78 results about "Immunoglobulin E" patented technology

Embodiments of the invention provide shaped masses (SM) comprising one or more drugs such as proteins or polypeptides and methods for forming and delivering such SM's. One embodiment provides a SM comprising a drug e.g., a protein or polypeptide having a biological activity in the body of a mammal. The SM is formed by compression of a precursor material (PM) comprising the drug wherein an amount of biologically active drug in the SM is a minimum level to that in the PM. Drugs which may be incorporated into the SM include insulin, incretins and immunoglobulins e.g., interleukin neutralizing antibodies or TNF-α-inhibiting antibodies. Embodiments of the invention are particularly useful for the oral delivery of drugs which would be degraded within the GI tract, wherein the SM containing the drug is formed as or incorporated into a tissue penetrating member which is inserted into the intestinal wall after oral ingestion.

The invention discloses adapter modified nano silver. A nano silver ball with the diameter of 10nm to 30nm is used as a kernel; and the outer surface of the silver ball is bonded with an adapter chain and an oligonucleotide chain. The invention also discloses a preparation method of the adapter modified nano silver, a reagent kit comprising the adapter modified nano silver, and application of the adapter modified nano silver to preparation of a reagent for detecting IgE (Immunoglobulin E). When used for carrying out the detection of IgE, the nano silver material provided by the invention has high sensitivity, short detection time (about 2h to 3h), simple and feasible operation and visual detection result; downhole semi-quantitative detection can be achieved in a visual mode without the need of an especially expensive detection apparatus; and the adapter modified nano silver has low cost, can realize bulk detection, and is suitable for popularization and utilization.

The invention discloses an immunoglobulin E immunoturbidimetry detection kit, and belongs to the technical field of clinical in-vitro detection reagents. The kit comprises a reagent R1, a reagent R2, and a calibration material. By adding a certain amount of silica coated magnetic nanoparticles into the reagent R1 and adding a certain amount of bovine serum albumin and Kathon-CG into the reagent R2, the stability and the analysis sensitivity of the kit are effectively improved, the linear range is also better, the reagent accuracy is high, and further popularization and application in markets are facilitated.

The invention discloses a marker and a primer for detecting pediatric asthma, belonging to the technical field of auxiliary diagnosis of pediatric asthma. According to the invention, the genotype of an SNP (single nucleotide polymorphisms) 290G/A site of a GATA3 gene 5' promoter region can be analyzed by adopting a PCR (Polymerase Chain Reaction) method through extracting the genomic DNA from the blood of children in an asthma group, and the relation between the 290G/A of the GATA3 gene and the Han-nationality pediatric asthma in Beijing of China is evaluated. The association research result indicates that the SNP290G/A of the GATA3 gene is associative to the pediatric asthma in Beijing area, is a high-risk factor of the pediatric asthma, and is higher in sensibility compared with the total IgE (immunoglobulin E) detected.

The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.

The present invention relates to an anti-atopic cream comprising: a first component comprising Houttuynia cordata, Acori gramineri Rhizoma, Saposhnikoviae Radix, Astragalus membranaceus Radix, Eriobotryae Folium, Sophorae flavescentis Radix, Saururus chinensis, Phellodendron bark, Centella asiatica, Arisaematis Rhizoma and Aster yomena; and a second component comprising glycerol, a caprylic or capric triglyceride, sunflower seed oil, butylene glycol, butylene glycol dicaprylate or dicaprate, macadamia seed oil, polyglyceryl-3 methylglucose distearate, PEG-4 olivate, meadowfoam seed oil, dimethicone, cetyl ethylhexanoate, oxidized corn oil, cetearyl alcohol, tocopheryl acetate, glyceryl acrylate or acrylic acid copolymer, stearyl glycyrrhetinate, sodium chloride, sodium acrylate or sodium acryloyl dimethyl taurate copolymer, algin, isohexadecane, caprylyl glycol, polysorbate 80, allantoin, caprylhydroxamic acid, propylene glycol, disodium EDTA and ceramide 3 and, in the anti-atopic cream, the first component and the second component are mixed in a weight ratio of between 5:5 and 7:3. According to the present invention, when the anti-atopic cream is applied to a DNCB induced atopic dermatitis mouse, the blood IgE is reduced and at the same time the amount of discharged histamine produced from the mast cells is suppressed, thereby making it possible to provide an anti-atopic cream having a therapeutic effect in atopic dermatitis.

