75results about How to "Increase irritation" patented technology

The invention provides a preparation method of a mixed pilatory of active peptide and stem cell exosome, and belongs to the technical field of pilatory preparation. The preparation method comprises the following steps: extracting the stem cell exosome; extracting an active extract; preparing an exosome entrapped active extract; preparing the liposome loaded active peptide; preparing the liposome loaded active peptide modified by the gallic acid modified chitosan; and preparing the mixed hair restorer. The prepared mixed hair restorer can provide a suitable growth environment for hair follicles and promote hair growth, the synergistic effect of the active peptide and the exosome can provide abundant signal molecules and enhance the stimulation effect on hair follicle cells, and the active peptide and the exosome can promote angiogenesis and increase the blood flow volume of scalp, so that the hair follicle can be effectively promoted. More nutrition and oxygen are provided for hair follicles, and the growth of hair is effectively promoted.

The invention discloses selenium disulfide shampoo with a good suspension effect and a preparation method of the selenium disulfide shampoo. The selenium disulfide shampoo comprises the following raw materials in percentage by weight: 0.05-1% of selenium disulfide particles; 0.2-6% of a high-molecular polymer capable of suspending selenium disulfide particles; 0.5 to 5% of a polyol; and 0.05%-0.1% of a chelating agent. The selenium disulfide shampoo has the advantage of being good in suspension effect, and the problems that in the using process of existing selenium disulfide shampoo, due to the fact that the dispersion uniformity and suspension stability of selenium disulfide in the shampoo are poor, the selenium disulfide is likely to be precipitated in a shampoo container, the concentration of the selenium disulfide before and after use is different, and the selenium disulfide cannot be precipitated in the shampoo container are solved. The treatment effect of the selenium disulfide shampoo on a patient is influenced.

The invention belongs to the technical field of cosmetics, and particularly relates to azelaic acid liposome as well as a preparation method and application thereof. The invention firstly provides a composition for preparing the azelaic acid liposome. The composition comprises an organic phase composition and a water phase composition which are used for preparing the azelaic acid liposome, the organic phase composition comprises 1, 2-propylene glycol, hydrogenated phosphatidylcholine and cholesterol; the aqueous phase composition includes an aqueous phase medium and azelaic acid. The invention further provides a method for preparing the composition into the azelaic acid liposome by utilizing a 1, 2-propylene glycol injection method, which comprises the following steps: mixing the components in the organic phase composition to obtain an organic phase solution; mixing the components in the water-phase composition to obtain a water-phase solution; and injecting the organic phase solution into the water phase solution for reaction, and finally performing high-pressure homogenization to obtain the azelaic acid liposome. According to the method, organic solvents do not need to be removed in the preparation process, and the obtained product is good in solubility, good in stability and high in safety and has the effects of removing acnes, controlling oil and whitening.

The invention belongs to the technical field of cosmetic preparations, and particularly relates to a composition containing triethanolamine and tranexamic acid modified hydroxytyrosol as well as a preparation method and application of the composition. According to the invention, hydroxytyrosol is modified by using triethanolamine and tranexamic acid through etherification and esterification reactions, the processing mode obviously enhances the electrification capability of hydroxytyrosol, and further obviously enhances the antibacterial strength of hydroxytyrosol, so that hydroxytyrosol is compounded with triethanolamine and tranexamic acid to replace a traditional preservative, and the antibacterial property of hydroxytyrosol is improved. And adverse reactions such as irritation and allergy of common preservatives are improved. According to the invention, the hydroxytyrosol is modified by using triethanolamine and tranexamic acid, and triethanolamine and tranexamic acid are functional components, so that triethanolamine and tranexamic acid can play roles in resisting oxidation, whitening and the like together with hydroxytyrosol in a cosmetic matrix while playing a role in improving the bacteriostasis of hydroxytyrosol.

