753 results about "Co enzyme q10" patented technology

A dietary supplement blend composition is disclosed, the basic formulation of the composition containing vitamins, minerals, and carotenoids. The composition can also contain bioflavonoids, cartilage protectors such as glucosamine or chondroitin, alpha-lipoic acid, coenzyme Q10, and a source of omega-3 fatty acids such as flax seed oil. The composition is beneficial for improving health and preventing disease, particularly for degenerative conditions. A method for supplementing the diet is also disclosed, wherein the quantity of daily rations of the dietary supplement blend composition is determined based on the person's age, body weight, and quality of diet.

Methods of enhancing the bio-availability of coenzyme Q10, and methods of supporting the cardiovascular system to accommodate the increase in cellular energy synthesis as a result of the bio-availability of coenzyme Q10 are described. Compositions which include coenzyme Q10, lactoferrin and / or angiogenin are described for use in the related methods, for multi-functional health applications.

Disclosed herein are methods to treat cognition disorders, particularly those associated with aging. The method comprises administering a combination of a carnitine and an oxidant. Preferably the oxidant is thioctic acid. Preferably 0.12 grams to 3 grams of carnitine (particularly ALC) and 0.12 and 1.5 grams of R-alpha-lipoic acid are administered. Optionally, coenzyme Q and / or creatine also are administered. Preferably 10 mg to 500 mg / day of coenzyme Q10 and 1 to 30 grams / day of creatine are administered. The same method can be used to treat cognition deficits associated with carbon monoxide poisoning, mild traumatic brain injury, Type 2 diabetes mellitus, obsessive-compulsive disorder, environmental toxin exposure, and other conditions.

Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of co-producing coenzyme Q10 and at least one ω-3 / ω-6 polyunsaturated fatty acid are provided. The strains may also be engineered to co-produce at least one C40 carotenoid. Methods of using the antioxidant products obtained (e.g., biomass and / or pigmented oils) in food and feed applications are also provided.

The present invention relates to a chemical combination and method for increasing delivery of Coenzyme Q10. The chemical combination comprises Coenzyme Q10 mixed with at least one chemical. The at least one chemical includes cyclic terpene containing essential oil(s) that permit unprecedented levels of Coenzyme Q10 to be made available for delivery and absorption, increasing bioavailability, as well as overcoming the previous limits. A transdermal patch including a layer containing Coenzyme Q10 is also provided.

The stable compositions of the present inventions comprise at least two different nanoemulsions stabilized by lecithin each of which containing a liquid lipid, at least two of said lipids are incompatible to each other. Particularly said compositions comprise as incompatible lipids tocopherol and Coenzyme Q10. Said composition are useful in cosmetics, in cell cultures and in nutrient compliments. Processes are described for preparing such compositions form lipids which are solid at room temperature.

The present invention relates generally to treatment of muscle pain and / or fatigue and to methods for treatment of side effects of statin therapy. In particular, the invention relates to the use of certain substituted benzoquinones, e.g. Coenzymes Q, particularly Coenzyme Q10 (Q10), in therapy. The invention also relates to the use of Q10 in combinative therapy with other agents such as uridine, its biological precursors or salts, esters, tautomers or analogues thereof ("uridine related compounds"). The invention is also directed to compositions, uses and combination packs or kits related to the treatment methods. In a preferred aspect the invention relates to a method of treatment of one or more side effects of statin therapy comprising administering to a subject in need of such treatment an effective amount of uridine, one of its biological precursors or a salt, ester, tautomer or analogue thereof either simultaneously, sequentially or separately to administration of an effective amount of at least one compound of Formula (I).

A dietary supplement is created, comprised of material from the following nutrients, vitamins, herbs, minerals, and food and plant substances and food and plant derivatives: lycopene, vitamin E, selenium, green tea, coenzyme Q10, garlic, folic acid, vitamin C, curcumin, seaweed, Cordyceps sinsensis mushroom, Lentinus edodes (shiitake) mushroom, and Ganoderma lucidum (reishi) mushroom. The composition is administered orally for individuals who wish to reduce their risk of disease, particularly cancer-risk.

