339 results about "Skin sensitization" patented technology

To provide a photopolymerizable inkjet ink, which contains photopolymerizable monomers containing at least one selected from the following compound group (A) compounds of which are negative for skin sensitization, and at least one selected from the following compound group (B) compounds of which are negative for skin sensitization, wherein the compound group (A) is a compound group consisting of caprolactone-modified dipentaerythritol hexaacrylate, polyethoxylated tetramethylol methane tetraacrylate, ethylene oxide-modified bisphenol A diacrylate, caprolactone-modified hydroxy pivalic acid neopentyl glycol diacrylate, polypropylene glycol diacrylate [CH₂═CH—CO—(OC₃H₆)n-OCOCH═CH₂ (n≈12)], hydroxyethyl acryl amide, trimethylol propane trimethacrylate, and tricyclodecane dimethanol dimethacrylate, and the compound group (B) is a compound group consisting of ethylene oxide-modified phenolacrylate, isostearyl acrylate, ethylene oxide-modified trimethylol propane trimethacrylate, stearyl methacrylate, and glycerin dimethacrylate.

A photopolymerizable inkjet ink including: at least one selected from the group consisting of (meth)acrylic acid esters negative for skin sensitization and (meth)acrylamides negative for skin sensitization; and at least one selected from the group consisting of vinyl ethers negative for skin sensitization, t-butyl methacrylate negative for skin sensitization, n-pentyl methacrylate negative for skin sensitization, and n-hexyl methacrylate negative for skin sensitization.

The invention discloses application of porous frame materials in masks. To solve the problems that a traditional mask matrix is high in irritation and poor in cleaning capacity, an added homogeneous preservative easily causes skin allergy and inflammation, and active matter can not be fully utilized, the high adsorbability and antibacterial property of the porous frame materials and the property of slowly releasing active ingredients are creatively utilized to solve the problems in the existing mask technology. Meanwhile, through many experiments and long-term exploration, screening criteria of the porous frame materials for different kinds of masks are established, and the interaction mechanism of the porous frame materials and guest molecules is studied according to the material structures.

The present invention provides methods for predicting the in vivo skin sensitizing activity of chemical compounds using a combination of mammalian cell models with multiple endpoint analysis, time and concentration response curves. The methods allow the determination of a predicted in vivo sensitization value of a compound—for example, a EC3 LLNA value, a GPMT value or a IVTI value—without the use of animals, with a high degree of accuracy. The methods involve detecting expression levels of genes implicated in skin sensitization, combining expression level data with concentration response data, conducting a computational analysis, and comparing test compound data to a database of known skin sensitizers.

Pharmacological test shows that the externally-used preparation of Cetirizine has ideal allergy resistant and anti-inflammatory action to the rat passive cutaneous anaphylaxis (Rat PCA) model and dimethylbenzene caused mouse otitis model, and also prevents the adverse effect to the central system caused by whole body administration. It is also found in the test, that the externally used preparation of Cetirizine also has very fine inhibitory action to dinitrofluorobenzene caused mouse porphyria hypersensitivity (PTH), the novel pharmacological action of the Cetirizine shows that the Cetirizine external preparation has good therapeutic action to skin inflammations which mainly include porphyria hypersensitivity.

The invention provides a production method for a sunscreen cream with plant extracts as main functional components. The production method comprises the following steps: 1, extraction of alcohol-soluble components in the shuck of mangosteen; 2, extraction of water-soluble polysaccharides in the shuck of mangosteen; 3, preparation of a chinaroot greenbrier cream; 4, manufacture of fine kudzu vine root powder; and 5, preparation of a matrix cream. The sunscreen cream prepared by using the method prevents symptoms like obstruction of pores and skin allergic diseases, exerts substantial effects on anti-inflammation, sterilization, skin nourishing, improvement of wrinkle resistance of the skin and effective delaying of skin ageing and has the advantages of enhanced safety and reduced cost; the sunscreen cream can effectively restore damaged skin, wherein the restoration effect of the sunscreen cream is incomparable with restoration effects of antioxidant substances like vitamin E; and the sunscreen cream enables synergy of ultraviolet ray absorbers to be performed, so a minimum usage amount of the sunscreen cream can exert a maximum protection effect.

The present invention provides effective and safe medicaments for the treatment of connective tissue diseases of the skin, particularly with respect to the treatment of cutaneous forms of Lupus Erythematous. The medicaments comprise as the therapeutically active ingredient a beta₂ adrenoceptor agonist. The invention furthermore relates to dermatological compositions without skin sensitization properties and which contain enantiomerically pure or enriched R-enantiomers of a beta₂ adrenoceptor agonist.

