Acupuncture point application medicine for treating postoperative insomnia as well as preparation method and use method of acupoint application medicine

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to an acupoint application medicine for treating postoperative insomnia and a preparation and use method thereof.The acupoint application medicine is prepared from coptis chinensis, cinnamon, cortex albiziae, amber, folium artemisiae argyi, polygala tenuifolia, tuber fleeceflower stem, spina date seed and poria with hostwood, the acupoint application medicine is applied on the first day after an operation, and the acupoint application medicine is used for 7 days in total. The traditional Chinese medicine composition can be used for well treating the postoperative insomnia, has the characteristics of simplicity, convenience, examination, low cost and the like, solves the problems that the existing single medicine cannot be used for effectively preventing and treating the postoperative insomnia, the adverse drug reaction caused by the medicine is prevented, the cost is high and the like, is easier for postoperative patients to accept, and provides a new clinical treatment strategy for preventing and treating the postoperative insomnia.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to an acupoint application medicine for treating postoperative insomnia, and a preparation method and a use method thereof. Background Art

[0002] Sleep is essential for maintaining healthy and normal bodily function. The sleep mechanism is regulated by the central nervous system, which regulates sleep and wakefulness. Neurotransmitters, growth factors, hormones, and other substances are involved in this process. Under the influence of disease, environmental, and psychological factors, abnormal secretion of these substances leads to central neurotransmitter disturbances, which in turn cause insomnia. Perioperative sleep disturbance generally refers to a clinical syndrome characterized by abnormal sleep quality or abnormal sleep behavior observed before, during, and after surgery. Previous studies have shown that the incidence of postoperative sleep disturbances in perioperative patients is as high as 65.7%-95.0%. Postoperative sleep disturbances can persist for a long time, with one study reporting that 49.7% of lung cancer surgery patients still experience sleep disturbances one year after surgery. Postoperative sleep disturbances often manifest for at least one day after surgery, with symptoms such as sleep fragmentation, frequent nighttime awakenings, difficulty falling asleep, insufficient sleep, early awakenings, and disrupted sleep rhythms. Perioperative sleep disturbances can lead to postoperative cognitive impairment, postoperative delirium, increased or sensitized postoperative pain, mood disorders, and other psychological problems, severely impacting prognosis. The precise mechanisms and treatments for postoperative sleep disorders remain unclear. Previous clinical studies have shown that gender, age, anxiety, preoperative comorbidities (sleep apnea, chronic pain), circadian rhythm disturbances, stress, pain, and ward environment may be high-risk factors for postoperative sleep disorders. Inadequate postoperative pain management can increase the risk of adverse postoperative events and is a significant risk factor for postoperative insomnia. Therefore, it is crucial to rationally assess patients' sleep status, identify those with sleep disorders, and provide appropriate treatment.

[0003] In Traditional Chinese Medicine, insomnia is referred to as "inability to sleep" or "insomnia." The primary symptom is the heart and brain, closely related to the spleen, stomach, liver, gallbladder, and kidneys. Its pathogenesis is generally attributed to restlessness and visceral dysfunction; yang excess and yin deficiency, resulting in a disharmony between yin and yang. Yin deficiency and excessive fire are common. The theory of "regulating the viscera and calming the mind" stems from Traditional Chinese Medicine's holistic approach of "unity of form and spirit," emphasizing that visceral dysfunction is the core pathogenesis of insomnia. This theory of visceral imbalance points to the involvement of the "five internal organs and six bowels" in insomnia, directly linking the body's sleep and wakefulness with them. The Yellow Emperor's Classic of Internal Medicine states: "When Wei Qi is unable to enter Yin, it remains in Yang. Retention in Yang leads to yang qi sufficiency, and when yang qi sufficiency is strong, the yang qiao flourishes. When it is unable to enter Yin, yin qi becomes deficient, resulting in difficulty closing the eyes." Traditional Chinese Medicine generally considers Yang's failure to enter Yin as the underlying pathogenesis of insomnia, while Yang excess and yin deficiency, resulting in disharmony between the Ying and Wei, are the primary causes of Yang's failure to enter Yin. In addition, patients are often anxious after surgery, which further leads to liver qi disharmony, qi stagnation turning into fire and damaging yin, making insomnia worse. The main principles of treatment are clearing heat and removing phlegm, soothing the liver and relieving depression.

