9results about How to "Expedited screening" patented technology

The invention relates to a biomarker combination for treating SHH subtype medulloblastoma, and aims to solve the problems that existing treatment targets are deficient, the curative effect is limited and precise treatment is insufficient. The invention reveals that an m6A-YTHDF2 signal axis is a novel treatment target of SHH-MB for the first time, the YTHDF2 regulates and controls the expression of a downstream target gene DENND2A through an m6A dependency mode, the high expression of the YTHDF2 is related to poor prognosis of a patient, and knock-down of the YTHDF2 can significantly inhibit the proliferation and balling ability of SHH-MB cells. According to the invention, the TET-ON regulated SHH-MB cell line capable of inducing to knock down YTHDF2 is constructed, and a tool is provided for drug screening; it is clear that a YTHDF2 inhibitor (such as DC-Y13-27 and the like) can achieve the anti-tumor effect by down-regulating DENND2A expression, and the drug sensitivity of SHH-MB tumor cells to a Hedgehog signal channel small molecule inhibitor Vismodegib (GDC-0449) is improved.

The invention provides a data screening method and device, equipment, a medium and a product, and the method comprises the steps: obtaining original data, and determining a target time scale for segmenting the original data; segmenting the obtained original data based on a target time scale to obtain at least one original data interval segment; for each original data interval segment in the at least one original data interval segment, determining a quality score corresponding to the original data interval segment; and if the quality score corresponding to the original data interval segment is greater than or equal to a preset quality score threshold, determining the original data interval segment as target data which is used for system identification. The data screening efficiency can be improved.

The invention belongs to the technical field of bioengineering and analytical chemistry, and provides a probe eZinCh-2 modified plasmid based on FRET (Fluorescence Resonance Energy Transfer) and application of the probe eZinCh-2 modified plasmid in zinc ion detection. According to the invention, the plasmid is constructed through molecular cloning and homologous recombination technologies, and is microinjected into a zebrafish embryo, so that a transgenic strain capable of stably inheriting and expressing the probe protein is successfully obtained; as a living body biological tool, the zebrafish of the strain is combined with a confocal microscope spectrum FRET technology, and real-time and quantitative monitoring and visual imaging of dynamic changes of zinc ions at living body, cell and tissue levels are achieved. The method solves the problem that real-time dynamic visual monitoring of the zinc ions cannot be realized in a living body model in the prior art, and is suitable for real-time microscopic quantitative analysis of the content of the zinc ions in model organisms such as zebra fish and the like.

The utility model belongs to the technical field of capsule conveying, and relates to a pneumatic soft capsule conveying device which comprises a feeding hopper arranged on a supporting frame, the feeding hopper is communicated with a vibration screening assembly, the vibration screening assembly and a pneumatic conveying system are installed in the supporting frame, the vibration screening assembly is respectively communicated with a material guiding slope and a circulation groove, and the circulation groove is communicated with a waste box. A discharging pipe is arranged at the lowest point of the material guiding slope, the pneumatic conveying system is communicated with the circulating groove and the discharging pipe, and a discharging roller is arranged in the discharging pipe. The soft capsules are screened through the vibration screening assembly, wizened and shrunk soft capsules are separated from normal soft capsules, the number of unqualified products in follow-up treatment is reduced, the time needed by manual sorting is shortened, the unqualified soft capsules and the normal soft capsules are pneumatically conveyed through the pneumatic conveying system, and the sorting efficiency is improved. The accumulation of waste materials in a production field is avoided, the cleanliness of the production environment is kept, and meanwhile, the damage risk of normal soft capsules in the conveying process is also reduced.

