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Compound composition of traditional Chinese medicine monomers for preventing and treating Alzheimer disease

A technology for Alzheimer's disease and composition, applied in the field of medicinal chemistry, can solve problems such as poor drugability, unsatisfactory clinical efficacy of single-target drugs, and large side effects, achieve clear targets and improve controllability and stability, the effect of concentration of medicinal substances

Inactive Publication Date: 2015-03-11
LANZHOU GENERAL HOSPITAL OF LANZHOU MILITARY REGION PLA
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AI Technical Summary

Problems solved by technology

Second, clinical practice has found that the clinical efficacy of highly specific single-target drugs is not satisfactory
[0009] At the same time, active compounds discovered for a single target have many problems such as poor druggability or large side effects

Method used

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  • Compound composition of traditional Chinese medicine monomers for preventing and treating Alzheimer disease
  • Compound composition of traditional Chinese medicine monomers for preventing and treating Alzheimer disease
  • Compound composition of traditional Chinese medicine monomers for preventing and treating Alzheimer disease

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Experimental program
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Effect test

Embodiment

[0038] The first is animal grouping, intervention and specimen collection:

[0039]Sixty 3-month-old APP695V717I transgenic mice were purchased from the Institute of Experimental Animals, Chinese Academy of Medical Sciences (license number: SCKK 20080013), weighing (30±4.5) g, male or female, C57BL / 6J mice of the same age and background 20 were used as blank control group. The selected animals were grouped using a random number table, and divided into control group, model group and drug group with 20 animals each. The intragastric solution of the control group and the model group was normal saline, and the intragastric solution of the drug group was a suspension of the composition of stilbene glucoside, ligustrazine and polygala saponin (compatibility according to the ratio of 3:2:2 respectively, wherein stilbene glycoside 30mg / kg, Trichozine 20mg / kg, Polygala saponin 20mg / kg, and the positive crossover design in the previous pre-experiment confirmed the best compatibility r...

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Abstract

The invention discloses application of a composition and a compatible method of ligustrazine, tenuigenin and stibene glucoside in preparation of a drug for treating Alzheimer disease. In the invention, the composition of ligustrazine, tenuigenin and stibene glucoside can be compatible according to a ratio to obviously prevent damage on the cognitive function of APP695V717I transgenic mice; proved by a Y electric maze experiment and a Morris water maze experiment, the composition of ligustrazine, tenuigenin and stibene glucoside can obviously improve the capabilities of passive avoidance, active avoidance and spatial memory exploration competence of the model mice, and has the obvious functions of preventing ageing hypomnesia and dysmnesia related to the Alzheimer disease; the further detection shows that the compatible composition of ligustrazine, tenuigenin and stibene glucoside can reduce deposition of age pigments in brains of AD transgenic mice, and improve the activity of acetylcholine esterase, so as to indicate that the composition of ligustrazine, tenuigenin and stibene glucoside compatible according to the ratio can treat the Alzheimer disease remarkably.

Description

technical field [0001] The invention relates to a compound composition of traditional Chinese medicine monomers and the medical application of its compatibility ratio in the treatment of Alzheimer's disease. The senile class deposition and the application of improving the activity of acetylcholinesterase belong to the field of medicinal chemistry. Background technique [0002] Trichozine, molecular formula: C 8 h 12 N 2 , molecular weight: 136, molecular structure: [0003] Polygala saponin: Molecular formula: C 30 h 45 C lO6 , molecular weight: 537.1277, molecular structure: [0004] Stilbene glycosides, molecular formula: C 20 h 22 o 9 , Molecular weight: 406, Molecular structure: [0005] The above three monomer components can be purchased directly in the market, and their content can be analyzed by high performance liquid chromatography. [0006] Alzheimer's disease (AD), also known as senile dementia, is a common neurological disease in the elderly. ...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61P25/28A61K31/4965
CPCA61K31/7034A61K31/4965A61K31/56A61K2300/00
Inventor 罗红波李芸石向群郭建魁张志强
Owner LANZHOU GENERAL HOSPITAL OF LANZHOU MILITARY REGION PLA
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