44results about How to "Increase irritation" patented technology

The invention discloses selenium disulfide shampoo with a good suspension effect and a preparation method of the selenium disulfide shampoo. The selenium disulfide shampoo comprises the following raw materials in percentage by weight: 0.05-1% of selenium disulfide particles; 0.2-6% of a high-molecular polymer capable of suspending selenium disulfide particles; 0.5 to 5% of a polyol; and 0.05%-0.1% of a chelating agent. The selenium disulfide shampoo has the advantage of being good in suspension effect, and the problems that in the using process of existing selenium disulfide shampoo, due to the fact that the dispersion uniformity and suspension stability of selenium disulfide in the shampoo are poor, the selenium disulfide is likely to be precipitated in a shampoo container, the concentration of the selenium disulfide before and after use is different, and the selenium disulfide cannot be precipitated in the shampoo container are solved. The treatment effect of the selenium disulfide shampoo on a patient is influenced.

The invention belongs to the technical field of cosmetic preparations, and particularly relates to a composition containing triethanolamine and tranexamic acid modified hydroxytyrosol as well as a preparation method and application of the composition. According to the invention, hydroxytyrosol is modified by using triethanolamine and tranexamic acid through etherification and esterification reactions, the processing mode obviously enhances the electrification capability of hydroxytyrosol, and further obviously enhances the antibacterial strength of hydroxytyrosol, so that hydroxytyrosol is compounded with triethanolamine and tranexamic acid to replace a traditional preservative, and the antibacterial property of hydroxytyrosol is improved. And adverse reactions such as irritation and allergy of common preservatives are improved. According to the invention, the hydroxytyrosol is modified by using triethanolamine and tranexamic acid, and triethanolamine and tranexamic acid are functional components, so that triethanolamine and tranexamic acid can play roles in resisting oxidation, whitening and the like together with hydroxytyrosol in a cosmetic matrix while playing a role in improving the bacteriostasis of hydroxytyrosol.

The utility model provides an amusement flying saucer turntable, which belongs to the technical field of amusement flying saucers, and comprises a flying saucer turntable, a left-right shaking component is arranged on the flying saucer turntable, the left-right shaking component comprises a plurality of arc-shaped grooves arranged on the flying saucer turntable, arc-shaped blocks are arranged in the arc-shaped grooves, and supporting blocks are arranged on the upper surfaces of the arc-shaped blocks. Safety seats are arranged on the upper surfaces of the supporting blocks; according to the utility model, the safety seat can shake, so that not only are the interestingness and the irritation of amusement increased, but also the bringing-in feeling of personnel is improved.

This invention discloses a mild and stable temperature-responsive microemulsion composition, its preparation method, and its applications, belonging to the fields of cosmetics and pharmaceutical technology. This invention uses a nonionic decyl glucoside and anionic sodium lauroyl glutamate, introducing tocopherol polyethylene glycol succinate and disodium EDTA, forming a dual stabilizing mechanism of "antioxidant + metal ion chelation," effectively protecting unstable active ingredients such as glycyrrhizin. Experiments show that in an accelerated test at 60℃, the retention rate of glycyrrhizin increased by more than 20%. The microemulsion composition prepared by this invention exhibits high stability, low irritation, and skin-targeted sustained-release properties.

The invention discloses a freckle-removing and whitening mask which is prepared from the following raw materials: chrysanthemum, pearl, radix angelicae, almond, poria cocos, rhizoma atractylodis macrocephalae, peach kernel, ginseng, mung bean, bletilla striata, cortex moutan, rhodiola rosea, silkworm larva, Chinese yam, honeysuckle and the like. The facial mask is a pure traditional Chinese medicine facial mask, has remarkable curative effects on whitening, removing freckles, removing acnes and minimizing pores, and can effectively reduce facial skin damage, effectively inhibit growth of facial germs, promote vigor of subcutaneous capillaries of the damaged face, improve metabolism of the skin and enable the facial skin to reappear in a compact and refined state. In addition, the facial mask can enhance the ability of facial skin to resist invasion and stimulation of external germs, form a natural protective barrier for the facial skin, well repair, moisten and care the facial skin, and keep the facial skin comfortable, beautiful and healthy for a long time. Pure traditional Chinese medicine raw materials are selected, chemical components are not added, and harm to facial skin and the body is avoided.

