16results about How to "Stable efficacy" patented technology

The invention provides traditional Chinese medicine fermented disaccharide encapsulated nano anti-dandruff, hair-growing and oil-controlling shampoo and a preparation method, and relates to the field of daily chemical products, and the shampoo comprises the following components: a compound fermentation product, lactobacillus crispatus, lactobacillus plantarum, a disaccharide activity protection system, a basic component and a nano oil-controlling component; the compound leavening is prepared from cacumen biotae, radix polygoni multiflori, radix ginseng, fructus cnidii and orchid; the disaccharide activity protection system comprises maltotetraose and trehalose; the disaccharide activity protection system wraps a fermented material formed by fermenting the compound fermentation product, the lactobacillus crispatus and the lactobacillus plantarum to form a disaccharide glassy state layer; the nano oil control component is prepared from calamine powder and chitosan-sodium alginate; the basic component is prepared from tea bran, radix sophorae flavescentis, herba ecliptae, radix notoginseng, fructus ligustri lucidi, tea saponin microcapsules and tremella polysaccharide. According to the invention, through fermentation conversion of the orchid, disaccharide glassy state protection and slow release of the nano calamine, activity enhancement, stable retention and accurate release are realized, and the effects of removing dandruff, relieving itching, controlling oil and growing hair are achieved.

The present application relates to the technical field of medical preparation, and discloses a Russian olive leaf extract composition, a preparation method and application. The composition comprises the following components in parts by weight: 10-20 parts of Russian olive leaf extract derivative, 10-15 parts of bitter gourd extract, 10-15 parts of pueraria extract, 5-10 parts of hawthorn extract and 5-10 parts of astragalus extract. The present application also provides a preparation method. Compared with the prior art, the Russian olive leaf extract composition prepared by the present application has the effects of reducing blood sugar, blood lipid and blood pressure, and is stable in drug efficacy, mild and safe.

The preparation process of the eczema cream comprises the following steps: S1, raw material pretreatment: coarsely crushing calcined calamine; removing impurities from cortex phellodendri, coarsely crushing, and removing impurities from indigo naturalis for later use; mixing the three components, performing superfine grinding, and sieving with a 100-mesh sieve to obtain a medicinal powder raw material; s2, substrate preparation: melting and stirring beeswax and sesame oil at 85-90 DEG C, and cooling to obtain a transparent substrate; s3, mixing and forming: mixing the medicinal powder raw materials and the transparent matrix according to the mass ratio of (2.07-1): 2.13, uniformly stirring at 85-90 DEG C, cooling, solidifying, sterilizing and packaging to obtain the eczema cream. According to the standardized preparation process and the quality inspection method of the eczema cream, by optimizing superfine grinding parameters, a matrix ratio and a quality control system, stable production and quality controllability of the eczema cream are achieved, and technical support is provided for preparation conversion.

This application discloses a method for preparing Nutmeg and Schisandra pills to improve depression-induced arrhythmia, including the following steps: S1, take nutmeg, costus root, aucklandia root, and long pepper, in parts by weight, 20-30 parts of nutmeg, 15-25 parts of costus root, 15-25 parts of aucklandia root, and 10-20 parts of long pepper, add water for distillation extraction, and collect the obtained volatile oil. This application uses extrusion spheroidization combined with fluidized bed coating technology to prepare sustained-release microcapsules, prolonging the duration of efficacy, reducing the frequency of medication, and avoiding excessive fluctuations in blood drug concentration, thus reducing the risk of adverse reactions. The volatile oil is fully extracted by sufficient steam distillation, combined with an appropriate ratio of β-cyclodextrin inclusion and spray drying process to reduce the loss of volatile oil and ensure the stability of the formulation efficacy. The high-dose ratio of medicinal materials can not only effectively regulate the patient's mood and improve the depressive state, but also improve myocardial blood supply, stabilize cardiac electrophysiology, and break the vicious cycle between depression and arrhythmia.

The invention relates to the technical field of application of pressure sore nursing instruments, in particular to traditional Chinese medicine fumigation equipment for nursing pressure sores of a critical bedridden patient, and the traditional Chinese medicine fumigation equipment comprises a movable base, a storage mechanism, a guide pipe, a steam mechanism, an adjusting mechanism, a shifting mechanism and a height adjusting mechanism. The liquid medicine is conveyed to a water pump of a steam mechanism through a guide pipe and then is converted into steam through an atomization spray head, the automatic process of traditional Chinese medicine pretreatment, liquid medicine conveying and steam generation is achieved, frequent manual operation is not needed, the nursing efficiency is improved, meanwhile, it is guaranteed that the steam medicine effect is stable, and meanwhile the nursing effect is improved. Through mutual cooperation of the shifting mechanism, the height adjusting mechanism and the adjusting mechanism, accurate positioning and uniform sweeping of pressure sore positions are achieved, the device is suitable for pressure sore parts (such as large-area pressure sores on the back and local pressure sores on the buttocks) of different patients, the situation that steam concentrates to stimulate wound surfaces is avoided, and nursing safety is improved.

