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259results about How to "Suitable for detection" patented technology

Early B-cell detection for selecting vaccines

The present invention discloses an affinity-binding assay comprising a particle having at least four copies of a target molecule and at least two binding molecules specific for the target molecule, wherein a first of the binding molecules is associated with a first label and a second of the binding molecules is associated with a second label, wherein a particle having the first label and a particle having the second label are distinguishable from a particle having both the first and second labels, wherein the first and second binding molecules each comprise at least two binding regions specific for the target molecule. The present invention also discloses a composition comprising a first binding molecule associated with a first label and a second binding molecule associated with a second label, wherein the signal obtained from the first and second labels is distinguishable from the combined signal of the first and second labels, characterized in that the first and second binding molecules each comprise at least two binding regions specific for essentially the same target molecule, preferably for essentially the same epitope on the target molecule and a method for selecting a synthetic antigen from a collection of at least three antigens comprising using the disclosed composition and method. The invention further discloses an antigen obtainable by the above-described method and capable of inducing an early immune response, a kit of parts to perform the method, the use of antigens selected by the methods for use as a vaccine, and the use of antibodies and antigens as a medicament.
Owner:PEPSCAN SYST +1

One-dimensional organic semiconductor spiral nano-wires with fluorescence response upon organic amine gases, and preparation method and application thereof

The invention relates to one-dimensional organic semiconductor spiral nano-wires with ultra-sensitive fluorescence response upon organic amine gases, and a preparation method and an application thereof. According to the invention, perylene imide derivatives comprising perylene and with asymmetric amphiphilic substituents on two ends are adopted as construction units; in a mixed liquid of a good solvent and a poor solvent, through pi-pi interactions between perylenes of a plurality of perylene imide derivatives comprising perylene and with asymmetric amphiphilic substituents on two ends, the one-dimensional organic semiconductor spiral nano-wires are obtained through self-assembly. The one-dimensional organic semiconductor spiral nano-wires have two significant advantages of a nano-grade spiral structure and good fluorescence quantum yield (up to 25%), such that the nano-wires are suitable to be used in fluorescence detection of organic amine in air. When a network-structured porous membrane woven by using the one-dimensional organic semiconductor spiral nano-wires contacts trace amine vapour (with a concentration of ppb-ppm level), the fluorescence is quenched.
Owner:INST OF CHEM CHINESE ACAD OF SCI
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