The application discloses a kind of method, system, equipment and storage medium suitable for ecological optimization scheduling of "artificial flood peak" of reservoir, belong to reservoir ecological scheduling technical field, this method first collects target river section basic environmental data and target fish spawning related information, constructs and verifies one-dimensional water power, water temperature model;Again, combine spawning information and model to determine spawning ground position and normalize data, calculate spawning scale and distribution characteristics;Subsequently, set spawning scale threshold, extract suitable water temperature, hydrological index and ecological scheduling time window of fish spawning by machine learning model;In window period, monitor and judge scheduling start condition, combined with forecast information of trunk stream and branch stream, to utilize branch stream hydrology water temperature condition, satisfy multiple spawning ground index as target to develop and execute scheduling scheme;Finally, the aforementioned method is used to calculate spawning scale during scheduling period, and the implementation effect of scheduling is evaluated.The application improves the accuracy of scheduling index and the feasibility of scheme, making the spawning scale statistics and effect evaluation more practical.

The present application relates to the technical field of nerve stimulation, and discloses a closed-loop vagus nerve precise blocking system and method based on physiological signal feedback, comprising a physiological signal monitoring unit for acquiring physiological signals of an individual in real time; a data acquisition and analysis module connected with the physiological signal monitoring unit, for receiving and analyzing the physiological signals, judging the physiological state of the individual, and generating a feedback signal; a stimulation device unit for outputting an electric stimulation signal based on the feedback signal, so that the vagus nerve stimulation reaches a functional block state; and a closed-loop feedback unit connected with the data acquisition and analysis module and the stimulation device unit, for dynamically adjusting the stimulation parameters according to the feedback signal and controlling the electric stimulation signal of the stimulation device in real time. Through the real-time monitoring and real-time feedback mechanism, the present application realizes functional block of the vagus nerve, and ensures the accuracy, safety and individualization of the inhibition operation.

The utility model relates to the wearable technical field, and provides multifunctional energy shorts which comprise an energy shorts body, the energy shorts body is provided with a control box connector and an electrode plate array capable of being flexibly combined, and the electrode plate array capable of being flexibly combined comprises a transverse combination mode, a longitudinal combination mode and an inclined combination mode. An electrode plate group is formed in each combination mode, and the electrode plate group in each combination mode and the muscle form a current conduction path. The electrode slice array which can be flexibly combined is arranged in the energy shorts, so that transverse, longitudinal and oblique combination modes can be formed among the electrode slices, and a current conduction path is formed between the electrode slices and muscles in each combination mode. Muscle stimulation can be flexibly and variously carried out according to user requirements, the muscle stimulation effect is improved, and meanwhile the use motivation and satisfaction degree of a user are improved.

A peripheral nerve stimulation system, comprising an percutaneous implanted lead (10), an adapter (20), a first cable (30), a stimulator (50) and a surface electrode, wherein the percutaneous implanted lead (10) can be inserted into the body of a patient through skin, and the percutaneous implanted lead (10) comprises a distal lead head (11) and a lead body (12) from a distal end to a proximal end, the distal lead head (11) comprising at least one electrode, the lead body (12) being formed by spirally winding at least one conductor wire (121), and the conductor wire (121) comprising a metal wire (122) and an insulating layer (123), which is arranged outside the metal wire (122) in a wrapping manner, such that the lead body (12) is of an open insulating spiral structure; the adapter (20) is electrically connected to the proximal end of the percutaneous implanted lead (10), the adapter (20) is electrically connected to the stimulator (50) by means of the first cable (30), and the stimulator (50) is used for sending an electrical stimulation pulse; and the surface electrode can be directly connected to the stimulator (50) or connected to the stimulator (50) by means of a second cable (72), and forms a stimulation loop together with the percutaneous implanted lead (10). By means of the peripheral nerve stimulation system, pain can be effectively suppressed, thereby improving the clinical treatment effect.