[0004] Currently, there is no consensus on the prevention and treatment of postoperative sleep disorders. Benzodiazepine sedatives and hypnotics such as estazolam are often used clinically to treat postoperative insomnia. While these drugs offer rapid onset of action and high patient tolerance, long-term use can be addictive and dependent, and insomnia can recur after discontinuation. Furthermore, postoperative pain is a significant risk factor for postoperative insomnia. Relying solely on sedatives and hypnotics fails to provide effective postoperative analgesia and is associated with adverse drug reactions and high costs. Summary of the Invention

[0005] The purpose of the present invention is to provide an acupoint application medicine for treating postoperative insomnia, and a preparation and use method thereof, so as to solve the problems that the current single reliance on medicine cannot effectively prevent and treat postoperative insomnia, and has adverse reactions due to the prevention and treatment of the medicine and high costs.

[0006] To achieve the above objectives, this application is implemented through the following technical solutions:

[0007] An acupoint application medicine for treating postoperative insomnia is composed of the following Chinese medicinal raw materials: coptis root, cinnamon bark, julibrissin bark, amber, wormwood leaf, polygala root, smilax china root, jujube seed and poria.

[0008] Furthermore, the weight ratio of the coptis root, cinnamon bark, julibrissin bark, amber, wormwood leaf, polygala root, celery striata, spinach seed and poria is 3:3:5:5:3:3:5:2:5.

[0009] Furthermore, auxiliary materials that can be used are also included to form a paste.

[0010] Furthermore, it also includes outer layer auxiliary materials.

[0011] Furthermore, the auxiliary materials include but are not limited to honey.

[0012] The preparation method of any of the above-mentioned acupoint application medicines for treating postoperative insomnia comprises the following steps:

[0013] S1 selects Chinese medicinal raw materials such as coptis root, cinnamon bark, julibrissin bark, amber, wormwood leaf, polygala root, smilax china, spinach seed and poria according to weight ratio;

[0014] S2. Wash the weighed Chinese medicinal materials respectively;

[0015] S3, drying the Chinese medicinal raw materials after cleaning in step S2 in a dryer for 10-15 minutes, and then pulverizing;

[0016] S4, grinding the medicine crushed in step S3 into ultrafine powder and mixing it evenly, then adding honey, mixing into a paste and storing it for later use.

[0017] The method for using any of the above-mentioned acupoint application medicines for treating postoperative insomnia comprises the following steps:

[0018] S5. Take the paste from step S4 and evenly apply it on the outer layer of auxiliary materials to form an ointment;

[0019] S6. Apply the ointment to the set acupuncture points;

[0020] S7. Apply the patch starting from the first day after surgery and remove it after 6 hours, twice a day for a total of 7 days. Furthermore, the acupoints set are Hegu, Shenmen and Neiguan.

[0021] The beneficial effects of the present invention are:

[0022] Among the nine Chinese medicinal herbs selected in the present invention, coptis root clears away heat and dampness, purges fire and detoxifies; cinnamon bark warms the middle and nourishes the kidney, dispels cold and relieves pain; julibrissin bark relieves depression and calms the mind; amber calms the nerves and soothes the mind, dispels blood stasis and stops bleeding; mugwort warms the meridians and stops bleeding, dispels cold and relieves pain; polygala root calms the mind and improves intelligence, and relieves depression; smilax glabra nourishes blood and soothes the mind; spinach seed calms the mind and soothes the mind, and promotes fluid production; poria calms the mind and soothes the mind, which can prolong the patient's sleep time and is commonly used to treat insomnia. Among them, polygala root combined with spinach seed exerts a calming effect through the synergistic effect of multiple components, multiple targets, and multiple pathways to achieve the purpose of treating insomnia. Acupoint application is a special external treatment method of traditional Chinese medicine. This method is mainly based on the meridian theory. Under the guidance of the traditional Chinese medicine meridian theory, drugs with the functions of nourishing yin, reducing fire, nourishing blood and calming the mind are applied to acupoints. By applying and stimulating the Hegu point, pain can be relieved and sedated, and qi and blood can be promoted; Neiguan point can expand the chest and regulate qi, calm the mind and soothe the mind; stimulating the Shenmen point can calm the mind and harmonize yin and yang. Through acupoint stimulation and medication, the drug's effects reach the internal organs, harmonizing yin and yang, blood and qi, improving sleep, regulating emotions, and relieving pain. This simple, convenient, effective, and inexpensive method addresses the current limitations of single medications for preventing and treating postoperative insomnia, the associated adverse drug reactions, and the high cost. This approach is more acceptable to postoperative patients and provides a new clinical treatment strategy for preventing and treating postoperative insomnia.