The invention provides an externally used medicament for expelling rheumatism, promoting blood circulation and relieving a pain and a preparation method thereof. The medicament is prepared from a pain-relieving liquid extract for affections by dampness, methyl salicylate, menthol, borneol, camphor, liguidamber resinoid and belladonna liquid extract. The externally used medicament for expelling the rheumatism, promoting the blood circulation and relieving the pain links the cause and the pathogenesis of a disease closely, has medicaments in compatibility with each other reasonably, expels the rheumatism, promotes the blood circulation and relieves the pain. Serving as an externally used cataplasm which is applied through skin, a stimulus to a gastrointestinal tract caused by oral preparations is avoided, and toxic and side effects on a whole body are lightened necessarily by a relatively slow absorption process through the skin without the reactions of skin sensibility and skin stimulus. Therefore, the externally used medicament improves the medicinal safety to a certain extent and provides a new choice for clinical medicinal safety after the medicament is delivered through the skin.

The invention relates to cationic nano emulsion with an anti-allergic effect. The cationic nano emulsion is characterized by comprising the following components in percentage by mass: 10-30% of a plant anti-allergic compound, 3-30% of glycerin, 5-30% of caprylic/capric triglyceride, 0.1-3% of cholesterol, 2-25% of glycolipid, 0.1-2% of polyquaternary ammonium salt-51, 0.05-0.3% of methylparaben and the balance of water, wherein the plant anti-allergic compound comprises the following components in percentage by mass: 15-30% of olive leaf extract, 5-10% of gorgonian extract, 10-20% of laminaria saccharina extract, 3-5% of piper methysticum extract and the balance of octyldodecanol; the average particle size of nanoparticles is 100-600 nm. The cationic nano emulsion has the benefit of capability of comprehensively and efficiently resisting a skin allergy symptom, is nontoxic to skin, penetrates the skin easily and can quickly achieve the anti-allergic effect.

The invention discloses a naringin contained facial mask and a preparation process thereof. Naringin is added into a facial mask liquid, a main ingredient of the naringin is flavonoid and acts synergistically with nicotinamide (B3) and vitamin B6, so that the facial mask has a prominent whitening effect; when the same whitening effect is achieved, the use amount of nicotinamide is effectively reduced, and the skin allergy risk caused by the product is reduced; beta glucan which can activate macrophage and neutrophilecell is supplemented, so that the facial mask can deep remove free radical and has a radiation protection effect; meanwhile, trehalose and polyglycerol are added into the facial mask liquid and jointly act, so that the moisturizing time can be effectively prolonged; and finally, glycine, glutamic acid and proline which are mild are adopted to adjust the pH value of the facial mask liquid to 4.0-5.3, and the pH value is close to the pH value of a body fluid of a human body, so that the facial mask liquid can deep enter skin cells, and the best skin whitening and brightening effect is achieved.

The invention relates to a bone healing tincture which has the functions of activating blood and dissolving stasis, relaxing tendons and activating collaterals, removing rheumatism, relieving swelling and pain, resisting inflammation and relieving itching and the like. The bone healing tincture is used for overcoming the defects that the existing bone healing tincture is not suitable for people with skin injury, and is non-greasy and fragrant as well as wide in application range. The bone healing tincture has obvious treatment effects on traumatic injury, cervical and lumbar spondylosis, rheumatoid arthritis, podagra, hand and foot numbness, skin injury and the like. In addition, the bone healing tincture is convenient to use and nearly free of causing skin allergy. According to the technical scheme, the medical ingredients and the content thereof in 50kg of white wine are as follows: 600 to 800g of radix clematidis, 250 to 400g of pseudo-ginseng, 30 centipedes, 600 to 900g of frankincense, 600 to 900g of myrrh, 300 to 500g of lycopodium clavatum, 300 to 500g of garden balsam stem and 300 to 500g of sorrel, wherein all the medical ingredients are soaked for 3 months; and the wine can be drunk in the manner of removing residues and taking out a decoction.

The invention discloses a plant compound preservative. The plant compound preservative is prepared from, by weight, 1-20 parts of a plant root extractive, 1-20 parts of a plant flower extractive, 10-30 parts of a plant leaf extractive and 1-10 parts of plant bark extractive. The plant root extractive is obtained by mixing and extracting 1-5 parts of scutellaria baicalensis, 0.1-1 part of radix sophorae flavescentis, 0.1-1 part of moss, 1-5 parts of cordate houttuynia and 1-5 parts of Chinese herbaceous peony. The plant flower extractive is obtained by mixing and extracting 5-10 parts of calendula, 1-10 parts of hibiscus mutabilis and 1-10 parts of honeysuckle. The plant leaf extractive is obtained by mixing and extracting 1-10 parts of lotus leaves, 5-10 parts of ginkgo leaves, 2-5 parts of rosemary leaves, 1-5 parts of olive leaves and 5-10 parts of perilla leaves. The plant bark extractive is obtained by mixing and extracting 5-10 parts of shaddock peel and 1-5 parts of cinnamon. The invention further discloses an acne removal skincare product containing the plant compound preservative. The plant compound preservative can effectively inhibit growth of microorganisms such as germs and fungi in skincare product, can prolong the service life of the skincare product and has the advantages of being free of toxicity or simulation or skin sensibility or the like.

