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Compound probiotic, application thereof for treating anaphylactic diseases and allergy free probiotic electuary for pregnant and lying-in women

A technology of compound probiotics and allergy probiotics, applied in the field of medicine, can solve the problem of low efficacy in preventing and treating allergies

Active Publication Date: 2013-06-26
贝因美(杭州)食品研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the above-mentioned patents can only promote the secretion of γ-interferon (IFN-γ), and the effective rate of preventing and treating allergies is not high.

Method used

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  • Compound probiotic, application thereof for treating anaphylactic diseases and allergy free probiotic electuary for pregnant and lying-in women
  • Compound probiotic, application thereof for treating anaphylactic diseases and allergy free probiotic electuary for pregnant and lying-in women
  • Compound probiotic, application thereof for treating anaphylactic diseases and allergy free probiotic electuary for pregnant and lying-in women

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The preparation of embodiment 1 compound probiotics

[0063] Bifidobacterium lactis Bi-07 0.3mg

[0064] Lactobacillus rhamnosus LR22 0.3mg

[0065] Lactobacillus acidophilus NCFM 0.3mg

[0066] After mixing, the compound probiotics are obtained. Among them, the content of Bifidobacterium lactis Bi-07 is 9.0×10 7 CFU / g, the content of Lactobacillus rhamnosus LR22 is 9.0×10 7 CFU / g, Lactobacillus acidophilus NCFM content is 6.0×10 7 CFU / g.

Embodiment 2

[0067] The preparation of embodiment 2 compound probiotics

[0068] Bifidobacterium lactis Bi-07 2g

[0069] Lactobacillus rhamnosus LR22 4g

[0070] Lactobacillus acidophilus NCFM 3g

[0071] After mixing, the compound probiotics are obtained. Among them, the content of Bifidobacterium lactis Bi-07 is 6.0×10 11 CFU / g, the content of Lactobacillus rhamnosus LR22 is 1.2×10 12 CFU / g, Lactobacillus acidophilus NCFM content is 6.0×10 11 CFU / g.

Embodiment 3

[0072] The preparation of embodiment 3 compound probiotics

[0073] Bifidobacterium lactis Bi-07 3g

[0074] Lactobacillus rhamnosus LR22 2g

[0075] Lactobacillus acidophilus NCFM 4g

[0076] After mixing, the compound probiotics are obtained. Among them, the content of Bifidobacterium lactis Bi-07 is 9.0×10 11 CFU / g, the content of Lactobacillus rhamnosus LR22 is 6.0×10 11 CFU / g, Lactobacillus acidophilus NCFM content is 8.0×10 11 CFU / g.

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Abstract

The invention relates to the field of medicines, and in particular to compound probiotic, application thereof for treating anaphylactic diseases and allergy free probiotic electuary for pregnant and lying-in women. The compound probiotic consists of bifidobacterium Bi-07, lactobacillus rhamnosus LR22, lactobacillus acidophilus NCFM. The compound probiotic not only can irritate secretion of IFN-gamma and IL-2 in animal body, but also inhibit secretion of immune globulin E (IgE) and IL-4 so as to prevent and treat anaphylactic diseases. The invention further provides a medical preparation comprising the compound probiotic and allergy free probiotic electuary for pregnant and lying-in women. The pharmacodynamic test shows that the medical preparation has remarkable effect of improving IL-2 and IFN-gamma. In addition, compared with the control group, the content of IgE in the test group is further remarkably reduced. Long-term clinical tests show that the medical preparation comprising the compound probiotic provided by the invention is free from untoward effects to human body.

Description

technical field [0001] The invention relates to the field of medicine, in particular to compound probiotics, their application in the treatment of allergic diseases and anti-allergic probiotic granules for pregnant and lying-in women. Background technique [0002] Allergy refers to an acquired potential to produce a harmful immune response to a normally harmless substance, and is an allergic disease. Clinically common pruritus, asthma, allergic rhinitis, allergic dermatitis such as eczema, urticaria and so on. It is generally believed that allergic reactions include early specific immune responses and late inflammatory responses. Allergens (eg, milk, pollen, mite dust) have been reported to form early allergic responses by stimulating high-affinity immunoglobulin (IgE) receptors. When IgE enters the blood, it comes into contact with the surface membranes of mast cells and basophils in the body's epithelial mucous membranes, such as the respiratory tract, gastrointestinal t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A23L1/29A61P37/08A61K31/702A23L33/00A61K35/745A61K35/747
Inventor 姜慧萍何光华储小军
Owner 贝因美(杭州)食品研究院有限公司
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