106 results about "Age pigment" patented technology

This invention relates to certain sugar esters of phytosterols of formula (I). These esters are useful for topical application, and for the treatment of skin condition, including age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, malfunction of matrix metalloproteases, malfunction of tyrosinases, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, nail or skin requiring cleansers, conditioning or treatment, and hair or scalp requiring shampooing or conditioning, and combinations thereof;Wherein,n=0, 1, 2, or 3; andR=H, —CH2OH, —CH(OH)—CH2OH, —CH(OH)—CH(OH)—CH2OH; andR1=Substituent selected from a sapogenin, steroid, or terpenoid.

The present invention describes compositions and methods for treating, preventing and improving hyperpigmentation, or other unwanted pigmentation of the skin, or other unwanted skin condition, such as age spots, aged skin, skin discoloration, etc., wherein the compositions include siRNA-gene silencing oligomers specific for tyrosinase. The compositions are used to treat a broad variety of pigmentation conditions, and are preferably applied to the skin, or are delivered by directed means to a site in need thereof.

The invention provides a Chinese herbal medicine compound freckle-removing and skin-whitening composition and an external preparation. The Chinese herbal medicine compound freckle-removing and skin-whitening composition is prepared by compounding the following Chinese herbal medicine extract serving as raw materials: 10 to 20 parts of Indian Buead, 8 to 16 parts of root of red-rooted salvia, 7 to 15 parts of Chinese angelica, and 8 to 16 parts of motherwort herb. The composition serving as an active ingredient is added into cosmetics to prepare the external preparation, has the effects of removing or fading color freckles and coloring matter, such as chloasma, chloasmahepaticum, malar rash, sunburn, age pigment and the like, and can improve dark and nonuniform complexion, nourish and moisten skin, and ensure that the skin has high elasticity; and the composition is mixed with arbutin, vitamin c (VC) and derivatives thereof, and vitamin B3 (VB3) to improve the effects of removing freckles and whitening skin.

The invention discloses whitening and spot eliminating cream and a preparation method thereof. The whitening and spot eliminating cream comprises an active ingredient and auxiliary materials, whereinthe active ingredient is a extracting solution of traditional Chinese medicine, and the traditional Chinese medicine comprises the following materials in percentage by weight: 5%-55% of conic gymnadenia rhizome, 15%-35% of ginseng flower, 5%-15% of flos albiziae, 5%-15% of honeysuckle, 15%-20% of flos rosae rugosae and 5%-10% of chrysanthemum. The whitening spot eliminating cream can restrain thegeneration of melanin, also has the functions of activating blood and dissolving stasis, clearing away heat and toxic materials, achieves the comprehensively regulated whitening and spot eliminating effect and is convenient to use; in addition, the whitening spot eliminating cream adds nanoscale titanium pigment to achieve instant whitening effect and can solve skin problems, i.e. chloasmata, butterfly spots, age pigments, and the like which are caused by chromatosis after being continuously used for 28 days.

The invention discloses an anti-aging traditional Chinese medicine composition, and belongs to the field of traditional Chinese medicines. The anti-aging traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3 g of Chinese magnoliavine fruit, 6 g of Chinese angelica, 12 g of spina date seed, 20 g of astragalus mongholicus, 3 g of ginseng, 25 g of Chinese yam, 6 g of medlar, 12 g of rehmannia, 4 g of rhodiola rosea, 10 g of poria cocos, 20 g of acanthopanax and 6 g of polygonum multiflorum. The anti-aging traditional Chinese medicine composition has the effects of activating metabolism of a human body, promoting blood circulation, improving an immunologic function of the human body, delaying degenerating and aging process of physiological functions of the human and the visceral organs, improving physique and physical strength, improving spirit and sleep and reducing age pigment, is used for delaying aging of the human body, and has no obvious toxic or side effect.

The invention belongs to the field of medicine and health care products, and particularly relates to a composition with speckle lightening and removing effects, a preparation method and application thereof. The invention aims to solve the technical problem of providing the brand new composition with speckle lightening and removing effects, in the basic prescription, the active ingredients of the composition are composed by the following raw medicines in parts by weight: 600-1000 parts of astragalus mongholicus, 300-700 parts of angelica sinensis and 200-600 parts of safflower carthamus; and in the optimized prescription, the active ingredients of the composition are composed by the following raw medicines in parts by weight: 600-1000 parts of astragalus mongholicus, 300-700 parts of angelica sinensis, 200-600 parts of safflower carthamus, 60-100 parts of aloe and 40-100 parts of grape seed extract. The application of the composition can realize the speckle lightening and removing and whitening facial effects. Human experiments show that: after the composition is taken for 1-3months, speckles are lightened, the removing effect is obvious, and the composition can be used for chloasma, freckles, age pigment, sunburn and the like, and has particularly obvious effect on curing the chloasma.

