Formula and preparation process of external ointment for relieving swelling and pain of bone joints

Abstract

The invention discloses a formula and a preparation process of an external ointment for relieving swelling and pain of bone joints. Comprising 3-9 parts of dragon's blood, 1-7 parts of frankincense, 1-8 parts of myrrh, 1-3 parts of pseudo-ginseng, 4-9 parts of ligusticum chuanxiong hort, 1-6 parts of salvia miltiorrhiza, 3-10 parts of safflower, 15-50 parts of impatiens balsamina, 2-12 parts of radix paeoniae alba, 10-35 parts of liquorice, 15-60 parts of lycopodium clavatum, 12-40 parts of pericarpium citri reticulatae viride, 12-40 parts of pericarpium citri reticulatae, 1-6 parts of centipede, 1-6 parts of ground beeltle, 3-10 parts of notopterygium root, 3-10 parts of radix angelicae pubescentis, 2-15 parts of eucommia ulmoides and 3-10 parts of radix achyranthis bidentatae. According to the ointment provided by the invention, the dragon's blood, the frankincense, the liniment, the pseudo-ginseng, the glucosamine sulfate and other components are added in the formula, so that the ointment can play a good role in relieving swelling and pain, is suitable for joint swelling and pain caused by various arthritis, and is convenient to use, stable in drug effect, good in swelling and pain relieving effect and free of toxic and side effects.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a formula and a preparation process of an external ointment for reducing swelling and relieving pain in bone and joints. Background Art

[0002] Osteoarthritis (OA) is a chronic joint disease characterized by degeneration of articular cartilage and secondary bone hyperplasia, and is mainly manifested by pain, stiffness, joint bone hypertrophy and dysfunction in and around the joints. In traditional Chinese medicine, osteoarthritis belongs to the category of arthralgia. In clinical practice, it is generally believed that the onset of the disease is most closely related to the kidney, spleen and liver. There are many causes of the disease, and "fall injury", "wind", "cold", "stasis", "deficiency" and "dampness" are the main causes. At the same time, the disease is also related to factors such as old age and strain.

[0003] The incidence of osteoarthritis in my country is over 80%, and it is more common in middle-aged and elderly people. Current treatments mainly include general treatments based on keeping warm, limiting exercise, and reducing joint wear, drug treatments represented by non-steroidal anti-inflammatory drugs and chondroprotective agents, and surgical treatments that are common in the late stages of arthritis. In comparison, traditional Chinese medicine for the treatment of osteoarthritis has the advantages of less toxic side effects, low prices, and definite efficacy.

[0004] However, the efficacy of Chinese medicines currently used to treat arthritis varies from person to person due to the different Chinese medicine ingredients and preparation processes they contain. In addition, the existing Chinese medicine plasters used to treat arthritis are mainly composed of Chinese medicines for promoting blood circulation, removing blood stasis, and relieving pain, so their efficacy is relatively limited. They are good for pain, but relatively insufficient for improving swelling, and need to be optimized.

[0005] Therefore, we propose a formula and preparation process of an external ointment for reducing swelling and relieving pain in bone and joints. Summary of the invention

[0006] The purpose of the present invention is to provide a formula and preparation process of an external ointment for reducing swelling and relieving pain in bone and joints, so as to solve the problems raised in the above-mentioned background technology.

[0007] To achieve the above object, the present invention provides the following technical solutions:

[0008] On one hand, the present invention provides a bone and joint swelling and pain relief external ointment, the formula of the ointment, calculated by weight, includes 3-9 parts of dragon's blood, 1-7 parts of frankincense, 1-8 parts of myrrh, 1-3 parts of Panax notoginseng, 4-9 parts of Chuanxiong, 1-6 parts of Salvia miltiorrhiza, 3-10 parts of safflower, 15-50 parts of Impatiens balsamina, 2-12 parts of white peony root, 10-35 parts of liquorice, 15-60 parts of Lycopodiella ciliata, 12-40 parts of Citrus aurantium, 12-40 parts of dried tangerine peel, 1-6 parts of centipede, 1-6 parts of earthworm, 3-10 parts of notopterygium root, 3-10 parts of angelica root, 2-15 parts of eucommia bark, 3-10 parts of achyranthes bidentata, 2-8 parts of papaya, 3-15 parts of cassia twig, 1-5 parts of ephedra, 1-5 parts of siler, 6-15 parts of menthol, 2-8 parts of millettia reticulata, 1-8 parts of astragalus, 3-15 parts of aconite, 3-15 parts of aconite and 10-30 parts of glucosamine sulfate.