The utility model discloses a skin mask based on the ultrasonic technology, and relates to the technical field of beauty masks, the skin mask comprises a mask shell, a vertical driving track is constructed on the inner side of the mask shell, a driving rod is rotatably mounted on the side, away from the mask shell, of the driving track, and the driving rod is sleeved with a plurality of movable blocks in a threaded mode; supporting rods are hinged to the multiple movable blocks, a fixing frame located on the inner side of the mask shell is jointly supported by the multiple supporting rods, an ultrasonic substrate is installed in the middle of the fixing frame, multiple ultrasonic high-frequency vibration emitters are arranged on the ultrasonic substrate, and a conduction mask layer is elastically installed at an inner side end opening of the mask shell; the conductive mask layer is located on the side, away from the mask shell, of the ultrasonic substrate. Through the high-frequency vibration effect, permeation of mask components can be promoted, the skin of a user can be stimulated by generating the ultrasonic waves with the specific frequency, the absorption rate of the skin of the user to the mask components is increased, the beautifying effect is improved, and safety and comfort are achieved.

The application provides a low-deuterium water red ginseng and rhodiola compound mask as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The low-deuterium water red ginseng and rhodiola compound mask provided by the application comprises the following raw materials: a red ginseng and rhodiola compound, low-deuterium water, hydroxyethyl cellulose, carbomer-980, carbomer-981, panthenol, 1,2-hexanediol, p-hydroxyphenylacetone, glycerol, dipropylene glycol, beta-glucan, sodium alginate, disodium EDTA, betaine, allantoin, 1,3-butanediol, PEG-40 hydrogenated castor oil and tromethamine; the red ginseng and rhodiola compound is composed of red ginseng extract and rhodiola extract. The low-deuterium water red ginseng and rhodiola compound mask provided by the application has the effects of antioxidation, whitening and anti-photoaging, and can realize synergistic whitening and anti-photoaging.

The invention relates to the technical field of whitening lotion, and particularly discloses whitening essence lotion and a preparation method thereof.The whitening essence lotion is prepared from, by mass, 67.6% of deionized water, 1% of glycerin, 0.2% of carbomer, 0.2% of xanthan gum, 7% of 1-3 butanediol, 2% of D-panthenol, 2% of polysorbate-60, 0.2% of ethylhexylglycerin, 17.8% of olive oil and 2% of traditional Chinese medicine extract; the traditional Chinese medicine extract is a mixed extracting solution of radix paeoniae alba, rhizoma atractylodis macrocephalae, white poria cocos and liquorice, and the ratio of the radix paeoniae alba to the rhizoma atractylodis macrocephalae to the white poria cocos to the liquorice is 2: 2: 2: 1. According to the whitening essence lotion, the theory of traditional Chinese medicine is used as a foundation stone, natural Chinese herbal medicines such as the radix paeoniae alba, the rhizoma atractylodis macrocephalae, the white poria cocos and the liquorice are selected as raw materials, active ingredients of the raw materials are extracted, and melanin generation can be effectively inhibited; the traditional Chinese medicine composition has the effects of whitening skin, fading spots and brightening skin color, realizes natural and healthy whitening effects, can provide lasting moisturizing and nourishing for skin, effectively improves the dry state of the skin, and enhances the elasticity and luster of the skin.

This invention relates to a frontal lobe localization method for transcranial magnetic stimulation (TMS) coils, a closed-loop TMS system, and an apparatus. The closed-loop TMS system includes: a TMS device comprising a robotic arm and a TMS coil mounted on the robotic arm; an EEG cap having multiple electrodes and multiple points positioned in the frontal lobe region, the EEG cap being used to collect evoked signals generated in the brain during the i-th TMS stimulation session, obtaining multiple evoked signals; and a stimulation localization device receiving the multiple evoked signals provided by the EEG cap, generating a control command for the (i+1)-th TMS stimulation session based on the multiple evoked signals, and sending the (i+1)-th TMS stimulation control command to the TMS device for the next TMS stimulation session.

