46 results about "Pediatric asthma" patented technology

The invention provides a novel method of treating respiratory diseases, e.g., pediatric asthma, in a continuing regimen with not more than one daily dose of the drug budesonide using a nebulizer.

The present invention relates to an albuterol inhalation solution, system, kit and method for relieving bronchospasm in children suffering from asthma. In one alternative embodiment, the solution of the present invention is a sterile, premixed, premeasured single unit dose of albuterol for asthmatic patients 2 to 12 years of age. The present solution may be free of anti-microbial preservatives, such as benzalkonium chloride. In another alternative embodiment, the solution of the present invention comprises about 0.63 mg or about 1.25 mg albuterol.

The present invention relates to an albuterol inhalation solution, system, kit and method for relieving bronchospasm in children suffering from asthma. In one alternative embodiment, the solution of the present invention is a sterile, premixed, premeasured single unit dose of albuterol for asthmatic patients 2 to 12 years of age. The present solution may be free of anti-microbial preservatives, such as benzalkonium chloride. In another alternative embodiment, the solution of the present invention comprises about 0.75 mg or about 1.5 mg albuterol sulfate.

The present invention relates to an albuterol inhalation solution, system, kit and method for relieving bronchospasm in children suffering from asthma. In one alternative embodiment, the solution of the present invention is a sterile, premixed, premeasured single unit dose of albuterol for asthmatic patients 2 to 12 years of age. The present solution may be free of anti-microbial preservatives, such as benzalkonium chloride. In another alternative embodiment, the solution of the present invention comprises about 0.63 mg or about 1.25 mg albuterol.

The invention discloses a marker and a primer for detecting pediatric asthma, belonging to the technical field of auxiliary diagnosis of pediatric asthma. According to the invention, the genotype of an SNP (single nucleotide polymorphisms) 290G/A site of a GATA3 gene 5' promoter region can be analyzed by adopting a PCR (Polymerase Chain Reaction) method through extracting the genomic DNA from the blood of children in an asthma group, and the relation between the 290G/A of the GATA3 gene and the Han-nationality pediatric asthma in Beijing of China is evaluated. The association research result indicates that the SNP290G/A of the GATA3 gene is associative to the pediatric asthma in Beijing area, is a high-risk factor of the pediatric asthma, and is higher in sensibility compared with the total IgE (immunoglobulin E) detected.

The invention discloses a traditional Chinese medicinal formula for treating children asthma. The formula comprises 5 to 8 g of mix-fried ephedra stem, 6 to 8 g of mulberry bark, 6 to 8 g of almond, 6 to 8 g of perillaseed, 25 to 40 g of gypsum, 6 to 8 g of pinellia ternate, 6 to 8 g of root of large-flowered skullcap, 6 to 8 g of balloonflower root, 6 to 8 g of Indian bread, 6 to 8 g of dried orange peel, 30 to 35 g of cordate houttuynia and 3 to 4 g of licorice. In the formula, mix-fried ephedra stem can disperse lung qi and relieve both asthma and exterior syndromes; pinellia ternate and perillaseed can depress qi, calm panting, relieve cough and reduce phlegm; the amount of gypsum is five times more than mix-fried ephedra stem, and gypsum can inhibit sweating and highlight the effects of lung diffusing and panting calming; cordate houttuynia, mulberry bark and root of large-flowered skullcap can clear lung-heat, and mulberry bark and root of large-flowered skullcap have the effects of cough relieving and panting calming; almond can disperse lung qi, descend adverse qi and calm panting; dried orange peel can rectify qi and transform phlegm; balloonflower root can diffuse lung qi and dispelling phlegm; licorice can relieve cough and resolve phlegm; and Indian bread can promote diuresis and clear dampness. The medicine provided in the invention has the advantages of a short treatment course, fast action, no toxic and side effects and no damage to immune system of children and enables children asthma not to easily recur.

