The present invention provides compositions and related methods for treating
interleukin-5 (IL-5) mediated diseases in children. [Solution] A method for treating a
disease in a child, comprising the steps of: a) identifying a child weighing less than 40 kg who has a
disease selected from the group consisting of
asthma, mild
asthma, moderate
asthma,
severe asthma, mild eosinophilic asthma, moderate eosinophilic asthma, severe eosinophilic asthma, poorly controlled eosinophilic asthma, etc.; and b) subcutaneously administering a therapeutically effective
dose of mepolizumab to the child, wherein the therapeutically effective
dose of the
antibody results in a maximum
plasma concentration (Cmax) of
antibody of approximately 10.1960 ± 0.3345 μg / mL and an
area under the curve [0-infinity] value of approximately 454.39 ± 15.8876 μg* / mL, thereby treating the
disease in the child.