The invention relates to the technical field of tobacco processing, in particular to a composition for improving sensory comfort of burley tobacco and a preparation method and application of the composition. The composition for improving the sensory comfort of the burley tobacco, provided by the invention, is prepared from the following components in parts by weight: 6 to 55 parts of sugar material, 12 to 110 parts of herbal extract, 1 to 8 parts of malic acid, 1 to 5 parts of linalool, 2 to 20 parts of glycerol and 45 to 72 parts of water, wherein the sugar material is prepared from high fructose corn syrup and fructose, the mass ratio of the high fructose corn syrup to the fructose is (5-45): (1-10), and the high fructose corn syrup is F60 high fructose corn syrup; the herbal extractum comprises licorice extractum, cocoa extractum, jujube extractum, sea-buckthorn extractum, dark plum extractum, benzoin extractum and lysimachia sikokiana extractum. According to the burley tobacco lining adopting the composition, the aroma quality of burley tobacco can be improved, the sensory comfort of burley tobacco can be remarkably improved, the irritation is reduced, the aftertaste is improved, and the smoke state is improved.

The invention provides a flexible neural electrode composite coating and a preparation method and application thereof, the flexible neural electrode composite coating comprises polycaprolactone containing an anti-inflammatory drug minocycline and a nanofiber of methacrylated silk fibroin, the surface of the nanofiber is modified with a conductive polymer poly (3, 4-ethylenedioxythiophene) in situ, and the conductive polymer poly (3, 4-ethylenedioxythiophene) is modified with a conductive polymer poly (3, 4-ethylenedioxythiophene). Cured methacrylated silk fibroin hydrogel is formed on the surface of the modified material. According to the composite coating, the electrochemical performance is remarkably improved, the inflammatory reaction is relieved, and the biocompatibility is improved through the hydrogel. The composite coating has high charge storage / injection capacity, low interface impedance and good biocompatibility, and can stably record bio-electricity signals for a long time. The invention provides the invasive flexible neural electrode composite coating with remarkable anti-inflammatory action, excellent electrochemical performance and long-term stability, and reliable technical support is provided for clinical application of neural electrodes.

The present application relates to the technical field of organic synthesis, in particular to a method for synthesizing 2,2'-dithiodi[N-butyl-benzamide] in water phase with ethyl acetate as additive. Sodium iodide and hydroiodic acid are used as key additives to synthesize 2,2'-dithiodi[N-butyl-benzamide], which has certain safety hazards. In view of the above problems, the present application provides a method for synthesizing 2,2'-dithiodi[N-butyl-benzamide] in water phase with ethyl acetate as additive, which is to use 2-butyl-1,2-benzisothiazoline-3-ketone as starting reaction material, sodium sulfide as reducing agent, and ethyl acetate as key additive to synthesize 2,2'-dithiodi[N-butyl-benzamide] in water under room temperature and closed condition. The method of the present application completely avoids the use of strong acid such as hydroiodic acid and sodium iodide. Moreover, the raw materials used are all conventional chemicals, the reaction system is mild, the operation process is safe and reliable, and it is suitable for large-scale production.

The present invention provides a hot and cold stimulator, belonging to the technical field of medical equipment. The hot and cold stimulator includes a hot and cold air supply device and a hot and cold pipe air outlet mechanism. The hot and cold air supply device includes a bottom plate, a hot air blower and a cold air blower, the hot air blower and the cold air blower are both fixed on the top surface of the bottom plate, the hot and cold pipe air outlet mechanism includes a hot air pipe, a hollow pipe, an elastic sealing component and an air outlet pipe, the hot air pipe is connected to the hot air blower, the cold air pipe is connected to the cold air blower, the air outlet pipe is connected and fixed to the ends of the hot air pipe and the cold air pipe, the elastic sealing component is fixed between the hollow pipe and the air outlet pipe, a motor is fixed at the bottom of the air outlet pipe, a baffle is fixed at the output end of the motor, and the baffle is slidably connected to the top surface of the hollow pipe. The present invention improves the continuity of hot and cold stimulation and enhances the stimulation effect when the hot and cold stimulator is used, and is more convenient to use.

