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102 results about "Huperzine U" patented technology
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Huperzine A is a naturally occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata and in varying quantities in other Huperzia species, including H. elmeri, H. carinat, and H. aqualupian.
Huperzia serrata endophytic fungus shiraia sp. strain for producing huperzine A
The invention discloses a huperzia serrata endophytic fungus for producing huperzine A, and belongs to the technical field of biological engineering. The fungus is obtained by separating from fern H. serrata living plant according to the endophytic fungus separation and purification technology, named as shiraia sp. slf-14 by microbial taxonomy authentication and collected in CCTCC on Nov. 6th, 2009 with the collection number of CCTCC No: M 209294. The strain can produce the huperzine A by liquid fermentation. The invention discovers the huperzine A contained in the shiraia sp. fermentation liquid for the first time, and provides a new path for seeking an active huperzine A component resource for treating senile dementia.
Owner:朱笃
New method for extracting and separating high-purity huperzine A from thousand-layer column
InactiveCN101693689AEasy to operateShort process cycleNervous disorderOrganic chemistryChemistryPhosphate
The invention relates to a new method for extracting and separating high-purity huperzine A from a thousand-layer column. The method comprises the following three technological steps: first, the preparation of extract liquor, second, the pre-separation of macroporous resin, and third, the purification by high-speed countercurrent chromatogram. The preparation of the extract liquor comprises immersing the grinded thousand-layer column in acid liquor, implementing diacolation and ultrasonic extraction, and obtaining the extract liquor for further use. The pre-separation of the macroporous resin comprises regulating the pH value of the extract liquor to 8 to 10, delivering the extract liquor through a macroporous resin column, eluting the extract liquor with alcohol of different concentration, and obtaining extract extractum after recovering solvent with alcohol eluent. The purification by high-speed countercurrent chromatogram comprises taking petroleum ether, n-butyl alcohol and phosphate buffer as the solvent system to purify the extractum by a high-speed countercurrent chromatogram method, and obtaining the high-purity huperzine A.
Owner:LIAOCHENG UNIV
Method for extracting high-purity huperzine A and huperzine B from medicinal plant phlegmariurus crutomerianus
ActiveCN102070527AAvoid dependenceReduce manufacturing costOrganic chemistryActivated carbonAcid water
The invention provides a method for extracting high-purity huperzine A and huperzine B from medicinal plant phlegmariurus crutomerianus, which greatly increases the basis for extracting the huperzine A and the huperzine B from new species. The invention discloses an overall method for separating and extracting the high-purity huperzine A and the high-purity huperzine B from the phlegmariurus crutomerianus. Pure products of the huperzine A and the huperzine B are obtained by adopting acid water extraction, passing ion exchange resin, concentrating, leaching, performing reverse-phase column chromatography, decoloring by using activated carbon, crystallizing and recrystallizing. In the overall separation process, requirements on environmental conditions are low, the separation time is short, and the purity is highest. Separation materials are easy to obtain and cheap; a separation operation process is simple and easy to control; the purification efficiency is high by crystallizing and recrystallizing; and used reagents are nontoxic.
Owner:湖南本草制药有限责任公司
Method for extracting and separating huperzine A and huperzine B from huperzia serrata
The invention relates to a method for extracting and separating huperzine A and huperzine B from huperzia serrata, which comprises total huperzine extraction and purification, and huperzine A / huperzine B separation and crystallization. The invention has the following advantages: acid soaking and ultrasonic repeated extraction can sufficiently precipitate total huperzines in the huperzia serrata; activated carbon and cation exchange resin are utilized to remove impurities; reversion phase chromatography columns are utilized to separate huperzine A and huperzine B; and concentration crystallization and recrystallization are respectively utilized to enhance the purity of the huperzine A and huperzine B. The invention effectively utilizes natural resources, enhances the recovery rate and extract content, and improves the economic benefit.