The invention relates to one natural therapy, relates to the field of traditional Chinese medicine science, and particularly relates to an externally-applied method of a traditional Chinese medicine capable of treating pediatric asthma. The externally-applied method comprises the steps of selecting 30 g of high-quality semen brassicae, 30 g of rhizoma corydalis, 15 g of gansui root, 15 g of herba asari and 9 g of earthworm, making the above raw materials into medicine cakes; incorporating 6 g of clove and 6 g of cortex cinnamomi; applying the medicine at three pairs of points of Dingchuan, Feishu and Gaomang; applying the medicine for 2 hours every time; during a diseased period, applying the medicine one time ever other five days and applying the medicine for 3 times in total; and during a remission period, applying the medicine one time ever other seven days and applying the medicine for 5 times in total. The externally-applied method is simple and practical in treating the pediatric asthma, causes small pains, has the advantages of wide application symptoms, good curative effect, low cost and few side effects, and is a promising method of the natural therapies. Therefore, the externally-applied method has prospects of entering in homes, moving toward the world and benefiting the humanity.

The invention discloses a traditional Chinese medicine preparation used for treating children asthma. The traditional Chinese medicine is prepared from Chinese herbal medicines of, by weight: 5 to 6 parts of fructus perillae, 5 to 6 parts of asiatic plantain seed, 6 to 8 parts of Chinese magnoliavine fruit, 3 to 5 parts of pinellia tuber, 3 to 6 parts of stiff silkworm, 2 to 4 parts of balloonflower root, 2 to 4 parts of saxifraga stolonifera, 2 to 4 parts of swollen furuncle, 3 to 5 parts of bignose rhinacanthus branchlet and leaf, 3 to 6 parts of ovate tylophora root and rhizome, 2 to 6 parts of Indian azalea, and 2 to 4 parts of oyster plant flower. According to the formula, fructus perillae, asiatic plantain seed, and Chinese magnoliavine fruit are adopted as monarch drugs; pinellia tuber and stiff silkworm are adopted as minister drugs; balloonflower root, saxifraga stolonifera, and swollen furuncle are adopted as assistant drugs; and bignose rhinacanthus branchlet and leaf, ovate tylophora root and rhizome, Indian azalea, and oyster plant flower are adopted as guide drugs. The traditional Chinese medicine is easy to prepare and to use. The traditional Chinese medicine is safe, and brings no side-effect. With the medicine, the treatment cost is low. The traditional Chinese medicine is an ideal medicine used for treating children asthma.

The invention belongs to the field of gene detection, and particularly relates to a gene detection kit for individualized medication of children asthma and application of the gene detection kit. The kit mainly comprises a primer mixed solution, a multiple PCR library amplification buffer solution, a digestion buffer solution, a connection buffer solution, ligase, a specific joint, a HiFi library amplification buffer solution, a positive/negative quality control product, a report system and a description. The kit can be used for detecting common asthma-relieving medicines for children, and has 31 genes and 41 gene polymorphic sites; and related gene detection and report analysis for predicting the curative effect and the adverse reaction of the children asthma medicines are realized, and recommendation is provided for medication of clinicians.

The invention relates to gene single nucleotide polymorphic sites related to asthma, a kit for treating asthma and an application of the kit. By carrying out genetic typing and single point and high order interaction and multi-site synergistic effect analysis on nine gene single nucleotide polymorphic sites, the result verifies that IL13 R110Q G, IL4-590C>T T, ADRB2 R16G A and FcER1B E237G G which are related to asthmatic pathogenesis of Chinese Han children are respectively risk alleles, and the risk factor of suffering from asthma by carrying four risk allele homozygotes is greatly improved; IL13 R110Q G, IL4-590C>T T, ADRB2 R16G A and FcER1B E237G G have a remarkable synergistic effect on risk of asthmatic pathogenesis. A reagent for detecting the four sites can be used for predicting asthma of Chinese Han children.