The coenzyme Q10 injection emulsion has coenzyme Q10 as the effective medicine component, and each 1000 ml emulsion contains coenzyme Q10 1-10g, vegetable oil for injection 0-200g, emulsifier 1-50g, isoosmotic regulator 5-50g, antioxidant 0.05-5g, pH regulator in the quantity of regulating pH value to 3.0-9.0, co-emulsifier 10-500g and water for injection for the rest. It provides the patient with treating medicine and essential nourishing matter. It has high physical stability and may be prepared into freeze dried preparation for further raised stability and convenient storing and transportation. The coenzyme Q10 injection emulsion has certain targeting effect, so that it has raised bioavailability and lowered toxic side effect.

The invention relates to a toothpaste containing coenzyme Q10 and a preparation method thereof, in particular to a composition of toothpastes, belonging to the field of oral healthcare products; based on weight percentage, the coenzyme Q10 in the toothpaste is 1-2% and Chinese herbal extract is 0.5-2%; the rest of accessories are conventional materials for preparing toothpastes. The formulation proportion of the components in the toothpaste is preferably as follows: 2% of coenzyme Q10 mixture, 0.7% of Chinese herbal extract, 35% of abradant, 1.5% of bonding agent, 35% of wetting agent, 0.2% of flavoring agent, 2.5% of foaming agent, 1.5% of essence and 21.6% of deionized water. The toothpaste containing coenzyme Q10 has the healthcare functions the same as the common toothpastes, such as brightening and cleaning the teeth, stopping bleeding of gums and healing oral ulcer; besides, the coenzyme Q10 and Chinese herbal extract permeate the gum cell membrane so that the gum cell obtains energy and tissue vigor is strengthened, thereby essentially conserving the gums, preventing periodontitis, gingivitis and gingival atrophy to reach the aim of strengthening the gums and fixing teeth.

The invention provides a nutrient composition for augmenting immune strength or physiological detoxification. The nutrient composition consists of an optimal combination of an effective amount of at least one vitamin antioxidant, at least one mineral antioxidant and a highly saturable amount of at least three high potency antioxidants. The at least one vitamin antioxidant can be vitamin C, bioflavonoid complex, vitamin E, vitamin B6 or beta-carotene and the at least one mineral antioxidant can be zinc or selenium. The at least three high potency antioxidants can be alpha lipoic acid, acetyl L-carnitine, N-acetyl-cysteine, co-enzyme Q10 or glutathione. Also provided is a nutrient composition for augmenting immune strength or physiological detoxification that consists of an optimal combination of an effective amount of at least three vitamin antioxidants, at least two mineral antioxidants and a highly saturable amount of at least three high potency antioxidants. Further provided is a method of stimulating immune system function or a method of augmenting a therapeutic treatment of a disease. The method consists of administering to an individual a nutrient composition of the invention one or more times a day over a period of about 5-7 weeks, the immune system function being stimulated to result in an increase of CD4+ cells of at least about 15% compared to pre-administration levels. A method of stimulating a physiological detoxification function of an individual or a method of augmenting a therapeutic treatment of a disease is also provided. The method consists of administering to an individual a nutrient composition of the invention one or more times a day over a period of about 5-7 weeks, the physiological detoxification function being stimulated to result in a decrease of one or more free radical markers by about 20% compared to pre-administration levels.

The invention discloses a dry powder composition with coenzyme Q10 and preparing method, which comprises the following parts: 1%-60% active coenzyme Q10, 10%-70% excipient, 10%-80% clad wall material, 1%-15% antioxidant and water.

An improved soft gelatin formulation and process methodology that increases single Coenzyme Q10 molecules presented to the absorption channels of the small intestines by providing medium chain triglycerides, Vitamin E and natural beta carotene to Coenzyme Q10 in a soft gel capsule to increase the absorption thereof.

A method is provided for producing a coenzyme Q10 / γ-cyclodextrin complex. This method provides that a mixture of γ-cyclodextrin and coenzyme Q10 is treated by homogenisation and inputting energy.

