68 results about "Senega Root" patented technology

The invention belongs to the technical field of traditional Chinese medicine fermentation, and particularly relates to a traditional Chinese medicine fermentation composition for regulating sleep as well as a preparation method and application thereof. The traditional Chinese medicine fermented composition for regulating sleep is prepared by fermenting spina date seeds, poria cocos, lily, liquorice, polygala tenuifolia, cortex albiziae, lotus seeds and Chinese yams serving as traditional Chinese medicine raw materials through probiotics. The traditional Chinese medicine raw materials with specific components are selected and subjected to gradient fermentation with specific strains, the prepared traditional Chinese medicine composition is remarkable in sleep adjusting effect, and the level of 5-hydroxytryptamine can be remarkably improved.

The invention provides a fingerprint spectrum and multi-component content determination method of a calamus-far nerve calming mixture, and relates to the field of quality control of traditional Chinese medicines. 31 common peaks are calibrated by establishing a fingerprint spectrum, and 24 common peaks can clearly belong to polygala tenuifolia. Meanwhile, synchronous content determination of seven components including chlorogenic acid, caffeic acid, ferulic acid, liquiritin, 2, 3, 5, 4 '-tetrahydroxy stilbene-2-O-beta-D-glucoside, 3, 6'-dimustard acyl sucrose and rosmarinic acid is realized. The method is good in precision, high in repeatability and stable and reliable in result, the medicine quality can be comprehensively and accurately reflected and controlled, and powerful support is provided for guaranteeing the safety and effectiveness of the calamus-far Ningmind mixture.

The invention provides a traditional Chinese medicine composition for treating cerebrovascular diseases and a preparation method and application thereof, and belongs to the technical field of biological medicine. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8 to 12 parts of rhizoma chuanxiong, 12 to 17 parts of radix paeoniae rubra, 13 to 18 parts of radix salviae miltiorrhizae, 8 to 12 parts of radix polygalae, 10 to 15 parts of rhizoma acori graminei, 27 to 32 parts of radix astragali seu hedysari, 0.3 to 0.7 part of borneol, 0.1 to 0.2 part of musk, 12 to 18 parts of radix angelicae sinensis, 6 to 12 parts of flos carthami, 7 to 12 parts of semen persicae and 5 to 7 parts of radix glycyrrhizae preparata. The traditional Chinese medicine composition disclosed by the invention has the curative effects of tonifying qi and activating blood, dispersing blood stasis and dredging collaterals, and restoring consciousness and inducing resuscitation. The traditional Chinese medicine composition can be combined with a leg electrical stimulation system to efficiently treat cerebral apoplexy hemiplegia and effectively treat vascular dementia, and has an obvious treatment effect on cerebrovascular diseases. The preparation method of the traditional Chinese medicine composition is simple, convenient and rapid, and is suitable for industrial production.

The application belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to an acupoint sticking medicine for preventing and treating long-term postoperative cognitive impairment of elderly patients and a use method thereof. The traditional Chinese medicine composition of the acupoint sticking medicine comprises Huangrenshen, Baishao, Danggui, Guijianyu, Shichangpu, Yuanzhi, Tianzhuhuang, Longchi, Fushen, Mosha, Huoxiang and Pelian. Under the guidance of the traditional Chinese medicine meridian theory, the physiological characteristics of the elderly patients are combined with the long-term postoperative rehabilitation demand, so that the effective components of traditional Chinese medicine are absorbed through the skin and jointly play a superimposed treatment role. The acupoint sticking medicine has a definite effect on preventing and treating long-term postoperative cognitive impairment of elderly patients, can significantly improve the long-term postoperative cognitive function score of the elderly patients, improve the long-term postoperative life quality and sleep quality, and is beneficial to the long-term postoperative rehabilitation of the elderly patients.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for relieving depression and clearing collaterals and a preparation, a pharmaceutical composition and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6-12 parts of radix bupleuri, 9-15 parts of radix curcumae, 6-12 parts of rhizoma acori graminei, 3-9 parts of fructus gardeniae, 3-9 parts of polygala tenuifolia, 9-15 parts of radix paeoniae rubra and 9-20 parts of cortex albiziae. The traditional Chinese medicine composition provided by the invention can be used for remarkably improving depression-like behaviors of mice with depression, reversing synaptic injury and improving the expression of synaptic associated proteins SYP and PSD-95. The anti-depression mechanism of the traditional Chinese medicine composition is that the traditional Chinese medicine composition has the effects of synergistically inhibiting activation of microglial cells and reducing the level of proinflammatory cytokines such as Tnf alpha, Il1beta and Il6, so that neuroinflammation is remarkably inhibited, and the traditional Chinese medicine composition has the advantages of novel formula, definite mechanism and definite curative effect for treating depression, particularly patients with anxiety and dysphoria symptoms.

