163 results about "SENILE PLAQUE FORMATION" patented technology

Aβ_N3pE-42 is a β amyloid protein that accumulates specifically as a major constituent of senile plaque in the brains of both sporadic and familial Alzheimer's disease patients. The invention provides antibodies that specifically recognize Aβ_N3pE-42 and can be expected to have a strong β amyloid-removing action. Particularly, humanized antibodies against Aβ_N3pE-42 are useful to treat human neurodegenerative diseases. Further, since Aβ_N3pE-42 is localized in the brain, the antibodies of the invention can avoid side effects such as kidney disorders caused by the formation of antigen-antibody complex in the blood. An agent for gene therapy using a vector in which a cDNA encoding a protein comprises the antigen-binding region of the antibody can be an efficient therapeutic drug for removing β amyloid from the brain.

The invention relates to a health-care product composition containing a placenta component and a preparation method thereof. The composition uses ganoderma lucidum polysaccharide and human placenta powder as basic effective components which can be formed together with at least one of vitamin E and vitamin C when necessary and pharmaceutically acceptable assistant components, wherein the weight ratio of the ganoderma lucidum polysaccharide to the human placenta powder expressed by amount of protein in the effective components is between 1 to 0.1 and 1 to 5, preferably between 1 to 0.1 and 1 to 1. Through tests, the composition not only can enhance immunological competence of human body, but also can delay senility, has remarkable fading effect on senile plaque or chloasma, and is remarkably superior to the prior homogeneous medicament and/or health-care products containing the placenta component on effect.

The invention relates to a pyrro-quinoline quinine (PQQ) sodium salt derivative and a preparation method thereof, belonging to the field of pharmacy. In the preparation method, PQQ is used as a raw material, and an acid-base neutralization reaction with PQQ is carried out in a basic solvent of sodium hydroxide to prepare the PQQ sodium salt derivative represented in the structural formula (I), wherein R1, R2 and R3 can be identical or different and respectively represents H, ammonium ion (NH3), potassium ion, sodium ion, magnesium ion, calcium ion or zinc ion, and at least one of R1, R2 and R3 is sodium ion. The invention has mild reaction conditions, easy product refining and purification, simple preparation steps and high yield more than 80%. The PQQ sodium salt derivative has the functions of inhibiting GSK-3 activity, reducing senile pigment formation in a transgenic mouse brain, reducing tau protein phosphorylation and the like. Thus, the PQQ sodium salt derivative can be medically used for treating senile dementia and other diseases.

There is provided a composition comprising a compound represented by general formula (I), wherein R^l represents a 5-iodothiophen-2-yl group or the like, and R² represents a 4-dimethylaminophenyl group or the like. This composition is useful for diagnosis of an amyloid-related disease such as Alzheimer's disease because the compound has high binding specificity to amyloid β protein, high permeability through the blood-brain barrier, and a property of being rapidly eliminated from sites other than senile plaques in the brain.

The invention provides a cosmetic composition containing Chinese herbal compounds which comprise, by weight, 10 to 20 parts of licorice flavonoids and 5 to 15 parts of an extract of Chinese herbal materials. According to the invention, effects of a plurality of Chinese herbal materials are integrated in the cosmetic composition, wherein, licorice flavonoids are used as a main whitening and anti-inflammatory component; combined usage of licorice flavonoids with other herbal materials enables multidirectional comprehensive care and conditioning of inhibiting melanogenesis, retaining moisture, removing acne and the like to be realized, thereby producing synergy effects of whitening, removing spots, retaining moisture, anti-wrinkling, resisting inflammation and removing acne, and eventually achieving the effect of simultaneous treatment of principal and subordinate symptoms. The cosmetic composition provided in the invention has a restoration effect on damaged skin and a good whitening effect on freckles, chloasma, senile plaque and melanin pigmentation caused by increase of age and pockmarks, and is a pure natural product at the same time, without toxicity and irritation.

An objective of the present invention is to provide a safe and effective vaccine therapy for Alzheimer's disease. A minus strand RNA viral vector carrying amyloid gene was constructed, and administered intranasally to 24- to 25-months-old APP transgenic mice. The level of serum anti-A 42 antibody was determined and showed to be markedly higher than the control. The results of histological investigation showed that the administration of a vector of the present invention markedly reduced senile plaques in all of the frontal lobe, parietal lobe, and hippocampus. The brain A level was also markedly reduced. Furthermore, the administration of a vector of the present invention did not result in lymphocyte infiltration in the central nervous system.

