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308 results about "Acetylcholine esterase" patented technology
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Acetylcholine esterase An enzyme present within the synaptic cleft that hydrolyses acetylcholine to choline and acetic acid, thus preparing the synapse for the passage of a new impulse.
Neurogenesis by muscarinic receptor modulation
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on muscarinic receptor modulation, such as via inhibition of acetylcholine esterase (AChE) activity, alone or in combination with another neurogenic agent to stimulate or activate the formation of new nerve cells.
Owner:BRAINCELLS INC
Alzheimer's disease treatment with multiple therapeutic agents delivered to the olfactory region through a special delivery catheter and iontophoresis
InactiveUS20120323214A1Reduce and preventAvoid destructionNervous disorderHead electrodesApoptosisExcitotoxicity
This invention describes the administration of multiple therapeutic agents with insulin in conjunction with bexarotene, ketamine, monoclonal antibodies Etanercept, IGF-1, and acetylcholine esterase inhibitors physostigmine, for treatment of Alzheimer's disease and other neurodegenerative diseases. Insulin, improves memory; also augments and amplifies the effects of the adjuvant therapeutic agents (paracrine and intracrine effects) and consequently reduces the β amyloid, its soluble precursors, prevents damage to the neuronal skeletal network (taupathy), and blocks glutamate excitotoxicity, reduces brain inflammation, prevents apoptosis, and increases the acetylcholine levels in the neurons and synapses; by using a combination of insulin, bexarotene, ketamine, Etanercept, IGF-1, and physostigmine therapeutic agents. The results are achieved by using the specially designed Iontophoresis incorporated olfactory mucosal delivery (ORE) catheter device located at the olfactory nerves, sphenoid sinus, and adjacent structures described here, to transport the large molecules of therapeutic agents to treat AD delivered to the CNS bypassing BBB from ORE.
Owner:WEDGE THERAPEUTICS
Transdermal rate-controlled delivery of Huperzine A for treatment of alzheimer's disease
This invention relates to a novel transdermal drug delivery system whereby Huperzine A ("Hup A"), a naturally occurred Acetylcholine esterase inhibitor traditionally used to alleviate memory problem, is formulated for transdermal administration suitable for the treatment of Alzheimer's Disease ("AD") to increase the efficacy and convenience for outpatient care of AD patients. A controlled-release skin patch designed for once-a-week application of Hup A is provided for easy AD medication according to the invention.
Owner:SAGITTARIUS LIFE SCI
Alzheimer's disease treatment with multiple therapeutic agents delivered to the olfactory region through a special delivery catheter and iontophoresis
InactiveUS20140012182A1Large deliveryAvoid destructionNervous disorderHead electrodesApoptosisExcitotoxicity
This invention describes the administration of multiple therapeutic agents with insulin in conjunction with bexarotene, ketamine, monoclonal antibodies Etanercept, IGF-1, and acetylcholine esterase inhibitors physostigmine, for treatment of Alzheimer's disease and other neurodegenerative diseases. Insulin, improves memory; also augments and amplifies the effects of the adjuvant therapeutic agents (paracrine and intracrine effects) and consequently reduces the β amyloid, its soluble precursors, prevents damage to the neuronal skeletal network (taupathy), and blocks glutamate excitotoxicity, reduces brain inflammation, prevents apoptosis, and increases the acetylcholine levels in the neurons and synapses; by using a combination of insulin, bexarotene, ketamine, Etanercept, IGF-1, and physostigmine therapeutic agents. The results are achieved by using the specially designed Iontophoresis incorporated olfactory mucosal delivery (ORE) catheter device located at the olfactory nerves, sphenoid sinus, and adjacent structures described here, to transport the large molecules of therapeutic agents to treat AD delivered to the CNS bypassing BBB from ORE.
