10 results about "Human thyroid" patented technology

A cricothyrotomy medical training device includes a ribbed tube representative of a human trachea, the ribbed tube having a first end and a second end. A first protrusion extends from the first end of the ribbed tube, the first protrusion being representative of a human thyroid cartilage. A second protrusion extends from the ribbed tube near the first end, the second protrusion being representative of a human cricoid cartilage. The second protrusion is longitudinally spaced between the first end and the second end. A first marking material is disposed at the first and second protrusions for representing a location of human skin. A second marking material disposed between the first and second protrusions to identify a location of a human cricothyroid membrane.

The invention relates to medical training aids. The claimed method includes preparing models of bone and cartilage structures and molds for blood vessel and thyroid models by 3D printing. A plastisol containing polyvinyl chloride is used for simulating a thyroid and blood vessels. This plastisol is poured into the molds for the blood vessel and thyroid models and held until it has cooled. A plastisol containing powdered graphite and a metal glitter for echogenicity is used for simulating lymph nodes and tumorous growths. Lengths of jute twine are laid in molds, into which a plastisol with added glitter is poured, the plastisol is held until it has cooled, and neck muscle models are cut out. A plastisol containing dyes is poured into a master neck mold to produce a skin model. The models of the muscles, vessels, thyroid, bone and cartilage structures, trachea, lymph nodes and tumorous growths are arranged in the master neck mold, into which a plastisol containing glitter is poured, the assembly is left to cool before being removed and the skin model is attached. The technical result is that the structure of the phantom more closely resembles the structure of a human thyroid.

The invention discloses a nucleic acid, a pharmaceutical composition containing the nucleic acid, a saRNA conjugate containing the nucleic acid, and a preparation method and application of the saRNA conjugate, and belongs to the technical field of biological medicines. The saRNA, the modified saRNA and the saRNA conjugate provided by the invention are combined with a promoter of a human thyroid hormone receptor beta (THRB) gene in a targeting manner, so that the expression of the THRB gene is activated. The saRNA, the modified saRNA and the saRNA conjugate provided by the invention have wide application prospects in the treatment application of the non-alcoholic fatty liver disease.

The invention belongs to the technical field of biological medicines, and particularly relates to a diagnosis and treatment integrated boron compound for targeting RET positive thyroid cancer and a preparation method of the diagnosis and treatment integrated boron compound. According to the present invention, by using the targeting property of Platinib on RET, and the high efficiency and the target accuracy of boron atoms, the selectivity and the targeting property on RET-positive refractory thyroid cancer are significantly improved, and the good antitumor effect is provided. In a cell experiment, the boron compound disclosed by the invention shows a remarkable proliferation inhibition effect on a human thyroid cancer cell line TT (the IC50 value is 5.56 nM). Animal experiment results show that the boron compound can effectively inhibit tumor growth. In addition, in acute and subacute toxicity tests, mice in an administration group do not have obvious poisoning symptoms, which indicates that the boron compound has safety.

A chimeric protein comprising an extracellular domain of human thyroid-stimulating hormone receptor (TSHR), said domain lacking a C-terminal segment comprising at least the segment from amino acid residue 301 to 413 of TSHR.

On the basis of a Galpha s-cAMP-PKA signal channel, which plays a normal physiological role in vivo, of thyroid stimulating hormone and the regulation and control effect of the thyroid stimulating hormone on thyroid hormone synthesis, a normal human thyroid follicular epithelial cell line Nthy-ori 3-1 is transformed into a TSHR overexpressed stable cell line for the first time, the expression quantity of TSHR in a cell membrane is obviously increased, and the TSHR expression level is improved; the response sensitivity of the Nthy-ori 3-1 cell to a thyroid stimulating hormone drug is obviously improved; by detecting the synthesis level of cAMP and thyroid hormone before and after the stimulation of the thyroid stimulating hormone, it is verified that the TSHR overexpression Nthy-ori 3-1 cell line established in the research has great superiority for determining the biological activity of the human thyroid stimulating hormone.

The present invention provides a seaweed polyketide compound with anti-tumor activity, its preparation method and application. The compound is a polyketide compound, and its raw materials are collected from Sargassum thunbergii in the waters of Nanji Island, Zhejiang Province, and obtained after separation and purification. When the polyketide compound is applied to drugs, it has proliferation inhibitory activity against human cervical cancer cells (HeLa), human renal clear cell adenocarcinoma cells (786-O), human gallbladder cancer cells (GBC-SD) and human thyroid cancer cells (CAL-62), and the half-maximal inhibitory concentration (IC50) is 9.4 μM, 9.1 μM, 3.2 μM, 6.1 μM, and it can be used to prepare anti-tumor drugs.

The application provides a kind of thyroid I-131 activity measurement system based on double-layer detector, for measuring I-131 activity in human thyroid, comprising: double-layer detector, for receiving the gamma ray emitted by I-131 to outside the body and converting the gamma ray into optical signal, with front and rear end CsI (TI) crystal and rear end CsI (TI) crystal arranged in front and rear adhesion;Nuclear electronics equipment, used with double-layer detector, for converting optical signal into electrical signal;Annular band, for fixing adhesion in human neck, with double-layer detector and nuclear electronics equipment arranged inside;Spectrum analysis module, for analyzing according to electrical signal, to obtain the energy spectrum of gamma ray;Detection efficiency calibration module, for calibrating the detection efficiency of double-layer detector, including OTT calibration unit and detection efficiency calibration unit;Energy spectrum analysis module, for analyzing the energy spectrum of gamma ray received by double-layer detector after calibration to obtain I-131 activity.

The present application relates to the technical field of in vitro diagnosis, in particular to a mouse monoclonal antibody against TPO and a preparation method and application thereof. The present application discloses a mouse monoclonal antibody against TPO and a preparation method and application thereof, wherein the mouse monoclonal antibody is named TPO-1#, the heavy chain variable region of the mouse monoclonal antibody TPO-1# has an amino acid sequence shown in SEQ ID NO. 1, and the light chain variable region has an amino acid sequence shown in SEQ ID NO. 2. In the present application, recombinant human thyroid peroxidase (TPO) is selected as an immunogen, 5-week-old female Balb / c mice are immunized, and a new specific mouse monoclonal antibody against TPO is obtained. A kit for detecting the concentration of Anti-TPO in serum is established by using the mouse monoclonal antibody prepared by the present application, and compared with the prior art, the detection technology has higher sensitivity, and has better correlation with the same type of detection kit of Roche.

The invention belongs to the technical field of medicine, and discloses a novel fumaric acid-chloroacetamide compound ZWH-01 with thyroid cancer resisting activity and a preparation method thereof.The compound is simple in synthetic route, mild and environment-friendly in reaction condition and high in yield, has remarkable growth inhibition activity on human thyroid undifferentiated cancer cells 8505c, and has good application prospects. And moreover, the compound can inhibit the migration and invasion of 8505c cells in a concentration-dependent manner, and has a good application prospect.