A massage stick relates to the technical field of massage instruments. The massage stick comprises a stick body, and a first massage head is arranged on the front side of the stick body; the second massage head is arranged above the rod body in a sliding mode and can slide in the front-back direction; and the elastic piece is arranged between the rod body and the second massage head so as to push or pull the second massage head to the front side, and the second massage head can be kept in contact with the body massage part. The technical scheme has the advantages of good massage effect and multi-point massage.

The utility model relates to an ear electrical stimulation head, which comprises a deformable base body. The conductive sleeve is arranged outside the base body in a wrapping manner, and is deformable and conductive; and the telescopic mechanism is arranged in the base body, is connected with the end part of the conductive sleeve, and can drive the conductive sleeve to stretch and deform. The ear electrical stimulation head is better in deformation and adaptability, not only improves the wearing comfort, but also improves the stimulation effect, and avoids the problem of single-point stabbing pain caused by poor fitting degree. The utility model further relates to an ear vagus nerve stimulator which comprises the ear electrical stimulation head, a driving mechanism and a control circuit board, the driving mechanism is in electrical signal connection with the control circuit board, the driving mechanism is connected with the telescopic mechanism, and the conductive sleeve is in electrical signal connection with the control circuit board. When the ear vagus nerve stimulator applying the ear electrical stimulation head is used, the ear cavity sizes of different users can be met through large deformation, and meanwhile the wearing comfort and the stable and comfortable stimulation effect are achieved.

The head-mounted cranial nerve stimulation device comprises a head-mounted support and two groups of stimulation assemblies, the head-mounted support comprises two adjusting parts and an adjusting belt, the two adjusting parts are respectively arranged at two ends of the adjusting belt, and each adjusting part is movably connected with the adjusting belt; and each group of stimulation components is rotationally connected to one adjusting part. During use, the position of the stimulation assembly relative to the adjusting belt is changed by moving the position of the adjusting part relative to the adjusting belt. The angle of the stimulation assembly is adjusted by rotating the stimulation assembly, so that the stimulation assembly is attached to the head of the user. Thus, through the adjusting part and the stimulation assembly, the head-mounted cranial nerve stimulation device is adjustable to adapt to the heads of different users, so that the head-mounted cranial nerve stimulation device achieves a better stimulation effect.

The application discloses an ultrasonic irradiation device, and relates to the technical field of ultrasonic irradiation equipment, which comprises an irradiation mechanism, an adjusting mechanism and a treatment area, wherein the ultrasonic emission end of the irradiation mechanism is located below a to-be-tested object; the adjusting mechanism is used for bearing the to-be-tested object and can adjust the position of the to-be-tested object according to the lesion depth inside the to-be-tested object, so that the lesion area of the to-be-tested object is coincident with the focal point of the irradiation mechanism; and the treatment area is used for containing the to-be-tested object and a coupling agent arranged between the ultrasonic emission end and the to-be-tested object; the treatment area has a boundary, and the boundary is used for limiting the flow of the coupling agent, so that the coupling agent accumulates and contacts the to-be-tested object. The application improves the treatment gain of stimulation and improves the safety and reliability of treatment.

The application belongs to the technical field of biological fermentation, and relates to a bacillus licheniformis SXZY-02 and application thereof, and comprises the following steps: a bacillus licheniformis (Bacillus licheniformis) SXZY-02 is separated from the surface of tobacco leaves, Lysinibacillus macroides ) and the strain preservation number is CCTCC NO:M 2025152; the bacillus licheniformis SXZY-02 is fermented to obtain a biological agent containing the bacillus licheniformis SXZY-02, and after fermentation optimization, the lipase activity is 8.99 U / mL; the biological agent containing the bacillus licheniformis SXZY-02 is applied to tobacco shred fermentation, fat is decomposed into free fatty acid, tobacco aroma quality and alcohol degree are effectively improved, and irritation is reduced. The technology provides a green and environment-friendly solution for tobacco quality upgrading, and meets the high-quality development direction of the industry.