Owner:WEDGE THERAPEUTICS
Scutellarin carbamate derivative, preparation method and use thereof
The invention discloses a 4'-carbamate derivative of scutellarin shown in formula (I), a preparation method of the compound and application of the compound in preparing medicines for preventing and / or treating various symptoms and diseases caused by acetyl cholinesterase and / or mediated by free radicals, such as vascular dementia and Alzheimer's disease. In the formula, each of R1, R2 and R3 independently represents H, C1-C12 alkyl or R6CO, wherein R6 represents C1-C12 alkyl, but R1, R2 and R3 are not H at the same time; each of R4 and R5 independently represents H, C1-C12 alkyl, C1-C6 fatty alcohol, or an ester formed by the C1-C6 fatty alcohol and C1-C6 carboxylic acid, the C1-C6 carboxylic acid, or an ester formed by the C1-C6 carboxylic acid and the C1-C6 fatty alcohol; or R4NR5 represents a morpholine ring, a piperidine ring, a 4-benzyl piperidine ring, a piperazine ring, the piperazine ring with the 4-position substituted by C1-C12 alkyl, or a tetrahydropyrrole ring.
Owner:SICHUAN UNIV
Use of cholinesterase antagonists to treat insulin resistance
InactiveUS20050049293A1Insulin resistance in skeletal muscle relating to insufficient responseGood release effectBiocideNervous disorderCholinesteraseAcetylcholine esterase
There is provided a method of reducing insulin resistance in a mammalian subject comprising administering a suitable acetylcholine esterase antagonist.
Owner:UNIVERSITY OF MANITOBA
Total alkaloid extract of seeds of harmel genus and effective monomer component thereof, and preparation and use thereof
The invention discloses preparation and application of total alkaloids extract and effective components in peganum plant seeds. The peganum plant (comprising harmel, multisectum peganum and peganum nigellastrum) seeds are heated, refluxed and extracted by ethanol, dissolved along with heat, acidulated by added 2 to 10 percent hydrochloric acid, and basified by ammonia water to separate out sediment; and the sediment is dried to obtain the total alkaloids extract mainly containing dehydrogenized peganine and peganine according to a proportion of between 0.18 to 1 and 4.30 to 1, wherein the content of the total alkaloids is more than 50 percent. The total alkaloids extract is separated by chromatography to obtain ten effective monomer components such as the dehydrogenized peganine, the peganine, and the like. Through thin layer chromatography and biological self-developing analysis, the total alkaloids extract and the effective monomer components thereof have the effect of resisting activity of acetylcholine esterase, and can be used for preparing medicament for resisting the activity of the acetylcholine esterase and medicament for treating neurodegenerative diseases.
Owner:SHANGHAI UNIV OF T C M +1
Method and composition for treating alzheimer-type dementia
ActiveUS20110071135A1Extended durationFunction increaseBiocideNervous disorderTolerabilityH1 Receptor Antagonist
There is described a method for increasing the maximal tolerated close and thus the efficacy of an acetyl choline esterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia by decreasing concomitant adverse effects by administration of said AChEI in combination with a non-anticholinergic antiemetic agent, whereby an enhanced acetyl choline esterase inhibition in the CNS of said patient is achieved and alleviation of the symptoms of Alzheimer type dementia in said patient is thereby improved to a greater extent. The use of a non-anticholinergic antiemetic agent for the preparation of a pharmaceutical composition for the treatment of Alzheimer type dementia in combination with an acetyl choline esterase inhibitor (AChEI) and pharmaceutical compositions comprising (a) a 5HT3 receptor antagonist, a dopamine antagonist, a H1-receptor antagonist, a cannabinoid agonist, aprepitant or casopitant as an antiemetic agent and (b) an acetylcholine esterase inhibitor are also described.
Owner:CHASE PHARMA CORP
Optical-purity meptazinol orits salts, and preparing method
InactiveCN1850804APharmacologically activeNervous disorderOrganic chemistryAbsolute configurationSingle crystal
This invention belongs to pharmacy field, it relates optical pure mei pu ta fen and its preparation method and application. Racemation mei pu ta fen is splited by optical pure tartaric acid evolving object to get optical pure monomer, enantiomeric excess testing is done through capillary electrophoresis method, their e.e.valude are both excess 99 percent. Laevorotation and dextrorotation mei put a fen absolute configuration is decided by single crystal X-diffraction method as S and R. the R(+)mei pu ta fen has srong activity in analgesia activity testing, but S(-)mei pu ta fen has more stronger activity in acetylcholine esterase restrain activity testing, analgesic medicine and senile dementia medicine can be further prepared.