This invention provides a nematidine and ritonavir combination tablet and its preparation method. The nematidine and ritonavir combination tablet is prepared by double-layer compression of materials corresponding to the ritonavir layer and the nematidine layer. The nematidine layer is composed of the following raw materials: 280-320 parts of nematidine, 200-250 parts of compound dispersant, 60-100 parts of filler, 20-50 parts of disintegrant, 10-25 parts of binder, and 2-3 parts of lubricant. The ritonavir layer is composed of 90-110 parts of ritonavir, 30-60 parts of filler, 6-10 parts of coating material, 40-100 parts of filler, 3-5 parts of lubricant, and 200-300 parts of binder. The nematamide and ritonavir combination tablets of the present invention have small initial dissolution fluctuations, stable onset time and efficacy; at the same time, the excipients adsorb less of the active ingredients, resulting in high drug recovery rate, good efficacy and good stability.

The application relates to the technical field of first-aid kits, in particular to a clinical nursing first-aid kit, which comprises a first-aid kit main body, inner cavities are formed in the two sides of the first-aid kit main body, side boxes are fixedly connected to the inner cavities, a medicine taking and self-wiping mechanism is arranged on the side boxes, the medicine taking and self-wiping mechanism comprises a sliding plate which is slidably connected to the inside of the side box, a plurality of mark points are arranged on the sliding plate, the device is an important equipment of the biomedical engineering industry, the independent medical silica gel medicine storage opening is vertically arranged on the sliding plate, a single clamping position is used to store a lincomycin medicine bottle, medicine separation type storage is realized, the mutual collision and extrusion of the bottle bodies during the transportation, hand carrying and vehicle carrying of the box body are avoided, the problems of glass bottle fragmentation, medicine leakage, label abrasion and falling are avoided, the silica gel medicine storage opening tightly holds and limits the bottle body, external vibration conduction is blocked, the decomposition of the effective components of the medicine, the stratification and deterioration of the suspended medicine liquid are prevented, and the stability of the medicine efficacy is ensured.

The invention discloses a constant-temperature self-heating traditional Chinese medicine acupoint patch and a preparation method thereof, and belongs to the technical field of medical supplies. The traditional Chinese medicine acupoint application comprises an outermost layer, a heating layer, a bonding layer, a medicine layer and release paper, the heating layer is formed by uniformly coating a constant-temperature self-heating material, the medicine layer comprises an anti-seepage ring arranged on the sticking layer, a positioning ring matched with the anti-seepage ring and a traditional Chinese medicine preparation, and the traditional Chinese medicine preparation is traditional Chinese medicine gel or traditional Chinese medicine ointment. Wherein the constant-temperature self-heating material is prepared from the following components in parts by mass: 10 to 20 parts of reduced iron powder, 0.5 to 3 parts of vermiculite, 1 to 5 parts of activated carbon, 0.5 to 3 parts of sodium chloride, 0.1 to 2 parts of poly (N-isopropylacrylamide), 0.1 to 2 parts of hydroxypropyl methyl cellulose and 5 to 10 parts of water. The traditional Chinese medicine acupoint application disclosed by the invention can stably maintain a proper temperature for a long time, promote transdermal absorption of traditional Chinese medicine components, enhance the stimulation effect on acupoints and improve the treatment effect.

The invention discloses a cerocaine mucilage, which is prepared from the following components in percentage by weight: 1 to 3 percent of cerocaine, 0.3 to 0.6 percent of sodium carboxymethyl cellulose, 0.1 to 0.3 percent of chitosan, 1 to 3 percent of glycerol, 0.03 to 0.08 percent of L-menthol, 0.1 to 0.6 percent of glacial acetic acid and purified water. The serocaine comprises serocaine a, serocaine b and serocaine c; the particle sizes D90 of the serocaine a, the serocaine b and the serocaine c are respectively 200 to 400 nm, 700 to 1100 nm and 1500 to 2000 nm; the dosage ratio of the sirocaine a to the sirocaine b to the sirocaine c is (1-1.5): 1: (0.5-1) according to the weight ratio. According to the prepared cerocaine mucilage, the action time is prolonged, the cerocaine mucilage is uniformly released, the drug effect is more stable, the surgical treatment requirement is met, and the stability is excellent.

This invention discloses a black bean vinegar health-preserving composition and its preparation method, belonging to the field of health food technology. The composition consists of only two raw materials: black beans and edible vinegar, in a ratio of 40:60 to 60:40, without any excipients or additives. The preparation method includes the steps of washing black beans, cooking and cooling, sealing and soaking in vinegar solution, and bottling and preservation. This invention features a simple and novel formula, high safety, low production cost, and suitability for large-scale production. It possesses health-preserving effects such as promoting hair growth and blackening, nourishing the liver and kidneys, promoting bowel movements, and assisting in regulating blood pressure and blood lipids. Furthermore, it enjoys extensive patent protection and has broad market application prospects.