The invention provides a preparation method and application of 4-butylresorcinol liposome, and belongs to the technical field of cosmetic raw material preparation. The 4-butylresorcinol liposome is prepared from the following components in percentage by weight: 5 to 15 percent of caprylic / capric triglyceride, 2 to 8 percent of hydrogenated lecithin, 0.1 to 3 percent of cholesterol, 1 to 10 percent of 4-butylresorcinol, 0.5 to 3 percent of emulsifier, 0.003 to 0.1 percent of pH (Potential of Hydrogen) regulator, 0.01 to 0.5 percent of metal ion chelating agent, 0.1 to 5 percent of antioxidant and 55 to 90 percent of solvent. The solubility, skin irritation and permeability of 4-butylresorcinol are improved by compounding hydrogenated lecithin, cholesterol and the emulsifier, and the problem that 4-butylresorcinol liposome is prone to being oxidized and discolored is solved through an antioxidant system composed of the pH regulator, the metal ion chelating agent and the compound antioxidant.

The invention provides application of manuka honey in skin antibiosis and anti-inflammation, and belongs to the technical field of cosmetics, the application comprises the following steps: (1) mixing rose petals, perilla roots, grape seeds and manuka honey, and adding the mixture into water to obtain an enzymolysis substrate; (2) sequentially adding pectinase, neutral protease and beta-glucanase into the enzymolysis substrate, and performing enzymolysis to obtain an enzymolysis product; (3) adding lactobacillus brevis, lactobacillus helveticus and bifidobacterium lactis into the enzymolysis product, and fermenting to obtain a fermentation product; (4) adding an ethanol aqueous solution into the fermentation product, stirring, filtering by using a filter membrane to obtain a supernatant, and concentrating the supernatant to obtain a mixed extract; and (5) preparing skin antibacterial and anti-inflammatory products from the mixed extract. The mixed extract disclosed by the invention is good in batch stability, relatively good in antibacterial and anti-inflammatory effects and low in irritation.

The utility model provides an amusement flying saucer turntable, which belongs to the technical field of amusement flying saucers, and comprises a flying saucer turntable, a left-right shaking component is arranged on the flying saucer turntable, the left-right shaking component comprises a plurality of arc-shaped grooves arranged on the flying saucer turntable, arc-shaped blocks are arranged in the arc-shaped grooves, and supporting blocks are arranged on the upper surfaces of the arc-shaped blocks. Safety seats are arranged on the upper surfaces of the supporting blocks; according to the utility model, the safety seat can shake, so that not only are the interestingness and the irritation of amusement increased, but also the bringing-in feeling of personnel is improved.

This invention discloses a mild and stable temperature-responsive microemulsion composition, its preparation method, and its applications, belonging to the fields of cosmetics and pharmaceutical technology. This invention uses a nonionic decyl glucoside and anionic sodium lauroyl glutamate, introducing tocopherol polyethylene glycol succinate and disodium EDTA, forming a dual stabilizing mechanism of "antioxidant + metal ion chelation," effectively protecting unstable active ingredients such as glycyrrhizin. Experiments show that in an accelerated test at 60℃, the retention rate of glycyrrhizin increased by more than 20%. The microemulsion composition prepared by this invention exhibits high stability, low irritation, and skin-targeted sustained-release properties.

The invention discloses a freckle-removing and whitening mask which is prepared from the following raw materials: chrysanthemum, pearl, radix angelicae, almond, poria cocos, rhizoma atractylodis macrocephalae, peach kernel, ginseng, mung bean, bletilla striata, cortex moutan, rhodiola rosea, silkworm larva, Chinese yam, honeysuckle and the like. The facial mask is a pure traditional Chinese medicine facial mask, has remarkable curative effects on whitening, removing freckles, removing acnes and minimizing pores, and can effectively reduce facial skin damage, effectively inhibit growth of facial germs, promote vigor of subcutaneous capillaries of the damaged face, improve metabolism of the skin and enable the facial skin to reappear in a compact and refined state. In addition, the facial mask can enhance the ability of facial skin to resist invasion and stimulation of external germs, form a natural protective barrier for the facial skin, well repair, moisten and care the facial skin, and keep the facial skin comfortable, beautiful and healthy for a long time. Pure traditional Chinese medicine raw materials are selected, chemical components are not added, and harm to facial skin and the body is avoided.