The invention discloses a solution for a facial mask for whitening faces and removing spots and a preparation method thereof. The solution contains traditional Chinese medicinal active components, isa traditional Chinese medicinal extraction solution of conic gymnadenia rhizome, ginseng flower, sweetacacia, honeysuckle, rose and chrysanthemum, and contains auxiliary materials including collagen peptide, water soluble azone, chitin, 1,3- butanediol, droxyethylcellulose and rose water. The inhibiting rate of the traditional Chinese medicinal composition for tyrosinase as an activating enzyme ofmelanin cells is as high as 94.3%; meanwhile, the traditional Chinese medicinal composition has the functions of promoting blood circulation by removing blood stasis, clearing away heat and toxic material and stimulating the metabolism of skin. A facial mask carrier is a conducting water soluble substrate and has good osmotic performance and moist-keeping performance under the condition of depreciating the collagen peptide of a special osmotic agent. Proved by a clinical test, the facial mask made of the traditional Chinese medicinal solution for whitening the faces and removing the spots caneffectively solve skin problems due to the pigmentation of chloasma, papilionaceous spots, age pigment and the like.

Topical personal care compositions containing amino acids and nicotinamide for potentiating glutathione synthesis within skin cells. The compositions can be used to improve skin appearance of chronological aging or photoaging, resulting from exposure to UV light / sunlight, or environmental pollutants. The compositions are also useful for attaining even skin color and reducing pigmentation, age spots and discoloration.

The invention relates to a cold cream for treating skin diseases and nourishing skin. The cold cream consists of animal oil and fat and a Chinese traditional medicine mixture tincture, wherein the Chinese traditional medicine mixture tincture consists of glycyrrhiza, pseudolarix, radix salviae miltiorrhizae, giant knotweed, safflower and partial honeycomb; the cold cream has the functions of nourishing skin, inhibiting bacteria and killing bacteria, activating blood and dissolving stasis and relieving itching and pain; the application of the cold cream has the effects of defering skin consenescence, fading age pigment and chloasma, removing wrinkle and beautifying faces; partial patients using the cold cream prove that the cold cream has good curative effects on acne, eczema, tinea cruris, tinea pedis, age pigment, scalding and freezing injury, etc.; because the cold cream consists of pure Chinese traditional medicine components, side effects such as cracking, molting, aging and keratinization do not occur; and the cold cream has the functions of prevention, treatment and face beautifying. The Chinese traditional medicine nutrition cold cream has the advantages of convenient preparation, obvious effect, safe use and low cost.

Preventing skin aging by targeting multiple causes by a single bullet is of primal scientific and consumer interest. A treatment based on compositions of compound (I) for cellular senescence to control cellular degradation offers such a solution to multiple skin ailments including skin degradation from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial dysfunction, age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, scalp dryness, skin depigmentation, intracellular dehydration, and combinations thereof;

The invention relates to sealwort sanye tea, which is prepared by raw materials in part by weight as follows: 30-35 parts of sealwort, 30-36 parts of mulberry leaves, 19-26 parts of persimmon leaves and 14-21 parts of lotus leaves. The sealwort sanye tea contains a plurality of active substances and 30 plus trace elements. The sealwort sanye tea has the effects of tonifying qi and yin, promoting circulation and removing stasis, moisturizing and nourishing skin, reducing weight and lipid, blackening hair and beard, removing stasis and toxin in blood and delaying body senescence, and has certain curative effects for preventing and treating various cancers. The sealwort sanyetea has a very remarkable effect for hypertension, hyperlipidemia, hyperglycemia, cardiocerebrovascular diseases, abnormal menstruation, hyperplasia of mammary glands, climacteric syndrome, malar rash, age pigment, sunburns, chloasma, dark circles, under-eye puffiness, leukotrichia and the like. The sealwort sanye tea is excellent beverage for nourishing skin, protecting health and delaying senescence.

A cosmetic compound containing safe and effective amount of boron nitride powder for skin, hair, and finger nails is disclosed, which can improve skin appearance by smoothing out lines and wrinkles, and can cover age pigment, blemishes, and discoloration.

