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Huperzia serrata endogenetic epiphyte and uses thereof

An endophytic fungus and Huperzia serrata technology, applied in the field of microorganisms, can solve the problems of difficulty in realizing industrialization, high cost, low chemical synthesis yield and the like, and achieve the effect of great application value.

Active Publication Date: 2011-02-09
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These areas are gradually losing their status as the regional dominant species of Huperzia serrata, so the direct harvesting of Huperzia serrata natural resources can no longer meet the market demand for Huperzine A
On the other hand, the chemical synthesis of huperzine A is also difficult to achieve industrialization due to low yield and high cost.

Method used

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  • Huperzia serrata endogenetic epiphyte and uses thereof
  • Huperzia serrata endogenetic epiphyte and uses thereof
  • Huperzia serrata endogenetic epiphyte and uses thereof

Examples

Experimental program
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Effect test

example 1

[0059] (1) Take the endophytic fungus strain of Hupermus serrata of the present invention, under aseptic conditions, pick a small amount of hyphae with an inoculation needle, insert it into a sterilized solid PDA medium test tube, and activate and cultivate it at 28±1°C for 72 Hour;

[0060] (2) Get the bacterial classification after activation culture, under aseptic condition, transfer into the liquid PDA seed culture medium that has been sterilized, 140rpm shaker culture under 28 ± 1 ℃ for 72 hours, get seed;

[0061] (3) The prepared improved PDA liquid culture medium is divided into 500ml Erlenmeyer flasks according to a 20% charging ratio, sterilized, and cooled for subsequent use. Under sterile conditions, inoculate 2F09P03B seeds according to 10% of the inoculum amount, and culture on a shaker at 140rpm at 28±1°C for 7 days;

[0062] (4) After the fermentation is complete, collect the culture, adjust the pH value to about 4.0, break the cells, let stand overnight, adju...

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Abstract

The invention discloses endophytic fungi from huperzia serrata. The invention is obtained through being separated from the living body of pteridophyta huperzia serrata by adopting endophytic fungi separation and purification technology, and is identified through biosystematics to be acremonium endophytium. The preservation number of the strain is CCTCC M 206118. The invention generates Huperzine A analogous compound through the strain liquid fermentation of the endophytic fungi from huperzia serrata, and is significant micro organism for searching the Huperzine A new resource of the active component for curing the presenile dementia.

Description

technical field [0001] The invention relates to the technical field of microbes, in particular to the endophytic fungus of Huperz serrata and its application. Background technique: [0002] Huperzine A, as a new-generation specific drug for the treatment of Alzheimer's disease, has a very promising market prospect. Its derivative ZT-1 is entering phase III clinical trials in EMEA, and product development is also actively underway. Currently, Huperzine A is mainly derived from the whole herb of Huperzia serrata. Although Huperxa serrata has a vast resource area, its distribution is scattered, the resource renewal cycle is long, and there are relatively few natural resources available for commercial exploitation. After years of extensive mining, the resources of Hupernia serrata in Zhejiang, Jiangxi, Fujian and other provinces in China are almost exhausted. The resources of Hunan, Guangxi, Sichuan and other provinces will also face the danger of being exhausted within two or...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/14
Inventor 黎万奎胡之璧周吉燕王峥涛
Owner SHANGHAI UNIV OF T C M
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