[0009] As a further scheme of the present invention: the formula of the above-mentioned ointment, calculated by weight, includes 4-7 parts of dragon's blood, 1-6 parts of frankincense, 2-6 parts of myrrh, 1-2 parts of Panax notoginseng, 4-7 parts of Chuanxiong, 2-5 parts of Salvia miltiorrhiza, 4-8 parts of safflower, 20-40 parts of Impatiens balsamina, 3-8 parts of white peony root, 15-30 parts of liquorice, 20-50 parts of Lycopodiella cuneata, 15-32 parts of green peel, 15-32 parts of tangerine peel, 1-4 parts of centipede, 1-4 parts of earthworm, 4-8 parts of Notopterygium wilfordii, 4-8 parts of Angelica dahurica, 4-12 parts of Eucommia bark, 4-8 parts of Achyranthes bidentata, 3-6 parts of papaya, 5-12 parts of cinnamon twig, 1-3 parts of ephedra, 1-3 parts of Saposhnikovia divaricata, 8-12 parts of menthol, 3-6 parts of Millettia spatholobi, 2-5 parts of Astragalus, 5-10 parts of Aconiti kusnezoffii, 5-10 parts of Aconiti kusnezoffii and 15-25 parts of glucosamine sulfate.

[0010] As a further scheme of the present invention: the formula of the above-mentioned ointment, calculated by weight, includes 5 parts of dragon's blood, 3 parts of frankincense, 4 parts of myrrh, 1 part of Panax notoginseng, 5 parts of Chuanxiong, 4 parts of Salvia miltiorrhiza, 3 parts of safflower, 30 parts of Impatiens balsamina, 6 parts of white peony root, 20 parts of liquorice, 30 parts of Lycopodiella cuneata, 18 parts of green peel, 24 parts of dried tangerine peel, 1 part of centipede, 1 part of earthworm, 5 parts of Notopterygium wilfordii, 7 parts of Angelica dahurica, 8 parts of Eucommia bark, 6 parts of Achyranthes bidentata, 5 parts of papaya, 8 parts of cinnamon twig, 1 part of ephedra, 1 part of Saposhnikovia divaricata, 10 parts of menthol, 4 parts of Millettia reticulata, 3 parts of Astragalus, 7 parts of Aconiti Kusnezoffii, 7 parts of Aconiti kusnezoffii and 20 parts of glucosamine sulfate.

[0011] As a further solution of the present invention: the frankincense and myrrh are both prepared by vinegar roasting method.

[0012] As a further solution of the present invention: the licorice is prepared by honey roasting method.

[0013] As a further solution of the present invention: the Eucommia ulmoides is prepared by salt-roasting method.

[0014] As a further solution of the present invention: the papaya is prepared by roasting with wine.

[0015] Another aspect of the present invention provides a preparation process of the above-mentioned bone and joint swelling and pain relieving external ointment, which comprises the following steps:

[0016] Step 1: Weigh the processed Chinese medicinal materials and glucosamine sulfate according to the formula;

[0017] Step 2: crush and sieve the components except menthol and glucosamine sulfate, put them into a container, soak them with ethanol, and reflux extract them twice at 80°C for 2 hours each time, combine and mix the two extracts, concentrate them to 60-80% of the original drug solution, filter them while hot, and concentrate the filtrate to a concentrated solution with a relative density of 1.45-1.50 at 30°C;

[0018] Step 3: Crush and sieve the menthol and mix it with glucosamine sulfate into the concentrated solution, stir evenly and defoam under negative pressure to obtain an external ointment for reducing swelling and relieving pain in bone and joints.

[0019] As a further solution of the present invention: the solid-liquid ratio of ethanol to medicinal materials in the container is 1:4-8, the concentration of ethanol is 50-75%, and the soaking time is 0.5-2h.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] The ointment provided by the present invention can achieve good swelling and analgesic effects by adding dragon's blood, frankincense, ointment, Panax notoginseng and glucosamine sulfate and other ingredients into the formula, is suitable for joint swelling and pain caused by various types of arthritis, is easy to use, has stable efficacy, good swelling and analgesic effects, and has no toxic side effects. DETAILED DESCRIPTION

[0022] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention more clearly understood, the present invention will be further described in detail below in conjunction with embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0023] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it can be directly on the other element or indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element.

[0024] It should be understood that the terms "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like to indicate directions or positional relationships are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific direction, be constructed and operate in a specific direction in the specification, and therefore should not be understood as limiting the present invention.

[0025] In addition, the terms "first", "second", and "third" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" or "second" may explicitly or implicitly include one or more of the features.

[0026] In the present invention, a formula of an external ointment for reducing swelling and relieving pain in bone and joints comprises, by weight, 3-9 parts of dragon's blood, 1-7 parts of frankincense, 1-8 parts of myrrh, 1-3 parts of Panax notoginseng, 4-9 parts of Chuanxiong, 1-6 parts of Salvia miltiorrhiza, 3-10 parts of safflower, 15-50 parts of Impatiens balsamina, 2-12 parts of white peony root, 10-35 parts of liquorice, 15-60 parts of smilax china, 12-40 parts of green peel, 12-40 parts of dried tangerine peel, 12-20 parts of tangerine peel, 12-30 parts of ... 40 parts, centipede 1-6 parts, earthworm 1-6 parts, notopterygium root 3-10 parts, angelica root 3-10 parts, eucommia ulmoides 2-15 parts, Achyranthes bidentata 3-10 parts, papaya 2-8 parts, cassia twig 3-15 parts, ephedra 1-5 parts, siler 1-5 parts, menthol 6-15 parts, millet spatholobus 2-8 parts, astragalus 1-8 parts, aconite 3-15 parts, aconite kusnezoffii 3-15 parts and glucosamine sulfate 10-30 parts; wherein,

[0027] Dragon's Blood is the resin of the sword-leaved dragon tree of the Liliaceae family. It has the effects of promoting blood circulation and dispersing blood stasis, relieving pain and stopping bleeding, and healing sores and promoting tissue regeneration. It is used for traumatic injuries, pain caused by blood stasis, stagnation of qi and blood in women, bleeding from trauma, and abscesses that do not heal for a long time.