The invention discloses a traditional Chinese medicine mask for whitening skin and a preparation method thereof. The traditional Chinese medicine mask comprises the following raw materials in parts by weight: 3-12 parts of felwort, 5-10 parts of polygala root, 4-8 parts of evodia rutaecarpa, 3-9 parts of tribulus terrestris, 5-15 parts of hyacinth bletilla, 5-10 parts of licorice, 3-12 parts of nard, 3-9 parts of angelica, 5-10 parts of radix sileris, 5-10 parts of rhizome of chuanxiong and 4-8 parts of polygonatum. The mask disclosed by the invention is capable of regulating qi and blood, dredging the channels, promoting blood circulation to remove blood stasis as well as nourishing the skin, can effectively solve the skin problems caused by chromatosis, such as chloasma, butterfly rash and age pigment, does not contain chemical additives, such as antibacterial agents and preservatives, is natural and environment-friendly, and does not have any toxic or side effect.

The invention provides a multi-phase emulsified facial mask which is good in whitening and beverage removing effects. The multi-phase emulsified facial mask is characterized by comprising inner oil phase, inner water phase, outer oil phase, outer water phase, a pH modifier and an emulsifier. The preparation method comprises the following steps: weighing the components according to parts, respectively preparing the inner oil phase, the inner water phase, the outer oil phase and a traditional Chinese medicine extract liquid, gradually adding the inner water phase into the inner oil phase, adding the emulsifier into the outer oil phase, further adding a mixture of the inner water phase and the inner oil phase, adjusting the pH, subsequently adding the traditional Chinese medicine extract liquid to prepare facial mask emulsion, thereby making the emulsified facial mask. Due to a W / OW / O system, the absorption of skin on the active components of traditional Chinese medicines is promoted while the active components of the traditional Chinese medicine extract liquid are not damaged, the effects of the active components are brought into play, and good whitening and beverage removing effects are achieved. The clinical experiment research shows that after the facial mask is used continuously for 28 days, the skin can be brightened, skin problems caused by stain and chromatosis such as chloasma, butterfly rash and age pigment can be relieved, and the effective rate is greater than 97%.

The compositions and methods of described herein comprise novel ingredients effective to reduce unwanted pigmentation, such as skin discoloration, freckles, age spots, liver spots, sun damage, tans, pigmented acne marks, scars, pigmented birthmarks, hyperpigmentation, post-inflammatory hyperpigmentation, post-injury hyperpigmentation, melasma, cholasma, after-burn scar, nail stain, yellowing of skin, dark circles under eyes, and the like. The composition may include additional ingredients accordingly for a colored cosmetic, moisturizer, cleanser, toner, and the like.

The invention discloses fresh skin acne-mite cream, wherein the fresh skin acne-mite cream is composed of water, ethanol, vitamin B6, vitamin B, vitamin E, allantoin, abietic acid, vitamin C, hexamidine dihydrochloride, sodium hyaluronate, tea-seed oil, egg oil, glycyrrhiza flavonoids, honeysuckle flower extract, ginseng extract, seabuckthorn fruit oil, phellodendron bark extract and aloe extract. The fresh skin acne-mite cream is used for treating acne caused by such reasons as mite and capable of inhibiting sebum overflow of oily skin, alleviating adverse reactions and reducing the formation of pigment impressions; the fresh skin acne-mite cream has the functions of whitening, resisting against wrinkle, slowing the ageing process and brightening the skin and can be also used for performing treatment, moisturization and care on normal skin and reducing the formation of age pigment.

The invention relates to an Aliya skin aging-resisting stock solution. The composition is prepared from vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin A, vitamin D, vitamin E, N-amino acid, apple vinegar, sodium hyaluronate, hydrolyzed gelatin and deionized water. The Aliya skin aging-resisting stock solution provided by the invention can improve the skin microcirculation, increase the skin metabolism rate, keep the skin tenderness, delay the skin aging, lubricate the skin, moisturize the skin for a long time, improve the skin luster and elasticity, effectively prevent and control age pigments, freckles and pigmentation, effectively promote cell regeneration, reduce wrinkle formation, effectively prevent folliculitis, skin allergy and cosmetic allergy, prevent the sunshine, and prevent the skin from being injured by ultraviolet rays.

Skin lightening additives and personal care compositions containing amino acids and PPAR activating fatty acids compounds. The compositions are useful for attaining even skin color and reducing pigmentation, age spots and discoloration.