The invention relates to a kit for Chinese pediatric asthma susceptibility gene SNP (single nucleotide polymorphism) genotyping and an application method of the kit for Chinese pediatric asthma susceptibility gene SNP genotyping, in particular to a kit for simultaneous qualitative genotyping of nine SNP loci of eight Chinese pediatric asthma susceptibility genes and an application method of the kit for simultaneous qualitative genotyping of the nine SNP loci of the eight Chinese pediatric asthma susceptibility gene. Genotypes of the nine SNP loci are obtained simultaneously by taking an rs1042713 locus of an ADRB2 gene, an rs1805010 locus of an IL-4R alpha gene, an rs20541 locus of an IL-13 gene, an rs1800925 locus of the IL-13 gene, an rs2495636 locus of an IL-13R alpha gene, an rs2243250 locus of an IL-4 gene, an rs1800629 locus of a TNF-alpha gene, an rs569108 locus of an MS4A2 gene and an rs528557 locus of an ADAM33 gene as detection objects, designing amplification primers and extension primers respectively aiming at mutation of the nine SNP loci, performing multiplex PCR (polymerase chain reaction) amplification and marker extension aiming at the nine SNP loci, and performing capillary electrophoresis. The kit for SNP genotyping is convenient to use, simple to operate, low in cost, high in flux and direct and reliable in detection results and is applicable to large-scale screening of Chinese pediatric asthma susceptibility gene SNP genotyping.

The invention discloses a volatile oil-containing traditional Chinese medicine composition for treating pediatric asthma. The traditional Chinese medicine composition is mainly prepared from the following raw materials in parts by weight: 2 parts of ephedra herb, 3-4 parts of semen armeniacae amarum, 3-4 parts of semen raphani, 3-4 parts of fructus perillae, 1-2 parts of semen brassicae, 3-4 parts of semen lepidii, 2 parts of rhizoma zingiberis, 2 parts of semen persicae, 2-3 parts of earthworm and 2-3 parts of bunge pricklyash seed. The preparation method comprises the following steps: (1) weighing the raw material medicines according to the weight part, adding water into the weighed raw material medicines, wherein the adding amount of the water is 8-12 times of the weight of the raw material medicines; extracting for twice, wherein the extraction of each time lasts for 60-90min; mixign decoction liquid, filtering out, and carrying out concentration under reduced pressure on filtrate; (2) when water decoction and extraction are carried out, collecting volatile oil and aromatic water mixture which are produced in a water decoction process, coating with auxiliary materials, then fully mixing the product with extracts obtained by means of water decoction so as to obtain a mixture. Pharmacological research proves that the traditional Chinese medicine composition has the functions of relieving cough and asthma, relieving bronchial spasm and adjusting immunological imbalance.

The invention relates to a self-adjusting pediatric asthma therapeutic apparatus which comprises a mask, an atomization cavity is connected to the mask, a first partition plate is arranged in the atomization cavity in a universal sliding fit mode, an air duct is arranged in the first partition plate, an atomization mechanism is connected to the air duct, and through universal connection of the first partition plate and the atomization cavity, when a patient wears the device, the atomization mechanism can be used for atomization. According to the device, the atomization cavity can be kept in a vertical state unintentionally, so that the applicability of the device is improved, the device is more suitable for a child patient to use, the device further comprises a valve mechanism for sealing the atomization cavity and a ventilation triggering mechanism for controlling the valve mechanism, and the atomization cavity is sealed by a valve when the patient exhales; the atomization cavity is allowed to atomize liquid medicine only when a patient inhales, airflow entering the air duct is enhanced through the arranged air bellow, and therefore the atomization efficiency of the device is improved when the patient inhales, waste of the liquid medicine is avoided, and the device is simple in structure, safe and effective.

The invention relates to traditional Chinese medicine composition for treating pediatric asthma in paracmasia. The traditional Chinese medicine composition is prepared by the following APIs(Active Pharmaceutical Ingredients) in parts by weight: 4-8 parts of semen brassicae, 4-8 parts of rhizoma corydalis, 2-4 parts of angelica dahurica, 2-4 parts of euphorbia kansui, 2-4 parts of asarum sieboldii, 2-20 parts of fresh ginger, 2-20 parts of syzygium aromaticum and 2-20 parts of cinnamomum cassia. The invention also relates to the application of the traditional Chinese medicine composition for treating the pediatric asthma in paracmasia. The traditional Chinese medicine composition disclosed by the invention has the advantages that 1, the preparation technology is simple, the total effective rate is high, and the use is convenient; 2, the blood serum EOS level can be reduced, the chronic inflammation in bronchus can be relived, and the occurrence and the development of asthma can be effectively reduced; 3, the lung function index of a children patient can be improved, resistance in an airway of the children patient can be reduced, and the asthma attacking degree can be reduced; 4, the syndrome integral of the children patient can be reduced, the asthma attacking frequency can be reduced, the living quality of the children patient can be obviously improved, and certain function for regulating biased constitution of the children patient can be obtained; 5, no wound can be generated, no toxic and side effects are generated, the asthma attacking can be delayed, the attacking degree can be relieved, and the living quality of the patient can be increased.

