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Huperzine A pellets preparation and its preparation method

A technology for Huperzine A pellets and Huperzine A, applied in the field of medicine, can solve problems such as low bioavailability, and achieve the effects of high bioavailability, improved drug stability, and uniform size

Inactive Publication Date: 2007-08-01
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to: provide a kind of huperzine A pellet preparation and preparation method thereof; The present invention provides pellet preparation aiming at the prior art, which solves the problem of low bioavailability, and is especially suitable for the elderly and swallowing tablets Or for patients who have difficulty taking capsules, the coating technology is used, which is conducive to the stability of ingredients, and can also cover up the bad taste and smell of the drug, and play a role in increasing stability and improving bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1 of the present invention: Huperzine A 10g

[0048] Take huperzine A, add microcrystalline cellulose with a ratio of 1:1000 to the drug powder and starch with a ratio of 1:2000 to the drug powder in the method of progressive dilution, sieve and mix step by step, and add an appropriate amount of ethanol with a concentration of 60%. Wetting agent, HPMC with a concentration of 5% is used as a binder to make soft materials, and then these materials are moved into a pellet machine, extruded into strips through a 1mm sieve, cut into granules, spheronized at a speed of 850r / min, and released Material, drying, with Opadry 2 as coating material, top spray coating: nozzle diameter 1mm, fluidization air volume 100m 3 / h, inlet air temperature 55°C, bed temperature 35°C, atomization pressure 0.15MPa, liquid spray rate 15mL / min, that is, this product is taken orally, twice a day, 1 pack (0.3g) each time.

Embodiment 2

[0049] Embodiment 2 of the present invention: Huperzine A 100g

[0050] After granulating the microcrystalline cellulose, add it to the coating pan, spray it with ethanol with a concentration of 60% to moisten it, roll it into small balls, then wet the mother pellets, then add huperzine A to roll and coat, repeat the operation, The rotating speed of the coating pan is 25r / min, and the preparation time is 10-12 hours. Take out the pan, select the pellets, and coat them. Opadry 2 is used as the coating material. The coating adopts the top spray method: the diameter of the nozzle is 1mm, and the fluidization air volume is 100m 3 / h, inlet air temperature 55°C, bed temperature 35°C, atomization pressure 0.15MPa, liquid spray rate 15mL / min.

Embodiment 3

[0051] Embodiment 3 of the present invention: Huperzine A 50g

[0052] Take huperzine A, mix it with 15% sorbitol, 25% microcrystalline cellulose, and 30% dextrin, and add 8% crospovidone, 10% CCMC -Na, 5% L-HPC, 5% stevioside and an appropriate amount of flavoring agent, mixed evenly, granulated, sized, and compressed into tablets to obtain orally disintegrating tablets.

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Abstract

The invention relates to a kind of huperzine A parvule preparation and it's preparing method which is made of huperzine A and certain diluents bases. The preparation is applicable to patients who have problem with degluting tablets or capsules; it can treat nonmalignant dysmnesia and can increase the patients' ability of directing memory, thought association, image recall, nonsense figure recognition and portrait recall; it can also improve the dysmnesia caused by brain organic affection or dementia.

Description

technical field [0001] The invention relates to a huperzine A pellet preparation and a preparation method thereof, belonging to the technical field of medicines. technical background [0002] Alzheimer's disease refers to the sustained impairment of acquired intelligence in old age, that is, the basically irreversible loss of intelligence and reduced social adaptability caused by organic brain damage. The main manifestations are: in terms of intelligence, there is loss of abstract thinking ability, insufficient reasoning, judgment and planning, and lack of attention; Forgotten, poor topographical, visual, and spatial orientation; in terms of verbal cognition, speaking is not fluent, and comprehensive ability is lacking. Statistics from European and American countries show that 6% to 12% of the elderly over the age of 60 develop dementia, and 20% to 40% of the elderly over the age of 85 develop dementia, and more than half of them are senile dementia. According to statistic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/435A61K9/20A61K9/48A61P25/28
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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