The invention relates to the technical field of traditional Chinese medicine compositions, and discloses a traditional Chinese medicine composition for athletes and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises 4 parts of ginseng, 8 parts of polygala tenuifolia, 20 parts of Chinese yam, 12 parts of bighead atractylodes rhizome, 4 parts of pseudo-ginseng, 15 parts of rhizoma polygonati, 12 parts of flax seed, 10 parts of wolfberry, 15 parts of radix ophiopogonis, 15 parts of prepared rehmannia root, 15 parts of prepared fleece flower root, 15 parts of longan aril, 10 parts of mulberry leaf, 12 parts of wild chrysanthemum flower, 10 parts of eucommia ulmoides, 12 parts of rhizoma cibotii, 12 parts of cortex acanthopanacis and 12 parts of radix achyranthis bidentatae. According to the traditional Chinese medicine composition for the athletes and the preparation method of the traditional Chinese medicine composition, the composition of a decoction formula and a beverage formula can help the athletes to accelerate elimination of exercise-induced fatigue, improve mental functions and enhance physique, physical strength, intelligence and memory; the composition of the weight-losing formula definitely provides a conditioning scheme for hyperlipemia obesity, obesity due to spleen deficiency and obesity due to qi deficiency.

The invention discloses a traditional Chinese medicine composition for treating anxiety insomnia. The traditional Chinese medicine composition is prepared from, by weight, 3-5 parts of rhizoma coptidis, 3-6 parts of cortex cinnamomi, 5-8 parts of fructus aurantii immaturus, 5-10 parts of radix curcumae, 5-8 parts of radix polygalae, 5-10 parts of fructus schizandrae, 5-8 parts of rhizoma chuanxiong and 1-3 parts of borneol. The traditional Chinese medicine composition can be used for preparing an external preparation navel patch, and the navel patch can be absorbed through the Shenque acupoint to play a whole regulation role. The navel patch disclosed by the invention has a remarkable curative effect on anxiety emotion caused by heart-kidney disharmony and qi stagnation and secondary anxiety insomnia symptoms such as difficulty in falling asleep, vexation, insomnia, dreaminess and easy awakening, is safe and convenient to use, provides a new solution for an external treatment method of anxiety insomnia, and has relatively high application and popularization values.

The present disclosure relates to a method of treating neuroinflammation. The disclosure, in one aspect. provides for the administration of an effective amount of at least the four herbal components Polygalae (thin leaf milkwort), Astragali (membranous milkvetch), Ligusticum chuanxiong and Angelica senensis (Chinese angelica), their roots or rhizomes, or extracts thereof to a subject with neuroinflammation.