Owner:重庆市秀山红星中药材开发有限公司
Plant endophytic fungi of huperzia serrata and application thereof in preparing huperzine A
InactiveCN103667070APromote growth and reproductionThere is a lot of room for production improvementFungiMicroorganism based processesMicroorganismMicrobiology
The invention relates to plant endophytic fungi of huperzia serrata. The biological classification and molecular biological identification are (Trichodermasp.) L44. The bacterium has been already preserved in China Center for Type Culture Collection, with the preserving number of CCTCC NO: M2013198. The invention further provides an application of the plant endophytic fungi of huperzia serrata in preparing huperzine A. The invention provides a novel microorganism for source of the huperzine A. The microorganism provided by the invention has the advantages of quick growth and reproduction, no limitation on external environments such as seasons and climates and large yield promoting space and the like. The wild resource of the medicinal plant huperzia serrata can be effectively prevented from being excessively excavated.
Owner:ZHEJIANG PHARMA COLLEGE
Huperzine A polymorph, its preparation method, medicinal composition containing huperzine A polymorph and its application
The invention discloses a huperzine A polymorph, its preparation method, a medicinal composition containing huperzine A polymorph and its application. Part of the huperzine A polymorph has better dissolvability than currently saled medicinal crystal forms, thus being more conducive to medicine absorption. Also, part of the huperzine A polymorph has substantially lower hygroscopicity than saled medicinal crystal forms, thus being more conducive to preparation and storage of medicinal preparations.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Huperzine a lyotropic liquid crystal preparation and preparation method thereof
ActiveCN106924172AImprove solubilityOvercome the disadvantages of insoluble in waterOrganic active ingredientsNervous disorderTO-18Organic solvent
The invention provides a huperzine a lyotropic liquid crystal preparation and a preparation method thereof. The huperzine a lyotropic liquid crystal preparation is prepared from the following components in parts by weight: 0.12 to 0.7 part of huperzine a, 10 to 18 parts of organic solvent, 12 to 70 parts of phospholipid, and 12 to 59.5 parts of grease. According to the huperzine a lyotropic liquid crystal preparation provided by the invention, the phospholipid, the grease and the organic solvent are used as carriers of the huperzine a, so that the solubleness of the huperzine a is effectively improved, the defect that the huperzine a is insoluble in water is overcome, the pharmacological function of the huperzine a is played favorably; meanwhile, under the condition of the limited component proportion, the huperzine a lyotropic liquid crystal preparation encounters water to form a lyotropic liquid crystal after being injected into a human body, so that the adhesion of a medicine and the preparation is improved, the medicine diffusion speed is retarded, the administration period is increased, the administration times are reduced, and thus the compliance of a patient is greatly improved.
Owner:武汉百纳礼康生物制药有限公司
Huperzia serrate endophytic fungus and application of huperzia serrate endophytic fungus in preparation of 8alpha,15alpha-epoxydized huperzine A
ActiveCN103667072AEasy to trainHas neuroprotective effectsFungiMicroorganism based processesPteridophyteCurative effect
The invention discloses a huperzia serrate endophytic fungus which is obtained from a pteridophyte, namely, a huperzia serrate plant by adopting a separating and purifying technology, is named Ceriporia lacerate HS-ZJUT-C13A and is collected in the China Center for Type Culture Collection on October 28, 2012 with the collection number CCTCC M 2012433. The strain provided by the invention can be used for preparing a compound, namely, 8alpha, 15alpha-epoxydized huperzine A with a nerve protection effect. A conversion method has the advantages of simple fermentation conditions, high substrate conversion rate and the like, is easily cultures the strain, has the potential of industrial large-scale production, is a novel way for obtaining the compound, protects valuable and rare medicinal huperziaceae plant resources from being damaged and can provide a novel thought for reliving the current situation of lack of huperzine A in clinical administration.
Owner:ZHEJIANG UNIV OF TECH
Method for extracting huperzine A from leaves of huperzia serrata
The invention discloses an extraction method of huperzine A. The extraction method comprises the following steps: fermentation treatment of leaves of huperzia serrata, diethyl ether soaking, centrifugation, water bath evaporation and cooling crystallization. By virtue of the extraction method, the yield and extraction purity of huperzine A can be greatly increased, and furthermore, the production cost is low; and the extraction method is suitable for industrial production.
