A method for segmentation of paint cracks on an ICGA image based on a conditional generative adversarial network includes: (1), collecting an original ICGA image, extracting a complete fundus oculography image, labeling it with gold standard, normalizing fundus oculography image and gold standard, splicing it into a group of images as sample data, distributing the sample into a training set and atest set according to proportion; (2) based on the principle of conditional generative countermeasure network, constructing the network of generators and discriminators; (3) inputting that data of thetraining set into the network for adversarial train, defining a loss function, and generating a paint crack image correspond to the original picture by the training generator; (4) in the testing phase, inputting the data of the test set, and getting the corresponding paint crack segmentation result diagram through the trained generator G. The segmentation method provided by the invention can be used for solving the problems that the sample size of the ICGA image is small and the acquisition of the contrast image is difficult, and has the characteristics of high accuracy of the segmentation result.