39 results about "AMBROXOL HYDROCHLORIDE" patented technology

The invention relates to an ambroxol hydrochloride oral solution which is prepared from the following raw and auxiliary materials in parts by weight: 0.3-0.6 part of ambroxol hydrochloride; 0.04 to 0.06 part by weight of benzoic acid; 0.3 to 0.6 part by weight of hydroxyethyl cellulose; 0.08 to 0.2 part by weight of sucralose; 0.15 to 0.4 part by weight of essence; and the balance of purified water. The preparation method comprises the following steps: S1, adding a base solution; S2, adding ingredients; and S3, filtering. The preparation method comprises the following steps: S1, hydroxyethyl cellulose pretreatment; S2, mixing; S3, seasoning; and S4, packaging. The invention provides an ambroxol hydrochloride oral solution and a preparation method thereof. The ambroxol hydrochloride oral solution is good in taste, high in stability and high in patient compliance. And the production process is simple, stable, controllable and easy to industrialize.

The invention discloses an ambroxol hydrochloride liquid filling detection method and system, and relates to the technical field of filling detection.The method comprises the steps that after ambroxol hydrochloride liquid filling is completed, a filling bottle is clamped to the position in front of a black background plate through a mechanical arm, a light source is controlled to collect a first to-be-detected image based on a first preset illumination parameter, and the first to-be-detected image is obtained; clamping the filling bottle to the front of the white background plate through a mechanical arm, and controlling the light source to collect a second to-be-detected image based on a second preset illumination parameter; processing the first preset illumination parameter to obtain a first coded image; processing the second preset illumination parameter to obtain a second coded image; and performing deviation analysis, and when the identifier is a difference identifier, generating an abnormal identifier, and sending the abnormal identifier to the user side. The technical problem that in the prior art, after ambroxol hydrochloride liquid is filled, the abnormal filling condition is difficult to accurately detect is solved, and the technical effects that the abnormal filling condition is effectively detected, and the product filling quality is guaranteed are achieved.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an ambroxol hydrochloride-containing oral liquid and application thereof, and the ambroxol hydrochloride oral liquid is composed of ambroxol hydrochloride, ligustrazine, meglumine, dextran 40, xylitol, carboxymethylcellulose, L-tryptophan, stevioside and purified water. The ligustrazine and the ambroxol hydrochloride play a synergistic effect, and the meglumine and the dextran 40 are combined for use, so that the stability of the ambroxol hydrochloride is improved. Accelerated experiments show that the ambroxol hydrochloride is stable in property and suitable for further industrial mass production.

The present invention relates to the field of pharmaceutical preparations, and particularly to an ambroxol hydrochloride solution, a preparation method thereof and an application thereof. In the present invention, diethylenetriaminepentaacetic acid is used as a stabilizer component of the ambroxol hydrochloride solution in a relatively small amount. Diethylenetriaminepentaacetic acid has strong coordination ability and can interact with other molecules in the solution, thereby greatly improving the stability of the ambroxol hydrochloride solution. The preparation method provided by the present invention is simple and easy to operate, does not require a light-proof environment, has low production cost, and is easy to industrialize. When the ambroxol hydrochloride solution provided by the present invention is used alone or applied to an inhalation preparation, no preservative component needs to be added, the quality is reliable, the safety is good, and it is more suitable for clinical use requirements.

The invention relates to the technical field of cell separation and extraction, and provides a method for extracting extracellular vesicles from induced sputum. Comprising the following steps: S1, atomizing and collecting induced sputum, picking out sputum plugs, and adding an isotonic phosphate buffer solution which contains 0.1 wt% of drocisteine and 0.1 wt% of tween-20 and has the pH value of 6.0 for dissolving, so as to obtain an induced sputum dissolving solution rich in extracellular vesicles; wherein the dissolving temperature is 37 + / -0.1 DEG C, and digestion is performed for 15 + / -1 min under the condition that the rotating speed of a shaking table is 50 + / -1 rpm; and S2, extracting the extracellular vesicles from the induced sputum dissolving solution through a negative pressure size exclusion chromatography method. According to the invention, the multi-component dissolving agent of the hydroxymethylsteine and the Tween-20 is adopted to promote the dissolving of sputum and protect protein and nucleic acid in extracellular vesicles from being degraded; the negative pressure size exclusion chromatography can accurately control the flow velocity driven by negative pressure, ensures stable migration of extracellular vesicles in a chromatographic column, and avoids vesicle rupture caused by too fast flow velocity or low separation efficiency caused by too slow flow velocity.

