Nerve-soothing traditional Chinese medicine application composition for treating endocrine insomnia and anxiety and preparation method of nerve-soothing traditional Chinese medicine application composition

Abstract

The invention provides a tranquilizing traditional Chinese medicine application composition for treating endocrine insomnia and anxiety and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20-25 parts of cinnamon, 6-10 parts of coptis chinensis, 10-15 parts of fructus evodiae, 10-20 parts of fructus psoraleae, 8-10 parts of scutellaria baicalensis, 10-20 parts of gordon euryale seeds, 20-25 parts of lily, 10-20 parts of spina date seeds, 5-10 parts of angelica sinensis, 3-7 parts of polygala tenuifolia, 5-15 parts of vine of multiflower knotweed, 3-5 parts of longan aril and 2-5 parts of nacre mother of pearl. The tranquilizing traditional Chinese medicine application composition for treating endocrine insomnia and anxiety provides a new choice for endocrine insomnia and anxiety, and the preparation method of the tranquilizing traditional Chinese medicine application composition provides a better pure traditional Chinese medicine preparation for patients with endocrine insomnia and anxiety. The clinical curative effect is obvious.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a tranquilizing traditional Chinese medicine patch composition for treating endocrine insomnia and anxiety and a preparation method thereof. Background Art

[0002] Insomnia, which is called "insomnia" in traditional Chinese medicine, is a type of disease caused by the lack of nourishment to the mind or the restlessness of the mind, and is characterized by the frequent inability to get normal sleep. Insomnia is mainly manifested by insufficient sleep time and depth, as well as the inability to eliminate fatigue and restore physical strength and energy. In mild cases, it is difficult to fall asleep, or sleep soundly, wake up from sleep, or cannot fall asleep again after waking up, and in severe cases, people can't sleep all night. Insomnia can cause fatigue, restlessness, general discomfort, listlessness, slow reaction, headache, and inability to concentrate. Its greatest impact is on the mental aspect. Severe cases can lead to functional diseases such as schizophrenia, depression, anxiety, autonomic dysfunction, and various systemic diseases, such as the cardiovascular system, digestive system, etc.

[0003] Insomnia is a very common phenomenon. The prevalence of insomnia is high and is on the rise. Endocrine insomnia and anxiety may be related to a variety of factors, including lifestyle, environment, mental and psychological state, and endocrine system diseases. The main causes are as follows:

[0004] 1. A large number of studies have confirmed that insomnia is caused by an imbalance in the regulation of the endocrine network. The endocrine network transmits hormones and neurotransmitters in a two-way manner to regulate sleep rhythms. The imbalance of the endocrine network system causes a series of neuroendocrine immune reactions, causing individuals to suffer from insomnia and anxiety, affecting their daily work and life. At the same time, some patients do not have enough understanding of the symptoms of endocrine disorders and the disease, and are prone to anxiety or depression. Anxiety or depression is accompanied by insomnia, which manifests as difficulty falling asleep, early awakening, or dreaming.

[0005] 2. Endocrine disorders can also cause weight changes. Some patients may be overweight, especially female patients. It is easy for changes in body shape to affect their mood and insomnia. Severe insomnia caused by endocrine disorders is related to emotions and the disease itself. Summary of the invention

[0006] The purpose of the present invention is to provide a Chinese medicine patch composition and preparation method for treating endocrine insomnia and anxiety, providing a new choice for endocrine insomnia and anxiety, and the preparation method thereof provides a better pure Chinese medicine preparation for patients with endocrine insomnia and anxiety. The clinical efficacy is significant.

[0007] The technical solution of the present invention is achieved in this way:

[0008] The invention provides a tranquilizing Chinese medicine patch composition for treating endocrine insomnia and anxiety. The composition is prepared from the following raw materials in parts by weight: 20-25 parts of cinnamon bark, 6-10 parts of coptis root, 10-15 parts of evodia rutaecarpa, 10-20 parts of psoralea corylifolia, 8-10 parts of scutellaria baicalensis, 10-20 parts of euryale ferox, 20-25 parts of lily, 10-20 parts of spiny jujube seeds, 5-10 parts of angelica sinensis, 3-7 parts of polygala tenuifolia, 5-15 parts of radix polygoni multiflori, 3-5 parts of longan pulp and 2-5 parts of mother-of-pearl.

