102 results about "Drug infusion" patented technology

Treatment of hypertension includes implantation of the discharge portion(s) of a catheter and/or electrical stimulation electrode(s) adjacent the tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and/or electrical pulses, are supplied by one or more implanted stimulators, through the catheter and possibly also a lead, tunneled subcutaneously between the stimulator and stimulation site. A microstimulator(s) may also/instead deliver electrical stimulation pulses. Stimulation sites include the carotid sinus and carotid body, among other locations. Treatments include drugs used for acute and/or chronic treatment of hypertension. In a number of embodiments, a need for or response to treatment is sensed, and the electrical and/or infusion pulses adjusted accordingly.

Introducing one or more stimulating drugs to the brain and/or applying electrical stimulation to the brain is used to treat epilepsy. At least one implantable system control unit (SCU) produces electrical pulses delivered via electrodes implanted in the brain and/or drug infusion pulses delivered via a catheter implanted in the brain. The stimulation is delivered to targeted brain structures to adjust the activity of those structures. The small size of the SCUs of the invention allow SCU implantation directly and entirely within the skull and/or brain. Simplicity of the preferred systems and methods and compactness of the preferred system are enabled by the modest control parameter set of these SCU, which do not require or include a sensing feature.

A local renal delivery system includes a flow isolation assembly and a local injection assembly. The flow isolation assembly in one mode is adapted to isolate only a partial flow region along the outer circumference along the aorta wall such that fluids inject there are maintained to flow substantially into the renal arteries. Various types of flow isolation assemblies and local injection assemblies are described.

Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to alleviate pain use at least one implantable system control unit (SCU), producing electrical pulses delivered via electrodes implanted in the brain and/or producing drug infusion pulses, wherein the stimulation is delivered to targeted areas in the brain. In some embodiments, one or more sensed conditions are used to adjust stimulation parameters.

The application discloses a drug infusion system comprising a base and a drug dispenser. The base is configured to receive a cannula that delivers a drug to beneath a wearer's skin. The base is attachable to the skin of the wearer. The reusable drug dispenser is removably attachable to the base and has a pump unit configured to establish fluid communication between a removably attachable drug reservoir and the cannula. The pump unit pumps the drug to the wearer upon activation by the wearer. The pump unit may have an inlet to contact the drug within the reservoir, which may be a needle. The pump unit may also have a receiving unit to receive the reservoir. Such a receiving unit may be a tubular for a cylindrical reservoir, or may have a cavity or an encasing unit to hold the reservoir.

When using a drug container having an identification tag fixed or detachably provided at a predetermined position of the container, the tag having drug data on a kind and a concentration of a drug and both or one of upper and lower limits of a flow rate on a continuous infusion and the upper and lower limits, time and flow rate on a one-shot administration recorded thereon, it is possible to ensure safety by prompting for a stop of injection by a warning when a setting beyond the upper and lower limits is performed and rewrite a liquid infusing time and a flow rate and so on required to be set according to symptoms of a patient.

System and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to the cortex of the brain to treat movement disorders uses at least one implantable system control unit (SCU), specifically an implantable signal/pulse generator (IPG) or microstimulator with two or more electrodes in the case of electrical stimulation, and an implantable pump with one or more infusion outlets in the case of drug infusion. In certain embodiments, a single SCU provides both electrical stimulation and one or more stimulating drugs. In some embodiments, one or more sensed conditions are used to adjust stimulation parameters.

Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each m^th successive group of applications of the treatment therapy or for each n^th detection cluster.

An adjustable infusion injection apparatus which is designed to be used in conjunction with a surgically implanted infusate injection port. The apparatus utilizes a catheter assembly and an introducer needle assembly. The catheter assembly is to be installed on the skin of the patient in alignment with the port and the introducer needle is to be inserted in conjunction with the catheter assembly to insert a catheter within an internal chamber of the port and then the introducer needle is then removed with the catheter to then be used to inject medication from an inlet tube. During installation a movable portion of said catheter assembly can be moved to abuttingly be in contact with the skin of the patient.

This document discusses, among other things, systems and methods that detect hypotension based on a measurement of thoracic impedance. It also provides an alert, a logging, or a therapy to treat the hypotension. Examples of anti-hypotension therapies include, among other things, pacing therapy, neural stimulation therapy, drug infusion therapy, or gene therapy.

Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to tissue affecting the penis to treat erectile dysfunction (for instance, following prostate surgery) uses at least one implantable system control unit (SCU) producing electrical pulses delivered via electrodes and/or producing drug infusion pulses, wherein the stimulating drug(s) are delivered via one or more pumps and infusion outlets.

Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.

Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each m^th successive group of applications of the treatment therapy or for each n^th detection cluster.

A method and apparatus for treatment of heart failure, hypertension and renal failure by stimulating the renal nerve. The goal of therapy is to reduce sympathetic activity of the renal nerve. Therapy is accomplished by at least partially blocking the nerve with drug infusion or electrostimulation. Apparatus can be permanently implanted or catheter based.

Systems and methods are provided for applying electrical stimulation and/or introducing one or more stimulating drugs to the brain to treat or prevent aphasia, including through use of at least one system control unit (SCU) for controlling electrical pulses delivered via electrodes implanted in the brain and/or for producing drug infusion pulses to targeted areas in the brain.

Methods, systems, and apparatus for the treatment of heart failure (both systolic and diastolic), hypertension, and arrhythmia in patients by stimulating one or more nerves, particularly peripheral nerves, using neurostimulation are described. The therapeutic treatment is accomplished by applying electrical signals to at least one or more nerves using cutaneous, subcutaneous, implantable, or catheter-based neurostimulation assemblies, alone or in combination with one or more additional therapy or stimulation devices associated with the patient's heart, and/or with one or more therapeutic drug infusions or therapies, such as immune modulation therapy (IMT).

Thrombolytic and/or anticoagulation therapy of the present invention includes implantation of the discharge portion(s) of a catheter and, optionally, one or more electrodes on a lead, adjacent tissue(s) to be stimulated. Stimulation pulses, i.e., drug infusion pulses and optional electrical pulses, are supplied by a stimulator implanted remotely, and through the catheter or lead, which is tunneled subcutaneously between the stimulator and stimulation site. Stimulation sites include the coronary arteries, coronary veins, cerebral arteries, other blood vessels, chambers of the heart, mesenteric vessels, deep vessels of the leg, and other locations. Disclosed treatments include drugs used for chronic treatment and/or prevention of thromboembolic disease, for acute treatment of thromboembolic disease, for acute treatment of thrombosis, and combinations of these. The invention reduces or eliminates the incidence of thromboembolic disease and related morbidities, improve symptoms resulting from thromboembolic disease, and improve patient quality of life.

Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to the brain to at least treat or prevent obesity and/or other eating disorders, as well as drug, nicotine and alcohol addiction, uses at least one system control unit (SCU) producing electrical pulses delivered via electrodes implanted in the brain and/or producing drug infusion pulses, wherein the stimulating drug(s) are delivered to targeted areas in the brain.

A system for performing an intraparenchymal drug infusion including a pump device, a delivery tube, a sensor, and a processor. The tube is fluidly coupled to the pump device, establishing an infusate pathway from the pump to an infusate exit port of the delivery tube. The sensor is positioned to sense a parameter indicative of pressure in the infusate pathway. Finally, the processor is programmed to generate information indicative of infusate delivery effectiveness of a drug infusion procedure based upon information from the sensor. In some embodiments, the processor generates a net infusion pressure profile, such as a pressure-time curve, and prompts display of the pressure profile to a neurosurgeon for subsequent evaluation of infusate delivery effectiveness.

The present invention is directed to a drug delivery pump apparatus, which comprises: (a) an expandable and contractible enclosure having an interior volume that defines a medication reservoir; (b) one or more electroactive polymer actuators; (c) a medication outlet port providing fluid communication between the interior volume of the contractible and expandable enclosure and an exterior of the delivery pump apparatus; and (d) a control unit electrically coupled to the one or more actuators and sending control signals to the same. The one or more electroactive polymer actuators act to reduce the interior volume of the contractible and expandable enclosure based upon the received control signals. The present invention is also directed to a method of delivering a liquid therapeutic agent to a patient. The method comprises: (a) providing the above infusion pump apparatus; (b) placing the outlet port of the infusion pump apparatus in fluid communication with a patient; and (c) sending the control signals to the one or more actuators to reduce the internal volume of the contractible and expandable enclosure, thereby forcing a portion of the liquid therapeutic agent within the medication reservoir through the outlet port and into the patient.

Disclosed is drug delivery for facilitating medical and/or procedures that are performed without “general anesthesia,” which is also described in the specification as the state of patient “unconsciousness” resulting from a drug administered by an anesthetist or anesthesiologist. Mixtures of sedative and analgesic drugs are adapted for safe and effective administration by devices to provide and maintain drug infusions that do not push the patient into unconsciousness and/or general anesthesia. Drug delivery devices are also disclosed that include the use of stored parameters and/or values that correlate to drug mixture delivery during a procedure, and a patient health monitor to measure and send signals regarding a patient health condition to a processor.