[0023] Figures in the specification

[0024] Figure 1 The Pittsburgh Sleep Quality Index (PSQI) rating scale is a typical example of the implementation of the present invention.

[0025] Figure 2 This is a Traditional Chinese Medicine symptom scoring scale for a typical case of the present invention.

[0026] Figure 3 This is a numerical rating scale (NRS) for a typical case of the implementation of the present invention. DETAILED DESCRIPTION

[0027] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the implementation examples described are only some of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0028] Example 1

[0029] The present invention provides an acupoint application medicine for treating postoperative insomnia, comprising the following Chinese medicinal ingredients: coptis root, cinnamon bark, julibrissin bark, amber, wormwood leaf, polygala root, smilax china root, spinach seed, and poria. The Chinese medicinal ingredients can be high-quality Chinese medicinal materials from different origins and sources.

[0030] The raw materials of coptis root, cinnamon bark, julibrissin bark, amber, wormwood leaf, polygala root, celery striata, spinulosa seed and poria are selected according to the following weight ratio: 3:3:5:5:3:3:5:2:5.

[0031] In this embodiment, honey is added to the acupoint application medicine for preparation to obtain a paste.

[0032] A method for preparing an acupoint application medicine for treating postoperative insomnia comprises the following steps:

[0033] S1. Weigh by weight 9g of Coptis chinensis, 9g of cinnamon bark, 15g of Albizia julibrissin bark, 15g of amber, 9g of Artemisia argyi, 9g of Polygala tenuifolia, 15g of Polygonum multiflorum, 6g of Ziziphus jujuba seeds, and 15g of Poria cocos.

[0034] S2. Add the weighed Chinese medicine into a clean container, and add clean water to the container to wash the medicine. After washing, take the medicine out of the container.

[0035] S3. The taken-out medicinal materials are sent into the dryer for drying. The drying time is 10 minutes. The dried Chinese medicines are taken out from the dryer and added to the Chinese medicine grinder for crushing.

[0036] S4. Grind the medicine into ultrafine powder and mix the crushed raw materials to make the various parts of the raw materials evenly mixed. Then add honey to the evenly mixed Chinese medicine, mix into a paste, dilute appropriately, and store in a container for later use.

[0037] S5. When using, take an appropriate amount of ointment from the spare container for storing medicine and apply it evenly on the special dressing.

[0038] S6. Apply the medicine to the Hegu, Shenmen, and Neiguan acupoints starting on the first day after surgery and remove it after 6 hours. Repeat this process twice a day for 7 days.

[0039] Example 2

[0040] The present invention provides an acupoint application medicine for treating postoperative insomnia, comprising the following Chinese medicinal ingredients: coptis root, cinnamon bark, julibrissin bark, amber, wormwood leaf, polygala root, smilax china root, spinach seed, and poria. The Chinese medicinal ingredients can be high-quality Chinese medicinal materials from different origins and sources.

[0041] The raw materials of coptis root, cinnamon bark, julibrissin bark, amber, wormwood leaf, polygala root, celery striata, spinulosa seed and poria are selected according to the following weight ratio: 3:3:5:5:3:3:5:2:5.