[0009] As a further improvement of the present invention, the following raw materials are prepared by weight: 21-24 parts of cinnamon, 7-9 parts of coptis, 11-14 parts of evodia rutaecarpa, 13-17 parts of psoralea corylifolia, 8.5-9.5 parts of scutellaria baicalensis, 13-17 parts of euryale ferox, 21-24 parts of lily, 12-17 parts of spiny jujube seeds, 6-9 parts of angelica, 4-6 parts of polygala, 7-12 parts of Polygonum multiflorum, 3.5-4.5 parts of longan pulp, and 3-4 parts of mother-of-pearl.

[0010] As a further improvement of the present invention, the following raw materials are prepared by weight: 22 parts of cinnamon, 8 parts of coptis, 12 parts of evodia rutaecarpa, 15 parts of psoralea corylifolia, 9 parts of scutellaria, 15 parts of Euryale ferox, 23 parts of lily, 15 parts of spiny jujube seeds, 7 parts of angelica, 5 parts of polygala, 10 parts of Polygonum multiflorum, 4 parts of longan pulp, and 3.5 parts of mother-of-pearl.

[0011] The present invention further protects a method for preparing the above-mentioned tranquilizing Chinese medicine patch composition for treating endocrine insomnia and anxiety, comprising the following steps:

[0012] S1. extracting cinnamon with supercritical fluid to obtain cinnamon oil;

[0013] S2. Slice Coptis chinensis, Lilium lily and Evodia rutaecarpa, add to water, heat to boiling, extract 2-3 times, filter, combine the filtrate, concentrate and dry to obtain an aqueous extract;

[0014] S3. Psoralea corylifolia, Scutellaria baicalensis, and Euryale ferox were crushed, added to an ethanol solution, heated for extraction, extracted 2-3 times, filtered, the filtrate was combined, concentrated, and dried to obtain an alcohol extract;

[0015] S4. Evenly mix the cinnamon oil, water extract and alcohol extract, add glycerin and mix thoroughly to prepare a tranquilizing Chinese medicine patch composition for treating endocrine insomnia and anxiety.

[0016] As a further improvement of the present invention, the conditions for supercritical fluid extraction in step S1 are pressure 25-35 MPa, temperature 40-50° C., and time 120-200 min.

[0017] As a further improvement of the present invention, the extraction time in step S2 is 2-4 hours.

[0018] As a further improvement of the present invention, the concentration of the ethanol solution in step S3 is 50-70wt%.

[0019] As a further improvement of the present invention, the temperature of the heating extraction in step S3 is 50-60° C. and the time is 1-2 h.

[0020] As a further improvement of the present invention, the amount of glycerol added in step S4 is 5-10 wt % of the total mass.

[0021] The present invention has the following beneficial effects:

[0022] This prescription is composed of cinnamon bark, coptis root, evodia rutaecarpa, psoralea corylifolia, scutellaria baicalensis, euryale ferox, and lily, and has the effects of connecting the heart and kidney, clearing fire and calming the mind. In the prescription, cinnamon bark is pungent and hot, warming yang and tonifying the kidney, coptis root is bitter and cold, clearing and descending heart fire, and the two are used together for cold and heat, which can balance water and fire, evodia rutaecarpa soothes the liver and purges fire, can lead fire back to its origin and make the heat go down, calm the mind and calm the mind, psoralea corylifolia nourishes the liver and kidney, replenishes essence and fills the marrow, scutellaria baicalensis clears heat and purges fire, euryale ferox nourishes the spleen and kidney, and lily clears the heart and calms the mind. In summary, the combination of cinnamon bark, coptis root, evodia rutaecarpa, psoralea corylifolia, scutellaria baicalensis, euryale ferox, and lily in this prescription has the effects of sweet and warm heat removal, connecting the heart and kidney, clearing fire, nourishing the heart and calming the mind.