Owner:FUDAN UNIV
Use and composition for treating dementia
ActiveUS8404701B2Maximize the effectSymptoms improvedBiocideNervous disorderMaximum tolerated doseAnti cholinergic
Owner:CHASE PHARMA CORP
Magnetic graphene enzyme-mimicking property-based acetylcholine visual-detection method
InactiveCN103712983ASmall particle sizeEvenly distributedMaterial analysis by observing effect on chemical indicatorPeroxidaseAcetylhomocholine
The invention relates to a magnetic graphene enzyme-mimicking property-based acetylcholine visual-detection method, belonging to the technical field of biosensing. A hydrothermal method is used for synthesizing Fe3O4 / rGO by one step, H2O2 (hydrogen peroxide) is catalyzed to oxidize a substrate TMB (tetramethylabenzidine) to generate blue by utilizing the peroxidase-like property of the Fe3O4 / rGO, and the characteristic absorption intensity of an oxidation product of the TMB at the wavelength of 652nm is detected to realize the detection of hydrogen peroxide; furthermore, the H2O2 can be catalyzed to oxidize and convert the colorless TMB into a corresponding blue product based on the Fe3O4 / rGO, and the blue product is combined with acetyl choline to decompose H2O2 in the presence of both acetylcholinesterase and choline oxidase, and a novel acetylcholine visual-sensing method is established. The invention aims to provide an acetylcholine colorimetric detection method, and according to the method, the operation is convenient and flexible, the detection cost is low, the sensitivity is high, and instruments and equipment are simple.
Owner:JIANGSU UNIV
Enzyme inhibition method for detecting carbamates
InactiveCN103323415ALow costSimple methodColor/spectral properties measurementsNitrobenzoic acidFormic acid
The invention relates to the chemical field and in particular to an enzyme inhibition method for detecting carbamates. Ethyl carbamate is oxidized by using an oxidant in the presence of an acetylcholine iodide substrate, a 5,5'-dithio bis-(2-nitrobenzoic acid) (DTNB) developer and an acetylcholin esterase with the activity of more than 200U / g, and then the absorbance variation value of the ethyl carbamate along with time at 3min is detected by spectrophotometry to obtain the inhibition condition of the ethyl carbamate on the acetylcholin esterase so as to obtain the content of the ethyl carbamate. The substrate and the developer used in the invention are low in cost; the inhibition rate is greatly increased since the ethyl carbamate is oxidized by using the oxidant; and the method is rapid, simple, high in sensitivity, mild and easily controlled in reaction conditions, simple in steps and easy to operate and needs less equipment. According to the principle of the method, a rapid kit is developed for the rapid detection of ethyl carbamates in alcoholic beverages and fermented foods.
Owner:GUANGZHOU INST FOR FOOD INSPECTION(GUANGZHOU INSPECTION CENT FOR WINE & SPIRITS) +1
Preparation for detecting organophosphorus pesticide residual test paper and its use method
InactiveCN101299029AEasy to prepareEnzyme richMaterial analysis by observing effect on chemical indicatorMicrobiological testing/measurementBiotechnologyCholinesterase
The present invention discloses a preparation method of a test paper for testing the residual organphosphorous pesticide and a using method thereof, wherein the preparation method comprises the following procedures: (1) preparing acetylcholine esterase with fresh blood of hen or female duck as raw material; (2) fixing the acetylcholine esterase on the filter paper; (3) slicing when the filter paper is frozen and dried. A substrate liquid, a color developing liquid and a sensitization liquid are provided. The principle is that the inhibition of the organphosphorous pesticide which is processed by the sensitization liquid to the acetylcholine esterase in the chicken or duck blood serum to make that the substrate of naphthyl acetate of the acetylcholine esterase can not be decomposed thereby that the displayed colors are not consistent when the fast blue B is added into to obtain the purpose of determining whether the sample contains the residual organphosphorous pesticide. The method of the invention has the advantages of low cost, simple and fast operation. The method is suitable for determining whether the residual organphosphorous pesticide exists in vegetable, fruit and food on-site.
