Medicine for treating alzheimer's disease
A technology for Alzheimer's disease and drugs, which can be used in drug combinations, pharmaceutical formulations, organic active ingredients, etc., and can solve the problems of high price, strong liver toxicity, and difficulty in clinical promotion and application.
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[0043] Protective Effect of Dehydroevodiamine Injected into Tail Vein of Rats on Alzheimer's Disease
[0044] (1) Experimental animals and groups
[0045] Male Wistar rats (provided by the Experimental Animal Center of Tongji Medical College, Huazhong University of Science and Technology), SPF grade, weighing 250-320 grams, 90 rats, were reared in a conventional environment. Divided into 6 groups, 15 rats in each group: ①Normal group; ②Sham operation group; ③Hcy group 1 (100 μM); ④Hcy group 2 (350 μM); ⑤Hcy group 1+folate / VitB12; ⑥Hcy group 2+folate / VitB12.
[0046] Rats were injected with homocysteine (homocystin, Hcy) to construct a compound Alzheimer's disease animal model, and the tail vein injection, intraperitoneal injection or intracerebroventricular injection could be selected. The rat tail vein injection method is: the rat is fixed under the awake state, slowly injects (injection speed is: 1ml / about 10 seconds) Hcy from the tail vein; the intraperitoneal injection...
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