The utility model relates to the technical field of aquaculture, in particular to an aquaculture fish fry screening device which can accelerate screening of fish fries, avoid the situation that fish fries are hurt due to fish fry fishing and improve screening efficiency. Comprising a screening box, a plurality of supporting legs, a plurality of friction bases, two screening net plates, a lifting assembly, a blocking assembly, a collecting assembly, a scattering assembly and a feeding assembly, the supporting legs are installed on the side walls of the left end and the right end of the lower portion of the screening box, the friction bases are installed at the bottoms of the supporting legs, and a partition plate is arranged in the middle of the screening box, so that the upper portion of the screening box is a screening cavity, and the lower portion of the screening box is a collecting bin; the two screening net plates are installed in the screening cavity, the hole diameter of the left screening net plate is larger than that of the right screening net plate, the lifting assembly is installed on the outer wall of the screening box, a plugging component is installed on the lifting assembly, the collecting assembly is installed in the collecting bin, a feeding component is installed on the side wall of the screening box, and the scattering assembly is installed on the lifting assembly.

The invention relates to the technical field of molecular biology and genetic engineering, and discloses sgRNA targeting a chicken CD30 gene and a combination and application thereof. The sgRNA and the sgRNA combination provided by the invention perform targeted knockout on the seventh exon region (transmembrane region) of the chicken CD30 gene, and the sgRNA knockout target of the chicken CD30 is transfected into a chicken fibroblast line DF-1 to prepare the CD30 knockout DF-1 cell, namely the CD30 / -DF-1 cell, and compared with a control group cell through detection, the CD30 expression quantity in the CD30 / -DF-1 cell is extremely low, and the result shows that the CD30 is successfully edited. The establishment of the CD30- / -DF-1 cell line provides an experimental material for deeply researching the functions of CD30.

The application belongs to the technical field of thermal insulation material detection, and relates to a thermal conductivity prediction method of anisotropic silicon oxide nanowire aerogel, comprising the following steps: 1, feature parameter extraction based on micro-morphology: taking a scanning electron microscope image of the silicon oxide nanowire aerogel as a modeling benchmark; 2, construction of a random entangled spline curve skeleton: parameterized skeleton generation is carried out by using a three-dimensional modeling software; 3, entity scanning and anisotropic cell establishment; 4, multi-physical field simulation based on an entity model; the application introduces porous medium heat transfer and microscale correction functions, significantly improves the prediction accuracy and application range, can accurately reflect the complex heat transfer mechanism inside the nanowire aerogel, and provides a reliable basis for optimizing material design.

The utility model relates to a hot melting device for high polymer material production, which comprises a hot melting cylinder provided with a heating module to realize melting treatment of high polymer raw materials; the crushing box is fixedly installed on the upper end face of the hot melting cylinder, and the upper end face of the crushing box is fixedly connected with a feeding port; the crushing mechanism is arranged on the crushing box, the crushing mechanism comprises two crushing rollers, a sieve plate, a driving assembly and two sets of knocking assemblies, the two crushing rollers are symmetrically arranged in the crushing box, the sieve plate is arranged at the lower ends of the two crushing rollers, and the driving assembly is arranged on the side wall of the crushing box; the driving assembly drives the two crushing rollers to rotate in opposite directions to crush the macromolecular raw materials, the crushed macromolecular raw materials fall on the sieve plate to be screened, the macromolecular raw materials with qualified volumes fall into the hot melting cylinder to be hot-melted, and the sieve plate is knocked by the knocking assembly, so that the screening of the crushed macromolecular raw materials by the sieve plate is accelerated.

The invention discloses pretreatment equipment for industrial waste recycling, and relates to the technical field of waste recycling, the pretreatment equipment comprises a waste crusher and a discharging frame arranged at an opening of the waste crusher, a screening plate capable of transversely moving in a reciprocating mode is arranged on the inner side of the discharging frame, and a plurality of screening channels arranged at equal intervals are formed in the screening plate; the industrial waste meeting the specification and located on the surface of the screening plate penetrates through the screening channel and then falls into the waste crusher. The two ends of the screening plate extend towards the inclined upper portion to form two sets of extending side plates which are symmetrically distributed, and the two sets of extending side plates are arranged in a comb-tooth-shaped structure. According to the waste crusher, along with transverse movement of the screening plate, waste originally accumulated at the inlet of the screening channel can be driven to move, the blocking phenomenon of the waste at the screening channel is reduced, and the falling position, located at the inlet of the waste crusher, of the waste is distributed more evenly; and the phenomenon that the crushing speed of the waste crusher is affected due to excessive falling of local waste is avoided.