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Liquid composition containing loratadine and ambroxol hydrochloride

A technology of ambroxol hydrochloride and loratadine, applied in medical preparations containing active ingredients, drug combinations, drug delivery, etc.

Inactive Publication Date: 2008-04-02
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because symptoms such as cough and sputum caused by respiratory allergies often occur successively, there are few domestic western medicines that can simultaneously treat multiple symptoms caused by respiratory allergies

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] This embodiment is oral liquid

[0032] Loratadine 100g

[0033] Ambroxol Hydrochloride 600g

[0034] Propylene glycol 20000g

[0035] Sorbitol 10000g

[0036] Glycerin 5000g

[0037] Citric acid (as anhydrous) 500g

[0038] Sodium chloride 500g

[0039] Sucralose 100g

[0040] Sodium Benzoate 100g

[0041] Disodium edetate 50g

[0042] Orange Flavor 75g

[0043] Add purified water to 100000ml

[0044]

[0045] Makes 1000 bottles

[0046] Preparation process: Add propylene glycol to a suitable container, then add loratadine and stir to dissolve, adjust the pH value to 2.5-3.0 to obtain solution 1; measure 60000ml of purified water, add ambroxol hydrochloride, stir to dissolve, then add sorbitol , citric acid, sodium chloride, sucralose and sodium benzoate, and finally add glycerin to adjust the pH value to 2.3-2.7 to obtain solution 2; measure 5000ml of water, add disodium edetate, stir and dissolve to obtain...

Embodiment 2

[0048] This embodiment is oral liquid

[0049] Loratadine 100g

[0050] Ambroxol Hydrochloride 600

[0051] Propylene glycol 20000g

[0052] Sorbitol 10000g

[0053] Glycerin 5000g

[0054] Citric acid (as anhydrous) 500g

[0055] Sodium chloride 500g

[0056] Sodium saccharin 200g

[0057] Sodium Benzoate 100g

[0058] Disodium edetate 50g

[0059] Apple flavor 75g

[0060] Add purified water to 100000ml

[0061]

[0062] Makes 1000 bottles

[0063] Preparation process: Add propylene glycol to a suitable container, then add loratadine and stir to dissolve, adjust the pH value to 2.5-3.0 to obtain solution 1; measure 60000ml of purified water, add ambroxol hydrochloride, stir to dissolve, then add sodium saccharin , citric acid, sodium chloride, sucralose and sodium benzoate, and finally add glycerin to adjust the pH value to 2.3-2.7 to obtain solution 2; measure 5000ml of water, add disodium edetate, stir and dissol...

Embodiment 3

[0065] This embodiment is oral liquid

[0066] Loratadine 100g

[0067] Ambroxol Hydrochloride 600

[0068] Propylene glycol 20000g

[0069] Sorbitol 10000g

[0070] Glycerin 5000g

[0071] Citric acid (as anhydrous) 500g

[0072] Sodium chloride 500g

[0073] Sodium saccharin 200g

[0074] Benzoic acid 100g

[0075] Disodium edetate 50g

[0076] Banana flavor 75g

[0077] Add purified water to 100000ml

[0078]

[0079] Makes 1000 bottles

[0080] Preparation process: Add propylene glycol to a suitable container, then add loratadine and stir to dissolve, adjust the pH value to 2.5-3.0 to obtain solution 1; measure 60000ml of purified water, add ambroxol hydrochloride, stir to dissolve, then add sodium saccharin , citric acid, sodium chloride, sucralose and benzoic acid, and finally add glycerin to adjust the pH value to 2.3-2.7 to obtain solution 2; measure 5000ml of water, add disodium edetate, stir and dissolve t...

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PUM

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Abstract

The invention discloses a drug combination with loratadine and ambroxol hydrochloride as the active components and with the treating functions of allergy, relieving cough and expelling phlegm. The drug combination contains stabilizer, pH regulator, preservative, taste masking agent and metalion complexing agent, etc, and the existing forms of the product are syrups and oral liquid.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing loratadine and ambroxol hydrochloride, which has the effects of antiallergic, cough relieving and expectorant. The pharmaceutical composition also contains stabilizers, pH regulators, preservatives, flavoring agents, sweeteners and metal ion complexing agents. It exists in the form of syrup and oral liquid. Background technique [0002] Loratadine is a long-acting tricyclic antihistamine that selectively inhibits histamine H1 receptors. Ambroxol hydrochloride can promote the synthesis and secretion of pulmonary surfactant, form a thin film on the surface of alveolar epithelium, increase the movement of bronchial cilia, and make sputum easy to cough up. Ambroxol hydrochloride can promote the secretion of sputum through the mucolytic effect, and it can crack the disulfide bonds of mucin in the sputum to reduce the viscosity of the sputum and make the sputum easy to cough up. Since sympto...

Claims

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Application Information

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IPC IPC(8): A61K31/4545A61K31/7048A61K9/08A61P37/08A61P11/10A61P11/14
Inventor 席红民
Owner BEIJING D VENTUREPHARM TECH DEV
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