[0023] The Chinese medicine patch composition for calming nerves for treating endocrine insomnia and anxiety provides a new choice for endocrine insomnia and anxiety, and the preparation method thereof provides a better pure Chinese medicine preparation for patients with endocrine insomnia and anxiety. The clinical efficacy is remarkable. DETAILED DESCRIPTION

[0024] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0025] Example 1

[0026] Raw material composition (by weight): 20 parts of cinnamon bark, 6 parts of coptis root, 10 parts of evodia rutaecarpa, 10 parts of psoralea corylifolia, 8 parts of scutellaria baicalensis, 10 parts of euryale ferox, 20 parts of lily, 10 parts of spiny jujube seed, 5 parts of angelica sinensis, 3 parts of polygala tenuifolia, 5 parts of radix polygoni multiflori, 3 parts of longan pulp, and 2 parts of mother of pearl.

[0027] This embodiment provides a method for preparing a tranquilizing Chinese medicine patch composition for treating endocrine insomnia and anxiety, comprising the following steps:

[0028] S1. extracting cinnamon with supercritical fluid to obtain cinnamon oil;

[0029] The supercritical fluid extraction conditions are: pressure 25 MPa, temperature 40°C, time 120 min;

[0030] S2. Slice Coptis chinensis, Lilium lily, and Evodia rutaecarpa, add to water, heat to boiling, extract for 2h, extract twice, filter, combine the filtrate, concentrate, and dry to obtain an aqueous extract;

[0031] S3. Psoralea corylifolia, Scutellaria baicalensis, and Euryale ferox were crushed, added to a 50 wt% ethanol solution, heated to 50 ° C, extracted for 1 h, extracted twice, filtered, the filtrate was combined, concentrated, and dried to obtain an alcohol extract;

[0032] S4. Mix cinnamon oil, water extract and alcohol extract evenly, add glycerin, the amount of glycerin added is 5wt% of the total mass, and mix well to prepare a Chinese medicine patch composition for treating endocrine insomnia and anxiety.

[0033] Example 2

[0034] Raw material composition (by weight): 25 parts of cinnamon bark, 10 parts of coptis root, 15 parts of evodia rutaecarpa, 20 parts of psoralea corylifolia, 10 parts of scutellaria baicalensis, 20 parts of euryale ferox, 25 parts of lily, 20 parts of spiny jujube seed, 10 parts of angelica sinensis, 7 parts of polygala tenuifolia, 15 parts of radix polygoni multiflori, 5 parts of longan pulp, and 5 parts of mother of pearl.

[0035] This embodiment provides a method for preparing a tranquilizing Chinese medicine patch composition for treating endocrine insomnia and anxiety, comprising the following steps:

[0036] S1. extracting cinnamon with supercritical fluid to obtain cinnamon oil;

[0037] The supercritical fluid extraction conditions are: pressure 35 MPa, temperature 50°C, time 200 min;

[0038] S2. Slice Coptis chinensis, Lilium lily, and Evodia rutaecarpa, add to water, heat to boiling, extract for 4h, extract 3 times, filter, combine the filtrate, concentrate, and dry to obtain an aqueous extract;

[0039] S3. Psoralea corylifolia, Scutellaria baicalensis, and Euryale ferox were crushed, added to a 70 wt % ethanol solution, heated to 60 ° C, extracted for 2 h, extracted 3 times, filtered, the filtrate was combined, concentrated, and dried to obtain an alcohol extract;

[0040] S4. Mix cinnamon oil, water extract and alcohol extract evenly, add glycerin, the amount of glycerin added is 10wt% of the total mass, and mix well to prepare a Chinese medicine patch composition for treating endocrine insomnia and anxiety.

