3 results about "Serum amyloid P" patented technology

This invention belongs to the field of biodetection technology, specifically relating to a monoclonal antibody combination capable of simultaneously recognizing equine and feline serum amyloid A (SAA) and its application. The monoclonal antibody combination comprises 6E10 and 5A6. The CDR sequences of the heavy and light chain variable regions of 6E10 are shown in SEQ ID NO. 1-6, and the CDR sequences of the heavy and light chain variable regions of 5A6 are shown in SEQ ID NO. 7-12. This antibody combination can highly specifically recognize and bind to recombinant equine and feline SAA proteins, achieving multiple uses with a single antibody and reducing raw material development and production costs. The colloidal gold test strip constructed based on this combination exhibits high specificity, high sensitivity, and a wide detection range, with no cross-reactivity. It is easy to operate and requires no complex instruments, providing a stable and reliable biorecognition tool for assessing and monitoring inflammation-related physiological states in animals.

The present disclosure relates to anti-SAA antibodies or fragments thereof, such as antibodies against human SAA1 or fragments thereof, that may be used in various therapeutic, prophylactic and diagnostic methods. The present antibodies or fragments thereof may be used to treat hematologic disorders such as acute myeloid leukemia, acute lymphoid leukemia, and myelodysplastic syndrome.

The application discloses a single-domain antibody of serum amyloid protein SAA, a nucleotide sequence coding the single-domain antibody is shown as SEQ ID NO:1, and an amino acid sequence of the single-domain antibody is shown as SEQ ID NO:2. The single-domain antibody of serum amyloid protein SAA provided by the application shows excellent stability in a range from normal temperature to 50 DEG C, especially can be stored for a long time under the condition of normal temperature to 50 DEG C, obviously reduces the difficulty of antibody storage, and effectively saves the cost of storage and transportation.