Owner:GUANGXI ACAD OF SCI
Application of acetylcholine esterase inhibitor medication of Yidancao extractive as cholinomimetic
InactiveCN1915292AEnhance pharmacological effectsRich sourcesNervous disorderDigestive systemDiseaseDepressant
An application of the motherwort's extract including leonurinine, leonurine, general leonurine, leonurine A, cadabine in preparing the medicines as acetylcholinesterase depressant for treating and preventing more than 20 diseases including senile dementia, Parkinson's disease, cardiovascular and cerebrovascular diseases, etc is disclosed.
Owner:郝书平
Conventional pesticide residue quick detecting method
InactiveCN1414371ARapid determinationRapid determination of residuesMicrobiological testing/measurementColor/spectral properties measurementsPesticide residueColor reaction
A quick residual detecting method for conventional pesticide features that the acetylcholine esterase from the liver of white rats is used as the source of the enzyme. The acetylcholine is used as the substrate. Under the action of acetylcholine esterase, the substrate is hydrolyzed so as to generate the sulfocholine and DTNB. The peak of the maximum absorption in the color reaction is at 412 nm.With concentration of enzyme being fixed, comparing OD412 value of the pesticide in different concentrations establishes the standard curvature. With being dipped and extracted, the sample to be measured is tested so as to obtain the value of OD412. Base on the value of OD412 of the sample to be measured, the residual concentration and the depression rate of the pesticide in the sample to be measured in determined.
Owner:江苏省农业科学院植物保护研究所
Neurogenesis by muscarinic receptor modulation
InactiveUS20110319386A1Lower Level RequirementsImprove suppression propertiesBiocideNervous disorderDiseaseCholinesterase
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on muscarinic receptor modulation, such as via inhibition of acetylcholine esterase (AChE) activity, alone or in combination with another neurogenic agent to stimulate or activate the formation of new nerve cells.
Owner:BRAINCELLS INC
Application of near infrared-emission fluorescent probe in quick pesticide residue detection
ActiveCN108318467AFast metabolismRapid responseFluorescence/phosphorescencePesticide residueEnzyme inhibition
The invention discloses application of a near infrared-emission fluorescent probe in quick pesticide residue detection and belongs to the technical field of quick pesticide detection. The probe is based on rhoda-fluor fluorescence matrix and has specific activity on acetylcholine esterase AChE; by means of an enzyme inhibition detection principle, the probe can be applied to quick detection of organophosphorus pesticide and carbamate pesticide residues in food. The acetylcholine esterase AChE is extracted from duck blood; in an appropriate probe substrate range, enzyme activity and an inhibition rate can be represented by quantitatively detecting fluorescence intensity change of the probe. Four pesticide detection standard curves have small error, and R<2> is larger than 0.98; vegetable pesticide adding standard recovery most reaches 80 to 110%, so that the near infrared-emission fluorescent probe disclosed by the invention can be applied to quantitative, ppb-grade and quick detectionof organophosphorus and carbamate pesticide residues in the food.
Owner:王铮
Chemiluminescence sensing detection method for organophosphorus pesticide residues and application thereof
The invention discloses a chemiluminescence sensing detection method for organophosphorus pesticide residues and application thereof. The method is characterized by comprising the following steps: by taking a chemiluminescent probe as an indicator, indicating the organophosphorus pesticides to inhibit the degree of reducing choline produced by acetylcholine chloride subjected to catalytic hydrolysis of acetylcholin esterase, coupling choline oxidase to catalyze choline to generate hydrogen peroxide, then oxidizing a luminescence probe to generate chemiluminiscence by virtue of hydrogen peroxide, carrying out a multi-step coupling reaction to realize sensing detection of the organophosphorus pesticide residues by utilizing a chemiluminescence apparatus. According to the sensing method, 96 samples can be detected within 20 minutes, and dichlorvos is taken as an example, the detection limit reaches 1nmol / L. The method is sensitive and rapid and can be used for blood sample monitoring of patients suffering from poisoning of foods, water samples and organophosphorus poisons.