[0042] In this embodiment, honey is added to the acupoint application medicine for preparation to obtain a paste.

[0043] A method for preparing an acupoint application medicine for treating postoperative insomnia comprises the following steps:

[0044] S1. Weigh by weight 6g of Coptis chinensis, 6g of cinnamon bark, 10g of Albizia julibrissin bark, 10g of amber, 6g of Artemisia argyi, 6g of Polygala tenuifolia, 10g of Polygonum multiflorum, 4g of Ziziphus jujuba seeds, and 10g of Poria cocos.

[0045] S2. Add the weighed Chinese medicine into a clean container, and add clean water to the container to wash the medicine. After washing, take the medicine out of the container.

[0046] S3. The taken-out medicinal materials are sent into the dryer for drying. The drying time is 10 minutes. The dried Chinese medicines are taken out from the dryer and added to the Chinese medicine grinder for crushing.

[0047] S4. Grind the medicine into ultrafine powder and mix the crushed raw materials to make the various parts of the raw materials evenly mixed. Then add honey to the evenly mixed Chinese medicine, mix into a paste, dilute appropriately, and store in a container for later use.

[0048] S5. When using, take an appropriate amount of ointment from the spare container for storing medicine and apply it evenly on the special dressing.

[0049] S6. Apply the medicine to the Hegu, Shenmen, and Neiguan acupoints starting on the first day after surgery and remove it after 6 hours. Repeat this process twice a day for 7 days.

[0050] Example 3

[0051] The present invention provides an acupoint application medicine for treating postoperative insomnia, comprising the following Chinese medicinal ingredients: coptis root, cinnamon bark, julibrissin bark, amber, wormwood leaf, polygala root, smilax china root, spinach seed, and poria. The Chinese medicinal ingredients can be high-quality Chinese medicinal materials from different origins and sources.

[0052] The raw materials of coptis root, cinnamon bark, julibrissin bark, amber, wormwood leaf, polygala root, celery striata, spinulosa seed and poria are selected according to the following weight ratio: 3:3:5:5:3:3:5:2:5.

[0053] In this embodiment, honey is added to the acupoint application medicine for preparation to obtain a paste.

[0054] A method for preparing an acupoint application medicine for treating postoperative insomnia comprises the following steps:

[0055] S1. Weigh by weight 12g of Coptis chinensis, 12g of cinnamon bark, 20g of Albizia julibrissin bark, 20g of amber, 12g of Artemisia argyi, 12g of Polygala tenuifolia, 20g of Polygonum multiflorum, 8g of Ziziphus jujuba seeds, and 20g of Poria cocos.

[0056] S2. Add the weighed Chinese medicine into a clean container, and add clean water to the container to wash the medicine. After washing, take the medicine out of the container.

[0057] S3. The taken-out medicinal materials are sent into the dryer for drying. The drying time is 10 minutes. The dried Chinese medicines are taken out from the dryer and added to the Chinese medicine grinder for crushing.

[0058] S4. Grind the medicine into ultrafine powder and mix the crushed raw materials to make the various parts of the raw materials evenly mixed. Then add honey to the evenly mixed Chinese medicine, mix into a paste, dilute appropriately, and store in a container for later use.

[0059] S5. When using, take an appropriate amount of ointment from the spare container for storing medicine and apply it evenly on the special dressing.

[0060] S6. Apply the medicine to the Hegu, Shenmen, and Neiguan acupoints starting on the first day after surgery and remove it after 6 hours. Repeat this process twice a day for 7 days.

[0061] The pharmacological effects of the selected drugs are as follows:

[0062] ① Coptis chinensis is bitter and cold in nature. It enters the heart, spleen, stomach, liver, gallbladder, and large intestine meridians. It clears heat and dampness, purging fire and detoxifying. According to modern pharmacological research, Coptis chinensis contains berberine and other ingredients that have inhibitory effects on bacteria (such as Shigella dysenteriae), endotoxins, and viruses. It also has antipyretic and anti-inflammatory properties, relieving high fever, alleviating inflammatory reactions, and has anti-ulcer effects.