The application provides an ambroxol oral dissolving film composition, a preparation method and application thereof. The ambroxol oral dissolving film composition comprises an active drug, a film forming material and a taste masking agent, and the active drug is 2-amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl) benzylamine and / or a pharmaceutically acceptable salt thereof, for example, ambroxol hydrochloride. The ambroxol oral dissolving film composition provided by the application has the advantages of thin thickness, good taste, stable properties, immediate dissolution in the oral cavity without drinking water, and fast oral absorption speed. Moreover, the ambroxol oral dissolving film composition has the advantages of simple process, high drug loading, good drug content uniformity, and good market prospect.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a pharmaceutical composition containing ambroxol and application of the pharmaceutical composition to children asthma. The pharmaceutical composition containing ambroxol is prepared from the following components in parts by weight: 10 to 30 parts of ambroxol hydrochloride and 30 to 60 parts of fructus polygoni orientalis extract. The ambroxol hydrochloride and the fructus polygoni orientalis extract are combined to form the novel pharmaceutical composition, and animal experiments show that the pharmaceutical composition can remarkably reduce the airway sensitivity of rats and reduce the IL-4 and IgE levels in serum of the rats.

The invention discloses an ambroxol hydrochloride preparation composition and a preparation method thereof, the ambroxol hydrochloride preparation composition contains hydroxyethyl cellulose, and the weight-average molecular weight of the hydroxyethyl cellulose is selected from 900000 to 1100000. By improving the prescription raw materials and the prescription process, the production equipment requirement and cost are greatly reduced while the product quality is ensured, and the preparation method is very suitable for large-scale industrial production.

The invention discloses a production process of an ambroxol oral solution, and belongs to the technical field of chemical medicinal preparations, the production process comprises the following steps: adding an aqueous solution containing ambroxol hydrochloride, clenbuterol hydrochloride, sorbitol, propylene glycol, glycerol, hydroxyethyl cellulose, DL-tartaric acid and sodium benzoate into a reaction kettle, and uniformly stirring to obtain the ambroxol hydrochloride oral solution, the clenbuterol hydrochloride, the sorbitol, the propylene glycol, the glycerol, the hydroxyethyl cellulose, the DL-tartaric acid and the sodium benzoate; the preparation method comprises the following steps: preparing in a production system passivated by hydroxyethyl diamine tetraacetic acid trisodium salt, treating by a two-stage series hollow membrane contactor, and finally filling a glass bottle with a liquid medicine. According to the preparation method disclosed by the invention, on the basis of prescription adjustment without adding antioxidants such as sodium pyrosulfite and the like, the impurities of the medicine in the production and storage processes are obviously reduced, the product stability and the clinical medication safety are improved, and the preparation process is simple and stable to operate and suitable for industrial production.

The invention discloses an HPLC (High Performance Liquid Chromatography) detection method for sucralose, sorbitol and cane sugar in an ambroxol hydrochloride oral solution. The HPLC detection method comprises the following steps: a, preparing a reference substance solution; b, preparing a test solution; c, respectively sucking the reference solution and the test solution and injecting into an HPLC-ELSD (High Performance Liquid Chromatography-Evaporative Light Scattering Detector); chromatographic conditions are as follows: a chromatographic column: a C18 column is connected in series with an amino column; and the mobile phase is 65% acetonitrile aqueous solution. The method is rapid, efficient and high in sensitivity, sucralose, sorbitol and cane sugar in the ambroxol hydrochloride oral solution can be accurately quantified at the same time, a simple and accurate method is provided for detection of the ambroxol hydrochloride oral solution, the quality of the ambroxol hydrochloride oral solution is guaranteed, a scientific basis is provided for clinical application of the ambroxol hydrochloride oral solution, and the method is worthy of popularization and application. Good application prospects are realized.

The invention relates to the field of pharmaceutical preparations, in particular to an ambroxol hydrochloride solution and a preparation method and application thereof. According to the invention, the diethylenetriaminepentaacetic acid is used as a stabilizer component of the ambroxol hydrochloride solution in a small amount, and the diethylenetriaminepentaacetic acid has strong coordination ability and can interact with other molecules in the solution, so that the stability of the ambroxol hydrochloride solution is greatly improved. The preparation method provided by the invention is simple and easy to operate, does not need a dark environment, is low in production cost and is easy for industrial production. The ambroxol hydrochloride solution provided by the invention does not need to be added with preservative components or when the ambroxol hydrochloride solution is applied to an inhalation preparation, is reliable in quality and good in safety, and is more suitable for clinical use requirements.

