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Composition for whitening and removing freckles and preparation thereof

A technology for whitening and freckle removal and a composition is applied in the field of compositions for whitening and freckle removal, which can solve the problems of large toxic and side effects on the human body, slow freckle lightening effect, and no progress, and achieves a technology with small toxic and side effects, good curative effect, and fast onset of effect. Effect

Inactive Publication Date: 2013-06-19
和心医药科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, in the prior art, the freckle-removing drug prepared by using tranexamic acid is only an oral preparation, and the freckle-removing effect is slow, and may have adverse effects on other organs of the human body, and has great toxic and side effects on the human body.
Those skilled in the art have been seeking for a long time to prepare the method of tranexamic acid anti-freckle topical preparation, but there is no progress

Method used

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  • Composition for whitening and removing freckles and preparation thereof
  • Composition for whitening and removing freckles and preparation thereof
  • Composition for whitening and removing freckles and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Active pharmaceutical ingredients include:

[0045] Tranexamic acid 1kg;

[0046] Ascorbic acid tetraisopalmitate 0.5kg;

[0047] Hydrophilic gel matrix includes:

[0048] Sodium polyacrylate 5kg;

[0049] Sodium carboxymethyl cellulose 1kg;

[0050] Gelatin 3kg;

[0051] Glycerin 20kg;

[0052] Aluminum hydroxide 0.05kg;

[0053] Silica 1kg;

[0054] Disodium Edetate 0.08kg;

[0055] Tartaric acid 0.9kg;

[0056] Polysorbate 80 0.3kg;

[0057] 37.17kg of purified water.

[0058] Put 6kg of glycerin into the first container, under stirring, add 1kg of sodium carboxymethylcellulose, and continue stirring until it becomes a translucent colloid, which is component A;

[0059] Take 14kg of glycerin and put it into the second container, add 0.05kg of aluminum hydroxide and 5kg of sodium polyacrylate under stirring, and continue stirring until it becomes a translucent colloid, which is component B;

[0060] Add purified water to the third container, under stirring, add tranexamic acid, ascorbyl t...

Embodiment 2

[0064] Active pharmaceutical ingredients include:

[0065] Tranexamic acid 5kg;

[0066] Ascorbic acid tetraisopalmitate 2kg;

[0067] Hydrophilic gel matrix includes:

[0068] Sodium polyacrylate 6kg;

[0069] Sodium carboxymethyl cellulose 0.8kg;

[0070] Gelatin 3kg;

[0071] Glycerin 25kg;

[0072] Aluminum hydroxide 0.06kg;

[0073] Silica 1kg;

[0074] Disodium Edetate 0.08kg;

[0075] Tartaric acid 0.9kg;

[0076] Polysorbate 80 0.6kg;

[0077] 55.56kg of purified water.

[0078] Put 8kg of glycerin into the first container, under stirring, add 1kg of sodium carboxymethylcellulose, and continue stirring until it becomes a translucent colloid, which is component A;

[0079] Take 17kg of glycerin and put it into the second container, add 0.06kg of aluminum hydroxide and 6kg of sodium polyacrylate under stirring, and continue stirring until it becomes a translucent colloid, which is component B;

[0080] Add purified water to the third container, under stirring, add tranexamic acid, ascorbyl t...

Embodiment 3

[0084] Active pharmaceutical ingredients include:

[0085] Tranexamic acid 2kg;

[0086] Ascorbic acid tetraisopalmitate 0.8kg;

[0087] Hydrophilic gel matrix includes:

[0088] Sodium polyacrylate 5.5kg;

[0089] Sodium carboxymethyl cellulose 1kg;

[0090] Gelatin 3kg;

[0091] Glycerin 25kg;

[0092] Aluminum hydroxide 0.06kg;

[0093] Silica 1kg;

[0094] Disodium Edetate 0.08kg;

[0095] Tartaric acid 0.9kg;

[0096] Polysorbate 80 0.3kg;

[0097] Purified water 60.36kg.

[0098] Put 7 kg of glycerin into the first container, add 1 kg of sodium carboxymethyl cellulose under stirring, and continue stirring until it becomes a translucent colloid, which is component A;

[0099] Take 18 kg of glycerin and put it into the second container, add 0.06 kg of aluminum hydroxide and 5.5 kg of sodium polyacrylate under stirring, and continue stirring until it becomes a translucent colloid, which is component B;

[0100] Add purified water to the third container, under stirring, add tranexamic acid, asco...

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Abstract

The invention provides a composition for whitening and removing freckles. The composition comprises following active components in parts by weight: 1-5 parts of tranexamic acid and 0.5-2 parts of ascorbate, wherein the structural formula of the ascorbate is shown as the specification, wherein R1, R2, R3 and R4 are C10-C20 alkyls; and the alkyls are selected from aromatic hydrocarbon groups and / or aliphatic groups. The composition has good effects of banishing the freckles, removing the freckles and whitening and can be used for chloasma, the freckles, age pigments, aestates and the like, has obvious effect aiming at the chloasma, and is stable and controllable; and meanwhile, an external preparation prepared from the composition provided by the invention can be used for a wounded part, and has fast effect, good curative effect and small toxic or side effect.

Description

Technical field [0001] The invention relates to a composition for whitening and removing freckles, in particular to a composition for whitening and removing freckles and a preparation thereof that can be used externally. Background technique [0002] Pigmentation refers to spots that are different in color from the surrounding area. It appears because of the increase in skin pigmentation, causing small spots such as black and yellowish brown on the skin. The medical name is "dyschromatic skin disease", which can generally be divided into yellowish brown. Spots (pregnancy spots, butterfly spots), freckles, sunburns, age spots and toxic melanosis, etc. The color of human skin depends on the content and distribution of melanin. In the process of skin metabolism and circulation, the tyrosine contained in melanocyte tissues is under the action of tyrosinase, dopachrome interconvertase, and DHICA oxidase, through dopa, dopaquinone, dopachrome, dihydroxy Intermediates such as indole a...

Claims

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Application Information

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IPC IPC(8): A61K31/375A61K31/195A61P17/00A61K8/67A61K8/44A61Q19/02
Inventor 龙本威张慧敏龚力平汤秀珍刘向兰张文献
Owner 和心医药科技(上海)有限公司
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