This invention provides a composition comprising: 5-15 parts by weight of dried plum, 10-20 parts by weight of cinnamon twig, 10-20 parts by weight of ginseng, 3-8 parts by weight of angelica root, 5-15 parts by weight of asarum, 10-30 parts by weight of dried ginger, 5-15 parts by weight of Sichuan pepper, 5-15 parts by weight of phellodendron bark, 3-8 parts by weight of coptis root, 20-40 parts by weight of bitter wine, 20-30 parts by weight of japonica rice, 10-20 parts by weight of honey, 3-8 parts by weight of lily bulb, 40-60 parts by weight of polygonum multiflorum stem, 40-60 parts by weight of monkey head mushroom, 3-8 parts by weight of polygala root, and 5-15 parts by weight of poria cocos (a traditional Chinese medicine composition). Further, the composition comprises: 20-40 parts by weight of hydrolyzed milk protein, 20-40 parts by weight of fish collagen peptide, and 20-40 parts by weight of soybean peptide (a biological product). This invention also provides pharmaceutical preparations (especially pills) comprising the above composition, biological products, and methods for preparing the same. The composition has a significant effect on improving sleep and has broad application prospects.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating co-disease of liver depression and spleen deficiency type depressive state and IBS (irritable bowel syndrome). The composition comprises radix pseudostellariae, poria cocos, raw coix seeds, fingered citron, polygala tenuifolia, roasted rhizoma atractylodis macrocephalae, lotus seed pulp, mint, roses, lilies, raw fructus gardeniae, fermented soybeans and raw hawthorn fruits. Liver soothing, depression relieving, spleen strengthening and heart nourishing are taken as core treatment rules, heat clearing, restlessness relieving, digestion promoting and stagnation removing are also taken, and the complex pathogenesis that the two are causal to each other is formed for gastrointestinal dysfunction caused by emotional discomfort. The formula is characterized in that the three internal organs of the heart, the liver and the spleen are treated at the same time, the four methods of tonifying, dredging, clearing and eliminating are used at the same time, balance is achieved between qi regulating and healthy qi supporting, and the formula is suitable for patients suffering from complex heart and body diseases with low mood, anxiety, dysphoria, insomnia, amnesia, abdominal fullness, inappetence, loose stool or loose stagnation.

The invention provides a traditional Chinese medicine compound external preparation for invigorating the kidney and strengthening Yang and a preparation method thereof, belongs to the technical field of traditional Chinese medicine preparations, and aims to solve the problems that the bioavailability of the first-pass effect of existing oral administration is low, and effective components of external ointment are difficult to penetrate through the skin. The preparation is a composite gel containing a penetration enhancer and a temperature-sensitive gel matrix, and the traditional Chinese medicine compound at least comprises various active ingredients of male silkworm moth, centipede, epimedium, rhizoma curculiginis, cistanche, schisandra chinensis, semen cuscutae, polygala tenuifolia, fructus cnidii, semen allii tuberosi, actinolite, sulfur, venenum bufonis, amethyst and borneol. According to the preparation disclosed by the invention, the transdermal permeation rate and the cumulative permeation amount of various active ingredients in the compound are improved in order of magnitude, so that an effective treatment concentration can be ensured to be reached in an in-vitro local or in-vivo system. In clinical application, the traditional Chinese medicine composition has better effect taking speed and treatment effect than external application or oral administration of traditional prescriptions with the same name.

The application discloses a kind of American ginseng compound antioxidant products, is prepared from the following mass fraction components extraction: American ginseng 20-30 parts, 15-25 parts of radix rehmanniae preparata, 20-28 parts of dogwood, 15-25 parts of radix scrophulariae, 15-25 parts of gardenia, 8-12 parts of safflower, 18-22 parts of chuanxiong, 20-26 parts of citrus aurantium, 18-25 parts of alocasia, 10-20 parts of polygala, 16-26 parts of Platycladus branchlet, 15-25 parts of hovenia dulcis thunb, after screening, cleaning, crushing, weighing, alcohol extraction, water extraction, concentration and the like step is made.Compared with prior art, the application obtains the beneficial effect: synergistic effect between components, by tonifying qi and invigorating the spleen, nourishing liver and kidney, clearing heart and detoxifying, promoting blood circulation and qi movement, it has the effect of root and original for senile dementia, using reasonable extraction method is beneficial to the extraction of each effective component;Since the components of the application are non-toxic commonly used medicinal materials, there is no harm to the body after use, and there is no side effect.

The present invention relates to a method for preparing pharmaceutical compositions and other herbal products derived from Traditional Chinese Medicine (TCM) herbs, including astragali root (Milkvetch - Huang Qi), Ligusticum chuanxiong (Chuan Xiong), Angelicae sinensis root (Chinese angelica - Dan Gui), and polygalae root (Thinleaf milkwort- Yuan Zhi). The method involves a single extraction of the TCM herbs by heating in a hydro-alcoholic solvent, where the alcohol may be ethanol. Figure 2 provides a summary description of an embodiment of the method. The invention also relates to products of the method of the invention, and their use in the treatment of stroke and various neurological disorders.