[0028] Frankincense is a resin exuded from the bark of the frankincense tree and other plants of the same genus in the olive family. It has a unique aroma and a slightly bitter taste. It has the effects of promoting blood circulation, relieving qi and relieving pain, reducing swelling and promoting tissue regeneration. It is used for chest pain, heart pain, stomach pain, dysmenorrhea, amenorrhea, postpartum blood stasis, abdominal pain due to stagnation, rheumatic pain, muscle spasm, traumatic injury, carbuncle, ulcer, etc. In this product, the frankincense is prepared by vinegar roasting, and the weight ratio of frankincense to vinegar is 20:1.

[0029] Myrrh is the dried resin of the olive family plant Myrrha or Hardyngula; it has the effects of dispersing blood stasis, relieving pain, reducing swelling and promoting tissue regeneration; it is often used to treat chest pain, heart pain, stomach pain, dysmenorrhea, amenorrhea, postpartum blood stasis, abdominal pain due to lumps, rheumatic pain, traumatic injuries, carbuncle, ulcers and other diseases; in this product, the myrrh is prepared by vinegar roasting, and the weight ratio of myrrh to vinegar is 15:1

[0030] Panax notoginseng is the dried root of Panax notoginseng, a plant of the Araliaceae family. It has the effects of removing blood stasis and stopping bleeding, promoting blood circulation and relieving pain. It is mainly used to treat bleeding, traumatic injuries, blood stasis, swelling and pain, etc.

[0031] Chuanxiong has the effects of promoting qi and relieving depression, removing wind and dampness, promoting blood circulation and relieving pain. It is often used to treat wind-cold headaches and dizziness, flank pain and abdominal pain, cold arthritis and muscle spasms, amenorrhea, dystocia, postpartum blood stasis and pain, carbuncle, ulcer, bruises and swellings;

[0032] Danshen is the dried root and rhizome of the plant Danshen of the Labiatae family. It has the effects of promoting blood circulation and removing blood stasis, relieving pain by promoting menstruation, clearing the heart and eliminating vexation, cooling blood and eliminating carbuncle. It is used for chest pain, abdominal pain, flank pain, accumulation of lumps, pain caused by heat, restlessness and insomnia, irregular menstruation, dysmenorrhea, amenorrhea, and sores and swelling.

[0033] Safflower is the dried flower of the safflower plant of the Asteraceae family. It is picked in summer when the flowers turn from yellow to red, and dried in the shade or in the sun. It has the effects of promoting blood circulation and menstruation, dispersing blood stasis and relieving pain. It is used for amenorrhea, dysmenorrhea, lochia retention, abdominal masses, chest pain, abdominal pain due to blood stasis, stabbing pain in the chest and ribs, injuries from falls, swelling and pain in sores, etc.

[0034] Impatiens balsamina, this product is the stem of Impatiens balsamina, a plant of the Impatiens family; its functions and indications are: removing rheumatism; promoting blood circulation; detoxification; it is commonly used for rheumatic pain, swelling and pain from falls, amenorrhea, dysmenorrhea, carbuncle, erysipelas, goose foot wind, snake and insect bites;

[0035] White peony root is a plant of the genus Paeoniae in the family Apocynaceae. It is pungent and bitter in taste and slightly toxic. It has the effects of warming the yang and removing dampness, replenishing the body, and strengthening the spleen and stomach. It is used to treat rheumatic cold pain, rheumatoid arthritis, lumbar muscle strain, physical weakness, limb convulsions, slow convulsions, dog bites, etc.

[0036] Licorice root; It has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving urgency and relieving pain, and harmonizing various medicines; It is often used for spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, abdominal and limb cramps and pain, carbuncle, sore and ulcer, and relieves the toxicity and potency of drugs;

[0037] Stretching grass is the dried whole herb of Lycopodium, a plant of the Lycopodiaceae family. It has the effects of dispelling wind and dampness, relaxing muscles and activating blood circulation. It is used for joint pain and difficulty in flexion and extension.