[0063] ② Cinnamon is pungent and sweet, and has a very warming nature. It enters the kidney, spleen, heart, and liver meridians. It has the effects of tonifying fire and yang, guiding fire back to its source, dispelling cold and relieving pain, and warming and unblocking the meridians. According to modern pharmacological research, cinnamon contains volatile oil components (such as cinnamaldehyde), which can relieve stomach cold, abdominal pain, diarrhea, stimulate gastric secretion, and improve loss of appetite.

[0064] ③ Albizia Julibrissin Bark is sweet and neutral in nature. It enters the Heart and Liver meridians. It relieves depression and calms the mind, promoting blood circulation and reducing swelling. According to modern pharmacological research, Albizia Julibrissin Bark contains saponins, which have sedative, hypnotic, and antidepressant effects, and can improve anxiety and sleep disorders.

[0065] ④ Amber is sweet and neutral in nature. It enters the heart, spleen, and small intestine meridians. It calms the nerves, dissipates blood stasis, and stops bleeding. According to modern pharmacological research, succinic acid and other components of succinate can reduce spontaneous activity, prolong pentobarbital sleep, and inhibit seizures.

[0066] ⑤ Mugwort is pungent and bitter in flavor and warm in nature. It enters the liver, spleen, and kidney meridians. It warms the meridians to stop bleeding, dispels cold and relieves pain; externally, it can dispel dampness and relieve itching. Modern pharmacological research shows that mugwort contains a variety of active ingredients, such as volatile oils, flavonoids, and polysaccharides, exhibiting diverse pharmacological effects, including antibacterial, anticoagulant, and antiasthmatic properties. It can significantly enhance the phagocytic capacity of reticuloendothelial cells and has an inhibitory effect on Staphylococcus aureus.

[0067] ⑥ Polygala root (Polygala tenuifolia) is bitter, pungent, and warm in nature. It enters the heart, kidney, and lung meridians. It calms the mind, improves intelligence, and eliminates phlegm and stimulates the mind. According to modern pharmacological research, Polygala tenuifolia contains polygala saponins, which can prolong sleep time, reduce spontaneous activity, and improve anxiety and depression.

[0068] ⑦ Polygonum multiflorum is sweet and slightly bitter in taste, and neutral in nature. It enters the Heart and Liver meridians. It nourishes the heart and calms the mind, dispels wind and unclogs the meridians. According to modern pharmacological research, Polygonum multiflorum contains anthraquinones and flavonoids, which can prolong pentobarbital-induced sleep and regulate neurotransmitter levels (such as serotonin).

[0069] ⑧Suanzaoren (Ziziphus jujuba) seeds are sour and sweet in taste and neutral in nature. They enter the heart, spleen, liver, and gallbladder meridians. They nourish the liver, nourish the heart, calm the mind, and relieve sweating and thirst. According to modern pharmacological research, jujube seeds contain jujubosides A and B and flavonoids (such as spinosin), which can prolong sleep time, regulate GABA neurotransmitters, and alleviate anxiety and insomnia.

[0070] 9. Poria has a sweet and mild flavor and is neutral in nature. It enters the heart and spleen meridians. It calms the mind and soothes the nerves, promotes diuresis, and reduces swelling. Modern pharmacological research and animal studies have shown that oral administration or injection of a decoction of Poria prolongs pentobarbital-induced sleep duration, significantly reduces neuroexcitability, and alleviates anxiety. Its polysaccharides enhance macrophage activity, inhibit the release of inflammatory factors, and reduce joint swelling and chronic inflammation.

[0071] Acupoint selection:

[0072] (1) Hegu: Located on the back of the hand, between the first and second metacarpal bones, at the midpoint of the radial side of the second metacarpal bone. It belongs to the Hand Yangming Large Intestine Meridian. Stimulating this point has the effects of calming and relieving pain, promoting menstruation, and clearing away heat and relieving exterior symptoms.

[0073] (2) Shenmen: Located at the wrist, on the ulnar side of the palmar transverse line, in the radial depression of the flexor carpi ulnaris tendon. It belongs to the Heart Meridian of Hand Shaoyin. It mainly treats heart disease, restlessness, palpitations, forgetfulness, insomnia and other diseases.

