14 results about "Thyroid-stimulating hormone" patented technology

The invention relates to the technical field of computers, and discloses an endocrine metabolism index real-time processing method based on edge calculation. The method comprises the following steps: acquiring time sequence data of blood glucose, insulin, cortisol and thyroid stimulating hormone collected by wearable equipment; constructing a lightweight linear state space model of the diagonal dominant sparse state transition matrix; initializing a noise covariance matrix; iterative Kalman filtering based on a sparse matrix inversion algorithm is executed; the observation noise covariance is dynamically adjusted according to the residual error; and when the filtering result exceeds a clinical critical value, triggering local early warning and uploading to the cloud. According to the scheme, the single filtering delay is controlled within 80 milliseconds while the numerical stability is guaranteed, and the early warning timeliness and the system energy efficiency are improved.

The present subject matter is directed to methods of treating Allan-Herndon-Dudley syndrome comprising administering 3,5-diiodothyropropionic acid (DITPA) to a subject in need thereof, wherein the DITPA administration reduces triiodothyronine (“T3”) serum levels to normal, increases T3 brain levels to normal, and maintains normal serum levels of thyroxine (T4) and thyroid stimulating hormone (TSH). The subject may be a child or an adult.

The present subject matter is directed to methods of treating Allan-Herndon-Dudley syndrome comprising administering 3,5-diiodothyropropionic acid (DITPA) to a subject in need thereof, wherein the DITPA administration reduces triiodothyronine (“T3”) serum levels to normal, increases T3 brain levels to normal, and maintains normal serum levels of thyroxine (T4) and thyroid stimulating hormone (TSH). The subject may be a child or an adult.

The present application relates to the technical field of medical data processing, in particular to a method for quickly evaluating thyroid stimulating hormone value, which comprises the following steps: S1, clinical data acquisition; S2, data quality control and feature construction; S3, double-task joint prediction; S4, age self-adaptive reference interval correction; and S5, output of explainable report. The present application compresses the TSH evaluation period from the traditional 2-4 hours to within 5 minutes, reduces the detection cost by about 80%, and greatly improves the accessibility of thyroid function abnormality screening.

On the basis of a Galpha s-cAMP-PKA signal channel, which plays a normal physiological role in vivo, of thyroid stimulating hormone and the regulation and control effect of the thyroid stimulating hormone on thyroid hormone synthesis, a normal human thyroid follicular epithelial cell line Nthy-ori 3-1 is transformed into a TSHR overexpressed stable cell line for the first time, the expression quantity of TSHR in a cell membrane is obviously increased, and the TSHR expression level is improved; the response sensitivity of the Nthy-ori 3-1 cell to a thyroid stimulating hormone drug is obviously improved; by detecting the synthesis level of cAMP and thyroid hormone before and after the stimulation of the thyroid stimulating hormone, it is verified that the TSHR overexpression Nthy-ori 3-1 cell line established in the research has great superiority for determining the biological activity of the human thyroid stimulating hormone.

The invention discloses an anti-thyroid stimulating hormone antibody and application thereof, and relates to the field of antibodies. The anti-thyroid stimulating hormone antibody disclosed by the invention comprises a heavy chain complementarity determining region and a light chain complementarity determining region, provides an important raw material source for thyroid stimulating hormone detection, and has good affinity or activity.

The invention discloses a method for establishing a reference interval of thyroid stimulating hormone in the early pregnancy stage of a pregnant woman. The method comprises the following steps: S1, collecting data and establishing a database; s2, performing data processing on the database obtained in the step S1, determining a data distribution type, and determining a reference interval; the interval combination obtained in the invention is convenient for assisting doctors in subsequent diagnosis and treatment, and in combination with the TSH reference interval, the pregnant women with thyroid diseases can be prevented from being neglected through the judgment standard.

The present invention addresses the problem of providing a new method for easily measuring the activity of thyroid stimulating hormone (TSH).　Provided is a reporter cell for measuring the activity of thyroid stimulating hormone (TSH). In the reporter cell, a TSH receptor gene that encodes a TSH receptor or an active fragment thereof and a reporter gene that encodes a reporter protein are introduced. The reporter gene is arranged under the control of a promoter of which the promoter activity is controlled depending on the activity of the TSH receptor or an active fragment thereof.

