Coenzyme Q10 injection

Abstract

The invention discloses the novel combined coenzyme Q10 parenteral solution, mainly containing the coenzyme Q10 as active component, polyethylene glycol 15-hydroxyl stearate as solubilizing agent and water for injection as solvent. One or more solvents of cosolvent, acidity regulator, osmoregulator and stabilizing agents can be also added. Low hemolyzation, extreme low histamine release and higher physiological tolerance of a novel solubilizing agent Solutol HS 15 adopted by the parenteral solution remarkably improves clinical medication security and the compliance of a patient; and the parenteral solution has the advantages of good stability, longer period of validity, higher medication convenience for a clinician, better storage and stable transportation, higher security for the clinical medication and better compliance of the patient. The parenteral solution also has the advantages of simple preparation technology, simple and convenient quality control and lower production cost, thereby being beneficial to industrialization production.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a coenzyme Q10 injection solubilized by a novel surfactant. Background technique [0002] Coenzyme Q10, also known as decenoquinone, also known as ubiquinone Q10 and ubiquinone-50, is a fat-soluble quinone compound and one of the important members of coenzyme Q. It has the common characteristics of vitamins and its chemical structure is similar to vitamin K. Coenzyme Q10 is widely found in the cells of plants and microorganisms, as well as in the hearts, livers, spleens and kidneys of animals. Coenzyme Q10 is a good biological drug, which has various biological functions, has the advantages of small dose, low toxicity, and can assist in the treatment of various diseases, and has been widely used in clinical practice. Coenzyme Q10 has the functions of natural anti-oxidation and activation of cell metabolism, which can significantly improve human immunity. Clinically, it is main...

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Problems solved by technology

[0012] The purpose of the present invention is to provide a new combination of coenzyme Q10 injection, to overcome the problem that the existing coenzyme Q10 injection is easy to produce turbidity and precipitation in the storage process and the content drops quickly, and at the same time, it can also reduce the existing coenzyme Q10. Toxic and side effects such as allergic reaction and hemolyticity caused by the use of a large amount of polysorbate 80 solubilized by the injection

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