The application discloses a kind of method, system, equipment and storage medium suitable for ecological optimization scheduling of "artificial flood peak" of reservoir, belong to reservoir ecological scheduling technical field, this method first collects target river section basic environmental data and target fish spawning related information, constructs and verifies one-dimensional water power, water temperature model;Again, combine spawning information and model to determine spawning ground position and normalize data, calculate spawning scale and distribution characteristics;Subsequently, set spawning scale threshold, extract suitable water temperature, hydrological index and ecological scheduling time window of fish spawning by machine learning model;In window period, monitor and judge scheduling start condition, combined with forecast information of trunk stream and branch stream, to utilize branch stream hydrology water temperature condition, satisfy multiple spawning ground index as target to develop and execute scheduling scheme;Finally, the aforementioned method is used to calculate spawning scale during scheduling period, and the implementation effect of scheduling is evaluated.The application improves the accuracy of scheduling index and the feasibility of scheme, making the spawning scale statistics and effect evaluation more practical.

The present application relates to the technical field of nerve stimulation, and discloses a closed-loop vagus nerve precise blocking system and method based on physiological signal feedback, comprising a physiological signal monitoring unit for acquiring physiological signals of an individual in real time; a data acquisition and analysis module connected with the physiological signal monitoring unit, for receiving and analyzing the physiological signals, judging the physiological state of the individual, and generating a feedback signal; a stimulation device unit for outputting an electric stimulation signal based on the feedback signal, so that the vagus nerve stimulation reaches a functional block state; and a closed-loop feedback unit connected with the data acquisition and analysis module and the stimulation device unit, for dynamically adjusting the stimulation parameters according to the feedback signal and controlling the electric stimulation signal of the stimulation device in real time. Through the real-time monitoring and real-time feedback mechanism, the present application realizes functional block of the vagus nerve, and ensures the accuracy, safety and individualization of the inhibition operation.

The utility model relates to the wearable technical field, and provides multifunctional energy shorts which comprise an energy shorts body, the energy shorts body is provided with a control box connector and an electrode plate array capable of being flexibly combined, and the electrode plate array capable of being flexibly combined comprises a transverse combination mode, a longitudinal combination mode and an inclined combination mode. An electrode plate group is formed in each combination mode, and the electrode plate group in each combination mode and the muscle form a current conduction path. The electrode slice array which can be flexibly combined is arranged in the energy shorts, so that transverse, longitudinal and oblique combination modes can be formed among the electrode slices, and a current conduction path is formed between the electrode slices and muscles in each combination mode. Muscle stimulation can be flexibly and variously carried out according to user requirements, the muscle stimulation effect is improved, and meanwhile the use motivation and satisfaction degree of a user are improved.

The invention relates to the technical field of biomedical materials, and particularly discloses a sodium hyaluronate composite filler for injection as well as a preparation method and application thereof. The composition provided by the invention comprises methoxy polyethylene glycol-poly-L-lactic acid nanoparticles, sodium hyaluronate and a dispersion medium. The composite filler can realize accurate positioning and filling of an injection position, is good in hydrophilicity and high in biocompatibility, can reduce inflammatory reaction after material implantation, can promote collagen regeneration earlier and better, and is safe and effective according to animal experiments.

The invention provides a genioglossus stimulator and an output control method thereof. The frequency range of a second electrical stimulation signal of the genioglossus stimulator is 1 KHZ and 20 KHZ, the current range is 0.1 mA and 20 mA, and the pulse width range is 10, 500 us. According to the genioglossus stimulator, the frequency of the second electrical stimulation signal of the genioglossus stimulator is increased, and the current tolerance of the genioglossus can be improved under high-frequency current stimulation, so that a user can have relatively good comfort and stimulation effect under relatively high current, and the user can fall asleep conveniently.