The present subject matter relates to a method of treating Alan Houghton Dudley syndrome, the method comprising administering 3,5-diiodothyropropionic acid (DITPA) to a subject in need thereof, wherein administration of DITPA reduces serum levels of triiodothyronine (“T3”) to normal, increases T3 brain levels to normal, and maintains normal serum levels of thyroxine (T4) and thyroid stimulating hormone (TSH). The subject may be a child or an adult.

The present invention provides multispecific antibodies against insulin like growth factor I receptor (IGF-1R) and thyroid stimulating hormone (TSH) receptor (TSHR), methods for their production, pharmaceutical compositions containing the multispecific antibodies, and uses thereof. More particularly, the presently disclosed invention provides bispecific IGF-lR and TSHR antibodies, and antigen binding fragments thereof.

THYROID STIMULATING HORMONE (TSH) LEVEL DETECTION APPARATUS

The application discloses a computer-aided system and storage medium for evaluating offspring development risk, relates to the technical field of medical information processing, and comprises an input module, a processing module and an output module. The input module receives thyroid stimulating hormone detection values and thyroid autoantibody detection values collected from a subject within 12 weeks of pregnancy. The processing module pre-stores a first threshold interval and a second threshold. The received detection values are compared in value. When a preset condition is met, the corresponding data record of the subject is marked as a to-be-tracked record, and an auxiliary evaluation result is generated. The output module outputs subsequent tracking management auxiliary information according to the auxiliary evaluation result. The storage medium stores program instructions that are executed by a processor to realize the above data processing steps. The application realizes automatic identification marking of specific groups of people, standardized follow-up guidance and dynamic state switching assistance, and effectively solves the problems of inconsistent processing procedures and missing follow-up in the prior art.

The utility model relates to the technical field of quantitative detection kits, and discloses a thyroid stimulating hormone quantitative detection kit which comprises a kit body, a clamping assembly is inserted into the middle end of the kit body, and rotary assemblies are fixedly connected to the interiors of the two ends of the clamping assembly. Firstly, a thyroid stimulating hormone reagent tube is inserted into the clamping assembly, then the clamping assembly is pressed downwards, the elastic assembly is compressed through the auxiliary synchronous movement of the rotary assembly in the pressing process of the clamping assembly, and then after the clamping assembly moves downwards to the bottom of the box body, the clamping assembly is clamped and limited through the positioning assembly; and finally, the sealing assembly is rotated to seal the upper end of the kit body, so that when the quantitative detection kit is used for transporting the thyroid stimulating hormone reagent tubes, the protection effect on the thyroid stimulating hormone reagent tubes can be effectively improved, and meanwhile, due to an independent mode, the contact with other thyroid stimulating hormone reagent tubes in the transportation process is reduced.

The invention provides a thyroid stimulating hormone antibody and application thereof in fluorescence immunochromatography detection. A heavy chain CDR1 sequence of the monoclonal antibody 8I22 is shown as SEQ ID NO: 1, a heavy chain CDR2 sequence of the monoclonal antibody 8I22 is shown as SEQ ID NO: 2, and a heavy chain CDR3 sequence of the monoclonal antibody 8I22 is shown as SEQ ID NO: 3; the sequence of the light chain CDR1 is as shown in SEQ ID NO: 4, the sequence of the light chain CDR2 is as shown in SEQ ID NO: 5, and the sequence of the light chain CDR3 is as shown in SEQ ID NO: 6. A heavy chain CDR1 sequence of the monoclonal antibody 9E6 is shown as SEQ ID NO: 11, a heavy chain CDR2 sequence of the monoclonal antibody 9E6 is shown as SEQ ID NO: 12, and a heavy chain CDR3 sequence of the monoclonal antibody 9E6 is shown as SEQ ID NO: 13; the sequence of the light chain CDR1 is as shown in SEQ ID NO: 14, the sequence of the light chain CDR2 is as shown in SEQ ID NO: 15, and the sequence of the light chain CDR3 is as shown in SEQ ID NO: 16. The antibody is high in sensitivity, low in detection limit and wide in linear range when being used for detecting thyroid stimulating hormone.