The invention relates to a marker for detecting pediatric asthma, belonging to the field of auxiliary diagnosis of pediatric asthma. The amplified product of semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) or real-time quantitative PCR is adopted as the marker, and is a specific primer aiming at a transient receptor potential vanilloid 2 (TRPV2) gene sequence; an amplification template is total RNA extracted from peripheral blood lymphocyte of a child and is transformed into cDNA by reverse transcription; and the amplified product has the length of 578bp and 95bp. When being used for detecting the TRPV2 gene expression level in the peripheral blood lymphocyte of the child in the asthma group, the marker is higher in sensitivity compared with detection of total IgE.

The invention discloses an application of a protein combined marker in preparation of a children asthma diagnostic reagent. The protein marker comprises protein apolipoprotein C3, apolipoprotein E andserum amyloid protein A. The protein combined type children asthma diagnostic reagent is simple to prepare and simple and easy to sample and detect, is capable of achieving quantitative detection, issmall in sample amount, high in diagnosis sensitivity and high in specificity, and is capable of achieving high-throughput detection.

The invention discloses application of LINC01503 serving as therapeutic target to preparation of medicines for treatment of pediatric asthma. According to comparison between LINC01503 and a normal control, expression of LINC01503 in asthma patients is increased remarkably; LINC01503 in M1 macrophage is evidently down-regulated while LINC01503 in M2 macrophage is evidently up-regulated. According to siRNA knock-down experiments, LINC01503 promotes activation of M1 macrophage and realizes expression up-regulation of M1 marker genes such as IL-6, TNF-alpha and CXCL10; LINC01503 inhibits activation of M2 macrophage and realizes expression down-regulation of M2 marker genes such as CD206 and CD209. By Western blot, the fact that LINC01503 has influences on macrophage activation mainly through promotion of EPK phosphorylation, so that pediatric asthma can be effectively treated by inhibition of LINC01503 and downstream signal routing thereof.

The invention discloses a reagent and reagent kit for detecting children asthma based on a GLCCI1 gene rs37969 site and an application. The reagent comprises a PCR reaction system, an SAP reaction system and an iPLEX extension system. The reagent kit comprises the reagent. The reagent is applied to preparation of the reagent kit for predicting the risk that children suffer from the asthma through the steps of performing PCR amplification, performing an SAP reaction, performing iPLEX extension, and performing gene sequencing, wherein if a genotype at the GLCCI1 gene rs37969 site is GG, the risk that the children generate asthma before 6 years old is small, if the genotype is TT, the children are susceptible crowds of the asthma and the risk that the children before 6 years old generate the asthma is increased, after ICS treatment, MMEF improvement or PD20 improvement is small, if the genotype is GT, the risk that the children before 6 years old generate the asthma is increased, and after ICS treatment, MMEF improvement or PD20 improvement is small. The reagent disclosed by the invention can be used for performing early genetics prediction on the generation of the asthma.

The invention discloses a traditional Chinese medicine composition for treating pediatric asthma. The traditional Chinese medicine composition is prepared from raw traditional Chinese medicinal materials and medicinal auxiliaries, wherein the raw traditional Chinese medicinal materials comprises the following components in parts by weight: 30-42 parts of rhizoma fagopyri dibotryis, 15-26 parts of folium mori, 21-30 parts of bamboo leaves, 21-30 parts of lotus leaves, 5-8 parts of fructus schisandrae chinensis, and 6-12 parts of semen raphani. Verified by clinical application, the traditional Chinese medicine composition is obvious in curative effect, reliable in action, mild in drug properties, free from toxic and side effects, the asthma symptoms of pediatric patients are completely relieved after one to two courses administration, neither cough nor asthma exits, and the lung auscultation is normal.

