8 results about "Vincamine" patented technology

The present invention relates to vincamine derivatives and preparation methods and applications thereof, and belongs to the technical field of preparation of vincamine derivatives. The vincamine derivatives disclosed in the present invention have the following advantages: (i) modification of the tail chain increases the lipid solubility of vincamine compounds, and does not affect the cerebral blood flow regulation of vincamine itself, which helps the carried drug to penetrate the blood-brain barrier, and exerts a brain protective effect, improving brain microcirculation disorders; (ii) the tertiary amine group in the parent nucleus structure of vincamine derivatives has the property of being ionizable under acidic conditions, and can achieve efficient carrying and lysosomal escape of nucleic acid drugs through charge adsorption, thereby improving intracellular transport; (iii) vincamine derivatives inherit various pharmacological activities inherent in vincamine and have high safety. Therefore, the vincamine derivatives disclosed in the present invention have good application prospects in brain-targeted delivery of drugs for treating brain diseases.

The application discloses a vinblastine synthase, an encoding gene thereof and an application, and belongs to the technical field of genetic engineering. By using transcriptome data of Vinca minor, a 2OGD enzyme, namely, vinblastine synthase Vm15G000668, is screened and obtained, and in-vitro purification finds that the vinblastine synthase Vm15G000668 can specifically catalyze conversion of longchun dimethylbiguanide into vinblastine, and a key catalytic step of vinblastine biosynthesis is analyzed. The application provides a high-efficiency and specific vinblastine synthetic biocatalyst, and provides technical support for large-scale and green preparation of vinblastine.

The invention relates to a vincamine derivative as well as a preparation method and application thereof, and belongs to the technical field of preparation of vincamine derivatives. Compared with the prior art, the vincamine derivative disclosed by the invention has the following advantages: (i) the modification of the tail chain increases the fat solubility of the vincamine compound, does not influence the cerebral blood flow regulation of the vincamine, and is beneficial for carrying drugs to penetrate through the blood brain barrier, exert the brain protection effect and improve the brain microcirculation disturbance; (ii) a tertiary amine group in a parent nucleus structure of the vincamine derivative has the property of being ionizable under an acidic condition, efficient carrying of nucleic acid drugs and lysosome escape can be achieved through a charge adsorption effect, and intracellular transport is improved; and (iii) the vincamine derivative inherits various inherent pharmacological activities of vincamine and has high safety. Therefore, the vincamine derivative disclosed by the invention has a good application prospect in the aspect of brain-targeted delivery of drugs for treating brain diseases.

The present invention relates to vincamine derivatives, a preparation method therefor and a use thereof. The disclosed vincamine derivatives have the following advantages: (i) modification of the tail chain increases the lipid solubility of a vincamine compound without affecting the cerebral blood flow regulation of vincamine itself, which helps a carried drug to penetrate the blood-brain barrier and exert a brain protective effect, improving brain microcirculation disorders; (ii) the tertiary amine group in the parent nucleus structure of the vincamine derivatives has the property of being ionizable under acidic conditions, which can achieve efficient carrying and lysosomal escape of nucleic acid drugs by means of charge adsorption, thereby improving intracellular transport; and (iii) the vincamine derivatives inherit the various pharmacological activities inherent in vincamine and have a high degree of safety. The disclosed vincamine derivatives have good application prospects in brain-targeted delivery of drugs for treating brain diseases.

The present application relates to a vincamine derivative, a preparation method therefor, and use thereof, and belongs to the technical field of preparation of vincamine derivatives. The vincamine derivative has the following advantages: (i) Modification of the tail chain increases the lipid solubility of vincamine compounds without affecting the cerebral blood flow regulation of vincamine itself, thereby helping the carried drug penetrate the blood-brain barrier, exert a brain-protective effect, and improve cerebral microcirculatory disorders. (ii) The tertiary amine group in the parent nucleus structure of the vincamine derivative is ionizable under acidic conditions, which enables efficient delivery and lysosomal escape of nucleic acid drugs through charge adsorption, thereby improving intracellular transport. (iii) The vincamine derivative inherits various pharmacological activities inherent to vincamine, and has high safety. Therefore, the vincamine derivative has good application prospects in brain-targeted delivery of drugs for treating brain diseases.

The invention discloses vincamine synthase as well as a coding gene and application thereof. Belongs to the technical field of gene engineering. A 2OGD enzyme, namely the vincamine synthase Vm15G000668, is obtained by screening through the application of vincamine transcriptome data, in-vitro purification discovers that the vincamine synthase Vm15G000668 can specifically catalyze vincamine to be converted into vincamine, and analysis of key catalysis steps of vincamine biosynthesis is completed. The invention provides an efficient and specific vincamine synthesis biocatalyst, and provides a technical support for large-scale and green preparation of vincamine.

The invention relates to a vincamine derivative as well as a preparation method and application thereof, and belongs to the technical field of preparation of vincamine derivatives. Compared with the prior art, the vincamine derivative disclosed by the invention has the following advantages: (i) the modification of the tail chain increases the fat solubility of the vincamine compound, does not influence the cerebral blood flow regulation of the vincamine, and is beneficial for carrying drugs to penetrate through the blood brain barrier, exert the brain protection effect and improve the brain microcirculation disturbance; (ii) a tertiary amine group in a parent nucleus structure of the vincamine derivative has the property of being ionizable under an acidic condition, efficient carrying of nucleic acid drugs and lysosome escape can be achieved through a charge adsorption effect, and intracellular transport is improved; and (iii) the vincamine derivative inherits various inherent pharmacological activities of vincamine and has high safety. Therefore, the vincamine derivative disclosed by the invention has a good application prospect in the aspect of brain-targeted delivery of drugs for treating brain diseases.

The present application relates to a long-changma class derivative and its preparation method and application, belong to long-changma class derivative preparation technical field. The long-changma class derivative disclosed by the present application has the following advantages: (i) the modification of the tail chain increases the fat solubility of the long-changma class compound, and does not affect the brain blood flow regulation of the long-changma class itself, helps to carry the drug to penetrate the blood-brain barrier, and plays a brain protection role, improves the brain microcirculation disorder; (ii) the tertiary amine group in the parent nucleus structure of the long-changma class derivative has the property of ionization under acidic conditions, can achieve efficient carrying and lysosome escape of nucleic acid drugs through charge adsorption, and improve intracellular transport; (iii) the long-changma class derivative inherits the inherent various pharmacological activities of long-changma, and has high safety. Therefore, the long-changma class derivative disclosed by the present application has good application prospect in brain-targeted delivery of drugs for treating brain diseases.