The invention discloses a porous core-shell microsphere with thermosensitivity and acid responsiveness and a preparation method of the porous core-shell microsphere, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: S1, carrying out a reaction on hyaluronic acid and 3, 3 '-dithiobis (propionyl hydrazide) to obtain hydrazide modified hyaluronic acid HA-TPH; s2, another part of hyaluronic acid is taken and modified with sodium periodate, and oxidized modified hyaluronic acid HA-CHO is obtained; s3, dissolving HA-TPH in water, and adding beclomethasone dipropionate to obtain a solution A; dissolving HA-CHO in water, and adding beclomethasone dipropionate to obtain a solution B; s4, the solution A and the solution B are mixed and then dropwise added into vegetable oil, and spherical gel particles are prepared through an emulsification method; s5, dissolving the shell layer material in dichloromethane, and then adding ambroxol hydrochloride and the gel particles to form an electronic injection suspension; and S6, preparing the porous core-shell microspheres by adopting a uniaxial electronic injection method. The microspheres prepared by the invention have both thermosensitivity and acid responsiveness, and the problems of inaccurate release, low utilization rate and the like of the traditional dosage form are solved.

The invention discloses a composition for treating idiopathic pulmonary fibrosis and a preparation method and application thereof. The composition for treating idiopathic pulmonary fibrosis is formed by mixing baicalin nanocrystals and ambroxol hydrochloride, and is prepared into various medical dosage forms through a conventional method, including oral preparations such as tablets, capsules, granules or oral liquid. The composition can remarkably improve rat idiopathic pulmonary fibrosis caused by bleomycin sulfate, relieve the symptom of rat pulmonary fibrosis by reducing the inflammatory factor content, the total protein content and collagen deposition, and improve the oral bioavailability of the monomer baicalin. The traditional Chinese medicine composition is suitable for preventing and treating idiopathic pulmonary fibrosis.

The present application relates to the technical field of nucleic acid extraction and purification, and particularly relates to a DNA and RNA co-extraction reaction reagent and an extraction method, the reaction reagent comprising a nucleic acid protective agent RP, a sample lysis and binding liquid LB, a protein washing liquid WB1, a nucleic acid rinsing liquid WB2, and a nucleic acid elution liquid EB; the nucleic acid protective agent RP comprising DTT, mercaptoethanol, TCEP, and sodium hydroxide; the sample lysis and binding liquid LB comprising Tris-HCl, benzenesulfonic acid, sodium citrate, guanidine hydrochloride, guanidine isothiocyanate, guanidine thiocyanate, urea, triton X-100, SDS, potassium chloride, sodium chloride, bromhexine, N-acetylcysteine, ambroxol hydrochloride, isopropyl alcohol, and anhydrous ethanol; the protein washing liquid WB1 comprising Tris-HCl, benzenesulfonic acid, sodium citrate, guanidine hydrochloride, guanidine isothiocyanate, guanidine thiocyanate, urea, triton X-100, sodium chloride, isopropyl alcohol, and anhydrous ethanol; the nucleic acid rinsing liquid WB2 comprising Tris-HCl, sodium chloride, isopropyl alcohol, and anhydrous ethanol; and the nucleic acid elution liquid EB being nuclease-free water; the reagent can rapidly and fully enrich and purify DNA and RNA of a sample simultaneously.

The invention provides an ambroxterol composition and a preparation process thereof, and particularly relates to the field of medicines. Each milliliter of the liquid preparation comprises 1-2mg of ambroxol hydrochloride, 0.5-1.5 [mu] g of clenbuterol hydrochloride, 10-20mg of sodium hydrogen sulfite, 1-4mg of hydroxyethyl cellulose and purified water. The toothpaste further comprises 243-247 mg of an amorphous sorbitol solution, 3-5 mg of pomegranate essence, 148-152 mg of glycerin, 1-3 mg of sodium benzoate and a proper amount of DL-tartaric acid. According to the preparation disclosed by the invention, the increase of an impurity B can be inhibited by adding sodium hydrogen sulfite, and the increase of an ambroxol impurity 14 and an unknown single impurity can be reduced by reducing the dosage of hydroxyethyl cellulose, so that the drug stability is improved.

