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Medicine for treating alzheimer's disease

A technology for Alzheimer's disease and drugs, which can be used in drug combinations, pharmaceutical formulations, organic active ingredients, etc., and can solve the problems of high price, strong liver toxicity, and difficulty in clinical promotion and application.

Inactive Publication Date: 2008-02-13
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such drugs are expensive, and tacrine is highly toxic to the liver, so it is difficult to promote clinical application

Method used

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  • Medicine for treating alzheimer's disease
  • Medicine for treating alzheimer's disease
  • Medicine for treating alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0043] Protective Effect of Dehydroevodiamine Injected into Tail Vein of Rats on Alzheimer's Disease

[0044] (1) Experimental animals and groups

[0045] Male Wistar rats (provided by the Experimental Animal Center of Tongji Medical College, Huazhong University of Science and Technology), SPF grade, weighing 250-320 grams, 90 rats, were reared in a conventional environment. Divided into 6 groups, 15 rats in each group: ①Normal group; ②Sham operation group; ③Hcy group 1 (100 μM); ④Hcy group 2 (350 μM); ⑤Hcy group 1+folate / VitB12; ⑥Hcy group 2+folate / VitB12.

[0046] Rats were injected with homocysteine ​​(homocystin, Hcy) to construct a compound Alzheimer's disease animal model, and the tail vein injection, intraperitoneal injection or intracerebroventricular injection could be selected. The rat tail vein injection method is: the rat is fixed under the awake state, slowly injects (injection speed is: 1ml / about 10 seconds) Hcy from the tail vein; the intraperitoneal injection...

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Abstract

The present invention provides a medicine for presenile dementia treatment, which takes dehydrogenation evodiamine as the active component. Studies proves that the dehydrogenation evodiamine has an inhibiting effect in notable pathological change of presenile dementia patients, which can not only reduce the senile plaque quantity of the presenile dementia, but also can reduce the phosphorylation tau protein level, therefore learning and memory impairment are dramatically improved. The medicine is an effective medicine for presenile dementia prevention and treatment.

Description

technical field [0001] The present invention relates to medicinal compounds, in particular to anti-Alzheimer's disease drugs. Background technique [0002] Alzheimer's disease (AD) is a common neurodegenerative disease, its main symptoms are memory loss, low cognitive ability and slow thinking, and progressive aggravation, finally unable to take care of itself and die, the course of the disease is generally 8 ~10 years. With the acceleration of the aging process of the society, the number of patients with AD has risen sharply, and it has become a serious disease that threatens the physical and mental health of the elderly, especially the elderly population, and has brought serious social, economic and family problems. [0003] The main pathological changes in the brain of AD patients are the formation of a large number of neurofibrillary tangles (neurofibrillary tangles, NFTs) and a large number of senile plaques, and their molecular markers are abnormally phosphorylated ta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P25/28
Inventor 王建枝
Owner HUAZHONG UNIV OF SCI & TECH
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