The invention discloses whitening and freckle-removing cream and a preparation method thereof. The whitening and freckle-removing Chinese medicinal preparation comprises the following components in percentage by weight: 5 to 55 percent of root of kudzu vine, 15 to 35 percent of platycladus, 5 to 15 percent of rehmannia root, 5 to 45 percent of yam, 15 to 20 percent of thuja sutchuenensis and 5 to10 percent of chrysanthemum. The cream provided by the invention can inhibit the formation of melanin while exerting a comprehensive regulating whitening and freckle-removing effect by promoting blood circulation, removing stasis, clearing heat and detoxifying the cream can be applied conveniently, and nano titanium white is added at the same time for achieving instant whitening effect. After thecream is used continuously for 28 days, the skin problems aroused by freckles, butterfly rash, age pigment and other chromatosis can be solved.

The invention provides a composition for whitening and removing freckles. The composition comprises following active components in parts by weight: 1-5 parts of tranexamic acid and 0.5-2 parts of ascorbate, wherein the structural formula of the ascorbate is shown as the specification, wherein R1, R2, R3 and R4 are C10-C20 alkyls; and the alkyls are selected from aromatic hydrocarbon groups and / or aliphatic groups. The composition has good effects of banishing the freckles, removing the freckles and whitening and can be used for chloasma, the freckles, age pigments, aestates and the like, has obvious effect aiming at the chloasma, and is stable and controllable; and meanwhile, an external preparation prepared from the composition provided by the invention can be used for a wounded part, and has fast effect, good curative effect and small toxic or side effect.

Methods and formulations are provided to reduce pigmentation in skin, using an array of compounds selected from benzimidazoles, phenylthioureas, phenyltiols, phenylamines, bi- and multicyclic phenols, thiopheneamines, and benzothiamides. The compounds preferably inhibit pigment systhesis in melanocytes through the tyrosinase pathway. The methods can be used for lightening skin, and for treating uneven skin complexions which result from hyperpigmentation-related medical conditions such as melasma, age spots, freckles, ochronosis, and lentigo. The compounds can be used medically or cosmetically.

The invention relates to a preparation method of composite animal model with the Alzheimer disease. A healthy male APP (amyloid protein precursor) / PS1 (presenilin) double transgenic mouse is chosen, and a 1mol / LAlcl3.6H2O solution is used for intraperitoneal injection contamination for 30 times, and 0.05mL of the solution is injected once. After being detected by the neuroethology and the morphology, the composite animal model with the Alzheimer disease, which is obtained by the method, has obviously lowered learning and memory capability compared with animals in a control group and has the typical morphologic features, such as age pigments, neurofibril tangle, amyloid protein deposition, granulovacuolar degeneration and the like, can better simulate the neurobehavioral reaction of the Alzheimer disease and has all typical morphological changes of the Alzheimer disease. The composite animal model with the Alzheimer disease can be used for screening medicaments and researching the mechanism of the Alzheimer disease.

The invention provides a composition for treating senile dementia and a preparation method and application of the composition, and belongs to the technical field of biological medicines. The providedcomposition comprises the following components by mass: 0.5-1 part of coenzyme Q10, 0.05-0.2 part of polysorbate, 0.3-0.8 part of medium-chain fatty acid triglyceride, 3-8 parts of gelatin, 3-8 partsof glycerinum and 3-8 parts of sorbitol. When the packing specification of the composition is less than or equal to 50 nm, the composition effectively penetrates through the blood brain barrier, enters the deep brain and reaches a target neuron; the neuron chondriosome is efficiently activated, the activity of chondriosome cytochrome C is improved, the synthesis of ATP (Adenosine Triphosphate) isstrengthened, the energy is provided for the neuron; the formaldehyde in the brain is reduced, the effect of promoting the formation of age pigments of formaldehyde is reduced, the purpose of clearingaway blocking of an intercellular space is fulfilled, the flow of an intercellular fluid is restored; the composition is non-toxic for the human body, has the capability of boosting immunity, and improves the memory of a dementia model mouse.

The compositions and methods of described herein comprise novel ingredients effective to reduce unwanted pigmentation, such as skin discoloration, freckles, age spots, liver spots, sun damage, tans, pigmented acne marks, scars, pigmented birthmarks, hyperpigmentation, post-inflammatory hyperpigmentation, post-injury hyperpigmentation, melasma, cholasma, after-burn scar, nail stain, yellowing of skin, dark circles under eyes, and the like. The composition may include additional ingredients accordingly for a colored cosmetic, moisturizer, cleanser, toner, and the like.