1. The name of the design product: packaging box (ambroxol hydrochloride oral solution). 2. The use of the design product: for product packaging. 3. The design points of the design product: in the combination of shape and pattern. 4. The picture or photo that best indicates the design points: front view.

1. The name of the product of this design: packaging box (Ambroxol Hydrochloride Injection). 2. Purpose of this design product: used for medicine packaging boxes. 3. The design key point of this appearance design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: main view. 5. The design for which protection is sought includes color.

1. The name of the product of this design: packaging box (Ambroxol Hydrochloride Oral Solution). 2. Purpose of this design product: This design product is used for product packaging. 3. The design key point of this appearance design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The application provides an ambroxol oral dissolving film composition, a preparation method and application thereof. The ambroxol oral dissolving film composition comprises an active drug, a film forming material and a taste masking agent, and the active drug is 2-amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl) benzylamine and / or a pharmaceutically acceptable salt thereof, for example, ambroxol hydrochloride. The ambroxol oral dissolving film composition provided by the application has the advantages of thin thickness, good taste, stable properties, immediate dissolution in the oral cavity without drinking water, and fast oral absorption speed. Moreover, the ambroxol oral dissolving film composition has the advantages of simple process, high drug loading, good drug content uniformity, and good market prospect.

This invention relates to an ambroxol oral solution. Specifically, this invention provides an ambroxol oral solution comprising ambroxol hydrochloride, clenbuterol hydrochloride, sucralose, mannitol, trehalose, hydroxyethyl cellulose, citric acid, sodium citrate, sodium bisulfite, glycine, glycerol, and water. The ambroxol oral solution of this invention effectively improves bitterness and its residue, has an excellent taste, and also exhibits excellent stability under light, high temperature, and high humidity, thus providing excellent storage and transportation stability and ensuring quality and safety.

The invention relates to a preparation method of ambroxol hydrochloride and an intermediate thereof, in particular to a preparation method of a structure shown in a formula II and a method for further preparing ambroxol hydrochloride. The ambroxol hydrochloride is obtained by taking o-aminobenzaldehyde as an initial raw material and sequentially carrying out three-step reaction of reductive amination, bromination and salification. The preparation method provided by the invention is a brand new technical route and is not reported in any literature and patent. According to the method, the yield of the product can be greatly improved, and the method is suitable for industrial production.

The utility model discloses an ambroxol hydrochloride oral solution filtering and stirring device which comprises a stirring box, the inner wall of the stirring box is rotationally connected with a driving rod through a sealing bearing, stirring blades are installed below the outer wall of the driving rod, a feeding port is formed in the top of the stirring box, a discharging valve is installed at the bottom of the stirring box, and a discharging port is formed in the bottom of the stirring box. And a cleaning structure is arranged above the stirring blades and comprises a screen. The utility model relates to the technical field of solution production equipment, through the cooperation of a screen, a fixing plate and a supporting plate, the screen is placed between the supporting plate and a pressing plate, after the screen is installed, a driving rod is used for driving a strip box to rotate, the screen can rotate around the driving rod, and under the driving of a transmission structure, the screen can rotate, so that the production efficiency is improved. Sediments in the oral liquid are filtered in advance, and the situation that excessive sediments are accumulated on the filter screen at the bottom in the subsequent filtering process, and the filtering effect is affected is avoided.

1. The name of the design product: packaging box (ambroxol hydrochloride oral solution). 2. The use of the design product: used for the outer packaging of the product. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: unfolded state reference drawing.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an ambroxol hydrochloride oral solution and a preparation process thereof, and the preparation process comprises the following steps: heating purified water to 60-80 DEG C, adding sorbitol and L-cysteine into the purified water, stirring and dissolving for 10-30 minutes, adding hydroxyethyl cellulose, uniformly dispersing, and cooling to 48-52 DEG C to obtain a first mixed solution; adding ambroxol hydrochloride, benzoic acid and glycerol into the first mixed solution, stirring until the ambroxol hydrochloride, benzoic acid and glycerol are completely dissolved, finally adding essence, and uniformly mixing; and finally, fixing the volume to a set volume by adopting purified water. According to the preparation method disclosed by the invention, through collaborative optimization of dual effects of L-cysteine and a specific feeding sequence, even if the content of sorbitol reducing sugar is greater than 0.3%, the content of an impurity B can still be controlled to be less than or equal to 0.3%, the content of an impurity F can still be controlled to be less than or equal to 0.2%, the deviation between the content of related substances and a reference preparation is less than or equal to + / -0.3%, and the stability is excellent.