[0074] (3) Neiguan: Located on the palmar side of the forearm, on the line connecting Quze and Daling, 2 inches above the transverse wrist crease, between the palmaris longus tendon and the radial flexor carpi tendon. It belongs to the hand Jueyin pericardium meridian. It can relax the chest, regulate qi, and calm the mind.

[0075] Typical cases:

[0076] From June 2023 to December 2024, 120 patients aged 20-65 years undergoing elective laparoscopic surgery, including gynecological procedures (myomectomy, hysterectomy, adnexectomy) and gastrointestinal procedures (radical colorectal cancer resection, partial gastrectomy), were enrolled in this randomized, single-blind, placebo-controlled study.

[0077] The drug obtained by weighing 9g of Coptis chinensis, 9g of Cinnamon Bark, 15g of Albizia Julibrissin Bark, 15g of Amber, 9g of Artemisia argyi, 9g of Polygala tenuifolia, 15g of Polygonum multiflorum, 6g of Ziziphus jujuba seeds, and 15g of Poria cocos in Example 1 was applied to the Hegu, Shenmen, and Neiguan acupoints starting on the first day after surgery, twice a day for a total of 7 days, as the experimental group; at the same time, a simple honey patch was applied to the Hegu, Shenmen, and Neiguan acupoints before bedtime, twice a day for a total of 7 days, as the control group. Among them, there were 60 patients in each of the experimental and control groups.

[0078] Preoperatively, patients' sleep was assessed using the Pittsburgh Sleep Quality Index (PSQI). The PSQI consists of seven items, each rated on a scale of 0 to 3, for a total score of 21. This score is negatively correlated with sleep quality, with higher scores indicating poorer sleep quality. One month after surgery, patients' TCM symptoms were assessed using the Traditional Chinese Medicine Symptom Score Scale. Symptoms such as difficulty falling asleep, insomnia, dreaminess, lack of energy, headache, dizziness, and restlessness are scored as 0, 2, 4, or 6, respectively, with higher scores indicating more severe symptoms. One month after surgery, patients' sleep was assessed again using the PSQI, and TCM symptoms were assessed using the TCM Symptom Score Scale. Pain was assessed using the Numerical Rating Scale (NRS) one day, seven days, and one month after surgery.

[0079] The gender, age and surgical type of the patients in the treatment group and the control group were recorded and analyzed. The general information of the two groups of patients is shown in Table 1.

[0080] Table 1 General analysis of patients in the two groups

[0081]

[0082] From the data analysis results shown in Table 1, it can be seen that there were no significant differences in gender, age and surgical type between the treatment group and the control group (P>0.05).

[0083] The PSQI scores of the treatment group and the control group before and after acupoint application were recorded and analyzed. The analysis included the comparison of the PSQI total score (Table 2) and the scores of each PSQI factor (Table 3). The results are shown in Tables 2 and 3.

[0084] Table 2 Comparison of PSQI scores between the two groups of patients before and after acupoint application treatment (scores, x±s)

[0085]

[0086] Table 3 Comparison of PSQI factor scores before and after treatment between the two groups [scores, M(Q1, Q2)]

[0087]

[0088] The data analysis results shown in Tables 2 and 3 show that before treatment, there was no statistically significant difference in the PSQI factor scores and total scores between the two groups (P>0.05). After treatment, within-group comparisons showed that the total PSQI score and each factor score in both groups were significantly lower than before treatment (P<0.001). Between-group comparisons showed that the total PSQI score and each factor score in the treatment group were significantly lower than those in the control group (P<0.001). This indicates that the acupoint application treatment of the present invention can significantly improve patients' sleep quality one month after surgery.

[0089] The TCM symptom score scale evaluations of the treatment group and the control group before and after acupoint application were recorded and analyzed. The results are shown in Table 4.