Provided is a traditional Chinese herbal composition for treating pulmonary nodules, a preparation method thereof, and a honeyed pill. The composition comprises: 30 parts by weight of Ziziphi Spinosae Semen, 20-30 parts by weight of Rehmaniae Radix, 30 parts by weight of Trichosanthis Radix, 40-50 parts by weight of Paeoniae Radix Alba, 30 parts by weight of Coicis Semen Preparata, 20 parts by weight of Ginseng Radix et Rhizoma, 10 parts by weight of Olibanum, 10 parts by weight of Myrrha, 20-30 parts by weight of Testudinis Carapax et Plastrum Preparata Cum Aceto, 20-30 parts by weight of Trionycis Carapax Preparata Cum Aceto, 30 parts by weight of Agrimoniae Herba, 10-20 parts by weight of Alpiniae Oxyphyllae Fructus, 5 parts by weight of Toosendan Fructus, 20 parts by weight of Poria, 10 parts by weight of Platycodonis Radix, and 10 parts by weight of Polygalae Radix.

The application discloses a traditional Chinese medicine composition for treating insomnia, anxiety depression and AD, a preparation method and application thereof. The traditional Chinese medicine composition adopts an ethanol extract of raw medicinal materials, and the raw medicinal materials include, by weight, 175-185 parts of polygala root, 160-170 parts of jujube seed, 90-100 parts of platycladus seed, 150-160 parts of jujube, 160-170 parts of fried licorice, 160-170 parts of astragalus, 150-160 parts of angelica, 150-160 parts of salvia miltiorrhiza, and 155-165 parts of schisandra chinensis. The raw medicinal materials in the traditional Chinese medicine composition are based on the polygala root, and are combined with the jujube seed, the platycladus seed, the jujube, the fried licorice, the astragalus, the angelica, the salvia miltiorrhiza and the schisandra chinensis. The components have a synergistic effect, can treat insomnia, anxiety depression and AD, and have the advantages of small side effect of traditional Chinese medicine and difficulty in drug resistance.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a qi-tonifying and beautifying pill and a preparation method thereof. The qi-tonifying and beautifying pill is prepared from the following main raw materials in parts by weight: 360g of chrysanthemum morifolium ramat, 26g of Changbai mountain ginseng slices, 52g of bighead atractylodes rhizome, 72g of astragalus membranaceus, 72g of mulberry, 120g of prepared rehmannia root, 22g of dried rehmannia root, 52g of poria cocos, 120g of angelica sinensis, 28g of processed polygala tenuifolia, 120g of salted morinda officinalis, 120g of fructus lycii, 22g of pepper, 28g of Chinese yam, 28g of poria with hostwood, 60g of salted semen cuscutae, 60g of eucommia ulmoides and 60g of rhizoma polygonati. According to the qi-tonifying and beauty-maintaining pill and the preparation method thereof, the qi-tonifying and beauty-maintaining pill is scientific in formula and strong in synergistic effect, and can achieve the effects of tonifying qi and blood and regulating internal organs together, so that the remarkable effects of tonifying qi and maintaining beauty are achieved; meanwhile, the preparation method is standard and efficient, the retention rate of active ingredients of the raw materials and the pill stability can be improved, the taste is improved, and the pill is convenient to take.

The invention provides a traditional Chinese medicine sleeping pillow which comprises a traditional Chinese medicine pillow inner, and the traditional Chinese medicine pillow inner comprises a pillow inner sleeve and a traditional Chinese medicine particle filling layer arranged in the pillow inner sleeve; the traditional Chinese medicine particle filling layer comprises the following components in parts by weight: 80-100 parts of chrysanthemum, 50-70 parts of crude dragon bone, 10-20 parts of sandalwood, 50-70 parts of processed polygala tenuifolia pulp, 45-65 parts of junci medulla, 55-65 parts of albizia flower, 55-65 parts of raw dens draconis, 8-10 parts of borneol, 80-100 parts of clove, 85-90 parts of rhizoma acori graminei, 85-95 parts of vine of multiflower knotweed, 85-95 parts of calcined magnet, 50-70 parts of folium artemisiae argyi and 50-70 parts of pericarpium citri reticulatae. The detachable traditional Chinese medicine pillow inner and plastic neck support structure is adopted, pillow inner replacement and essential oil supplementation are facilitated, and maintenance is convenient and fast; ergonomic design improves use comfort and adapts to neck physiological curves of different crowds.

