Coenzyme Q10 injection emulsion and its preparing process

A technology of coenzyme and emulsion, which is applied in the field of medicine, can solve the problems that coenzyme Q10 injection lacks in vivo targeting, the dosage form is difficult to meet the needs of treating diseases, and the variety of clinical drugs is single, so as to facilitate individualized drug administration and improve biological quality. The effect of utilization, convenient storage and circulation

Inactive Publication Date: 2006-11-08
YUTAI MEDICINE SCI TECH HANZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obviously, the existing dosage forms of the drug are difficult to meet the needs of the diseases it treats
Tablets, capsules, etc. are difficult to take for patients with dysphagia, and both tablets and capsules have disadvantages such as low bioavailability
Because coenzyme Q10 is a fat-soluble drug, on the one hand, the concentration in the injection solution, that is, the solubility is limited, so that the variety of clinical drugs is single; on the other hand, the drug is easy to precipitate during storage, and the physical stability is not good; Q10 injection lacks good in vivo targeting and low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Coenzyme Q10 injection emulsion, the emulsion is a fat emulsion for injection, taking 1000ml as an example, it is composed of 15.0g egg yolk lecithin, 100g refined soybean oil, 4.00g coenzyme Q10, 1.00g vitamin E, 50.0g glycerin, poloxamer f 68 10.0 g is prepared and then added with water for injection to 1000 ml, and the pH value is adjusted to 3-9 to prepare.

Embodiment 2

[0026] Coenzyme Q10 injection emulsion, the emulsion is a submicron emulsion for injection, taking 1000ml as an example, it is made of soybean lecithin 10.0g, coenzyme Q105.00g, vitamin E 0.500g, 1,2-propanediol 100g, poloxamer F 68 After 20g is prepared, add water for injection to 1000ml, and adjust the pH value to 3-9 to prepare.

Embodiment 3

[0028] Coenzyme Q10 injection emulsion, the emulsion is a microemulsion for injection, taking 1000ml as an example, it is made up of 6.00g of coenzyme Q10, 0.100g of vitamin E, 300g of 1,2-propanediol, 30g of poloxamer, and 15g of glycerin. Prepared by adjusting the pH value to 3-9 with water to 1000ml.

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Abstract

The coenzyme Q10 injection emulsion has coenzyme Q10 as the effective medicine component, and each 1000 ml emulsion contains coenzyme Q10 1-10g, vegetable oil for injection 0-200g, emulsifier 1-50g, isoosmotic regulator 5-50g, antioxidant 0.05-5g, pH regulator in the quantity of regulating pH value to 3.0-9.0, co-emulsifier 10-500g and water for injection for the rest. It provides the patient with treating medicine and essential nourishing matter. It has high physical stability and may be prepared into freeze dried preparation for further raised stability and convenient storing and transportation. The coenzyme Q10 injection emulsion has certain targeting effect, so that it has raised bioavailability and lowered toxic side effect.

Description

(1) Technical field [0001] The invention relates to the technical field of medicine, in particular to an injection emulsion containing coenzyme Q10 and a freeze-dried preparation thereof. (2) Background technology [0002] Coenzyme Q10 is one of the important members of coenzyme Q, which is a kind of quinone compound. Also known as ubiquinone, universal quinone, derivatives of oxidized coenzyme Q10, etc. Coenzyme Q10 is widely found in yeast, leaves and seeds of plants, and in the heart, spleen, liver and kidney of animals. [0003] Clinically, coenzyme Q10 is an important antioxidant and immune enhancer. It is mainly used to treat diseases of heart, lung and liver. In recent years, many studies have been carried out on the extraction and preparation of coenzyme Q10 raw materials. Japan has been engaged in the production of this product for more than 30 years and has an absolute advantage in technology. There are also many relevant researches at home and abroad on the pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61K9/107A61K9/19A61P37/04A61P39/06
Inventor 马佳萍高青
Owner YUTAI MEDICINE SCI TECH HANZHOU
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