The invention provides a sunscreen spray capable of rapidly forming a film, and belongs to the technical field of cosmetics. The sunscreen cream is prepared from the following raw materials in percentage by weight: 1 to 3 percent of ethylhexyl methoxycinnamate, 1 to 3 percent of diethylhexyl butyramido triazone, 2 to 4 percent of sunscreen synergist, 4 to 6 percent of humectant, 1 to 2 percent of skin conditioner, 5 to 6 percent of emulsifier, 1 to 2 percent of glyceryl stearate citrate, 0.8 to 1.4 percent of polydimethylsiloxane, 0.03 to 0.06 percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.05 to 0.1 percent of phenoxyethanol, 0.1 to 0.3 percent of methylparaben and the balance of water. The sunscreen spray disclosed by the invention is fast in film forming, good in waterproofness and high in sunscreen index.

A peripheral nerve stimulation system, comprising an percutaneous implanted lead (10), an adapter (20), a first cable (30), a stimulator (50) and a surface electrode, wherein the percutaneous implanted lead (10) can be inserted into the body of a patient through skin, and the percutaneous implanted lead (10) comprises a distal lead head (11) and a lead body (12) from a distal end to a proximal end, the distal lead head (11) comprising at least one electrode, the lead body (12) being formed by spirally winding at least one conductor wire (121), and the conductor wire (121) comprising a metal wire (122) and an insulating layer (123), which is arranged outside the metal wire (122) in a wrapping manner, such that the lead body (12) is of an open insulating spiral structure; the adapter (20) is electrically connected to the proximal end of the percutaneous implanted lead (10), the adapter (20) is electrically connected to the stimulator (50) by means of the first cable (30), and the stimulator (50) is used for sending an electrical stimulation pulse; and the surface electrode can be directly connected to the stimulator (50) or connected to the stimulator (50) by means of a second cable (72), and forms a stimulation loop together with the percutaneous implanted lead (10). By means of the peripheral nerve stimulation system, pain can be effectively suppressed, thereby improving the clinical treatment effect.

The utility model discloses a skin mask based on the ultrasonic technology, and relates to the technical field of beauty masks, the skin mask comprises a mask shell, a vertical driving track is constructed on the inner side of the mask shell, a driving rod is rotatably mounted on the side, away from the mask shell, of the driving track, and the driving rod is sleeved with a plurality of movable blocks in a threaded mode; supporting rods are hinged to the multiple movable blocks, a fixing frame located on the inner side of the mask shell is jointly supported by the multiple supporting rods, an ultrasonic substrate is installed in the middle of the fixing frame, multiple ultrasonic high-frequency vibration emitters are arranged on the ultrasonic substrate, and a conduction mask layer is elastically installed at an inner side end opening of the mask shell; the conductive mask layer is located on the side, away from the mask shell, of the ultrasonic substrate. Through the high-frequency vibration effect, permeation of mask components can be promoted, the skin of a user can be stimulated by generating the ultrasonic waves with the specific frequency, the absorption rate of the skin of the user to the mask components is increased, the beautifying effect is improved, and safety and comfort are achieved.

The application provides a low-deuterium water red ginseng and rhodiola compound mask as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The low-deuterium water red ginseng and rhodiola compound mask provided by the application comprises the following raw materials: a red ginseng and rhodiola compound, low-deuterium water, hydroxyethyl cellulose, carbomer-980, carbomer-981, panthenol, 1,2-hexanediol, p-hydroxyphenylacetone, glycerol, dipropylene glycol, beta-glucan, sodium alginate, disodium EDTA, betaine, allantoin, 1,3-butanediol, PEG-40 hydrogenated castor oil and tromethamine; the red ginseng and rhodiola compound is composed of red ginseng extract and rhodiola extract. The low-deuterium water red ginseng and rhodiola compound mask provided by the application has the effects of antioxidation, whitening and anti-photoaging, and can realize synergistic whitening and anti-photoaging.