[0038] Qingpi is the dried young or immature fruit peel of the Rutaceae plant Citrus aurantium and its cultivated varieties; it has the effects of soothing the liver and dispelling qi, eliminating stagnation and removing stagnation; it is used for chest and flank pain, hernia pain, breast lumps, breast abscesses, food stagnation and qi stagnation, and abdominal pain;

[0039] Tangerine peel is the dried mature peel of the citrus plant and its cultivated varieties of the Rutaceae family. The mature fruits are picked, the peel is peeled, and dried in the sun or at low temperature. It tastes bitter and spicy and is warm in nature. It enters the lung and spleen meridians. It has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm. It is often used to treat abdominal distension, loss of appetite, vomiting and diarrhea, and cough with excessive phlegm.

[0040] Centipede is the dried body of the Scolopendra subspinipes, an animal of the Scolopendra family. It has the effects of calming wind and relieving spasms, dredging meridians and relieving pain, attacking toxins and dispersing knots. It is used for internal movement of liver wind, spasms and convulsions, infantile convulsions, stroke, hemiplegia, tetanus, rheumatism, hemiplegia, sores, scrofula, snake and insect bites.

[0041] The Chinese herb Eupolyphaga sinensis is salty in taste and cold in nature. It enters the liver meridian and has the effects of breaking blood and removing blood stasis, and repairing tendons and bones. It is used for traumatic injuries, tendon injuries and fractures, blood stasis and amenorrhea, abdominal pain caused by postpartum blood stasis, and lumps in the abdomen.

[0042] Qianghuo, warm in nature, can relieve the symptoms of cold and dampness, and is used for exogenous wind-cold, headache without sweating, cold-damp arthralgia, and rheumatic pain in the upper limbs;

[0043] Angelica dahurica is the dried root of the Umbelliferae plant Angelica sinensis. It has the effects of dispelling wind and dampness, relieving numbness and relieving pain. It is used for wind-cold-dampness arthralgia, pain in the waist and knees, headache caused by hidden wind in Shaoyin meridians, and headache caused by wind-cold and dampness.

[0044] Eucommia ulmoides is the bark of Eucommia ulmoides, a plant of the Eucommia family. Its functions and indications are: nourishing the liver and kidney, strengthening the tendons and bones, calming the fetus, treating back pain, weak feet and knees, residual urine, itchy vagina, miscarriage, restless fetus, high blood pressure, etc. In this recipe, Eucommia ulmoides is roasted with salt water. First, mix the Eucommia ulmoides with salt water, wait until the salt water is absorbed, stir-fry over low heat until dry, until the white silk in the Eucommia ulmoides bark can be gently torn, then it can be taken out of the pot. Roasting Eucommia ulmoides with salt can lead the drug into the kidney meridian, enhancing the effect of Eucommia ulmoides in nourishing the liver and kidney and strengthening the tendons and bones. The ratio of Eucommia ulmoides to salt is 100:2.

[0045] Achyranthes bidentata is the dried root of Achyranthes bidentata, a plant of the Amaranthaceae family. It has the functions of removing blood stasis and promoting menstruation, nourishing the liver and kidney, strengthening tendons and bones, promoting diuresis and relieving stranguria, and guiding blood downward. It is used for amenorrhea, dysmenorrhea, soreness of waist and knees, weakness of tendons and bones, stranguria, edema, headache, dizziness, toothache, mouth sores, hematemesis, and epistaxis.

[0046] Papaya is the dried nearly mature fruit of the Malus sphenanthera, a plant of the Rosaceae family. It has the effects of relaxing muscles and tendons, harmonizing the stomach and removing dampness. It is used to treat dampness, stiffness and cramps, soreness and pain in the waist and knee joints, vomiting and diarrhea caused by summer heat, cramps and pain, beriberi and edema, etc. In this recipe, papaya is prepared by wine roasting. The papaya slices are mixed with rice wine until the rice wine is absorbed, and then fried over low heat until dry. The purpose of roasting papaya with wine is mainly to introduce the medicine into the blood and enhance the rheumatic and analgesic effects of papaya. The ratio of papaya to rice wine is 100:20.

[0047] Cinnamon twig is the dried young branch of cinnamon bark of Lauraceae. It is pungent and sweet, warm in nature, and enters the heart, lung, and bladder meridians. It has the effects of sweating and relieving muscles, warming and unblocking meridians, assisting yang and transforming qi, and balancing and descending qi. It is often used for colds, cold pain in the abdomen, amenorrhea due to cold blood, joint pain, phlegm, edema, palpitations, etc.

[0048] Ephedra, a traditional Chinese medicine for dispelling wind and cold, is a plant of the genus Ephedra in the family Ephedraceae. It is rich in alkaloids and is the main resource for extracting ephedrine.

[0049] Saposhnikovia root is pungent and sweet in taste and slightly warm in nature. It has the effects of dispelling wind and relieving exterior symptoms, relieving dampness and relieving pain, and stopping spasms. It is used for external symptoms, urticaria itching, rheumatic arthralgia, tetanus, spleen deficiency and dampness.

[0050] Menthol has the effects of dispelling wind, clearing heat and detoxifying. It is mainly used to treat headache, red eyes, exogenous wind-heat, sore throat and teeth, itchy skin, etc.