The invention belongs to the technical field of medicament preparation and discloses a medicament for assisting pediatric asthma rehabilitation and a preparation method and device thereof. The medicament for assisting pediatric asthma rehabilitation is used for lung-heat cough and asthma. An adult usually takes the medicament 20 ml every time three times a day, and the amount is reduced accordingto conditions of children; 5-7 days form a course of treatment, and the medicament is taken for two courses of treatment at most. The preparation device is provided with a machine boxy, a water injection pipe is sleeved with the machine box, and a medicine tank is in pin connection with the right end of the water injection pipe. A water injection port and a medicine discharge port are separated sothat the blending proportion can be more accurately adjusted, and pharmacy is more precise and scientific; the heating temperature can be adjusted, the frequency of the stirring rotating speed can beadjusted, and the medicine effect of medicinal materials can be more fully exerted; a plurality of irrigation pipes are arranged so that multiple bottles of medicaments can be simultaneously irrigated, and the preparation efficiency is greatly improved; the medicament plaster uses medicament and seasonal bias, tepid properties are used for treating some diseases with cold syndromes, the effect ofconquering cold with yang is achieved to the largest extent, and the effect of treating both symptoms and root causes is achieved.

The invention discloses a medicament for assisting pediatric asthma rehabilitation. The medicament is prepared from the following components: radix astragali, radix salviae miltiorrhizae, rhizoma dioscoreae, radix isatidis, radix paeoniae alba, radix platycodonis, sandalwood, radix scutellariae, radix glycyrrhizae, schisandra chinensis, rhizoma dioscoreae, cordyceps sinensis, folium eriobotryae, arillus longan, pericarpium citri tangerinae, vegetable oil, fructus jujubae, venenum apis, a plant concentrated solution, a flavoring agent and vitamins. The weight parts of the components are as follows in parts by weight: 10 to 15 parts of radix astragali, 10 to 15 parts of radix salviae miltiorrhizae, 10 to 15 parts of rhizoma dioscoreae and 10 to 15 parts of radix isatidis. The medicament is mainly prepared from radix astragali, radix salviae miltiorrhizae, rhizoma dioscoreae, radix isatidis, radix paeoniae alba, radix platycodonis, sandalwood, radix scutellariae, radix glycyrrhizae, schisandra chinensis, rhizoma dioscoreae, cordyceps sinensis, folium eriobotryae, arillus longan, pericarpium citri tangerinae, vegetable oil, fructus jujubae, venenum apis and the plant concentrated solution, so that the purposes of pure nature, no additive and high-efficiency treatment of asthma can be achieved. Meanwhile, the vitamins, the flavoring agent, the vegetable oil, the red dates and the bee venom are added in an auxiliary manner, and then the medicament has sour and sweet taste while the vitamin content in the bodies of children is supplemented, so that the children can take the medicament more easily, and the treatment effect is guaranteed.

The invention discloses a medicine suction device for pediatric asthma treatment. The device comprises a medicine outlet end which is of an existing nipple structure, and a round through hole is formed in the center of the medicine outlet end in a penetrating manner; an atomizing part comprises an air blowing part and a venturi tube part, the air blowing part comprises an annular shell, the venturi tube part is fixedly arranged on one side of the annular shell, an air blowing pipe is arranged in the annular shell, one end of the air blowing pipe penetrates through the annular shell and is fixedly connected and communicates with the venturi tube part, the venturi tube part is fixedly connected with a conveying tube, and the other end of the conveying tube is inserted into the medicine outlet end so that atomized medicine liquid atomized through the venturi tube part can be sucked in through the medicine outlet end. The medicine suction device does not need to depend on electric energy or compressed gas for atomization and can assist infants in breathing, the medicine suction effect is guaranteed, meanwhile, the breathing assisting intensity can be determined by a user according to the situation, and the good treatment effect is achieved.