Dry powder composition containing CoQ10 and preparation process thereof

A composition and coenzyme technology, applied in the direction of medical preparations containing active ingredients, drug combinations, pharmaceutical formulas, etc., can solve the problems of difficult industrial scale production and complicated operation, achieve stable storage, simple preparation method, and expand the scope of application Effect

Inactive Publication Date: 2007-05-30
ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] US6,197,349 increases the solubility of coenzyme Q10 by providing a stable fine powder dispersion of solid compounds, but this process is complex in operation and difficult to produce on an industrial scale

Method used

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  • Dry powder composition containing CoQ10 and preparation process thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Add 130g of modified starch Co01 (National Starch and Chemical Company, Bridgewater, N.J.) into 400ml of deionized water, heat to 70°C, and dissolve it fully, then add 50g of sucrose, after the above-mentioned modified starch and sucrose form a uniform system, cool down to about 45°C to obtain an aqueous phase. The oily phase was obtained after melting 12.5 g of coenzyme Q10 mixed with 2.5 g of dl-α-tocopherol at 55°C. Then the oil phase is mixed with the water phase matrix, and the primary emulsion is obtained after shearing with a conventional shearing machine for 10 minutes. The particle size of the emulsion droplets in the primary emulsion is about 1000nm, and then the primary emulsion is homogenized under a pressure of 1000Pa. The second time, the emulsion with an average particle diameter of 150nm is obtained.

[0035] The obtained emulsion was spray-dried in a laboratory to finally obtain a dry powder composition of 180 g, wherein the content of coenzyme Q10 was...

Embodiment 2

[0038]Put 128kg of gum arabic, 40kg of sucrose and 2.0kg of sodium ascorbate into 300kg of deionized water, heat up to 70°C with stirring, and keep warm for 1hr to form a transparent solution, which is then cooled to 55°C to obtain an aqueous phase. 25 kg of coenzyme Q10 melt containing 2.0 kg of monoglyceride was mixed with the above-mentioned water phase matrix, and the primary emulsion was obtained by colloidal grinding cycle. The average particle size of emulsion droplets in this primary emulsion is 1200nm. The primary emulsion is homogenized by a high-pressure homogenizer under a pressure of 1500Pa. During the homogenization process, the particle size of emulsion droplets is monitored until it reaches about 100nm.

[0039] The homogenized emulsion was spray-dried to finally obtain 175.6 kg of dry powder composition, wherein the content of coenzyme Q10 was 11.3%.

[0040] The dry powder composition has good cold water dispersibility and can be applied to water-based food o...

Embodiment 3

[0042] Put 92kg of gelatin (50Bloom, Rouuseust, Wuzhou, China) into 400kg of deionized water, stir at 70°C to make it fully dissolve, then add 20kg of sucrose and 1.5kg of sodium ascorbate, the above matrix forms a uniform transparent solution and cool down to 60°C To obtain the water phase, heat 44.0kg of coenzyme Q10 to 55°C to form a melt, add 2.0kg of mixed tocopherols to the melt to form an oil phase, then mix the water phase with the oil phase, and form primary emulsification under the pulverization of the colloid mill Liquid, the average particle size of emulsion droplets in this emulsion is about 1000nm. Use a high-pressure homogenizer to homogenize the primary emulsion under a pressure of 1500 Pa, and monitor the particle size of the emulsion droplet until it reaches about 100 nm during the homogenization process.

[0043] Next, use a thin-film evaporator to condense the homogeneous emulsion to about 200kg of water, so that the solid content of the final emulsion obta...

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Abstract

The invention discloses a dry powder composition with coenzyme Q10 and preparing method, which comprises the following parts: 1%-60% active coenzyme Q10, 10%-70% excipient, 10%-80% clad wall material, 1%-15% antioxidant and water.

Description

technical field [0001] The invention relates to a dry powder composition containing coenzyme Q10 and a preparation method thereof. Background technique [0002] The chemical name of coenzyme Q10 is 2,3-dimethoxy-5-methyl-6-(3-methylbutenyl-2) 10 - Benzoquinone, a metabolic activator with the molecular formula C 59 h 90 o 4 , the structural formula is as follows: [0003] [0004] It can activate cellular respiration, accelerate the production of adenosine triphosphate (ATP), and play a first-aid role in detoxification; it can change the hypoxic state of cells and tissues, and has better protection and improvement effects on liver, brain, heart muscle and nervous system; it It can also enhance the non-specific immunity in the body. Coenzyme Q10 is a natural antioxidant produced by the cell itself, which can inhibit the peroxidation of mitochondria, protect the integrity of the biofilm structure, have a very specific enhancement effect on immunity, increase the phagocy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K9/14A61P1/16A61P31/14A61P9/00A61P35/00A61P3/06
Inventor 邵斌周迪许新德章鹏飞王燕峰
Owner ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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