Owner:安徽省鸿运生物医药股份有限公司
Method for hydroponic breeding of huperzine serrate and induced improvement to huperzine a of huperzine serrate
InactiveCN103518599AAlleviate the current situation of resource shortageReduce manufacturing costCultivating equipmentsSoilless cultivationElicitorNutrient solution
The invention discloses a method for hydroponic breeding of huperzine serrate and induced improvement to huperzine a of the huperzine serrate. According to the method, wild naturalized huperzine-serrate branches with stem tips are used as cuttings, and rapid hydroponic breeding of the huperzine serrate is achieved in a nutrient solution containing hormones and precursor substances with a certain ratio; compared with conventional soil cutting, the method realizes that rooting time is short, the breeding coefficient is large, and the rooting percentage is as high as 98%. The precursor substances enable the huperzine a content of the hydroponic huperzine serrate to be increased by 70% compared with wild plants; the leaf surfaces or / and the roots of the plants are sprinkled with elicitors in a certain concentration, so that a secondary metabolism system of the huperzine serrate is regulated, the huperzine a content of the hydroponic huperzine serrate is increased 1.3-1.6 times, the yield of the huperzine a is increased, and the situation of shortage of huperzine-serrate resources is alleviated to a certain degree. Besides, the method achieves low production cost and a short cultivation period, is not restricted by the natural environment and climate, and has broad application prospects and high popularization value.
Owner:CHANGSHA HUIRI BIOLOGICAL TECH
Injectable long-acting microsphere suspension contg.
InactiveCN1723895AGood suspension effectGuaranteed pass rateOrganic active ingredientsNervous disorderMicrosphereDrug release
A durable micro-spherical suspension of huperzine A without sudden release for treating senile hypomnesia and AD is disclosed. Its preparing process features that the PLGA-COOH or PLA-COOH is used and its process is simplified. Its action period is 20-40 days.
Owner:SHENYANG PHARMA UNIVERSITY
Concentration and mental performance amplifying formulation
InactiveUS20120177732A1Improve focus performanceIncrease mental performancePowder deliveryBiocideRHODIOLA ROSEA ROOTVinpocetine
A concentration and mental performance amplifying formulation comprising rhodiola rosea and geranium oil, together with at least one of vinpocetine, phosphatidylcholine, caffeine and Salix alba (White Willow Bark). In another aspect, there is disclosed a concentration and mental performance amplifying formulation comprising: rhodiola rosea, geranium oil, and at least one of anhydrous caffeine and nicotine. In yet another aspect, there is disclosed a concentration and mental performance amplifying formulation as last described which further comprises: Vinpocetine, or Vincamine together with Huperzine-A, or Vinca minor (Periwinkle) together with Huperzine-A; PhosphatidylCholine or Bacopa monnieri (Brahmi) or Mucuna pruriens; Nicotinamide Adenine Dinucleotide Hydrate; and Salix alba (White Willow Bark). Also described is a method of amplifying concentration and mental performance in a human subject by administering such formulations to such a subject.
Owner:BUCKLEY MICHAEL SCOTT
Huperzine A double-layer osmotic pump controlled release tablets and preparation method thereof
InactiveCN101485639AStable blood concentrationReduce the number of dosesOrganic active ingredientsNervous disorderDrug release ratePolyethylene glycol
The invention discloses a huperzine A double-layer osmotic pump controlled-release tablet. The tablet comprises a double-layer tablet core consisting of a drug containing layer and a pushing layer, and a semipermeable coating membrane coating the double-layer tablet core, wherein one side of the drug containing layer of the coating membrane is provided with a drug release hole; the drug containing layer of the tablet core contains huperzine, a suspending agent, osmotic pressure active matters and pharmaceutical excipients which are all in effective dosage; the pushing layer contains an expanding agent, a permeation enhancer, and a binder; and the coating membrane contains polyethylene glycol used as a plasticizer, the weight gain of the coating membrane against the weight of the tablet core is between 8 and 20 percent, and the aperture of the drug release hole on the surface of the drug containing layer of the coating membrane is between 0.2 and 2.0 millimeters. The invention also discloses a method for preparing the controlled-release tablet. After patients take the controlled-release tablet, the blood concentration of the patients is relatively stable; the accumulated drug release rate in 12 hours reaches more than 90 percent, thereby greatly reducing the drug taking frequency of the patients; and the invention provides a novel formulation which is safer, more effective, stable, controllable and convenient for application in clinically treating senile dementia.