[0051] Millettia reticulata is the dried vine stem of the leguminous plant Millettia spatholobi. It has the effects of promoting blood circulation, replenishing blood, regulating menstruation and relieving pain, and relaxing tendons and activating collaterals. It is also effective in treating rheumatic pain, numbness and paralysis, blood deficiency and sallow complexion, irregular menstruation, dysmenorrhea, amenorrhea and gynecological diseases.

[0052] Astragalus is the root of Astragalus mongolica or Astragalus membranaceus, a plant of the genus Astragalus in the Leguminosae family. It has the effects of strengthening the spleen and replenishing the middle, raising yang and lifting the sunken, strengthening the body's defense system and strengthening the exterior, promoting urination, and removing toxins and promoting tissue regeneration. It is mainly used to treat spleen qi deficiency syndrome, lung qi deficiency syndrome, qi deficiency and spontaneous sweating syndrome, qi and blood deficiency, sores that are difficult to heal or ulcers that are difficult to heal for a long time, etc.

[0053] Chuanwu, the dried root of the Ranunculaceae plant Aconitum, has the effects of dispelling wind and dampness, warming the meridians and relieving pain. It is often used for wind-cold-dampness arthralgia, joint pain, cold pain in the heart and abdomen, pain caused by cold hernia, and anesthesia and pain relief.

[0054] Aconitum kusnezoffii is the dried root of Aconitum kusnezoffii, a plant of the Ranunculaceae family. It has the effects of dispelling wind and dampness, warming the meridians and relieving pain. It is used for wind-cold-dampness arthralgia, joint pain, cold pain in the heart and abdomen, pain caused by cold hernia, and anesthesia and pain relief.

[0055] Glucosamine sulfate, glucosamine sulfate, is a natural amino monosaccharide and an important component necessary for the synthesis of proteoglycans in the matrix of human articular cartilage. Amino monosaccharides can stimulate chondrocytes to produce glycoproteins with normal polymer structures, inhibit certain enzymes that can damage articular cartilage (such as collagenase and phospholipase A2), inhibit the production of superoxide free radicals that damage cells, prevent corticosteroids and certain non-steroidal anti-inflammatory drugs from damaging chondrocytes, and reduce the release of endotoxin factors that damage cells.

[0056] Embodiment 1:

[0057] In the present embodiment, a bone and joint swelling and analgesic external ointment is provided, wherein the formula of the ointment is calculated by weight components, including 5 parts of dragon's blood, 3 parts of frankincense, 4 parts of myrrh, 1 part of Panax notoginseng, 5 parts of Chuanxiong, 4 parts of Salvia miltiorrhiza, 3 parts of safflower, 30 parts of Impatiens balsamina, 6 parts of white peony root, 20 parts of licorice, 30 parts of Lycopodiella cuneata, 18 parts of green peel, 24 parts of dried orange peel, 1 part of centipede, 1 part of Eucommia bark, 5 parts of Notopterygium wilfordii, 7 parts of Angelica dahurica, 8 parts of Eucommia bark, 6 parts of Achyranthes bidentata, 5 parts of papaya, 8 parts of cinnamon twig, 1 part of ephedra, 1 part of Saposhnikovia divaricata, 10 parts of menthol, 4 parts of Millettia reticulata, 3 parts of Astragalus, 7 parts of Aconiti kusnezoffii, 7 parts of Aconiti kusnezoffii and 20 parts of glucosamine sulfate, wherein:

[0058] The frankincense and myrrh are both prepared by vinegar roasting, the licorice is prepared by honey roasting, the eucommia is prepared by salt roasting, and the papaya is prepared by wine roasting.

[0059] The preparation process of the above-mentioned bone and joint swelling and pain relieving external ointment is as follows:

[0060] Step 1: Weigh the processed Chinese medicinal materials and glucosamine sulfate according to the formula;

[0061] Step 2: crush and sieve the components except menthol and glucosamine sulfate, put them into a container, soak them with ethanol, and reflux extract them twice at 80°C for 2 hours each time, combine and mix the two extracts, concentrate them to 60-80% of the original drug solution, filter them while hot, and concentrate the filtrate to a concentrated solution with a relative density of 1.45-1.50 at 30°C;

[0062] Step 3: Crush and sieve the menthol and mix it with glucosamine sulfate into the concentrated solution, stir evenly and defoam under negative pressure to obtain an external ointment for reducing swelling and relieving pain in bone and joints.

[0063] Specifically, the solid-liquid ratio of ethanol to medicinal materials in the container is 1:6, the concentration of ethanol is 65%, and the soaking time is 1 hour.