[0041] Example 3

[0042] Raw material composition (by weight): 22 parts of cinnamon bark, 8 parts of coptis root, 12 parts of evodia rutaecarpa, 15 parts of psoralea corylifolia, 9 parts of scutellaria baicalensis, 15 parts of euryale ferox, 23 parts of lily, 15 parts of spiny jujube seed, 7 parts of angelica sinensis, 5 parts of polygala tenuifolia, 10 parts of Polygonum multiflorum vine, 4 parts of longan pulp, and 3.5 parts of mother-of-pearl.

[0043] This embodiment provides a method for preparing a tranquilizing Chinese medicine patch composition for treating endocrine insomnia and anxiety, comprising the following steps:

[0044] S1. extracting cinnamon with supercritical fluid to obtain cinnamon oil;

[0045] The supercritical fluid extraction conditions are: pressure 30 MPa, temperature 45°C, time 150 min;

[0046] S2. Slice Coptis chinensis, Lilium lily, and Evodia rutaecarpa, add to water, heat to boiling, extract for 3h, extract 3 times, filter, combine the filtrate, concentrate, and dry to obtain an aqueous extract;

[0047] S3. Psoralea corylifolia, Scutellaria baicalensis, and Euryale ferox were crushed, added to a 60 wt% ethanol solution, heated to 56 ° C, extracted for 1.5 h, extracted 3 times, filtered, the filtrate was combined, concentrated, and dried to obtain an alcohol extract;

[0048] S4. Mix cinnamon oil, water extract and alcohol extract evenly, add glycerin, the amount of glycerin added is 7wt% of the total mass, and mix well to prepare a Chinese medicine patch composition for treating endocrine insomnia and anxiety.

[0049] Example 4

[0050] Raw material composition (by weight): 21 parts of cinnamon bark, 7 parts of coptis root, 11 parts of evodia rutaecarpa, 13 parts of psoralea corylifolia, 8.5 parts of scutellaria baicalensis, 13 parts of euryale ferox, 21 parts of lily, 12 parts of spiny jujube seed, 6 parts of angelica, 4 parts of polygala, 7 parts of Polygonum multiflorum, 3.5 parts of longan pulp, and 3 parts of mother-of-pearl.

[0051] This embodiment provides a method for preparing a tranquilizing Chinese medicine patch composition for treating endocrine insomnia and anxiety, comprising the following steps:

[0052] S1. extracting cinnamon with supercritical fluid to obtain cinnamon oil;

[0053] The supercritical fluid extraction conditions are: pressure 30 MPa, temperature 45°C, time 150 min;

[0054] S2. Slice Coptis chinensis, Lilium lily, and Evodia rutaecarpa, add to water, heat to boiling, extract for 3h, extract 3 times, filter, combine the filtrate, concentrate, and dry to obtain an aqueous extract;

[0055] S3. Psoralea corylifolia, Scutellaria baicalensis, and Euryale ferox were crushed, added to a 60 wt% ethanol solution, heated to 56 ° C, extracted for 1.5 h, extracted 3 times, filtered, the filtrate was combined, concentrated, and dried to obtain an alcohol extract;

[0056] S4. Mix cinnamon oil, water extract and alcohol extract evenly, add glycerin, the amount of glycerin added is 7wt% of the total mass, and mix well to prepare a Chinese medicine patch composition for treating endocrine insomnia and anxiety.

[0057] Example 5

[0058] Raw material composition (by weight): 24 parts of cinnamon bark, 9 parts of coptis root, 14 parts of evodia rutaecarpa, 17 parts of psoralea corylifolia, 9.5 parts of scutellaria baicalensis, 17 parts of euryale ferox, 24 parts of lily, 17 parts of spiny jujube seed, 9 parts of angelica, 6 parts of polygala tenuifolia, 12 parts of Polygonum multiflorum, 4.5 parts of longan pulp, and 4 parts of mother-of-pearl.