The invention discloses a natural lipstick and a preparation method thereof. The natural lipstick is prepared from the following components in percentage by mass: 0.2%-1% of alpha-bisabolol, 15%-20% of white beeswax, 7%-10% of candelilla wax, 2%-6% of natural functional components, 0.25%-0.45% of plant essential oil, 3%-7% of natural toner and the balance of natural grease. The natural lipstick disclosed by the invention has the effects of strong bacteriostasis and sterilization and the like; the lipstick is finer and smoother to use, and has good effects of resisting oxidation, slowing down aging and the like. Experiments prove that a user is not allergic to the lipstick disclosed by the invention, and the lipstick has good effects of moistening, preventing chap and the like, and is adjustable in color.

The invention relates to the technical field of whitening lotion, and particularly discloses whitening essence lotion and a preparation method thereof.The whitening essence lotion is prepared from, by mass, 67.6% of deionized water, 1% of glycerin, 0.2% of carbomer, 0.2% of xanthan gum, 7% of 1-3 butanediol, 2% of D-panthenol, 2% of polysorbate-60, 0.2% of ethylhexylglycerin, 17.8% of olive oil and 2% of traditional Chinese medicine extract; the traditional Chinese medicine extract is a mixed extracting solution of radix paeoniae alba, rhizoma atractylodis macrocephalae, white poria cocos and liquorice, and the ratio of the radix paeoniae alba to the rhizoma atractylodis macrocephalae to the white poria cocos to the liquorice is 2: 2: 2: 1. According to the whitening essence lotion, the theory of traditional Chinese medicine is used as a foundation stone, natural Chinese herbal medicines such as the radix paeoniae alba, the rhizoma atractylodis macrocephalae, the white poria cocos and the liquorice are selected as raw materials, active ingredients of the raw materials are extracted, and melanin generation can be effectively inhibited; the traditional Chinese medicine composition has the effects of whitening skin, fading spots and brightening skin color, realizes natural and healthy whitening effects, can provide lasting moisturizing and nourishing for skin, effectively improves the dry state of the skin, and enhances the elasticity and luster of the skin.

The invention relates to the technical field of gastrointestinal postoperative rehabilitation physiotherapy equipment, in particular to gastrointestinal postoperative rehabilitation physiotherapy equipment with electric stimulation, which comprises a vertical frame, a cross arm, an adjusting device and an atomizing device, the vertical frame is fixedly connected with the cross arm, a transverse module is arranged on the cross arm, the output end of the transverse module is fixedly connected with the adjusting device, and the atomizing device is fixedly connected with the adjusting device. The atomization device is communicated with the adjusting device through a pipeline, and the adjusting device is used for conducting gastrointestinal electrical stimulation. The vertical frame is used for fixing the cross arm, the cross arm is provided with the transverse module, the transverse module converts torque into linear displacement in the mode that a motor drives a lead screw nut pair, the mode in the prior art is not repeated, the output end of the transverse module is used for driving the adjusting device to linearly move, after the adjusting device is moved to the intestines and stomach, fixed-point stimulation is conducted, and the atomization device is filled with medicine. Medicine is heated to generate medicine gas, and local hot compress is performed on a patient through the medicine gas to assist physical therapy.

This invention relates to a frontal lobe localization method for transcranial magnetic stimulation (TMS) coils, a closed-loop TMS system, and an apparatus. The closed-loop TMS system includes: a TMS device comprising a robotic arm and a TMS coil mounted on the robotic arm; an EEG cap having multiple electrodes and multiple points positioned in the frontal lobe region, the EEG cap being used to collect evoked signals generated in the brain during the i-th TMS stimulation session, obtaining multiple evoked signals; and a stimulation localization device receiving the multiple evoked signals provided by the EEG cap, generating a control command for the (i+1)-th TMS stimulation session based on the multiple evoked signals, and sending the (i+1)-th TMS stimulation control command to the TMS device for the next TMS stimulation session.