Owner:FUJIAN MEDICAL UNIV
Medicinal compositions improving brain function and method for improving brain function
An alkyl ether derivative represented by the formula: wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.
Owner:TOYAMA CHEM CO LTD
Method and composition for treating alzheimer-type dementia
ActiveUS8877768B2Maximize the effectSymptoms improvedBiocideNervous disorderTolerabilityH1 Receptor Antagonist
There is described a method for increasing the maximal tolerated close and thus the efficacy of an acetyl choline esterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia by decreasing concomitant adverse effects by administration of said AChEI in combination with a non-anticholinergic antiemetic agent, whereby an enhanced acetyl choline esterase inhibition in the CNS of said patient is achieved and alleviation of the symptoms of Alzheimer type dementia in said patient is thereby improved to a greater extent. The use of a non-anticholinergic antiemetic agent for the preparation of a pharmaceutical composition for the treatment of Alzheimer type dementia in combination with an acetyl choline esterase inhibitor (AChEI) and pharmaceutical compositions comprising (a) a 5HT3 receptor antagonist, a dopamine antagonist, a H1-receptor antagonist, a cannabinoid agonist, aprepitant or casopitant as an antiemetic agent and (b) an acetylcholine esterase inhibitor are also described.
Owner:CHASE PHARMA CORP
Preventive/remedy for urinary disturbance
InactiveUS20070021391A1Enhances elimination function of bladderReduce collection functionCompound screeningBiocideSide effectCholinesterase inhibition
It is intended to provide a preventive / remedy for urinary disturbance containing a compound, which shows an acetylcholine esterase inhibitory activity but substantially has no butyrylcholine esterase inhibitory activity, showing no side effect and being safe and efficacious without inhibiting the urine collection function; a preventive / remedy for dry mouth induced by the administration of a remedy for urinary disturbance and a preventive or remedy for hyperactive bladder not accompanied by dry mouth; and a method of screening a substance preventing / treating urinary disturbance without inhibiting the urine collection function characterized by comprising measuring and comparing the acetylcholine esterase inhibitory activity and the butyrylcholine esterase inhibitory activity of a test compound.
Owner:TAKEDA PHARMA CO LTD
Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on muscarinic receptor modulation, such as via inhibition of acetylcholine esterase (AChE) activity, alone or in combination with another neurogenic agent to stimulate or activate the formation of new nerve cells.
Owner:BRAINCELLS INC
Benzothiazolo [3, 2,-a]-miazine derivant and uses thereof
The invention belongs to the technical field of medicine and relates to thiazole [3, 2-a] pyrimidine derivatives and the application thereof. The general structure formula is shown on the right: Thiazole [3, 2-a] pyrimidine derivatives and additive salts of pharmaceutically applicable acids of the compounds are used as acetylcholine esterase inhibitors. R1 can be substituted arbitrarily and selectively by one or two substituent groups independently selected from C1-C6 alkyls, C1-C6 alkoxyls, amino alkoxyls arbitrarily and selectively substituted from C1-C10, substituted or unsubstituted amidine formyl alkoxyls, hydroxyl and halogens; R2 is independently selected from hydrogen, C1-C6 alkyls, phenyl substituted by arbitrarily and selectively substituted amino alkoxyls from C1-C10, phenyl substituted by substituted or unsubstituted amidine formyl alkoxyls, and phenyl substituted by hydroxyl; R3 is independently selected from methyl and ethoxyl. The derivatives are used for enhancing the memory of patients with aphrenia or Alzheimer.