[0059] This embodiment provides a method for preparing a tranquilizing Chinese medicine patch composition for treating endocrine insomnia and anxiety, comprising the following steps:

[0060] S1. extracting cinnamon with supercritical fluid to obtain cinnamon oil;

[0061] The supercritical fluid extraction conditions are: pressure 30 MPa, temperature 45°C, time 150 min;

[0062] S2. Slice Coptis chinensis, Lilium lily, and Evodia rutaecarpa, add to water, heat to boiling, extract for 3h, extract 3 times, filter, combine the filtrate, concentrate, and dry to obtain an aqueous extract;

[0063] S3. Psoralea corylifolia, Scutellaria baicalensis, and Euryale ferox were crushed, added to a 60 wt% ethanol solution, heated to 56 ° C, extracted for 1.5 h, extracted 3 times, filtered, the filtrate was combined, concentrated, and dried to obtain an alcohol extract;

[0064] S4. Mix cinnamon oil, water extract and alcohol extract evenly, add glycerin, the amount of glycerin added is 7wt% of the total mass, and mix well to prepare a Chinese medicine patch composition for treating endocrine insomnia and anxiety.

[0065] Test case 1 efficacy evaluation:

[0066] 180 people diagnosed with sleep disorders due to endocrine disorders, aged 36-42 years old, were recruited, and a three-month trial was conducted with the blank group not applying the Chinese medicine patch composition for treating endocrine insomnia and anxiety of the present invention, and the intervention group of Examples 1-5. 1g / person was applied to the temples 1h before sleep every day, and the Pittsburgh Sleep Quality Index Questionnaire (PSQI) was used for follow-up after three months to evaluate the efficacy. The results are shown in Table 1.

[0067] Table 1 Comparison of PSQI total scores before and after intervention (mean value of total score X±s points)

[0068] Group Number of people Before intervention After intervention Blank Group 30 16.29±4.21 16.59±4.82 Example 1 30 16.18±3.45 3.25±2.19 Example 2 30 16.21±4.09 3.44±2.08 Example 3 30 16.25±3.48 3.08±2.14 Example 4 30 16.23±4.13 3.15±2.10 Example 5 30 16.27±4.28 3.19±2.07

[0069] As can be seen from the above table, the tranquilizing Chinese medicine patch compositions for treating endocrine insomnia and anxiety prepared in Examples 1-5 of the present invention have a good effect on improving the sleep disorders of people suffering from sleep disorders, among which Example 3 has the best effect.

[0070] After treatment, the efficacy evaluation method was made by referring to the "Guidelines for Clinical Research of New Chinese Medicines" and the SPIEGEL scale score combined with the reduction rate method. The PSQI scale reduction rate was used to evaluate the efficacy, which was divided into 4 levels: clinical cure: PSQI scale reduction rate>75%. Significant effect: PSQI scale reduction rate>50%. Effective: PSQI scale reduction rate>25%. Ineffective: PSQI scale reduction rate<25%. After the efficacy score was scored, the efficacy of each group was compared, and the results are shown in Table 2.

[0071] Table 2

[0072]

[0073]

[0074] It can be seen from the above table that the tranquilizing Chinese medicine patch compositions for treating endocrine insomnia and anxiety prepared in Examples 1-5 of the present invention have a good therapeutic effect on the sleep disorders of people suffering from sleep disorders.

[0075] The comparison of patients' anxiety scores before and after is shown in Table 3.

[0076] Table 3

[0077] Group Before treatment After treatment Blank Group 51.28±9.25 50.28±10.24 Example 1 50.94±9.34 38.02±7.32 Example 2 51.23±10.03 39.58±8.22 Example 3 51.09±11.55 37.52±8.47 Example 4 50.82±9.38 40.13±9.23 Example 5 50.91±10.17 39.47±8.64

[0078] It can be seen from the above table that the tranquilizing Chinese medicine patch compositions for treating endocrine insomnia and anxiety prepared in Examples 1-5 of the present invention have a good effect on improving the anxiety of people suffering from sleep disorders.

[0079] The comparison of depression scores of patients before and after is shown in Table 4.