Owner:普尔药物科技开发(深圳)有限公司
Method for producing A by using huperzia serrata prothallium
InactiveCN102577951AProtect resourcesSmall difference in contentHorticulture methodsPlant tissue cultureHuperzine UHuperzia serrata
The invention discloses a method for producing huperzine A by using huperzia serrata prothallium. The huperzine A is produced from in vitro huperzia serrata prothallium by mass culture. The method is simple and easy to operate, provides new ways for sources of the huperzine A, and protects resource of wild huperzia serrata simultaneously.
Owner:NORTHWEST UNIV
Method for extracting huperzine A from serrate clubmoss herb
ActiveCN104262251AEasy to operateSuitable for industrial productionOrganic chemistryAcid dissolutionHuperzine U
The invention discloses a method for extracting huperzine A from a serrate clubmoss herb. The method comprises the following steps: (1) pre-treatment; (2) ultrasonic countercurrent extraction: carrying out ultrasonic countercurrent extraction on the serrate clubmoss herb and filtering to obtain leach liquor; (3) membrane separation and purification: centrifuging, and carrying out ultrafiltration and nanofiltration on the leach liquor to obtain trapped fluid; (4) concentration, namely concentrating the trapped fluid into paste; (5) acid dissolution, dissolving the paste by using acid liquid, filtering, and adjusting pH to alkalinity; (6) extraction: extracting by using chloroform and collecting extract liquor; (7) concentration: concentrating the extract liquor to obtain dry powder; (8) crystallization and recrystallization: dissolving to obtain the dry powder, crystallizing and recrystallizing to obtain white crystals; and (9) drying, namely drying the white crystal to obtain a huperzine A product. According to the method disclosed by the invention, the purity of the huperzine A extracted from the serrate clubmoss herb is greater than or equal to 99%, the product yield is greater than or equal to 0.026%, the final yield is 50-55%, and the yield, yield coefficient and purity of huperzine A is high, the extraction time is short, and the cost is low; therefore, the method for extracting huperzine A from a serrate clubmoss herb is suitable for industrial production.
Owner:HUNAN HUACHENG BIOTECH
Novel method for extracting huperzine A from huperzia serrata
The invention relates to a novel method for extracting huperzine A from Huperziaserrataf.longipetiolata (Spring) Ching, and relates to the technical field of medicines. The novel method comprises the technical scheme as follows: (1) preparing extracting liquid; (2) purifying the extracting liquid; (3) preparing the total alkaloid of huperzia serrata; (4) preparing a rough product of huperzine A; and (5) preparing high-purity huperzine A, thus obtaining the white solid huperzine A with the purity of 98% to 99%. The novel method of extracting the huperzine A provided by the invention has the advantages that: (1) the new resource huperzia serrata is served as the raw material; and the single source of the medicine and technology method for extracting huperzine A from huperziaserrataf.longipetiolata (Spring) Ching are expanded; (2) 20% to 60% of ethanol water is adopted for extracting, therefore, little damage is brought to instruments and equipment, and low toxic and side effects are generated; and (3) the huperzine A is enriched through a reverse phase (Middle Pressure Liquid Chromatography) is adopted, thus, the cost is low, the purity is high, the yield is high, and the mass industrial production can be easily carried out.
Owner:GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
Huperzine A pellets preparation and its preparation method
The invention relates to a kind of huperzine A parvule preparation and it's preparing method which is made of huperzine A and certain diluents bases. The preparation is applicable to patients who have problem with degluting tablets or capsules; it can treat nonmalignant dysmnesia and can increase the patients' ability of directing memory, thought association, image recall, nonsense figure recognition and portrait recall; it can also improve the dysmnesia caused by brain organic affection or dementia.