The invention discloses a medicament for repairing skin and a preparation method thereof. The medicament comprises the following raw materials in part by weight: 0.9 to 150 parts of ginseng, 5 to 295 parts of bletilla, 20 to 300 parts of tree poney, 10 to 250 parts of Chinese angelica, 15 to 120 parts of cassia bark, 0.8 to 150 parts of glossy ganoderma and 0.5 to 150 parts of pollen. The preparation method comprises the following steps of: putting the raw materials into a container; adding water to flood the raw materials; decocting for 30 to 80 minutes hermetically or evaporating and decocting for 60 to 120 minutes; taking decoction out; adding the water to flood the raw materials; decocting hermetically or evaporating and decocting for the second time and the third time; mixing the decoction at three times; and packaging to form the medicament. The medicament achieves the effect of treating diseases such as skin allergy pruritus, blain scars, chloasma, butterfly rash, cyasma, senile plaque, sunburn, genetic freckles, fat granules, imbalance in sebum secretion, blackhead trichopore and the like which are caused by acnes, tinea corporis, acne rosacea, blood streak, hormone and the like safely and quickly under the synergistic action of the Chinese medicinal herbs.

Compounds, compositions and methods are contemplated in which senile plaques and/or neurofibrillary tangles are labeled using compounds with improved permeability across the blood brain barrier and improved selective binding to senile plaques and/or neurofibrillary tangles. Contemplated compounds are derivatives of FDDNP or curcumin, which most preferably have improved solubility in aqueous solvents. Labeling is typically performed using a PET detectable label, and especially ¹¹C and ¹⁸F.

The invention belongs to the field of skin care products and provides a skin care condensed liquid and a preparation method thereof and application. The skin care condensed liquid can be widely used for whitening skin, preventing pimples (acnes, comedos and acne rosacea and the like) and stain (freckle, chloasma and senile plaques and the like) and recovering trauma color marks. The skin care condensed liquid is made of a series of ingredients which have sterilization and anti-inflammation effects, eliminate free radicals, improve immunity, promote skin regeneration and restrain melanocyte activity functions. Therefore, the skin care condensed liquid can efficiently permeate the skin, directly reach innermost layers of comedo and stain parts and have a rapid therapeutic effect against various skin problems. The skin care condensed liquid can further be prepared into various dosage forms to be widely applied to the field of whitening and skin care.

The invention relates to an application for extracting natural compound (I) from black mulberry, the compound (I) has strong inhibition effect for tyrosinase and is applied for preventing skin mottle, freckle, senile plaque or the like skin chromatosis and whitening, and the compound (I) is a food additive. The activity of the compound (I) is strong proved by the mensuration of the inhibition activity, the compound (I) has good stability and obvious growth inhibition action for the melanoma cell, can reduce the activity of the tyrosinase in the melanoma cell and biological synthesis level of the melanin in the cell.

The invention discloses pearl barley yellow wine and a production method thereof. The production method comprises the following steps: after glutinous rice and pearl barley are steamed, adding rhizopus into the mixture to perform saccharification, adding cool boiled water into the mixture, then adjusting alcohol content, fermenting the mixture for 5 to 10 years at the temperature of between 25 and 28 DEG C, then adding saccharomyces into the fermented mixture to reduce sugar degree, filtering the mixture, clarifying the filtrate, and pasteurizing the clarified solution; or after the saccharification, adding saccharomyces into the mixture to reduce sugar degree, adjusting alcohol content, fermenting the mixture for 5 to 10 years at the temperature of between 25 and 28 DEG C, filtering the fermented mixture, clarifying the filtrate, and pasteurizing the clarified solution. The protein content of the product is 4.8 to 7.8 percent, the total ester is 3.0 to 4.18 g/L, the sugar degree is 100 to 120 g/L, the alcohol degree is 20 to 30 percent, the total acid is 0.2 to 0.60 percent, and the amino acid content is 1.10 to 1.34 mg/ml. The pearl barley yellow wine has the advantages that: the pearl barley yellow wine keeps the efficacies of pearl barley such as strengthening spleen and removing dampness, relaxing tendon and removing numbness, clearing away heat and eliminating pus and the like; and after drinking, the pearl barley yellow wine can treat frequent micturition of the old, keep human skin shining and delicate, and has good curative effects of removing comedo, freckle, senile plaque, cyasma and butterfly rash, desquamation, acne, rhagades, pachylosis and the like.

The invention provides an amino thiazole derivative compound, a tautomer thereof, a medicinal salt thereof and a preparation method thereof. The amino thiazole derivative compound, the tautomer thereof, or the medicinal salt thereof provided by the invention has effects of inhibiting acetylcholinesterase and senile plaque aggregated by beta- amyloid (A beta), and can be used for treating, improving or preventing cognitive decline related neurological diseases, such as Alzheimer disease, vascular dementia, slight cognitive impairment and other dementia with oxidative stress participation.