[0064] Embodiment 2:

[0065] In the present embodiment, a bone and joint swelling and analgesic external ointment is provided, wherein the formula of the ointment is calculated by weight components, including 7 parts of dragon's blood, 5 parts of frankincense, 4 parts of myrrh, 1 part of Panax notoginseng, 6 parts of Chuanxiong, 4 parts of Salvia miltiorrhiza, 5 parts of safflower, 25 parts of Impatiens balsamina, 4 parts of white peony root, 18 parts of licorice, 25 parts of Lycopodiella cuneata, 22 parts of green peel, 26 parts of dried tangerine peel, 1 part of centipede, 1 part of Eupolyphaga sinensis, 6 parts of Notopterygium wilfordii, 5 parts of Angelica dahurica, 6 parts of Eucommia bark, 7 parts of Achyranthes bidentata, 4 parts of papaya, 10 parts of cinnamon twig, 1 part of ephedra, 3 parts of Saposhnikovia divaricata, 12 parts of menthol, 5 parts of Millettia reticulata, 3 parts of Astragalus, 6 parts of Aconiti kusnezoffii, 6 parts of Aconiti kusnezoffii and 22 parts of glucosamine sulfate, wherein:

[0066] The frankincense and myrrh are both prepared by vinegar roasting, the licorice is prepared by honey roasting, the eucommia is prepared by salt roasting, and the papaya is prepared by wine roasting.

[0067] The preparation process of the above-mentioned bone and joint swelling and pain relieving external ointment is as follows:

[0068] Step 1: Weigh the processed Chinese medicinal materials and glucosamine sulfate according to the formula;

[0069] Step 2: crush and sieve the components except menthol and glucosamine sulfate, put them into a container, soak them with ethanol, and reflux extract them twice at 80°C for 2 hours each time, combine and mix the two extracts, concentrate them to 60-80% of the original drug solution, filter them while hot, and concentrate the filtrate to a concentrated solution with a relative density of 1.45-1.50 at 30°C;

[0070] Step 3: Crush and sieve the menthol and mix it with glucosamine sulfate into the concentrated solution, stir evenly and defoam under negative pressure to obtain an external ointment for reducing swelling and relieving pain in bone and joints.

[0071] Specifically, the solid-liquid ratio of ethanol to medicinal materials in the container is 1:6, the concentration of ethanol is 65%, and the soaking time is 1 hour.

[0072] Embodiment 3:

[0073] In the present embodiment, a bone and joint swelling and analgesic external ointment is provided, wherein the formula of the ointment is calculated by weight components, including 9 parts of dragon's blood, 3 parts of frankincense, 2 parts of myrrh, 3 parts of Panax notoginseng, 8 parts of Chuanxiong, 2 parts of Salvia miltiorrhiza, 5 parts of safflower, 30 parts of Impatiens balsamina, 3 parts of white peony root, 25 parts of licorice, 20 parts of Lycopodiella cuneata, 30 parts of green peel, 15 parts of dried orange peel, 1 part of centipede, 1 part of Eucommia ulmoides, 5 parts of Notopterygium wilfordii, 5 parts of Angelica dahurica, 3 parts of Eucommia ulmoides, 6 parts of Achyranthes bidentata, 4 parts of papaya, 6 parts of cinnamon twig, 1 part of ephedra, 5 parts of Saposhnikovia divaricata, 12 parts of menthol, 8 parts of Millettia spatholobi, 2 parts of Astragalus, 6 parts of Aconiti kusnezoffii, 6 parts of Aconiti kusnezoffii and 22 parts of glucosamine sulfate, wherein:

[0074] The frankincense and myrrh are both prepared by vinegar roasting, the licorice is prepared by honey roasting, the eucommia is prepared by salt roasting, and the papaya is prepared by wine roasting.

[0075] The preparation process of the above-mentioned bone and joint swelling and pain relieving external ointment is as follows:

[0076] Step 1: Weigh the processed Chinese medicinal materials and glucosamine sulfate according to the formula;

[0077] Step 2: crush and sieve the components except menthol and glucosamine sulfate, put them into a container, soak them with ethanol, and reflux extract them twice at 80°C for 2 hours each time, combine and mix the two extracts, concentrate them to 60-80% of the original drug solution, filter them while hot, and concentrate the filtrate to a concentrated solution with a relative density of 1.45-1.50 at 30°C;

[0078] Step 3: Crush and sieve the menthol and mix it with glucosamine sulfate into the concentrated solution, stir evenly and defoam under negative pressure to obtain an external ointment for reducing swelling and relieving pain in bone and joints.

[0079] Specifically, the solid-liquid ratio of ethanol to medicinal materials in the container is 1:6, the concentration of ethanol is 65%, and the soaking time is 1 hour.

[0080] Comparative Example 1:

[0081] The difference between this comparative example and Example 1 is that the amounts of dragon's blood, frankincense, ointment and Panax notoginseng in the formula are halved.

[0082] Comparative Example 2:

[0083] The difference between this comparative example and Example 1 is that the formula does not contain dragon's blood, frankincense, ointment and Panax notoginseng.

[0084] Comparative Example 3:

[0085] The difference between this comparative example and Example 1 is that the amount of glucosamine sulfate in the formula is halved.

[0086] Comparative Example 4:

[0087] The difference between this comparative example and Example 1 is that the formula does not contain glucosamine sulfate.

[0088] Comparative Example 5:

[0089] The difference between this comparative example and Example 1 is that the amounts of dragon's blood, frankincense, liniment, Panax notoginseng and glucosamine sulfate in the formula are halved.

