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Composition for treating senile dementia and preparation method and application of composition

A technology of Alzheimer's disease and composition, which is applied in the field of biomedicine, can solve the problems of inability to protect neurons, fail to save neurons from death, and excessive drug diameter, so as to reduce the effect of promoting formation, enhance ATP synthesis, and improve Vitality effect

Active Publication Date: 2019-03-22
CAPITAL UNIVERSITY OF MEDICAL SCIENCES +1
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, some studies have shown that some AD drugs developed can pass through the blood-brain barrier. It is difficult to understand that the drugs still cannot save the death of neurons in the deep brain.
However, our latest research has revealed the reason for the failure of the drug: the diameter of the drug is too large to penetrate the intercellular space <50 nanometers, and reach the neurons in the deep brain through the flow of intercellular fluid, which cannot protect the neurons effect

Method used

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  • Composition for treating senile dementia and preparation method and application of composition
  • Composition for treating senile dementia and preparation method and application of composition
  • Composition for treating senile dementia and preparation method and application of composition

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preparation example Construction

[0030] The present invention provides the preparation method of above-mentioned composition, comprises the steps:

[0031] (1) mixing coenzyme Q10, polysorbate, medium-chain fatty acid triglycerides, gelatin, glycerin, sorbitol and absolute ethanol to obtain an organic phase;

[0032] (2) mixing the organic phase with water 3 to 8 times the volume of the organic phase to obtain a mixed solution;

[0033] (3) heating the mixed solution to 60-80°C, stirring, evaporating and concentrating to 0.3-0.8 times the volume of the organic phase to obtain a nanoemulsion;

[0034] (4) placing the nanoemulsion in an environment of 0-4°C and continuing to stir to obtain a suspension of nano-coenzyme Q10;

[0035] (5) After homogenizing the nano-coenzyme Q10 suspension, vacuum freeze-drying to obtain a composition for treating senile dementia.

[0036] In the invention, firstly, coenzyme Q10, polysorbate, medium-chain fatty acid triglyceride, gelatin, glycerin, sorbitol and absolute ethanol...

Embodiment 1

[0047] Preparation of Nanopackaged Coenzyme Q10

[0048] Main raw materials: coenzyme Q10 (CAS: 303-98-0, Xi'an Siji Biotechnology Co., Ltd.), polysorbate-80 (CAS: 9005-65-6, Hubei Guangao Biotechnology Co., Ltd.), medium chain fatty acid glycerol Triesters (CAS: 73398-61-5, Shanghai Shucan Industrial Co., Ltd.), gelatin (CAS: 9000-70-8, Zhengzhou Givaudan Chemical Products Co., Ltd.), glycerin (CAS: 56-81-5, Shanghai Yien Chemical Technology Co., Ltd.), sorbitol (CAS: 142-77-8, Meilan Chemical brand is Meilan Industrial (Shanghai) Co., Ltd.), absolute ethanol (CAS: 64-17-5, Shanghai Fangye Chemical Co., Ltd. Putuo Branch), purified water (laboratory deionized water).

[0049] Preparation method: adopt the original emulsification-low temperature-high pressure method to prepare nano-packaged coenzyme Q10

[0050] ① Accurately weigh 0.78g of coenzyme Q10, 0.1g of polysorbate-80, 0.5g of medium-chain fatty acid triglycerides, 5g of gelatin, 5g of glycerin, and 5g of sorbitol; ...

Embodiment 2

[0056] Penetration of blood-brain barrier by nanopackaged coenzyme Q10

[0057] Detection method: high performance liquid chromatography (HPLC)

[0058] Detection process:

[0059] Instruments and reagents: HP1100 high performance liquid chromatography (HP1100, Agilent Technologies Co.Ltd, USA); nitrogen blowing instrument (KL512J, Beijing Kang Technology Co., Ltd.). Coenzyme Q10 standard product (BBI company, purity greater than 99.9%). Preparation of coenzyme Q10 standard solution: Accurately weigh coenzyme Q100.0250g into 25mL volumetric flasks respectively, dissolve coenzyme Q10 in ethanol and adjust the volume to the mark, shake well for later use, and prepare 1g / L standard stock solution. Before the determination, dilute to the use concentration with the mobile phase according to the standard curve.

[0060] Chromatographic conditions: Phenomenex C18 column (5μm, 250mm×4.6mm i.d.) is used as the chromatographic column; methanol-ethanol (volume ratio: 20:80) is used as...

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Abstract

The invention provides a composition for treating senile dementia and a preparation method and application of the composition, and belongs to the technical field of biological medicines. The providedcomposition comprises the following components by mass: 0.5-1 part of coenzyme Q10, 0.05-0.2 part of polysorbate, 0.3-0.8 part of medium-chain fatty acid triglyceride, 3-8 parts of gelatin, 3-8 partsof glycerinum and 3-8 parts of sorbitol. When the packing specification of the composition is less than or equal to 50 nm, the composition effectively penetrates through the blood brain barrier, enters the deep brain and reaches a target neuron; the neuron chondriosome is efficiently activated, the activity of chondriosome cytochrome C is improved, the synthesis of ATP (Adenosine Triphosphate) isstrengthened, the energy is provided for the neuron; the formaldehyde in the brain is reduced, the effect of promoting the formation of age pigments of formaldehyde is reduced, the purpose of clearingaway blocking of an intercellular space is fulfilled, the flow of an intercellular fluid is restored; the composition is non-toxic for the human body, has the capability of boosting immunity, and improves the memory of a dementia model mouse.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a composition for treating senile dementia, a preparation method and application thereof. Background technique [0002] Alzheimer's disease (AD) is a neurodegenerative disease with insidious onset and progressive development. Clinically, it is characterized by comprehensive dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality and behavior changes. The etiology is still unknown. The world spends hundreds of billions of dollars every year to develop AD drugs, but none of them have entered Phase IV clinical trials. Dementia faces the dilemma that there is no cure and memory loss cannot be reversed. The current clinical dementia drugs such as memantine, donepezil, curcumin, etc. have significant curative effect in the initial stage of dementia, but gradually lose their clinical curat...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/26A61K47/14A61K47/42A61K47/10A61K31/122A61P25/28
CPCA61K9/5123A61K9/5146A61K9/5169A61K31/122A61P25/28
Inventor 童志前崔德华韩鸿宾
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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