According to the technical scheme, the ultrasonic cleaning equipment for the atomizer of the ambroxol hydrochloride solution for inhalation is characterized by comprising an ultrasonic cleaning machine, a cleaning cavity is formed in the top of the ultrasonic cleaning machine, and a top plate is fixedly connected to the top of the ultrasonic cleaning machine through two supporting rods. By arranging the rotating assembly and the first position adjusting assembly, the rotating assembly adjusts the atomizing cup to rotate around the axis of the first rotating shaft, and meanwhile, the first position adjusting assembly can drive the atomizing cup to rotate in the tangent plane of the rotating face of the rotating assembly; the atomizing cups can be cleaned in the cleaning cavity, the positions and the directions of the atomizing cups are changed greatly, cleaning dead corners are avoided, the cleaning effect and quality are improved, meanwhile, the multiple clamping assemblies can separate the multiple atomizing cups, the situation that the attached positions cannot be fully cleaned due to the fact that the atomizing cups are attached to one another is avoided, and the cleaning effect is improved. And the cleaning effect and quality are further improved.

The invention relates to polydeuterated analog forms of ambroxol and related compounds (including bromhexine and the ambroxol salt, ambroxol hydrochloride), compositions comprising same, and methods of preventing and / or treating various diseases and medical conditions involving the administration of polydeuterated analogs of ambroxol and related compounds.

The invention discloses ambroxol hydrochloride syrup and a preparation process thereof, and belongs to the technical field of pharmaceutical preparations. The ambroxol hydrochloride syrup comprises ambroxol hydrochloride, a stabilizing cosolvent, a sweetening agent, a preservative, a pH regulator, essence and a solvent. Wherein the stable cosolvent is a composition of propylene glycol, meglumine and propylene carbonate, and the sweetening agent is a composition of cane sugar and a functional sweetening agent. The preparation process comprises the steps of low-temperature pretreatment of the main drug and the stable cosolvent, dissolution and mixing of the auxiliary materials, pH adjustment and essence addition, constant-volume filtration, encapsulation and the like. Through the synergistic effect of a composite stable cosolvent system and a specific preparation process, the storage stability of ambroxol hydrochloride is remarkably improved, meanwhile, the taste of the preparation is optimized, the preparation is wide in applicable crowd, the preparation process is simple and controllable, and good clinical application value and industrialization prospects are achieved.

The embodiments of this application disclose a liquid formulation, a cartridge for an aerosol generating system, and an aerosol generating system, wherein the liquid formulation comprises a solvent and ambroxol hydrochloride, and the atomization conversion rate of the ambroxol hydrochloride in the liquid formulation is 90% or more, or the atomization conversion rate of the ambroxol hydrochloride is 80% or more, or the atomization conversion rate of the ambroxol hydrochloride is 70% or more, or the atomization conversion rate of the ambroxol hydrochloride is 60% or more.

This invention proposes a compound ambroxol sustained-release microsphere and its preparation method. The compound ambroxol sustained-release microsphere comprises ambroxol hydrochloride, clenbuterol hydrochloride, and a cellulose ester sustained-release material, effectively controlling the dissolution differences between ambroxol hydrochloride and clenbuterol hydrochloride, enabling simultaneous and stable release of both drugs and avoiding efficacy fluctuations due to different release rates. Furthermore, the microsphere utilizes a hot-melt extrusion process, ensuring uniform dispersion of the two active pharmaceutical ingredients within the sustained-release material, thus resolving the uniformity issue caused by low clenbuterol hydrochloride content. The preparation process requires no organic solvents, eliminating solvent residues and preventing degradation or reactions of the active pharmaceutical ingredients in solvents, thereby improving product stability.

The present invention provides an orally disintegrating ambroxol film composition, its preparation method, and use. The orally disintegrating ambroxol film composition comprises an active drug, a film-forming material, and a flavoring agent, where the active drug is 2-amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine and / or its pharmacologically acceptable salt, such as ambroxol hydrochloride. The orally disintegrating ambroxol film composition according to the present invention has the advantages of being thin, pleasant to the taste, stable, instantly dissolving in the oral cavity without the need for water, and having a fast oral absorption rate. Furthermore, the orally disintegrating ambroxol film composition is simple to process, has a high drug loading, and has good drug content uniformity, making it a promising market.