[0090] Comparative Example 6:

[0091] The difference between this comparative example and Example 1 is that the formula does not contain dragon's blood, frankincense, ointment, Panax notoginseng and glucosamine sulfate.

[0092] Test Example 1:

[0093] Anti-inflammatory and analgesic effect experiments:

[0094] 1 Experimental animals: SPF Kunming mice, weighing 20±2 g, were provided by the Experimental Animal Center of Guizhou Medical University. The experimental animal use license is: SYXK(Guizhou)2014-001.

[0095] 2 Experimental method: After 1 week of conventional adaptive feeding of mice, the mice were randomly divided into 10 groups, each with 10 mice. One group was not administered as a blank control group, and the remaining 9 groups were administered with the ointments prepared in Examples 1-3 and Comparative Examples 1-6. The depilatory cream was applied to both sides of the spine of the back of the mice (1cm×1cm) to remove hair. After 5 minutes, it was cleaned with gauze. The mice in the blank control group were not treated; the remaining groups took 0.25ml / mouse of the corresponding ointment and applied it on the shaved skin of the mice, and fixed it with gauze. All mice were applied once a day for 10 consecutive days. On the 10th day, 0.6% acetic acid 0.02mL / g was injected intraperitoneally in each group of mice, and the number of twists of the mice within 30 minutes was recorded immediately, and the analgesic percentage was calculated: analgesic percentage (%) = (number of twists in the blank control group - number of twists in the drug administration group) / average number of twists in the blank control group × 100%.

[0096] 3 Experimental results: The results are expressed as mean ± standard deviation. See Table 1.

[0097]

[0098]

[0099] Table 1

[0100] 4 Conclusion:

[0101] Combined with the data in Table 1, it can be seen that the ointments provided in Examples 1-3 of the present invention all have good analgesic effects, and the ointment prepared with the formula amount of Example 1 has the best analgesic effect;

[0102] By comparing and observing Example 1 and Comparative Examples 1-6, it can be seen that adding an appropriate amount of dragon's blood, frankincense, liniment, Panax notoginseng and glucosamine sulfate to the ointment can effectively improve the analgesic effect of the ointment. When the content of dragon's blood, frankincense, liniment, Panax notoginseng and glucosamine sulfate is reduced, the analgesic effect of the ointment is significantly reduced. When dragon's blood, frankincense, liniment, Panax notoginseng and glucosamine sulfate are not added, the analgesic effect of the ointment will be greatly reduced.

[0103] Test Example 2:

[0104] Xylene-induced ear swelling experiment in mice

[0105] 1 Experimental animals and grouping The operation was the same as in Experimental Example 1. All 10 groups of mice were treated with drug 1 once a day for 10 consecutive days.

[0106] 2 Experimental methods: 30 minutes after drug intervention on the 10th day, 30 μL of xylene was applied to both sides of the right ear of the mouse, and the left ear was used as a control. 30 minutes after the application of xylene, the mouse was killed by cervical dislocation. The two ears were cut along the auricle baseline, and round ear pieces were punched at the same position with an 8 mm diameter puncher. The mass was weighed on an electronic balance, and the swelling degree and swelling inhibition rate were calculated. Swelling degree = right ear piece weight - left ear piece weight. Swelling inhibition rate = (average swelling degree of blank control group - average swelling degree of drug group) / average swelling degree of blank control group × 100%.

[0107] 3 Experimental results: The results are expressed as mean ± standard deviation, as shown in Table 2:

[0108] Group Swelling degree (mg / kg) Inhibition rate (%) Blank control group 3.2±0.2 - Example 1 1.4±0.1 56.3 Example 2 1.6±0.2 50.0 Example 3 1.6±0.2 50.0 Comparative Example 1 1.9±0.2 40.6 Comparative Example 2 2.3±0.2 28.1 Comparative Example 3 1.8±0.2 43.6 Comparative Example 4 2.2±0.2 31.3 Comparative Example 5 2.3±0.2 28.1 Comparative Example 6 2.7±0.2 15.6

[0109] Table 2

[0110] 4 Conclusion:

[0111] Combined with the data in Table 1, it can be seen that the ointments provided in Examples 1-3 of the present invention all have a good detumescence effect, and the ointment prepared with the formula amount of Example 1 has the best analgesic effect;

[0112] By comparing and observing Example 1 and Comparative Examples 1-6, it can be seen that adding appropriate amounts of dragon's blood, frankincense, ointment, Panax notoginseng and glucosamine sulfate to the ointment can effectively improve the detumescent effect of the ointment.

