The invention relates to an architecture structural design method of technical sphere, in particular to a hybrid reinforcing bars design method for a large span prestressed beam with binding and non-binding, whose steps comprise definition of a section size, prediction of a general area of binding sectional Ap, definition of a general area of binding non-prestressed reinforcement As1, calculation of binding prestressed lost copyright ln1, checking of binding design in common using status, checking of binding bearing ability, definition of an area of non-binding sectional Apn2, definition of a general area of hybrid reinforcing bars in non-prestressed reinforcement As2, calculation of non binding prestressed lost copyright ln2, checking of limit in common use of the hybrid reinforcing bars, checking of checking of the bearing ability limit of the hybrid reinforcing bars. The invention changes a part of binding sectional to non-binding sectional for the large span prestressed beam with binding design under the status of meeting the common use, the anti-knock, and the requirement of structure, and bearing ability often is more than enough, while the invention reduces the impact of structure by the ultrastrong bearing ability in a status of improving the common running ability and makes construction more convenience.