A composition for treating senile dementia, its preparation method and application
A technology of Alzheimer's disease and composition, which is applied in the field of biomedicine, can solve the problems of inability to protect neurons, fail to save neurons from death, and excessive drug diameter, so as to reduce the effect of promoting formation, enhance ATP synthesis, and improve Vitality effect
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[0030] The present invention provides the preparation method of above-mentioned composition, comprises the steps:
[0031] (1) mixing coenzyme Q10, polysorbate, medium-chain fatty acid triglycerides, gelatin, glycerin, sorbitol and absolute ethanol to obtain an organic phase;
[0032] (2) mixing the organic phase with water 3 to 8 times the volume of the organic phase to obtain a mixed solution;
[0033] (3) heating the mixed solution to 60-80°C, stirring, evaporating and concentrating to 0.3-0.8 times the volume of the organic phase to obtain a nanoemulsion;
[0034] (4) placing the nanoemulsion in an environment of 0-4°C and continuing to stir to obtain a suspension of nano-coenzyme Q10;
[0035] (5) After homogenizing the nano-coenzyme Q10 suspension, vacuum freeze-drying to obtain a composition for treating senile dementia.
[0036] In the invention, firstly, coenzyme Q10, polysorbate, medium-chain fatty acid triglyceride, gelatin, glycerin, sorbitol and absolute ethanol...
Embodiment 1
[0047] Preparation of Nanopackaged Coenzyme Q10
[0048] Main raw materials: coenzyme Q10 (CAS: 303-98-0, Xi'an Siji Biotechnology Co., Ltd.), polysorbate-80 (CAS: 9005-65-6, Hubei Guangao Biotechnology Co., Ltd.), medium chain fatty acid glycerol Triesters (CAS: 73398-61-5, Shanghai Shucan Industrial Co., Ltd.), gelatin (CAS: 9000-70-8, Zhengzhou Givaudan Chemical Products Co., Ltd.), glycerin (CAS: 56-81-5, Shanghai Yien Chemical Technology Co., Ltd.), sorbitol (CAS: 142-77-8, Meilan Chemical brand is Meilan Industrial (Shanghai) Co., Ltd.), absolute ethanol (CAS: 64-17-5, Shanghai Fangye Chemical Co., Ltd. Putuo Branch), purified water (laboratory deionized water).
[0049] Preparation method: adopt the original emulsification-low temperature-high pressure method to prepare nano-packaged coenzyme Q10
[0050] ① Accurately weigh 0.78g of coenzyme Q10, 0.1g of polysorbate-80, 0.5g of medium-chain fatty acid triglycerides, 5g of gelatin, 5g of glycerin, and 5g of sorbitol; ...
Embodiment 2
[0056] Penetration of blood-brain barrier by nanopackaged coenzyme Q10
[0057] Detection method: high performance liquid chromatography (HPLC)
[0058] Detection process:
[0059] Instruments and reagents: HP1100 high performance liquid chromatography (HP1100, Agilent Technologies Co.Ltd, USA); nitrogen blowing instrument (KL512J, Beijing Kang Technology Co., Ltd.). Coenzyme Q10 standard product (BBI company, purity greater than 99.9%). Preparation of coenzyme Q10 standard solution: Accurately weigh coenzyme Q100.0250g into 25mL volumetric flasks respectively, dissolve coenzyme Q10 in ethanol and adjust the volume to the mark, shake well for later use, and prepare 1g / L standard stock solution. Before the determination, dilute to the use concentration with the mobile phase according to the standard curve.
[0060] Chromatographic conditions: Phenomenex C18 column (5μm, 250mm×4.6mm i.d.) is used as the chromatographic column; methanol-ethanol (volume ratio: 20:80) is used as...
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