[0080] Table 4

[0081] Group Before treatment After treatment Blank Group 62.57±10.49 60.29±11.15 Example 1 61.44±9.48 50.48±9.45 Example 2 62.41±10.18 48.97±7.88 Example 3 60.93±9.95 46.52±8.64 Example 4 61.37±11.25 49.63±8.11 Example 5 62.10±9.82 48.47±9.05

[0082] It can be seen from the above table that the tranquilizing Chinese medicine patch compositions for treating endocrine insomnia and anxiety prepared in Examples 1-5 of the present invention have a good effect on improving depression in people with sleep disorders.

[0083] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A Chinese medicine patch composition for calming the nerves for treating endocrine insomnia and anxiety, characterized in that: The following raw materials are prepared by weight: 20-25 parts of cinnamon bark, 6-10 parts of coptis root, 10-15 parts of evodia rutaecarpa, 10-20 parts of psoralea corylifolia, 8-10 parts of scutellaria baicalensis, 10-20 parts of euryale ferox, 20-25 parts of lily, 10-20 parts of spiny jujube seeds, 5-10 parts of angelica sinensis, 3-7 parts of polygala tenuifolia, 5-15 parts of radix polygoni multiflori, 3-5 parts of longan pulp and 2-5 parts of mother-of-pearl.

2. The Chinese medicine patch composition for calming nerves for treating endocrine insomnia and anxiety according to claim 1, characterized in that: The following raw materials are prepared by weight: 21-24 parts of cinnamon bark, 7-9 parts of coptis root, 11-14 parts of evodia rutaecarpa, 13-17 parts of psoralea corylifolia, 8.5-9.5 parts of scutellaria baicalensis, 13-17 parts of euryale ferox, 21-24 parts of lily, 12-17 parts of spiny jujube seeds, 6-9 parts of angelica sinensis, 4-6 parts of polygala tenuifolia, 7-12 parts of radix polygoni multiflori, 3.5-4.5 parts of longan pulp and 3-4 parts of mother-of-pearl.

3. The Chinese medicine patch composition for calming nerves for treating endocrine insomnia and anxiety according to claim 2, characterized in that: The following raw materials are prepared by weight: 22 parts of cinnamon bark, 8 parts of coptis root, 12 parts of evodia rutaecarpa, 15 parts of psoralea corylifolia, 9 parts of scutellaria baicalensis, 15 parts of euryale ferox, 23 parts of lily, 15 parts of spiny jujube seed, 7 parts of angelica sinensis, 5 parts of polygala tenuifolia, 10 parts of radix polygoni multiflori, 4 parts of longan pulp, and 3.5 parts of mother-of-pearl.

4. A method for preparing a Chinese medicine patch composition for treating endocrine insomnia and anxiety as claimed in any one of claims 1 to 3, characterized in that: The following steps are involved: S1. extracting cinnamon with supercritical fluid to obtain cinnamon oil; S2. Slice Coptis chinensis, Lilium lily and Evodia rutaecarpa, add to water, heat to boiling, extract 2-3 times, filter, combine the filtrate, concentrate and dry to obtain an aqueous extract; S3. Psoralea corylifolia, Scutellaria baicalensis, and Euryale ferox were crushed, added to an ethanol solution, heated for extraction, extracted 2-3 times, filtered, the filtrate was combined, concentrated, and dried to obtain an alcohol extract; S4. Evenly mix the cinnamon oil, water extract and alcohol extract, add glycerin and mix thoroughly to prepare a tranquilizing Chinese medicine patch composition for treating endocrine insomnia and anxiety.

5. The preparation method according to claim 4, characterized in that: The conditions of supercritical fluid extraction in step S1 are pressure 25-35 MPa, temperature 40-50° C., and time 120-200 min.

6. The preparation method according to claim 4, characterized in that: The extraction time in step S2 is 2-4 hours.

7. The preparation method according to claim 4, characterized in that: The concentration of the ethanol solution in step S3 is 50-70wt%.

8. The preparation method according to claim 4, characterized in that: The temperature of the heating extraction in step S3 is 50-60° C. and the time is 1-2 h.

9. The preparation method according to claim 4, characterized in that: The amount of glycerol added in step S4 is 5-10 wt % of the total mass.

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