrity of the SPECT planar imaging image, effectively segmenting the region of interest and extracting feature information, and quickly calculating the weight of the thyroid gland, and can efficiently complete the weight measurement of the thyroid gland while ensuring accuracy, and can be used for clinical thyroid diseases During the treatment, the dosage was estimated according to the weight of the thyroid gland.
Owner:XIDIAN UNIV
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