The invention relates to the biotechnical field, and discloses a construction method of an engineering bacterium for producing coenzyme Q10, the engineering bacterium and an application of the engineering bacterium. The bacterium has a Latin scientific name of Rhodobacter sphaeroides, is named as an NHU-ZDD strain, is preserved in China General Microbiological Culture Collection Center on April 13, 2012, and has a preservation number of CGMCC No.5998. The invention provides a method for improving the output of the coenzyme Q10 by modifying EMP pathway related metabolism pathways. The method can improve the synthesis capability of the coenzyme Q10 by about 30%, and is suitable for the large-scale industrialized production of the coenzyme Q10.

A formulation of Coenzyme Q10, beta-carotenes, Vitamin E, and medium chain triglycerides in rice bran oil and an optional thickener, such as bee's wax, is provided in a soft gel capsule so that a maximum of the Coenzyme Q10 is absorbed by the human body. Generally, about 60 mg of Coenzyme Q10 is the normal amount provided daily to a healthy sedentary adult.

The invention relates to a coenzyme Q10 oral emulsion and its preparation method, wherein the constituents include coenzyme Q10 0.1-80%, medicinal oil 1-95%, emulsifying agent 0.5-30%, auxiliary emulsifying agent 0-10%, anti-oxidant 0.001-15%, and balancing purified water. The emulsion can be prepared through inversion phase emulsification method, PIT emulsification method, alternative liquid feeding emulsification method, or continuous emulsification method.

The invention relates to a purification process for preparing high-purity coenzyme Q10 from crude coenzyme Q10 extracts obtained from thallus fermentation, which belongs to the technical field of compound separation purification. The purification process is characterized by sequentially comprising the following steps of: carrying out adsorbent resin adsorption, elution, concentration, crystallization and recrystallization on the crude coenzyme Q10 extracts; then, carrying out chromatography on a silicagel column; and purifying and refining by using a petroleum ether -aether or normal hexane-ethyl acetate mixed solvents as eluant. The invention has the following advantages that by adopting an adsorbent resin, good adsorption performance can be exerted on the coenzyme Q10, the desorption operation is simple, the stability is good, and the adsorbent resin can be reused many times; and by combining the adsorbent resin with the silica gel chromatography method, the silica gel utilization rate is high, the required silica gel is low quantity and can maintain good purification effect after being reused more than 10 times, the waste quantity of the silica gel is small, and the solvents can be recycled so that the purpose of environment protection is achieved. The production operation is simple and convenient, and the purity of the obtained coenzyme Q10 is higher than or equal to 98 percent.

An aqueous composition specifically adapted for supporting physical performance. The liquid composition comprises, consists of, or consists essentially of ribose, a saccharide such as glucose or dextrose, coenzyme Q10, ATP, caffeine, and D-pinitol in conjunction with minerals and electrolytes. The orally-consumed liquid composition may be sold as a shelf-stable ready-to-drink liquid, or as a liquid concentrate or in solid form, such as a powder, granulate, or tablet to be added to water or other fluid. The liquid composition physiologically enhances essential energy stores and provides a supply of ingredients which support physiological generation and regeneration of ATP.

A method for separating and purifying coenzyme Q10 from a microorganism comprises the following steps of: (1) crushing, (2) extracting, (3) chromatography and (4) crystallization. With the adoption of the method for preparing the coenzyme Q10, the extraction rate and yield of the coenzyme Q10 can be guaranteed, and the quality conformance of a coenzyme Q10 product can be further ensured. The method is simple in technology, low in production cost and small in environmental pollution and is appropriate for industrial production.

The present invention provides a method of increasing the absorbability of oxidized coenzyme Q10 by preparing the oxidized coenzyme Q10 as a composition in the presence of a lysolecithin and an oil and fat. The composition of the present invention comprising oxidized coenzyme Q10, a lysolecithin and an oil and fat, wherein the weight ratio of the lysolecithin to the oxidized coenzyme Q10 is not less than 0.7, shows superior absorption of oxidized coenzyme Q10 and can be utilized for food, food with nutrient function, food for specified health uses, nutritional supplement, nutritional product, animal drug, beverage, feed, pet food, cosmetics, pharmaceutical product, therapeutic drug, preventive drug and the like.