![Benzothiazolo [3, 2,-a]-miazine derivant and uses thereof](https://images-eureka.patsnap.com/patent_img/1881496d-6911-4373-ba47-54fe15ff043b/s2008100102071c00011.PNG "Benzothiazolo [3, 2,-a]-miazine derivant and uses thereof")
![Benzothiazolo [3, 2,-a]-miazine derivant and uses thereof](https://images-eureka.patsnap.com/patent_img/1881496d-6911-4373-ba47-54fe15ff043b/s2008100102071d00011.PNG "Benzothiazolo [3, 2,-a]-miazine derivant and uses thereof")
![Benzothiazolo [3, 2,-a]-miazine derivant and uses thereof](https://images-eureka.patsnap.com/patent_img/1881496d-6911-4373-ba47-54fe15ff043b/s2008100102071d00021.PNG "Benzothiazolo [3, 2,-a]-miazine derivant and uses thereof")
Owner:SHENYANG PHARMA UNIVERSITY
Card for fast testing residual pesticide
InactiveCN101693916ASensitive detectionImprove anti-interference abilityMicrobiological testing/measurementAcetylcholine esteraseBio engineering
A card for fast testing residual pesticide belongs to the technical field of biological engineering, and comprises two layers of plastic plates, wherein one of the plastic plates is provided with a sampling hole and an observation hole, one face of the plastic plate is provided with water-absorbing paper and an enzyme bar for fixing drosophila melanogaster acetylcholine esterase, the water-absorbing paper opposites the sampling hole, the enzyme bar opposites the observation hole, and the water-absorbing paper is connected with the enzyme bar. A base sheet for fixing indoxyl acetic ester is bonded on the other plastic plate at the position corresponding to the enzyme bar, and a baffle is arranged between the base sheet and the enzyme bar. When the sample and the indoxyl acetic ester in the enzyme bar pre-react, the baffle is drawn out to make the enzyme bar and the base sheet contact. The card for fast testing residual pesticide has the advantages of wide application range, delicate testing and fast and simple operation.
Owner:SHANGHAI JIAO TONG UNIV
Protein and amorphous metal organic framework compound and preparation method thereof
ActiveCN111909924AHigh embedding rateImprove stabilityOxidoreductasesCarrier-bound/immobilised peptidesKetoneOxidative enzyme
The invention discloses a protein and amorphous metal organic framework compound and a preparation method thereof. The organic framework compound has a 2 nm-50 nm mesoporous structure. The preparationmethod comprises the following step of enabling a protein, zinc ions and an organic ligand to react in a solvent, wherein the organic ligand is a compound containing an imidazole group; the protein is one or a combination of several kinds of cytochrome C, cytochrome P450, horse radish peroxidase, alcohol dehydrogenase, lipase, acetylcholin esterase, laccase, a green fluorescent protein, glucose dehydrogenase, glucose oxidase, trypsin, bacillus subtilis protease, carbonic anhydrase, aldehyde ketone reductase, amylase, saccharase, superoxide dismutase, urease and catalase. The preparation method of the protein and amorphous metal organic framework compound provided by the invention is simple to operate and mild in condition, the obtained product is high in protein embedding rate and good inprotein stability, and the biologic al activity of the protein is reserved to a greater extent.
Owner:TSINGHUA UNIV
Medicinal compositions improving brain function and method for improving brain function
An alkyl ether derivative represented by the formula:wherein R1, R2, R3, R4, m and n are as defined in the specification, or salts thereof exhibits synergistically improved anti-hypoxic activity when combined with a compound having an acetylcholine esterase inhibitory activity. Therefore, the combination according to the present invention is useful as a method for improving cerebral function. Further, a pharmaceutical composition containing the compound relating to the combination according to the present invention is useful for treatment and prevention of dysfunction of cerebral acetylcholine neurons in the sequelae of cerebrovascular dementia, senile dementia, Alzheimer's disease and ischemic cerebral lesion and in the cerebral apoplexy or the memory impairment caused by selective neuronal death.
Owner:TOYAMA CHEM CO LTD
Construction method for light-induced electrochemical immunosensor for detecting double tumour markers
InactiveCN107860923AEasy to separateInhibitory complexAlkaline earth titanatesMaterial analysis by electric/magnetic meansAntigenStrontium titanate
The invention discloses a construction method for a double-component light-induced electrochemical immunosensor based on a dendritic titanium dioxide nano-rod-strontium titanate (B-TiO2 NRs-SrTiO3) hetero-junction, and through the method, detecting alpha-fetoprotein and carbohydrate antigen 153 simultaneously an be achieved. The B-TiO2 NRs-SrTiO3 hetero-junction is synthesized by utilizing a hydrothermal method, so that carrier separation and hole transportation are promoted, and the photocurrent density produced by the B-TiO2 NRs-SrTiO3 is remarkably increased by compared with that produced by B-TiO2 NRs. On the basis of the B-TiO2 NRs-SrTiO3 hetero-junction, beta-galactosidase and acetylcholin esterase are taken as a signal marker for specifically catalyzing hydrolysis of p-aminobenzypylgalactoside and acetylcholine to produce p-aminophenol and choline in situ to serve as sacrificial electron donors respectively for distinguishing photocurrent signals. Because of proper signal difference, the sensor can realize high-sensitivity detection of the alpha-fetoprotein and the carbohydrate antigen 153.