The present invention discloses a salicylic acid deep eutectic solvent and a preparation method and application thereof. The salicylic acid deep eutectic solvent is formed by combining salicylic acid, L-carnitine and an optional polyol under intermolecular forces, so that the molecular polarity in the salicylic acid deep eutectic solvent is changed, the hydrogen bond-related effect with water and the van der Waals force-related effect are enhanced, the water solubility of salicylic acid is increased, and the transdermal permeability of L-carnitine and salicylic acid is improved. The prepared skin care products and toiletries do not need to add too many auxiliary materials, have good skin feel, and are mild and non-irritating. The preparation method provided by the present invention combines a variety of deep eutectic solvent preparation methods in the preparation process, the reaction conditions are mild, the time is short, it is conducive to industrial production, and the reaction is thorough, and the available range of multiple substances can be increased at the same time.

The present application relates to the field of microorganisms and biotechnology, and particularly relates to a rhizobium huathuanguense and application thereof in degrading beta-carotene in tobacco leaves. The rhizobium huathuanguense is preserved in the Guangdong Microbial Digital Museum Center, and the preservation number is GDMCC No: 63067, and the preservation date is December 20, 2022. The strain is applied to tobacco leaves, especially cigar tobacco leaves, can effectively reduce the content of carotenoids in the fermentation process of cigar tobacco leaves, increase the content of farnesyl acetone, methyl heptenone, geranyl acetone and other substances, can strengthen the bean aroma, woody aroma and nutty aroma of tobacco leaves, and improve the sensory indexes such as aroma quality, aroma amount, offensive odor and irritability of tobacco leaves.

The invention relates to an IL-2 mutant protein and application thereof. The invention specifically provides an IL-2 mutant protein. Compared with an IL-2 wild type, the mutant protein at least comprises one mutation site. The mutation can regulate the affinity between IL-2 and IL-2R alpha or IL-2R beta gamma, so as to regulate the activation of immune cells.

The utility model relates to the technical field of massage equipment, and provides a massager which comprises a shell and a driving mechanism arranged in the shell, the shell comprises a massage part, and the massager is characterized in that a ball part is arranged on the massage part and comprises a plurality of balls arranged in an annular shape, and the balls are arranged in the shell. The driving mechanism is used for driving all balls of the ball part to rotate along the circumferential direction of the ring, and each ball is configured to rotate on the massage part. When the massager is used, the driving mechanism drives the balls to rotate in the circumferential direction of the ring, the balls press and stimulate the massaged portion, meanwhile, friction force is generated when the balls scrape the massaged portion of the human body, the balls passively rotate, the massaged portion is scraped and stimulated, and the massage effect is improved. The stimulation effect is improved through multiple stimulation, and the massage experience of the user is improved.

This utility model relates to a portable electrostimulation rehabilitation device. The portable electrostimulation rehabilitation device of this utility model includes: a base; a main body of the device detachably mounted on the base; a stimulation module detachably mounted on the base; and a connecting line including a first outer tube, a second outer tube, a fixed rod, a rotating plate, rotating rods, and electrical wires. The first and second outer tubes are connected by the fixed rod. Two rotating rods are fixed to both sides of the rotating plate. The first and second outer tubes are respectively sleeved on the outside of the two rotating rods, clamping the rotating plate in the middle. The first and second outer tubes have through holes. The electrical wires pass through the rotating plate, with their two ends wound in either the forward or reverse direction around the rotating rods sleeved inside the first or second outer tubes, and then passing through the through holes to be electrically connected to the main body of the device or the stimulation module. The portable electrostimulation rehabilitation device of this utility model has the advantages of convenient operation and good stimulation effect.