Owner:BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
Hormone-autotrophic huperzia serrata in-vitro thallus cloning line for producing huperzine-a
InactiveCN103975857AImprove productivityPlant tissue cultureHorticulture methodsBiotechnologyHuperzine U
The invention discloses a hormone-autotrophic huperzia serrata in-vitro thallus cloning line for producing huperzine-a. A method comprises the steps are of (1.1) preparing materials; (1.2) preparing a germfree material from an explant and; (1.3) inoculating the germfree material to a prepared thallus differentiation starting culture medium for culture; (1.4) partitioning a thallus tissue subjected to inducible proliferation into small blocks, transferring the small blocks into a thallus subculture multiplication culture medium for directional culture; (1.5) subculturing the hormone-autotrophic huperzia serrata in-vitro thallus cloning line for producing the huperzine-a. Thallus of the hormone-autotrophic huperzia serrata in-vitro thallus cloning line is directly harvested for preparing tea or serving as an additive of tea, so that a novel health-protection product for resisting aging and enhancing memory can be developed; the medical component, namely huperzine-a, can be extracted from the thallus, so that extremely high economical and social values can be achieved.
Owner:JIANGXI NORMAL UNIV
Dietary supplement compositions
ActiveUS20160193273A1Good for healthImproved well-beingBiocideKetone active ingredientsCholinesterase inhibitionDietary supplement
This document provides dietary supplement compositions. For example, dietary supplement compositions having an acetylcholinesterase inhibitor (e.g., huperzine A), a Bacopa monnieri extract, acetyl-L-carnitine or acetyl CoA, and a curcuminoid (e.g., curcumin) are provided.
Owner:MELALEUCA INC
Sustained release preparation containing memantine hydrochloride and huperzine A and preparation method thereof
InactiveCN101756970ANervous disorderAmine active ingredientsMemantine HydrochlorideImmediate release
The invention relates to sustained release preparation containing memantine hydrochloride and huperzine A and preparation method thereof. The sustained release preparation includes quick release component and slow release component, wherein the memantine hydrochloride is the quick release component which represents the characteristic of quick release in vitro dissolution test and can be released by more 80% 30min later, while huperzine A represents the characteristic of slow release in vitro dissolution test and is released by 10-30% in the first hour, by 40-60% in 6 hours, by 60-80% in 12 hours and by more than 80% in 18 hours. The sustained release preparation is mild, has long-term effect and can reduce the application time (only once a day) and improve the compliance of the patient. The invention further discloses the vitro release characteristic and the preparation method of the sustained release preparation.
Owner:北京利乐生制药科技有限公司
Application and preparation method of huperzine A gelatin nanoparticle loaded microspheres
ActiveCN107149595ASolve the sudden release problemPowder deliveryOrganic active ingredientsNanoparticleMedicine
The invention discloses application and a preparation method of huperzine A gelatin nanoparticle loaded microspheres. According to drug release amount requirements of huperzine A and drug release characteristics of nanoparticles and microspheres, nanoparticles and microsphere preparations are combined so as to solve the problem of burst release of huperzine A sustained-release preparations, and sustained release is realized.
Owner:YANTAI UNIV
Injectable sustained-release microspheres of huperzine a compoounds
InactiveUS20040266813A1Shorten the timeImprove the quality of lifePowder deliveryBiocidePharmaceutical preservativesExcipient
Sustained-release microspheres of Huperzine A compounds, the preparation and use thereof, said sustained-release microspheres comprise Huperzine A compounds represented by the formula (Ia) and biodegradably pharmaceutically acceptable polymer excipients, wherein, X and Y independently represent hydrogen or methyl, Z1 and Z2 independently represent hydrogen or in combination represent
Owner:SHANDONG LUYE PHARMA CO LTD
Huperzine-A oral cavity disintegration tablet and its preparation method
ActiveCN1823769AThe result is obviousSimple preparation processOrganic active ingredientsNervous disorderMANNITOL/SORBITOLAlcohol
An oral disintegrating tablet of huperzine A contains proportionally huperzine A as the cholinesterase depressant, mannitol as diluent and the alcohol solution of PVP-K30 as adhesive. Its preparing process is also disclosed.