The application discloses a traditional Chinese medicine combined incense bead for soothing nerves and helping sleep, which is prepared from the following raw materials in a mass ratio: 5g of agarwood, 5g of sandalwood, 3g of Chinese flowering crabapple, 4g of fried Chinese date seed, 2g of polygala, 2g of lavender, 1g of natural borneol camphor and 16g of cypress stick powder. The application adds fried Chinese date seed to the traditional liver-soothing incense material to supplement the heart-nourishing and liver-nourishing effect, adds polygala to communicate the heart and kidney, and adds lavender to soothe nerves, so that three types of insomnia core pathogenesis, i.e., liver stagnation, heart blood deficiency and heart-kidney disharmony, can be solved at the same time. The single formula covers multiple types of insomnia, and the nerve-soothing effect is much better than that of the single formula. The natural borneol camphor is added as a meridian-inducing transdermal absorption carrier in the combined incense bead formula, so that the technical defect that the effective components of the traditional incense bead only float on the body surface and have weak effect is solved.

The invention relates to the technical field of biological medicine, in particular to application of Kaixin powder in preparation of medicine for treating triple negative breast cancer, and the Kaixin powder is prepared from ginseng, polygala tenuifolia, poria cocos and rhizoma acori graminei according to the mass ratio of 1: 1: 1-2: 1. The Kaixin powder extract can significantly inhibit the growth of triple negative breast cancer tumors in animal bodies and has no obvious toxicity, and the anti-TNBC drug effect of the Kaixin powder extract is not achieved by directly acting on tumor cells, but inhibits the tumor progress through overall regulation and control in the animal bodies.

The invention relates to the technical field of traditional Chinese medicine analysis, in particular to a construction method of a characteristic spectrum of a traditional Chinese medicine compound preparation for treating senile dementia. The method is creatively characterized in that detection of characteristic peaks is realized through extraction, preparation and purification of an extract and specific gradient selection under a specific mobile phase condition. According to the method, seven chemical components in the traditional Chinese medicine compound preparation can be analyzed, seven characteristic peaks including epimedin C, ginsenoside Rd, pachymic acid, dehydrotumuloic acid, alpha-asarone, polygala mountain ketone III and tenuigenin are identified, verification research on specificity, precision, repeatability and stability is carried out on the method, and it is proved that the method is accurate and reliable. The technical means is used as a method for overall evaluation of the traditional Chinese medicine compound preparation, and a quality control system of the traditional Chinese medicine compound preparation is comprehensively improved.

The invention discloses a traditional Chinese medicine compound composition for treating hyperthyroidism as well as a preparation method and application of the traditional Chinese medicine compound composition. The traditional Chinese medicine compound composition is prepared from the following raw materials: 3-17 parts of cortex moutan, 6-26 parts of polygonum cuspidatum, 3-17 parts of radix curcumae, 6-26 parts of fried rhizoma atractylodis macrocephalae, 8-32 parts of parched white paeony root, 4-20 parts of rhizoma pinellinae praeparata, 3-17 parts of fried szechwan chinaberry fruit, 6-26 parts of oriental wormwood, 1-11 parts of honey-fried polygala tenuifolia, 8-32 parts of selfheal, 3-17 parts of fructus forsythiae, 6-26 parts of radix scrophulariae, 13-47 parts of calcined oyster shell and 8-32 parts of kelp. The composition is screened and determined under the guidance of traditional Chinese medicine theories in combination with modern research progress (especially the latest research conclusion of treating the disease by iodine-containing drugs), and clinical experiment results show that the composition has better effects of reducing TSH and the like and improving symptoms of patients, and is good in safety. And compared with methimazole for treating hyperthyroidism, the composition has better effects of reducing TRAb and FT3 and improving symptoms of patients.