The composition for improving the scalp condition of the present disclosure has a significantly excellent anti-inflammatory effect through a synergistic effect of a combination of glucolactone and climbazole, thereby having a significantly excellent effect of improving dandruff, scalp pruritus, scalp hypertrophy keratin or seborrheic head dermatitis. In addition, the composition for improving the scalp condition of the present disclosure has a significantly excellent effect of strengthening the scalp barrier by reducing the transdermal moisture loss amount. In addition, the composition for improving the scalp state of the present disclosure also has significantly excellent effects of improving cutin loss, improving scalp odor, or improving scalp irritation.

The utility model provides an auxiliary sperm taking device. The auxiliary sperm taking device comprises a sperm taking barrel, a silicon rubber sleeve and a pressing mechanism. A penetrating sperm collecting cavity is formed in the sperm collecting barrel in the axial direction; the silica gel sleeve is arranged in the sperm taking cavity, the penis can penetrate through the silica gel sleeve, and when the silica gel sleeve moves back and forth along the penis, the inner wall of the silica gel sleeve can rub the penis; the pressing mechanism comprises a rotating shaft, a pressing block and a driving assembly. The driving assembly is adjusted to drive the multiple rotating shafts to rotate synchronously, so that the multiple pressing blocks extrude the outer wall of the silica gel sleeve, the outer wall of the silica gel sleeve can deform inwards after being extruded, and therefore friction between the silica gel sleeve and the penis becomes tight; the driving assembly is adjusted to drive the multiple rotating shafts to synchronously and reversely rotate, so that the multiple pressing blocks cancel extrusion on the outer wall of the silica gel sleeve, at the moment, the silica gel sleeve is restored, friction between the silica gel sleeve and the penis becomes loose, the friction tightness between the silica gel sleeve and the penis can be conveniently adjusted according to needs, the stimulation effect on the penis is improved, and the sperm taking efficiency of the device is improved.

The invention relates to a tumbler-type amusement facility, comprising a small turntable, on which at least one seat capable of rotating relative to the turntable is arranged; a vertical rotating shaft seat for the seat to rotate around is arranged on the small turntable; when the seat is stationary on the small turntable, the vertical center line of the seat is roughly perpendicular to the small turntable, and at this time, the vertical center line is a vertical stationary center line A; a swing mechanism capable of making the seat swing with the vertical stationary center line A as a swing reference line is also arranged on the small turntable, and a constantly changing angle α is formed between the vertical rotating shaft seat and the vertical stationary center line A when the seat moves; a tumbler-type swinging function is added on the basis of the traditional rotating function of the spinning cup, so that a new way of playing that rotates and swings at the same time is realized, thereby greatly increasing the fun and excitement of the spinning cup and meeting the entertainment needs of young people who like excitement and new ways of playing.

The embodiment of the invention provides a stimulation device and system, and relates to the field of nerve regulation and control. The stimulation device comprises a stimulation unit used for being electrically connected with at least one electrode and configured to determine a target detection parameter set based on adjusted stimulation parameter information and a corresponding relation between preset stimulation parameter information and the detection parameter set when current stimulation parameter information is switched to adjusted stimulation parameter information; and detecting the physiological signal collected by the at least one electrode based on each detection parameter in the target detection parameter set, and determining whether to adjust at least one detection parameter in the target detection parameter set based on a detection result. According to the embodiment of the invention, the detection parameters and the stimulation scheme can be associated, synchronous optimization of adjustment of the detection parameters and the stimulation scheme is realized, the matching degree between the detection parameters and the stimulation scheme is improved, and the detection effect and the stimulation effect are improved.