The invention provides a nutritional powder with walnut oil powder and tartary buckwheat powder. The nutritional powder comprises 50wt%-85wt% of tartary buckwheat powder, 11wt%-46wt% of walnut oil powder and the balance food additives. The invention also provides a preparation method of the nutritional powder with walnut oil powder and tartary buckwheat powder. Walnut oil powder which contains linoleic acid, linolenic acid and various fat-soluble vitamins is added in the nutritional powder of the invention, wherein the linoleic acid of walnut oil powder also contains seven of the eight kinds of necessary amino acid for the human health, has rich nutrition, has important functions of effectively preventing cardiovascular disease and preventing and curing cerebral apoplexy and cerebral haemorrhage and also has effects for preventing freckles and senile plaques; and after eaten for long time, the nutritional powder has functions that the skin can become delicate and smooth, the face can become white, tender and pink and the effect of beauty and weight reduction can be realized.

The invention discloses a plant whitening and freckle-removal mask and a preparation method thereof. The plant whitening and freckle-removal mask is prepared from the following components in parts byweight: 10 to 12 parts of rose extract, 5 to 7 parts of silkworm larva extract, 15 to 20 parts of mulberry leaf extract, and 15 to 20 parts of lavender extract. The plant whitening and freckle-removalmask has the advantages that the metabolism of skin surface cells is activated, the content of SOD (superoxide dismutase) is increased, the skin is fine, the skin pores are shrunk, the moisturizing is kept, the water is sustained, the synthesis of collagen protein is promoted, the elasticity of the skin is enhanced, the wrinkles are removed, and the effects of beautifying face and skin, as well as moisturizing and preventing wrinkles are realized; the generation of melanocyte can be inhibited, the activity of tyrosinase is decreased, the chloasma, freckle, cyasma, senile plaque and acne scarare removed, and the effects of fading melanocyte, removing freckle and whitening are realized.

The invention relates to peach blossom porridge with the effects of beautifying and nourishing skin. The technical scheme is that: the peach blossom porridge consists of 60 to 80 percent of glutinous rice, 5 to 8 percent of Chinese yam, 1 to 3 percent of Chinese wolfberry, 5 to 8 percent of brown sugar, 3 to 9 percent of red date, 8 to 12 percent of peach flower flake, 7 to 11 percent of peanut and 15 to 20 percent of red bean. Compared with the conventional porridge, the peach blossom porridge has the advantages that: peach flower flakes are added, so the peach blossom porridge has the effects of dilating blood vessels, dredging meridians, moistening skin, ensuring that the excretion of lipofuscin which can promote human bodies to grow old is accelerated, and preventing and eliminating freckles, chloasma and senile plaque.

In certain aspects, provided herein are RNA complexes (e.g., asymmetric RNA complexes, such as asiRNAs and lasiRNAs) that inhibit tyrosinase expression and are therefore useful for reducing melanin production and for treating pigmentation-related disorders associated with excessive melanin production, such as melasma and age spots.

The invention provides healthy white spirit with kudzu vine flavor and anti-hypertension effect and a brewing method thereof. The healthy white spirit comprises the following raw materials in parts by weight: 1 part of fresh kudzu vine particles, 2 parts of purified water and 0.01 part of yeast; the fresh kudzu vine particles are made from timely harvested fresh kudzu vine root blocks selected from a well-bred kudzu vine root planting base; the yeast is a special tailor-made yeast which comprises more than 20 Chinese herbal medicines of ephedra, liquorice, white asarum and the like; and the purified water is alkalescent spring water or deep well water with pH value of 7.0-7.2. The method for brewing the method, provided by the invention, comprises the making steps of timely excavating, shaving, washing, crushing, granulating, steaming, mashing, fermenting and distilling. The product prepared by the method has the advantages of clear and transparent wine quality, good sensory effect, soft and sweet taste, no sharp taste, pure kudzu vine flavor, low degree and no floccus and has the effects of treating headaches, lowering blood pressure, reducing blood fat, expanding blood vessels, regulating blood sugar level, eliminating senile plaques and the like.

The invention discloses milk powder for resisting wrinkles and moistening skin of women, which is prepared by mixing the following raw materials: 1-15g of fish collagen protein powder, 0.1-1g of soy isoflavones, 1-20mg of vitamin A, 1-20mg of vitamin B1, 1-20mg of vitamin B2, 1-20mg of vitamin B6, 1-20mg of vitamin C, 0.1-1g of vitamin E powder, 1-10g of fructooligosaccharide, and 72.9-97.795g of milk powder. The milk powder can prevent sebum diffusion, balance oil and fat, make skin glossy and elastic, inhibit melanogenesis and chronic melanin deposition, prevent and treat chloasma, freckles, senile plaques and pigmented spots, and eliminate acnes and the like, and is particularly suitable for being taken by people with dry skin.

