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Ambroxol hydrochloride granule

A technology of ambroxol hydrochloride and granules, which is applied in the field of ambroxol hydrochloride granules, can solve the problems of not being able to be made satisfactorily, taking and being convenient to carry, losing practical application value, and being inconvenient for children to take. Caking, long retention period, and stable drug effect

Inactive Publication Date: 2005-06-22
北京金康驰医药投资有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Because ambroxol hydrochloride has extremely strong bitter taste, so present ambroxol hydrochloride preparation dosage form is based on capsule, tablet and oral liquid, and these dosage forms are inconvenient for children to take, but can't be made into another person's satisfaction at present, Granules that meet drug standards and are easy to take and carry, easy to absorb, and suitable for children
The major difficulty in preparing granules with ambroxol hydrochloride is that it is difficult to screen out effective flavoring agents to cover its strong bitterness. When the amount of flavoring agent (usually the amount of sucrose is 700 times that of ambroxol hydrochloride to cover up its bitterness) is used for flavoring, the granules are easy to absorb moisture, agglomerate, and drug because the sugar content is too high. Efficiency is reduced, and it is easily deteriorated, cannot be preserved, and loses practical application value

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 10 g of ambroxol hydrochloride, 200 g of lactose, 650 g of sucrose, 3 g of stevioside, 15 g of firmenich and orange essence, and an appropriate amount of 1% povidone PVP solution are prepared into granules.

Embodiment 2

[0035] 17g of ambroxol hydrochloride, 600g of lactose, 500g of sucrose, 27g of stevioside, 130g of Firmenich and orange essence, and an appropriate amount of copovidone S-630 were prepared into granules.

Embodiment 3

[0037] 15g of ambroxol hydrochloride, 515g of lactose, 500g of sucrose, 10g of stevioside, 60g of firmenich, 40g of orange essence and an appropriate amount of 1% povidone PVP solution are prepared into granules.

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PUM

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Abstract

The invention discloses an ambroxol hydrochloride granule, whose ingredients (by weight ratio) include ambroxol hydrochloride 10-17 parts, lactose 170-670 parts, sucrose 170-670 parts, stevioside 3-27 parts, Firmenich and fragrant citrus essence 3-138 parts, and right amount of binding agent. The invention relates to an ambroxol hydrochloride pelletized granule has the advantages of convenience in carrying, accurate quantitative determination, good taste, high biological availability, thus is especially suitable for children.

Description

technical field [0001] The invention relates to a medicine for treating acute and chronic respiratory diseases, in particular to ambroxol hydrochloride granules. Background technique [0002] Ambroxol hydrochloride is mainly used for thick sputum and difficulty in coughing up sputum caused by acute and chronic respiratory diseases. , and increase the concentration of antibiotics in bronchial secretions, which have antioxidant and anti-inflammatory effects. Ambroxol hydrochloride is widely used clinically for the treatment of respiratory diseases, the treatment of children's respiratory tract infection, the treatment of neonatal respiratory tract infection and the combined use of hormones to prevent neonatal hyaline membrane disease, the treatment of children's asthma, otitis media with otitis media, etc. Treatment and postoperative lung function of elderly patients with breast cancer has a certain protective effect. It is a kind of drug with little toxicity, safe and effect...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/137A61P11/00
Inventor 赵敬民赵良彬
Owner 北京金康驰医药投资有限公司