The invention relates to the technical field of tobacco processing, in particular to a composition for improving sensory comfort of burley tobacco and a preparation method and application of the composition. The composition for improving the sensory comfort of the burley tobacco, provided by the invention, is prepared from the following components in parts by weight: 6 to 55 parts of sugar material, 12 to 110 parts of herbal extract, 1 to 8 parts of malic acid, 1 to 5 parts of linalool, 2 to 20 parts of glycerol and 45 to 72 parts of water, wherein the sugar material is prepared from high fructose corn syrup and fructose, the mass ratio of the high fructose corn syrup to the fructose is (5-45): (1-10), and the high fructose corn syrup is F60 high fructose corn syrup; the herbal extractum comprises licorice extractum, cocoa extractum, jujube extractum, sea-buckthorn extractum, dark plum extractum, benzoin extractum and lysimachia sikokiana extractum. According to the burley tobacco lining adopting the composition, the aroma quality of burley tobacco can be improved, the sensory comfort of burley tobacco can be remarkably improved, the irritation is reduced, the aftertaste is improved, and the smoke state is improved.

The invention provides a flexible neural electrode composite coating and a preparation method and application thereof, the flexible neural electrode composite coating comprises polycaprolactone containing an anti-inflammatory drug minocycline and a nanofiber of methacrylated silk fibroin, the surface of the nanofiber is modified with a conductive polymer poly (3, 4-ethylenedioxythiophene) in situ, and the conductive polymer poly (3, 4-ethylenedioxythiophene) is modified with a conductive polymer poly (3, 4-ethylenedioxythiophene). Cured methacrylated silk fibroin hydrogel is formed on the surface of the modified material. According to the composite coating, the electrochemical performance is remarkably improved, the inflammatory reaction is relieved, and the biocompatibility is improved through the hydrogel. The composite coating has high charge storage / injection capacity, low interface impedance and good biocompatibility, and can stably record bio-electricity signals for a long time. The invention provides the invasive flexible neural electrode composite coating with remarkable anti-inflammatory action, excellent electrochemical performance and long-term stability, and reliable technical support is provided for clinical application of neural electrodes.

The present application discloses a transcranial electrical stimulation device and system based on multimodal data, the device comprising: an analog front-end module, an ADC acquisition module, a blood oxygen detection module, a control module, a transcranial electrical stimulation module, and an acquisition and stimulation integrated module. A preset stimulation scheme is obtained through the control module, and the preset stimulation scheme is adjusted according to a third EEG signal, pulse data, and blood oxygen data of a target object to obtain a target stimulation scheme, and a target control instruction corresponding to the target stimulation scheme is determined; the target control instruction is transmitted to the transcranial electrical stimulation module, and the transcranial electrical stimulation module controls the acquisition and stimulation integrated module to perform transcranial electrical stimulation on the target object according to the target control instruction, so as to improve the stimulation effect of transcranial electrical stimulation on the target object. By adopting the embodiments of the present application, the stability of tES stimulation therapy is improved.

The present application relates to the technical field of organic synthesis, in particular to a method for synthesizing 2,2'-dithiodi[N-butyl-benzamide] in water phase with ethyl acetate as additive. Sodium iodide and hydroiodic acid are used as key additives to synthesize 2,2'-dithiodi[N-butyl-benzamide], which has certain safety hazards. In view of the above problems, the present application provides a method for synthesizing 2,2'-dithiodi[N-butyl-benzamide] in water phase with ethyl acetate as additive, which is to use 2-butyl-1,2-benzisothiazoline-3-ketone as starting reaction material, sodium sulfide as reducing agent, and ethyl acetate as key additive to synthesize 2,2'-dithiodi[N-butyl-benzamide] in water under room temperature and closed condition. The method of the present application completely avoids the use of strong acid such as hydroiodic acid and sodium iodide. Moreover, the raw materials used are all conventional chemicals, the reaction system is mild, the operation process is safe and reliable, and it is suitable for large-scale production.