The invention relates to an anti-ageing Chinese medicament healthcare wine, which is prepared from the following raw materials in part by weight: 15 to 18 parts of sanchi, 13 to 17 parts of ginseng, 16 to 19 parts of fleece-flower root, 9 to 15 parts of rhizoma polygonati, 14 to 16 parts of medlar, 9 to 16 parts of herba epimedii, 6 to 11 parts of honey, and 290 to 335 parts of distilled spirit. The preparation method comprises the following steps of: removing impurities from the sanchi, the ginseng, the fleece-flower root, the rhizoma polygonati, the medlar and the herba epimedii; drying the sanchi, the ginseng, the fleece-flower root, the rhizoma polygonati, the medlar and the herba epimedii respectively, and crushing the sanchi, the ginseng, the fleece-flower root, the rhizoma polygonati, the medlar and the herba epimedii to have the particle size of over 80 meshes; then uniformly mixing and stirring the powder with the honey and the distilled spirit; sealing the mixture and storing the mixture at a shady place for a certain period of time; and filtering the mixture to obtain liquid for use. The Chinese medicament healthcare wine prepared by the method contains flavone, saponin, polysaccharide and rich trance elements; practices prove that the healthcare wine has no toxic or side effect and can be taken for a long term; and the healthcare wine has a simple preparation method, is convenient to take and particularly has obvious effects of eliminating senile plaques and delaying sexual decline of old people.

The invention provides a multifunctional wart and nevus removing cream, which is an external application cream especially for removing warts and naevus on a human body and aims to beautify appearance by removing wart, nevus, freckle, verruca plana, verruca vulgaris, plane warts, ecphyma, birthmark, senile plaque, corn and other skin defects on the human body on the premise that scar is not left and patients do not feel pain. The cream is prepared by blending oleum fructus bruceae, alcohol, glutinous rice flour, sodium carbonate, calcium hydroxide, medical talc powder, pearl powder and fresh jig juice, wherein the powdered solids and liquids are respectively mixed, and are uniformly stirred in a container until paste is obtained. When the cream is used, the paste is applied to warts, and the warts can be removed in 3-7 days.

The invention discloses an amyloid fibrillar oligomer conformational epitope polypeptide and application of the amyloid fibrillar oligomer conformational epitope polypeptide. The polypeptide provided by the invention is a protein (1) or (2) as follows: the polypeptide (1) has an amino acid sequence shown in SEQ ID NO.1 in the sequence table, and the polypeptide (2) is derived from the polypeptide (1) by replacement and/or deletion and/or insertion of one or more amino acid residues in the amino acid sequence of SEQ ID NO.1 in the sequence table and has the same function as the polypeptide (1). The studies show that the polypeptide and antibodies thereof have the following benefits: the polypeptide can effectively stimulate production of a specific antibody against amyloid fibrillar oligomer in vivo, and the antibody can inhibit aggregation and cytotoxicity of amyloid, improve space memory in experimental animals, and reduce content of senile plaques and/or content of amyloid-beta (A-beta) in the brain.

The invention provides a method for preparing a skin-whitening and beautifying spot-removing essence formula, which belongs to the technical field of a spot-removing essence solution. The formula comprises the following bulk drugs in parts by weight: 12-15 parts of ginseng, 17-20 parts of arbutin, 4-7 parts of lucid ganoderma, 5-8 parts of aloe, 2-5 parts of licorice, 5-8 parts of sea-buckthorn, 17-20 parts of saffron, and 14-17 parts of edible alcohol. The skin-whitening and beautifying spot-removing essence formula can be used for treating freckles on face, chloasma, butterfly rash, senile plaques, lead or mercury poisoning black spots, severe deep freckles, acne, acne marks, pustule acnes, and rough, yellow and dark skin, and is capable of smoothing wrinkles, contracting pores, tightening skin, lightening black eyes and eye bags, restoring couperose skin, allergic skin, verruca plana, and fat granules. The essence formula has the advantages of difficult recurrence, better curative effect, and low treatment cost.

The invention discloses a whitening and spot-removing composition and a preparation method thereof. The whitening and spot-removing composition is prepared from the following raw materials: seville orange flower, angelica dahurica, Poria cocos, Chinese wolfberry and peach kernels. The whitening and spot-removing composition prepared by the method can be prepared into any commonly used orally taken preparation formulation, has obvious treatment effect on chloasma, ephelides, acnes, comedo, blackhead, senile plaque and sunburn, has a total effective rate of more than 96 percent, and makes the skin be whitened and tender and have high resilience.

The invention relates to a whitening containing iPS living cell fluid and biological polypeptides. The cosmetic comprises, by mass, 0.1-3% of biological polypeptides, 1-10% of a PS living cell fluid, 0.1-10% of hyaluronic acid, and the balance deionized water. The cosmetic can effectively solve the skin problems caused by pigmentation of chloasma, malar rash, senile plaque and the like, also solves the problem of bad drug penetration or use inconvenience due to short drug carrier retention time, and has a wide application prospect.