Owner:UNIV OF JINAN
11-replaced oxoisoaporphine derivatives as well as synthetic method and application thereof
InactiveCN103923010AStrong inhibitory activityGood potential medicinal valueOrganic active ingredientsSenses disorderKetoneStructural formula
The invention discloses a series of 11-replaced oxoisoaporphine derivatives as well as a synthetic method and an application thereof. The synthetic method comprises the following steps: (1) carrying out ring closing reaction on 3-chlorophthalic anhydride and phenylethylamine as raw materials so as to construct a 10-Cl-1-azabenzanthrone parent body; (2) nitrating the parent body compound so as to obtain a 11-site nitrated product, and reducing the 11-site nitrated product so as to obtain 11-amino-10-chlorine-7H-dibenzoquinoline-7-ketone; and (3) reacting the 11-amino-10-chlorine-7H-dibenzoquinoline-7-ketone with an acyl chloride compound connected with piperidine so as to obtain a corresponding target product. Through study, the applicant finds that the series of derivatives have very strong inhibitory activity on acetylcholin esterase and are expected to be used for treating AD (Alzheimer Disease), cerebrovascular dementia and related diseases caused by cholinergic neurotransmitter reduction. The structural formula of the 11-replaced oxoisoaporphine derivatives is shown in descriptions.
Owner:GUANGXI NORMAL UNIV
Detection method of organophosphorus pesticide
ActiveCN103421880AEasy to observeHigh extraction recoveryMaterial analysis by observing effect on chemical indicatorMicrobiological testing/measurementEnzyme inhibitionAcetylcholine esterase
The inventive aims to overcome the defects of the conventional enzyme inhibition-type biosensor and provides a visual identification method for detecting a micro-trace organophosphorus pesticide. When the detection method is adopted to detect the organophosphorus pesticide, on one hand, an adopted AChE liquid (Acetylcholine Esterase) is not subjected to solidification treatment, so that the highest activity of the AChE liquid is kept, and the detection sensitivity is improved; on the other hand, the extraction and recovery rate of the organophosphorus pesticide in a sample to be detected is improved through an adopted extracting solution, so that the detection sensitivity is improved to 0.01 ng / L. The detection method can be extensively applied to the detection of micro-trace organophosphorus pesticide residue in grains, vegetables, fruits and other agricultural products as well as the environment, and can also be used in the safety evaluation of agricultural products and the environment, the pollution condition monitoring of the organophosphorus pesticide, and the like.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)
3-aminoalkaneacylamino-rutaecarpine and 3-aminoalkaneacylamino-7,8-dehydrorutaecarpine derivative
InactiveCN101597294AStrong inhibitory activityHigh selectivityOrganic active ingredientsSenses disorderDiseaseAcetylcholine esterase
The invention discloses a 3-aminoalkaneacylamino-rutaecarpine and 3- aminoalkaneacylamino-7,8-dehydrorutaecarpine derivative and a synthetic method and an appliance thereof. As shown in experiments, the 3-aminoalkaneacylamino-rutaecarpine and 3-aminoalkaneacylamino-7,8-dehydrorutaecarpine derivative of the invention has strong inhibition perforance on acetylcholine esterase and good inhibition selectivity and the inhibition ability to acetylcholine esterase is 500 times higher than that to butyrylcholine esterase. The compound is shown to have an application prospect of being the medicines for curing Alzheimer's disease, cerebral vascular dementia, etc.
Owner:SUN YAT SEN UNIV
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