[0113] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A bone and joint swelling and pain relieving external ointment, characterized in that: The formula of the ointment is calculated by weight and comprises 3-9 parts of dragon's blood, 1-7 parts of frankincense, 1-8 parts of myrrh, 1-3 parts of Panax notoginseng, 4-9 parts of Chuanxiong, 1-6 parts of Salvia miltiorrhiza, 3-10 parts of safflower, 15-50 parts of Impatiens balsamina, 2-12 parts of white peony root, 10-35 parts of liquorice, 15-60 parts of Lycopodiella cuneata, 12-40 parts of green peel, 12-40 parts of dried tangerine peel, 1-6 parts of centipede, 1-6 parts of earthworm, 3-10 parts of Notopterygium wilfordii, 3-10 parts of Angelica dahurica, 2-15 parts of Eucommia bark, 3-10 parts of Achyranthes bidentata, 2-8 parts of papaya, 3-15 parts of cassia twig, 1-5 parts of ephedra, 1-5 parts of Saposhnikovia divaricata, 6-15 parts of menthol, 2-8 parts of Millettia spatholobi, 1-8 parts of Astragalus, 3-15 parts of Chuanwuji, 3-15 parts of Aconitum kusnezoffii and 10-30 parts of glucosamine sulfate.

2. The external-use ointment for reducing swelling and relieving pain in bone and joints according to claim 1, characterized in that: The formula of the ointment is calculated by weight and comprises 4-7 parts of dragon's blood, 1-6 parts of frankincense, 2-6 parts of myrrh, 1-2 parts of Panax notoginseng, 4-7 parts of Chuanxiong, 2-5 parts of Salvia miltiorrhiza, 4-8 parts of safflower, 20-40 parts of Impatiens balsamina, 3-8 parts of white peony root, 15-30 parts of liquorice, 20-50 parts of Lycopodiella cuneata, 15-32 parts of green peel, 15-32 parts of dried tangerine peel, 1-4 parts of centipede, 1-4 parts of earthworm, 4-8 parts of Notopterygium wilfordii, 4-8 parts of Angelica dahurica, 4-12 parts of Eucommia bark, 4-8 parts of Achyranthes bidentata, 3-6 parts of papaya, 5-12 parts of cassia twig, 1-3 parts of ephedra, 1-3 parts of Saposhnikovia divaricata, 8-12 parts of menthol, 3-6 parts of Millettia spatholobi, 2-5 parts of Astragalus, 5-10 parts of Aconiti kusnezoffii, 5-10 parts of Aconiti kusnezoffii and 15-25 parts of glucosamine sulfate.

3. The external-use ointment for reducing swelling and relieving pain in bone and joints according to claim 1, characterized in that: The formula of the ointment is calculated by weight and includes 5 parts of dragon's blood, 3 parts of frankincense, 4 parts of myrrh, 1 part of Panax notoginseng, 5 parts of Chuanxiong, 4 parts of Salvia miltiorrhiza, 3 parts of safflower, 30 parts of Impatiens balsamina, 6 parts of white peony root, 20 parts of liquorice, 30 parts of Lycopodiella cuneata, 18 parts of green peel, 24 parts of dried tangerine peel, 1 part of centipede, 1 part of earthworm, 5 parts of Notopterygium wilfordii, 7 parts of Angelica dahurica, 8 parts of Eucommia bark, 6 parts of Achyranthes bidentata, 5 parts of papaya, 8 parts of cassia twig, 1 part of ephedra, 1 part of Saposhnikovia divaricata, 10 parts of menthol, 4 parts of Millettia reticulata, 3 parts of Astragalus, 7 parts of Aconiti kusnezoffii, 7 parts of Aconiti kusnezoffii and 20 parts of glucosamine sulfate.

4. A bone and joint swelling and pain relieving external ointment according to claims 1-3, characterized in that: The frankincense and myrrh are both prepared by vinegar roasting method.

5. A bone and joint swelling and pain relieving external ointment according to claims 1-3, characterized in that: The licorice is prepared by honey roasting method.

6. A bone and joint swelling and pain relieving external ointment according to claims 1-3, characterized in that: The Eucommia ulmoides is prepared by a salt-roasting method.

7. A bone and joint swelling and pain relieving external ointment according to claims 1-3, characterized in that: The papaya is prepared by a wine-roasting method.

8. A process for preparing a bone and joint swelling and pain relieving external ointment according to any one of claims 1 to 7, characterized in that: The following steps are involved: Step 1: Weigh the processed Chinese medicinal materials and glucosamine sulfate according to the formula; Step 2: crush and sieve the components except menthol and glucosamine sulfate, put them into a container, soak them with ethanol, and reflux extract them twice at 80°C for 2 hours each time, combine and mix the two extracts, concentrate them to 60-80% of the original drug solution, filter them while hot, and concentrate the filtrate to a concentrated solution with a relative density of 1.45-1.50 at 30°C; Step 3: Crush and sieve the menthol and mix it with glucosamine sulfate into the concentrated solution, stir evenly and defoam under negative pressure to obtain an external ointment for reducing swelling and relieving pain in bone and joints.

9. The preparation process of the external ointment for reducing swelling and relieving pain in bone and joints according to claim 8, characterized in that: The solid-liquid ratio of ethanol to medicinal materials in the container is 1:4-8, the concentration of ethanol is 50-75%, and the soaking time is 0.5-2h.

Images