The invention relates to medical dressing, and in particular relates to medical biological whitening and spot-removing dressing and a preparation method thereof. D-arbutin, camellia oil, linoleic acid, almond oil and astaxanthin are taken as main components for whitening and spot removing, and together with components such as azone, glycerinum, vitamin C and vitamin E, and due to reasonable matching, the medical biological whitening and spot-removing dressing can be prepared, the components can effectively infiltrate into the base layer of skin, the activity of tryosinase can be effectively inhibited, oxygen free radicals can be efficiently eliminated, generation of melanin can be prevented, existing melanin can be also decomposed, cells can be activated, spots on faces can be faded, skin problems caused by chromatosis such as chloasma, malar rash and age pigment can be gradually solved, damage caused by chemical components such as hormone to skin can be remedied, the effects of comprehensive and rapid treatment on both symptoms and root causes can be achieved, and the skin can be whitened and moistened and is glossy and smooth. The medical biological whitening and spot-removing dressing is simple in preparation method, convenient to use and convenient to popularize.

The invention provides a method for constituting presenile dementia bandicoot model by injecting Hcy to caudal vein, abdomen or ventriculus laterali cerebri of the bandicoot, which can induce the brain mantle and hippocampal cortex amyloid of the bandicoot to deposit to generate age pigment and lead tau undertake exceeding abnormal phosphorylation as well as appear compound symptom like academic handicap and dysmnesia, etc. The model can be used for defending presenile dementia, screening new medicines, appraising the curing effect and researching the nosogenesis.

The invention discloses a traditional Chinese medicine composition for treating age pigment. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-21 parts of astragalus membranaceus, 12-18 parts of coix, 9-15 parts of loofah sponge, 3-9 parts of flos carthami, 3-9 parts of ligusticum wallichii, 8-12 parts of Chinese angelica, 8-12 parts of rheum officinale, 6-12 parts of dried radix rehmanniae, 6-12 parts of cortex moutan, 6-12 parts of flower of common tulip, 6-12 parts of rhizoma drynariae, and 6-12 parts of radix ophiopogonis. According to the traditional Chinese medicine composition for treating age pigment, the 12 natural traditional Chinese medicines are selected for scientific compatibility, the formula is simple, the raw materials cooperate with each other to achieve the effects of clearing heat, removing toxicity, weakening pigment and removing freckles, and the traditional Chinese medicine composition takes effect fast, treats both symptoms and root causes, and is free of toxic and side effects; the traditional Chinese medicine composition is simple in preparation method, convenient to take and low in cost, and has the effective rate reaching 95% or above.

The invention relates to Chinese medicinal herb beautifying and whitening acne and speckle removal facial mask cream, and belongs to the technical field of health-care beautifying plant ointments for skin. A proper amount of egg white serving as a blending substrate is added into angelica dahurica, pearl, giant typhonium rhizome and bletilla, so that the mixture is blended to form paste. When used, the facial mask cream is blended uniformly, is applied to a face uniformly to form a thin layer (the thickness is between 0.5 and 1 millimeter), and is washed by warm water about 15 to 20 minutes later. The facial mask cream has the obvious effects of skin whitening and acne and speckle removal, and has the obvious curative effect on brown speckles, malar rashes, allergic skin erythema, age pigments, acne and dermatitis. In the facial mask cream, according to theories such as the blood circulation promoting, blood stasis removal, wind dispelling wind, detoxification, skin nourishing and the like in traditional Chinese medical science of China, an enhanced Chinese medicinal herb mixture is prepared by processing Chinese medicinal herbs serving as raw materials in a scientific formula according to the compatible principle of monarch medicaments, ministerial medicaments, adjuvant medicaments and conductant medicaments, so the facial mask cream has high pertinence and comprehensiveness, is suitable for various skins, does not have side effects, and has the comprehensive effect of healthy beautifying, nutritional skin care, prevention and treatment.

The invention discloses application of a composition and a compatible method of ligustrazine, tenuigenin and stibene glucoside in preparation of a drug for treating Alzheimer disease. In the invention, the composition of ligustrazine, tenuigenin and stibene glucoside can be compatible according to a ratio to obviously prevent damage on the cognitive function of APP695V717I transgenic mice; proved by a Y electric maze experiment and a Morris water maze experiment, the composition of ligustrazine, tenuigenin and stibene glucoside can obviously improve the capabilities of passive avoidance, active avoidance and spatial memory exploration competence of the model mice, and has the obvious functions of preventing ageing hypomnesia and dysmnesia related to the Alzheimer disease; the further detection shows that the compatible composition of ligustrazine, tenuigenin and stibene glucoside can reduce deposition of age pigments in brains of AD transgenic mice, and improve the activity of acetylcholine esterase, so as to indicate that the composition of ligustrazine, tenuigenin and stibene glucoside compatible according to the ratio can treat the Alzheimer disease remarkably.