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: A: e.g., Benzene, E: e.g., -CH2-, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R1, R2, R3: e.g., a halogen atom, R4: e.g., a C1-C6 alkyl group, R5: e.g., a hydrogen atom, R6a, R6b, R6c, R6d: e.g., a hydrogen atom, R7: e.g., a hydrogen atom, R8: e.g., a hydrogen atom, n1, n2, n3: e.g., 1.

The utility model relates to a double-chamber pressurizing type pesticide spraying device, which belongs to the field of agricultural instruments and comprises a box body, a first storage tank, a second storage tank and straps, the first storage tank and the second storage tank are detachably connected to the interior of the box body, and the straps are fixedly connected to the back of the box body. A spraying mechanism which extends to the outside of the box body and is used for spraying the pesticide discharged from the first storage tank and the second storage tank in a pressurized manner is arranged in the box body, and a mixing structure which is used for uniformly mixing a single barrel of pesticide liquid is arranged outside the box body. According to the double-chamber pressurization type pesticide spraying device, the first storage tank and the second storage tank are arranged to be independent of each other, complete physical isolation of pesticides is achieved, cross contamination between the pesticides is avoided, and the stability of the pesticide effect is guaranteed; the flow proportion of the medicine discharged from the first storage tank and the second storage tank can be rapidly changed without complex cleaning and replacing operation, the switching time is greatly shortened, and the advantage that the medicine is completely physically isolated is achieved.

The present application relates to the technical field of cosmetics, more particularly to a whitening mask, comprising a mask base solution and a mask non-woven fabric, wherein the mask base solution comprises at least 3-5 parts of jojoba oil, 0.2-0.3 parts of D-pantothenyl alcohol, 5-10 parts of a filtrate of a fermentation product of schizochytrium sp., 1-3 parts of dicaprylyl carbonate, 0.5-3 parts of a whitening composition, 2-3 parts of nicotinamide, 0.01-0.3 parts of tetrahydroxypropyl ethylenediamine, 0.01-0.2 parts of tocopheryl acetate, 5.7-15 parts of an auxiliary agent, and 60-80 parts of deionized water. The whitening composition is formulated to make the base solution system of the prepared whitening mask have excellent whitening effect, effectively inhibit the activity of tyrosinase, make the skin not easy to produce melanin, and achieve the effect of effectively whitening the skin.

An object of the present invention is to provide a compound having an anti-inflammatory activity or a pharmacologically acceptable salt thereof. The solution of the present invention is a compound of general formula (1) or a pharmacologically acceptable salt thereof. wherein the symbols in the formula are defined below: A: e.g., Benzene, E: e.g., -CH2-, G: e.g., a 5-membered aromatic heterocyclic ring, X: e.g., cyclohexane, J: e.g., a 5-membered aromatic heterocyclic ring, Y: e.g., a phenyl group, R1, R2, R3: e.g., a halogen atom, R4: e.g., a C1-C6 alkyl group, R5: e.g., a hydrogen atom, R6a, R6b, R6c, R6d: e.g., a hydrogen atom, R7: e.g., a hydrogen atom, R8: e.g., a hydrogen atom, n1, n2, n3: e.g., 1.

This invention discloses a theophylline sustained-release tablet and its preparation method, belonging to the field of pharmaceutical formulation technology. The technical solution includes the following steps: 1) preparation of a pore-forming agent; 2) preparation of a blocking agent; 3) premixing: anhydrous theophylline and a hydrophilic gel framework material are premixed to obtain a premixed powder; 4) first granulation: the prepared pore-forming agent aqueous solution is added to the premixed powder, granulated, dried, and sized to obtain granules one; 5) second granulation: the prepared blocking agent ethanol solution is added to granules one, granulated, dried, and sized to obtain granules two; 6) tableting: a lubricant is added to granules two, and tablets are compressed using a tableting machine to obtain theophylline sustained-release tablets. This invention provides a theophylline sustained-release tablet and its preparation method with good sustained-release effect, long duration of action, and good batch-to-batch repeatability. The preparation method is simple and requires no heating; the prepared theophylline sustained-release tablets show good compatibility with the reference formulation.

The application discloses a membrane separation and purification process of high-purity effective components of Astragalus and Angelica and a capsule preparation thereof, and belongs to the technical field of traditional Chinese medicinal material processing and preparation. The application solves the technical problems of high ash residue and low capsule bioavailability in the preparation process of the existing Astragalus and Angelica capsules. The application comprises the following steps: raw material pretreatment, countercurrent extraction, coarse filtration through a ceramic microfiltration membrane, nanofiltration separation of the filtered clear filtrate into a solvent-resistant nanofiltration membrane system, and obtaining refined Astragalus and Angelica medicinal powder after elution and drying. The application realizes the precise purification goal of "only removing impurities and not removing medicine", can reduce the inorganic ash content in the extraction liquid by more than 50%, and efficiently retains core medicinal components such as astragaloside and angelica polysaccharide. The prepared Astragalus and Angelica capsules are accurate in effective component content, have small gastrointestinal irritation, and are good in storage stability.