42 results about "Serum amyloid P" patented technology

Provided are methods for the detection and diagnosis of acute coronary syndrome or ACS. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of ACS. At least two new biomarkers for ACS are thus disclosed, MMP-3 and SGOT. Altogether the concentrations of twelve analytes provide a sensitive and selective picture of the patient's condition, namely, whether the patient is suffering a heart attack. Other important biomarkers for ACS are described, including but not limited to IL-18, Factor VII, ICAM-1, Creatine Kinase-MB, MCP-1, Myoglobin, C Reactive Protein, von Willebrand Factor, TIMP-1, Ferritin, Glutathione S-Transferase, Prostate Specific Antigen (free), IL-3, Tissue Factor, alpha-Fetoprotein, Prostatic Acid Phosphatase, Stem Cell Factor, MIP-1-beta, Carcinoembryonic Antigen, IL-13, TNF-alpha, IgE, Fatty Acid Binding Protein, ENA-78, IL-1-beta, Brain-Derived Nerotrophic Factor, Apolipoprotein A1, Serum Amyloid P, Growth Hormone, Beta-2 microglobulin, Lipoprotein (a), MMP-9, Thyroid Stimulating hormone, alpha-2 Macroglobulin, Complement 3, IL-7, Leptin, and IL-6. Kits containing reagents to assist in the analysis of fluid samples are also described.

The present invention addresses the problem of providing a reagent kit, measurement kit, and measurement method for immunologically measuring serum amyloid A with high accuracy and high sensitivity, without using an alcohol designated as a hazardous material in the fire protection code. The present invention provides a reagent kit that is for measuring serum amyloid A and that contains: first particles labelled and modified with a first binding substance capable of specifically binding to serum amyloid A; and at least one nonionic surfactant having a molecular weight of 1000 or less.

Functionalized pentraxin-2 (PTX-2) protomers and functionalized PTX-2 pentamers, methods for preparing functionalized PTX-2 protomers and functionalized PTX-2 pentamers, pharmaceutical compositions including functionalized PTX-2 pentamers, and methods for using the same are described herein.

The present invention is directed to diagnosing, determining, and / or monitoring type 2 diabetes, pre-diabetes, insulin resistance, and their related conditions by detecting levels and modulations of Serum amyloid A protein (SAA), SAA variants and / or the phenotypic ratio of SAA. The present invention is also directed to methods for identifying and evaluating therapeutic treatments for type 2 diabetes, pre-diabetes, insulin resistance, and their related conditions by monitoring SAA, SAA variants, and / or the phenotypic ration of SAA.

RNA interference is provided for inhibition of serum amyloid A mRNA expression in glaucomas involving SAA expression.

The present application discloses a test strip for joint detection of C-reactive protein and serum amyloid A, a kit and a preparation method for the test strip. The test strip comprises a bottom plate, a sample pad, a binding pad, a reaction pad and a water-absorbing pad; the binding pad is coated with fluorescent microspheres jointly labeled with CRP antibody and CRP broadened rabbit anti-antibody, SAA antibody and SAA broadened chicken anti-antibody joint label Fluorescent microspheres; CRP detection line, SAA detection line, CRP widening line and SAA widening line are formed on the reaction pad. The test strip and the test kit containing the test strip of this application can simultaneously quantitatively detect the content of CRP and SAA in the sample, with high sensitivity, good specificity, fast detection speed, and a very wide linear range. The linear range of CRP is 0.5-600mg / L, the linear range of SAA is 3-800mg / L, which reduces the repeated dilution of samples in clinical practice and improves the efficiency of clinical diagnosis.

The invention discloses a kit for measuring serum amyloid A content by scattering turbidimetry. The composition of the kit is simple, adding alfalfa saponin can combine with cholesterol to reduce total cholesterol in serum, and can effectively eliminate the interference of cholesterol. The kit is carried out by nephelometry, and the linear range, correlation and sensitivity of the detection are higher than the existing kits, which significantly improves the sensitivity of serum amyloid A detection and solves the problem of existing serum amyloid A detection reagents. Box detection sensitivity, low precision, and narrow linear range.