The invention belongs to the technical field of biology and discloses a novel extraction process of coenzyme Q10. The novel extraction process of the coenzyme Q10 takes coenzyme Q10 fermentation liquid as a raw material and comprises the following steps: extracting through an organic solvent, carrying out base-alcohol saponification, carrying out chromatography through a silica gel column, crystallizing through absolute ethyl alcohol, and carrying out suction filtration and vacuum drying to prepare the coenzyme Q10 product. The process is simple to operate, low in pollution, low in requirements on instruments and equipment and low in cost.

The present invention provides a composition superior in water-dispersibility / solubility, workability and tabletability, which contains coenzyme Q10, casein, and a saccharide other than polysaccharides, at a particular ratio. The composition can be utilized for food, food with nutrient function claims, food for specified health uses, nutritional supplement, nutritional product, animal drug, drinks, feed, pharmaceutical product, quasi-drug, cosmetic and the like.

The invention relates to a method for purifying coenzyme Q10. The method comprises the following steps: an upper column solution containing the coenzyme Q10 is subjected to chromatography through a silica gel column; and a mixed solvent of n-hexane and low-grade alcohol or a mixed solvent of n-hexane and low-grade ketone is subjected to elution to obtain eluent; and the eluent is decompressed, is condensed to be dried and is added with ethanol to obtain the coenzyme Q10. Through an elution mode, the method greatly reduces the difficult degree of the reclaiming operation of a subsequent solvent; and simultaneously, the content of effective ingredients of the coenzyme Q10 is improved.

There is provided a coenzyme Q10-containing composition having a high coenzyme Q10 content and excellent stability and bioavailability of coenzyme Q10, without using synthetic emulsifiers such as glycerin fatty acid esters, polyglycerin fatty acid esters, organic acid monoglycerides or sucrose fatty acid esters.The coenzyme Q10-containing liquid composition is obtained by dispersing and emulsifying coenzyme Q10 in an aqueous liquid containing a water-soluble substance consisting of octenylsuccinate starch and dextrin, and glycerin. The liquid composition may be dried to prepare a coenzyme Q10-containing solid composition.

The invention provides a novel process for fermenting coenzyme Q10 based on online oxygen consumption rate control. Oxygen consumption rate is controlled at 30-150mmol / L*h during fermentation of coenzyme Q10 strain production, so that growth of thallus and starting and accumulation of coenzyme Q10 synthesis are promoted. Yield of coenzyme Q10 is evidently increased, unit energy consumption is lowered, and production cost is lowered greatly. The novel process is simple to control, high in operability, energy-saving and the like.

The invention discloses the novel combined coenzyme Q10 parenteral solution, mainly containing the coenzyme Q10 as active component, polyethylene glycol 15-hydroxyl stearate as solubilizing agent and water for injection as solvent. One or more solvents of cosolvent, acidity regulator, osmoregulator and stabilizing agents can be also added. Low hemolyzation, extreme low histamine release and higher physiological tolerance of a novel solubilizing agent Solutol HS 15 adopted by the parenteral solution remarkably improves clinical medication security and the compliance of a patient; and the parenteral solution has the advantages of good stability, longer period of validity, higher medication convenience for a clinician, better storage and stable transportation, higher security for the clinical medication and better compliance of the patient. The parenteral solution also has the advantages of simple preparation technology, simple and convenient quality control and lower production cost, thereby being beneficial to industrialization production.

The present disclosure provides for a scientific formulation useful in the treatment and prevention of human and animal diseases. A biologically effective amount of each of the components of the formulation is administered to patients in pill (or capsule) form via multiple different and identifiable pills. The compounds of the formulation are segregated into different pill types, and contain various amounts of the compounds Curcumin, Genistein, Squalamine, Vitamin E, N-Acetyl-Cysteine, Methylselenocysteine, Zinc Gluconate, B Complex, Lentinen, Coenzyme Q10 Acetyl-L-Carnitine, Lipoic Acid, Resveratrol, and Vitamin C. Furthermore, Arabinoxylan and / or Peperine may be added to the various pill formulations.