[0090] Table 4 Comparison of TCM syndrome scores between the two groups before and after treatment (scores, x±s)

[0091]

[0092] The data analysis results shown in Table 4 show that before treatment, there was no statistically significant difference in the TCM syndrome scores between the two groups of patients (P>0.05). After treatment, the TCM syndrome scores of both groups were significantly higher after treatment than before treatment, with a statistically significant difference (P<0.001). Compared with the control group, the TCM syndrome scores of the experimental group were significantly lower than those of the control group, with a statistically significant difference (P<0.001). This shows that the use of the acupoint application therapy of the present invention after surgery can significantly improve the patients' TCM discomfort symptoms and reduce the TCM syndrome scores.

[0093] The pain NRS scores of the patients in the treatment group and the control group on the first day, the seventh day and the first month after surgery were recorded and analyzed. The results are shown in Table 5.

[0094] Table 5 Comparison of NRS scores of postoperative pain between the two groups of patients (points, x±s)

[0095]

[0096] The data analysis results shown in Table 5 show that there was no statistically significant difference in the NRS pain scores between the two groups on the first postoperative day (P>0.05). On the seventh day and one month after surgery, the NRS pain scores in the treatment group were significantly lower than those in the control group, with statistically significant differences (P<0.001). This indicates that the acupoint application therapy of the present invention can significantly improve postoperative pain symptoms and reduce postoperative pain scores.

[0097] The above clinical data demonstrate that the present invention is effective in treating postoperative insomnia and can significantly alleviate postoperative pain without adverse reactions. This invention utilizes Traditional Chinese Medicine (TCM) syndrome differentiation combined with drug administration at TCM meridian acupoints, enabling the drug to penetrate the skin and deliver its therapeutic effect internally. This unique approach has been demonstrated in preventing postoperative adverse reactions, particularly postoperative insomnia. The present invention also offers low production costs and can significantly reduce hospitalization costs.

[0098] Although the embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the invention, and the scope of the invention is defined by the appended claims and their equivalents.

Claims

1. An acupoint application medicine for treating postoperative insomnia, characterized in that: It is composed of the following Chinese medicinal ingredients: coptis root, cinnamon bark, julibrissin bark, amber, wormwood leaf, polygala root, smilax china, spinach seed and poria.

2. The acupoint application medicine for treating postoperative insomnia according to claim 1, characterized in that: The weight ratio of the coptis root, cinnamon bark, julibrissin bark, amber, wormwood leaf, polygala root, celery striata, spinulosa seed and poria is 3:3:5:3:3:5:2:

5.

3. The acupoint application medicine for treating postoperative insomnia according to claim 1, characterized in that: Also included are auxiliary materials that can be used to form a paste.

4. The acupoint application medicine for treating postoperative insomnia according to claim 3, characterized in that: The auxiliary materials include but are not limited to honey.

5. The acupoint application medicine for treating postoperative insomnia according to claim 1, characterized in that: Also includes outer layer accessories.

6. The method for preparing the acupoint application medicine for treating postoperative insomnia according to any one of claims 1 to 5, characterized in that: The following steps are involved: S1 selects Chinese medicinal raw materials such as coptis root, cinnamon bark, julibrissin bark, amber, wormwood leaf, polygala root, smilax china, spinach seed and poria according to weight ratio; S2. Wash the weighed Chinese medicinal materials respectively; S3, drying the Chinese medicinal raw materials after cleaning in step S2 in a dryer for 10-15 minutes, and then pulverizing; S4, grinding the medicine crushed in step S3 into ultrafine powder and mixing it evenly, then adding honey, mixing into a paste and storing it for later use.

7. The method for using the acupoint application medicine for treating postoperative insomnia according to any one of claims 1 to 6, characterized in that: The following steps are involved: S5. Take the paste from step S4 and evenly apply it on the outer layer of auxiliary materials to form an ointment; S6. Apply the ointment to the set acupuncture points; S7. Start applying the patch on the first day after surgery and remove it after 6 hours. Apply it twice a day for a total of 7 days.

8. The method for using the acupoint application medicine for treating postoperative insomnia according to claim 7, characterized in that: The set acupoints are Hegu, Shenmen and Neiguan.

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