The invention relates to the technical field of traditional Chinese medicine, and provides a medicine for treating radiotherapy-induced leucopenia and a preparation method and application thereof.The medicine comprises a traditional Chinese medicine composition, and the traditional Chinese medicine composition comprises ginseng, rhizoma atractylodis macrocephalae fried with bran, poria cocos, Chinese yam, pericarpium citri reticulatae, radix aucklandiae, fructus amomi, radix astragali preparata, angelica sinensis, fried semen ziziphi spinosae and processed polygala tenuifolia. When the traditional Chinese medicine composition acts on mammals, it is verified that the traditional Chinese medicine composition has a good curative effect on leucopenia and / or bone marrow hematopoietic tissue area reduction caused by radiotherapy, and the level of pro-inflammatory cytokines increased due to radiotherapy in serum of the mammals is lowered.

The invention provides a nerve-soothing and sleep-aiding compound for improving sleep quality and application of the nerve-soothing and sleep-aiding compound. The nerve soothing and sleep aiding compound for improving sleep quality comprises the following components in parts by weight: 10-30 parts of a spina date seed extract, 5-15 parts of a polygala tenuifolia extract, 2-5 parts of sandalwood, 2-3 parts of bergamot, 2-3 parts of corydalis tuber, 1-2 parts of albizia flower, 1-2 parts of chamomile, 2-3 parts of lavender, 3-5 parts of sweet orange and 8-20 parts of a poria cocos extract. According to the nerve-soothing and sleep-aiding compound for improving the sleep quality and the application thereof, the nerve-soothing and sleep-aiding compound adopts various natural plant extracts and functional components, is safe and free of side effects, does not generate drug dependence and drug resistance after being used for a long time, is suitable for being used by people with various sleep disorders, and is free of toxic and side effects. According to the compound, through the synergistic effect of various components, the sleep time can be remarkably shortened, the sleep time can be prolonged, the sleep depth can be improved, the sleep quality can be effectively improved, and the compound has a good improvement effect on sleep disorders caused by pressure, anxiety and the like.

The invention provides a modified suhuquan mixture and a preparation method thereof, the modified suhuquan mixture comprises salted fructus alpiniae oxyphyllae, radix linderae, fried mantis egg-case, fructus rosae laevigatae, steamed fructus corni, salted eucommia ulmoides, Chinese yam, radix astragali, rhizoma cimicifugae, bran-fried rhizoma atractylodis macrocephalae, prepared polygala tenuifolia and calcined dragon bone, and the preparation method comprises the following steps: weighing raw materials according to a prescription; decocting the raw materials; determining the content; determining an extraction process and preparing the flavored suoquan mixture. The traditional Chinese medicine composition has the effects of tonifying middle-Jiao and Qi, tonifying Qi and relieving desertion, reinforcing kidney to strengthen yang, securing essence and reducing urination, calming heart and tranquilizing mind, strengthening spleen and tonifying kidney, inducing astringency and relieving desertion, can reinforce kidney tonifying and Qi tonifying, securing essence and reducing urination after being matched, can effectively improve the symptoms of frequent urination, night enuresis, frequent urination and urgent urination of a patient, can be used for quality control of the modified Huoquan mixture, and has a wide application prospect. Therefore, the mixture not only keeps the characteristics of quick absorption and quick effect of the decoction, but also overcomes the trouble of decocting the decoction, and has the advantages of improving the taste, being convenient to carry, take and preserve and the like.

The invention relates to the technical field of preparation and application of traditional Chinese medicine compositions, and particularly discloses a traditional Chinese medicine composition for treating Alzheimer's disease and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 3-9 parts of ginseng, 3-10 parts of morinda officinalis, 6-12 parts of dogwood, 3-10 parts of rhizoma acori graminei, 3-10 parts of polygala tenuifolia, 3-6 parts of rhodiola rosea, 3-6 parts of China rose, 2-3 parts of hypericum perforatum, 3-6 parts of saussurea involucrate, 9-15 parts of cortex lycii radicis, 3-12 parts of golden cypress and 1-5 parts of agilawood. The traditional Chinese medicine composition provided by the invention accords with the traditional Chinese medicine treatment concept of tonifying deficiency and filling marrow, inducing resuscitation and soothing nerves, dredging collaterals and eliminating evil, and tonifying spleen and assisting transportation, not only can relieve damage of neurons, but also can reverse alzheimer disease related disorder signal channels in neuronal cells, microglial cells and astrocytes.