Provided are methods for the detection and diagnosis of Hypothyroidism. The methods are based on the discovery that altered levels of selected analytes in sample fluid, typically blood samples, of patients are supportive of a diagnosis of Hypothyroidism. At least twenty-four new biomarkers for hypothyroidism are thus disclosed (singly or in any combination), Thyroid Stimulating Hormone, Interleukin-12p40, Tumor Necrosis Factor Alpha, Tissue Factor, Interleukin-15, Insulin, Immunoglobulin E, Growth Stimulating Hormone, Calcitonin, Prostate-Specific Antigen, Interleukin-4, Granulocyte Macrophage Colony Stimulating Factor, Matrix Metalloproteinase 9, Lymphotactin, Fatty Acid Binding Protein, Alpha Fetoprotein, Alpha-2 Macroglobulin, Serum Glutamic Oxaloacetic Transaminase, Matrix Metalloproteinase 3, Cancer Antigen 125, Mumps Antibody, Double Stranded DNA Antibody, Proliferating Cell Nuclear Antigen Antibody, Smith Antibody, or Herpes Simplex Virus 1 Glycoprotein D Antibody. Altogether the concentrations of one or more of these analytes, as well as Thyroid Stimulating Hormone, or any combination thereof, provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering from Hypothyroidism. Kits containing reagents to assist in the analysis of fluid samples are also described.

The invention provides a test strip for screening specific animal fur and scurf allergens IgE (Immunoglobulin E). The test strip is coated with an animal fur and scurf antigen marked by colloidal gold. The test strip utilizes a colloidal gold marking technology; firstly, the colloidal gold mark is used for marking the specific animal fur and scurf allergens; then the marked allergens are uniformly sprayed on a cellulose acetate membrane or a nitrocellulose membrane to prepare a test strip product to carry out allergen detection; the test strip is simple and convenient to operate, accurate in result and low in cost and can realize multi-term free detection.

The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.

The invention provides a test strip for screening specific aquatic products allergens IgE (Immunoglobulin E). The test strip is coated with an aquatic products antigen marked by colloidal gold. The test strip utilizes a colloidal gold marking technology; firstly, the colloidal gold mark is used for marking the specific aquatic products allergens; then the marked allergens are uniformly sprayed on a cellulose acetate membrane or a nitrocellulose membrane to prepare a test strip product to carry out allergen detection; the test strip is simple and convenient to operate, accurate in result and low in cost and can realize multi-term free detection.

The invention discloses a kit and method for detecting STAT3 gene mutation of high IgE (Immunoglobulin E) syndrome. The kit comprises (i) a blood DNA (Deoxyribonucleic Acid) extraction reagent; (ii) PCR (Polymerase Chain Reaction) amplification reaction liquid for detecting a system; (iii) a reagent for sequencing the system; wherein primers comprise amplification primers and sequencing primers for amplifying whole exon sequences of STAT3 genes. In addition, a Sanger sequencing technology is used. According to the method disclosed by the invention, the mutation of whole exons of the STAT3 genes in the body of a patient with the high IgE syndrome can be quickly detected out. The detecting results obtained by through the invention can be used for assisting in diagnosis of the high IgE syndrome, which has an important reference significance for early intervention and early treatment.

The invention provides a test strip for screening specific tetanus antitoxin allergen IgE (Immunoglobulin E). The test strip is coated by a tetanus antitoxin antigen labeled by colloidal gold. The colloidal gold labelling technology is utilized in the invention; the specific tetanus antitoxin allergen is labelled by using colloidal gold for the first time; then, the labelled allergen is uniformly sprayed on a cellulose acetate membrane or a nitrocellulose membrane, therefore, the test strip is prepared for detecting allergens; the test strip disclosed by the invention is simple and convenient to operate, accurate in result and low in cost; and a number of free tests can be realized.

The invention provides a test strip for screening specific albumen allergens IgE (Immunoglobulin E). The test strip is coated with an albumen antigen marked by colloidal gold. The test strip utilizes a colloidal gold marking technology; firstly, the colloidal gold mark is used for marking the specific albumen allergens; then the marked allergens are uniformly sprayed on a cellulose acetate membrane or a nitrocellulose membrane to prepare a test strip product to carry out allergen detection; the test strip is simple and convenient to operate, accurate in result and low in cost and can realize multi-term free detection.

The invention provides a test strip for screening specific fruits allergens IgE (Immunoglobulin E). The test strip is coated with a fruits antigen marked by colloidal gold. The test strip utilizes a colloidal gold marking technology; firstly, the colloidal gold mark is used for marking the specific fruits allergens; then the marked allergens are uniformly sprayed on a cellulose acetate membrane or a nitrocellulose membrane to prepare a test strip product to carry out allergen detection; the test strip is simple and convenient to operate, accurate in result and low in cost and can realize multi-term free detection.