Ambroxol hydrochloride oral solution and preparation method thereof

A technology of oral administration of ambroxol hydrochloride and ambroxol hydrochloride, which is applied in the field of pharmaceutical production formula and preparation, can solve problems such as absorption speed and slow onset of effect, influence on therapeutic effect, and children's reluctance to actively take it, and achieve rapid onset of effect , good compliance effect

Inactive Publication Date: 2009-01-28
扬州市三药制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] As we all know, ambroxol hydrochloride has the functions of relieving asthma and antitussive, and the existing medical field uses it as an active ingredient. At present, most of the medicines with ambroxol hydrochloride as the active ingredient in the market are solid preparations, injections or compound preparations. Children take it , it is necessary to divide a tablet or ...

Method used

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Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0021] 1. Formula per 1000ml

[0022] Ambroxol Hydrochloride 3g

[0023] Sodium Benzoate 2g

[0024] Stevioside 0.3g

[0025] Citric acid 3.2g

[0026] Sucrose 300g

[0027] Flavor 1.5g

[0028] 2. Process steps

[0029] 1. Add the purified water into the sugar pot and heat it with steam until it boils, then add sucrose and sodium benzoate, stir continuously until completely dissolved, filter, and make simple syrup after cooling.

[0030] 2. Dissolve ambroxol hydrochloride, stevioside, citric acid and sodium benzoate in purified water respectively.

[0031] 3. Slowly add the ambroxol hydrochloride aqueous solution into the configuration tank filled with simple syrup, turn on the mixer, and after stirring evenly, add stevioside aqueous solution, citric acid aqueous solution, sodium benzoate aqueous solution and essence intermittently one by one, supplement with purified water To the full amount, stir for 1.5 hours, and use the infusion pump to circulate repeatedly up and...

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PUM

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Abstract

The invention discloses an ambroxol hydrochloride oral solution and a preparation method thereof, and relates to a preparation method of western medicine, in particular to a medical production formula used for curing bronchitis and a preparation method thereof; the preparation method comprises the following steps: sucrose, preservatives and purified water are dissolved in a mixing mode so as to prepare simple syrup; the ambroxol hydrochloride, corrigents and preservatives are dissolved by the purified water so as to prepare ambroxol hydrochloride solution; the ambroxol hydrochloride solution and the simple syrup are stirred and mixed evenly, the corrigents and the preservatives are added successively and discontinuously and then the purified water is added to adjust the concentration. The invention has simple and reasonable process, and is easy to operate practically and the produced products have good stability; the products can used as common phlegm-eliminating drugs, has functions of increasing the liquid level of the respiratory tract, reducing mucus secretion, enhancing the secretion of pulmonary surfactant and the movement of cilium and preventing cough to a certain extent, and is applicable to acute respiratory disease and chronic respiratory disease, such as ropy sputum and difficult cough caused by acute bronchitis and chronic bronchitis, bronchial asthma and pulmonary tuberculosis, etc.

Description

technical field [0001] The invention relates to a preparation method of medicine, in particular to a production formula and preparation method of medicine for treating bronchitis. Background technique [0002] As we all know, ambroxol hydrochloride has the functions of relieving asthma and antitussive, and the existing medical field uses it as an active ingredient. At present, most of the medicines with ambroxol hydrochloride as the active ingredient in the market are solid preparations, injections or compound preparations. Children take it , it is necessary to divide a tablet or a pill into several doses, and it is difficult to control the dosage accurately. Secondly, it has a spicy taste of the medicine, and children are reluctant to take it actively, which greatly affects the therapeutic effect. In addition, the fixed preparation needs to be disintegrated first, and then dissolved, so that the human body can absorb it, and the absorption speed and onset of effect are rela...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/137A61P11/06A61P11/14
Inventor 解家顺祝瑞章
Owner 扬州市三药制药有限公司
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