The invention belongs to the technical field of traditional Chinese medicine lozenges, and particularly discloses a traditional Chinese medicine lozenge with functions of clearing heat, relieving cough and reducing sputum and a preparation method of the traditional Chinese medicine lozenge. The raw materials comprise the following components in parts by weight: 2-6 parts of bulbus fritillariae cirrhosae, 4-8 parts of radix stemonae, 2-4 parts of radix asteris, 1-5 parts of bulbus lilii, 2-6 parts of radix polygalae, 2-8 parts of fructus momordicae, 2-4 parts of radix glycyrrhizae, 2-8 parts of herba pteridis multifidae, 3-8 parts of rhizoma polygoni cuspidati, 1-5 parts of lithocarpus terminalis, 4-8 parts of machilus nigrum, 4-10 parts of sow thistle, 2-10 parts of egg shells, 4-12 parts of snow pears, 2-6 parts of a filler and 2-6 parts of an adhesive. 2-6 parts of a flow aid, 40-60 parts of a high and low temperature resistant solution and 4-12 parts of a deodorant. The outer surface of the traditional Chinese medicine lozenge is covered with the high and low temperature resistant protective layer, the high and low temperature resistance of the traditional Chinese medicine lozenge can be improved, and the storage environment of the traditional Chinese medicine lozenge can be improved by improving the high and low temperature resistance of the traditional Chinese medicine lozenge.

The invention relates to a composition with a sleep quality improving function and a preparation method thereof, and belongs to the technical field of cosmetics and external preparations. The composition comprises gamma-aminobutyric acid, isosorbide dimethyl ether, a plant extract compound (pink passion fruit, spina date seed, polygala tenuifolia and prepared rehmannia root), aromatic essential oil (lavender oil, sandalwood oil and agilawood extract), menthol, ammonium polyacryloyldimethyl taurine and a moisturizing and preservative system. Isosorbide dimethyl ether and gamma-aminobutyric acid are premixed to form a permeation precursor solution, so that the problem of difficulty in transdermal penetration of gamma-aminobutyric acid is solved; through a specific preparation technology, gradient sleep-aiding release based on essential oil volatility difference and gel wrapping is constructed, and the staged sleep-aiding effects of instant cooling, dysphoria blocking, relaxation inducing, synergistic interaction and all-night slow-release deep sleep maintaining are achieved. The composition disclosed by the invention is high in transdermal absorption rate, controllable in fragrance release time sequence and lasting in sleep aiding effect, and has a good application prospect.

The invention discloses a traditional Chinese medicine composition for preventing and treating climacteric insomnia. The traditional Chinese medicine composition is mainly prepared from cortex moutan, mantis egg-case, poria cocos, rhizoma anemarrhenae, pericarpium citri reticulatae, folium apocyni veneti, cortex albiziae, polygala tenuifolia, roses, herba lycopi, pericarpium arecae, fructus liquidambaris and the like according to a certain weight ratio. The traditional Chinese medicine can be prepared into any common oral dosage form. The whole formula has the effects of nourishing blood and soothing liver, activating blood and removing stasis, promoting qi circulation and inducing diuresis, and nourishing yin and clearing heat, and has an exact curative effect on preventing and treating climacteric insomnia.

The application belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine composition for treating cognitive impairment and a preparation method thereof. The preparation method of the traditional Chinese medicine composition comprises the following steps: S1. adding modified mesoporous silicon dioxide to water extracts of ginseng, poria cocos, polygala, acorus gramineus, bupleurum, radix curcumae, cyperus rotundus and chuanxiong, grinding, vacuum drying, and preparing an intermediate product; and S2. mixing the intermediate product with microcrystalline cellulose, mannitol, sodium carboxymethyl starch and a stabilizer, adding a binder, extruding and rounding, drying, sieving, and preparing the traditional Chinese medicine composition. The method is simple in steps and easy to put into production. The obtained traditional Chinese medicine composition can significantly improve the oxidative stress damage of a vascular dementia model rat.