Owner:哈尔滨科信必成医药科技发展有限公司
Huperzia serrata endogenetic epiphyte and uses thereof
Owner:SHANGHAI UNIV OF T C M
Bacillus amyloliquefaciens SXZ-N2 strain producing huperzine A and huperzine B and usage
The invention provides a bacillus amyloliquefaciens SXZ-N2 strain producing huperzine A and huperzine B. The strain can produce huperzine A and huperzine B. The strain is named as SXZ-N2 and belongs to bacillus amyloliquefaciens. The strain is collected in China Center for Type Culture Collection (CCTCC) on September 14, 2017 in Wuhan University, Wuhan, China, with a postal code of 430072 and a collection number of CCTCC NO: M2017510. A 16S rDNA sequence of the strain is shown as SEQ ID (sequence identifier) NO. 1. The bacillus amyloliquefaciens SXZ-N2 strain can be used for fermentation preparation of huperzine A and huperzine B. Microbial fermentation conditions are as follows: a formula of a culture medium comprises 5g / L yeast powder, 6g / L peptone, 5g / L sodium chloride and 8g / L sucrose; a pH (potential of hydrogen) is 8.0, culture conditions are as follows: 32 DEG C, 150r / min, and fermentation culture lasts for 10 days.
Owner:SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
Synthesis method of (-)-huperzine A
The invention belongs to the technical field of medicine synthesis, and particularly relates to a synthesis method of (-)-huperzine A. According to the synthetic method, 1, 4-cyclohexanedione monoethylene ketal is used as a raw material, chemical synthesis of (-)-huperzine A is completed at a high yield, the chemical purity and optical purity of the obtained product are high (greater than 99%), the variety of impurities is few, only one impurity WB0002 in known WB0001, WB0002, WB0003, WB0004, WB0005 and WB0006 is contained, the content of the impurity WB0002 can be controlled to be 0.005% or below, and the yield of (-)-huperzine A is greatly improved. A novel and more effective chemical synthesis method from a raw material medicine to the (-)-huperzine A is provided for synthesis of the (-)-huperzine A.
Owner:杭州易合生物医药科技有限公司
Compositions and methods for increasing growth hormone levels
A composition for increasing GH levels in a mammal including effective amounts of huperzine A and secretagogue amino acids and methods thereof.
Owner:ACCESS BUSINESS GRP INT LLC
Drug composition for enhancing memory of people rapidly exposed to high altitude, and preparation method thereof
The present invention discloses a drug composition for enhancing memory of people rapidly exposed to a high altitude. The drug composition comprises an active component and an auxiliary material, wherein the active component comprises taurine, ovolecithin, acetyl-L-carnitine, and huperzine a, and the auxiliary material comprises lactose, MCC and magnesium stearate, or comprises lactose and magnesium stearate. The drug composition has the following beneficial effects that: based on different mechanisms such as provision of essential nutrients for nerve cells, free radical removing, neurotransmitter acetylcholine precursor complementing, central cholinergic system regulation, and the like, a comprehensive effect is acted on human body, drug combination advantages are presented, and improvement of memory of people rapidly exposed to a high altitude is achieved.
Owner:URUMQI GENERAL HOSPITAL LANZHOU MILITARY AREA CHINESE P L A
Huperzine A high-producing strain and method for producing huperzine A by fermenting same
Owner:HUNAN AGRICULTURAL UNIV
Huperzine A polymorphism body, preparation method thereof, pharmaceutical composition comprising polymorphism body and application thereof
The invention discloses a huperzine A polymorphism body, a preparation method thereof, a pharmaceutical composition comprising the polymorphism body and an application thereof. Partial of the huperzine A polymorphism body has better solubility than that of a commercially available medicinal crystal form and is more beneficial to absorption of medicine. Partial of the huperzine A polymorphism body has much lower hygroscopicity than that of the commercially available medicinal crystal form and is more beneficial to preparation and storage of medicine preparations.
Owner:SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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