The invention relates to a preparation method of a placenta sub-totipotential stem cell active factor for beauty and skin care. The preparation method comprises the steps of separating and culturing placenta sub-totipotential stem cells and preparing the active factor. The preparation of the active factor comprises the steps of taking P3 generation placenta sub-totipotential stem cells, carrying out inoculation and digestion, carrying out ice ultrasonic cell breakage, and collecting supernatant; then, dropping in trichloroacetic acid, performing an ice bath, carrying out low-temperature centrifugation, and abandoning the supernatant; adding precooling acetone to wash sediment, conducting low-temperature centrifugation, abandoning the acetone, resuspending the sediment, and conducting filtering the product with a filter film of which the thickness is 0.1 micrometer, wherein the concentrations of the obtained SCF, a FGF, VEGF, EGF, and KGF are all larger than 20000 pg/ml. The preparationmethod of the placenta sub-totipotential stem cell active factor for beauty and skin care adopts a culture system free of heterologous animal serum, and reduces the risks of introducing heterologousanimal viruses; at the same time, there is no hormone at all in the culture system, so that possible skin allergic reaction caused by the hormones is avoided; the active factor is prepared by the adoption of the low-temperature precipitation method, so that the activity of the active factor is guaranteed.

The invention provides a dog-skin plaster and a preparation technique thereof. The dog-skin plaster is made from a substrate and raw herbal materials of black-plaster dog-skin plasters. The mass ratio of the raw herbal materials is the same as the mass ratio in the prescription of the black-plaster dog-skin plaster. A processed radix aconiti replaces an unprocessed radix aconiti, and a processed kusnezoff monkshood root replaces an unprocessed kusnezoff monkshood root, wherein no lead is contained. The preparation uses an ethanol extracting technology and a volatile-oil extracting technique to replace the extracting technology of frying vegetable oil in the original preparation, which can completely extract drug ingredients, without such disadvantages as drug ingredients being easily destroyed by high temperature and air pollution which are generated by the extracting technique of frying vegetable in the original preparation; the new substrate replaces the original black-plaster substrate, which has the advantages of larger drug quantity, easy putting up and off, good compatibility, release property and skin penetration property, without toxic lead content. The unprocessed radix aconiti and the unprocessed kusnezoff monkshood root in the original prescription are replaced respectively by the processed radix aconiti and the processed kusnezoff monkshood root, thus ensuring the effectiveness and safety of the preparation and eliminating the skin sensitization caused by the original dog-skin plaster.

The invention discloses a hair and body wash powder and relates to the technical field of daily-use chemical industry. The hair and body wash powder can be prepared from 10-60% of traditional Chinese medicine ingredients, 20-70% of tea bran powder, 13.0-20% of zeolite powder, 0.5-1.5% of grapefruit essence and 0.5-1.5% of preservative; the traditional Chinese medicine ingredients include root bark of white mulberry, root of red-rooted salvia, fresh ginger and white poria at the ratio of 3:2:2:1. In the hair and body wash powder, camellia-seed oil and traditional Chinese medicine ingredients are added, the camellia-seed oil can be used for nourishing skin and has the function of removing red and swollen caused by skin injury; the traditional Chinese medicine ingredients have the effects of relieving pain and itch of allergic skin and inhibiting bacteria, meanwhile, mild surface active ingredients are also used, and as compared with most chemical synthetic raw materials, the moderate surface active ingredients are safer, have less toxic and side effect and lower irritation property, are not liable to cause skin microecosystem dissonance, such as skin allergy and inflammation. Natural plant ingredients are used for nursing skin, so that the hair and body wash powder is safe and particularly suitable for the people with sensitive skin and the infants.

The invention provides an antipollution composition. The antipollution composition comprises the following components in parts by weight: 1 to 40 parts of butanediol, 1 to 40 parts of 1,3-propanediol,0.1 to 10 parts of hydrolytic sclerotium gum, 0.02 to 10 parts of sodium hyaluronate, 0.2 to 10 parts of trehalose, 0.1 to 30 parts of panthenol, 0.1 to 3 parts of p-hydroxyacetophenone, 0.01 to 20 parts of beta-glucosan, 0.01 to 5 parts of dipotassium glycyrrhizinate, 0.01 to 20 parts of tremella fuciformis extract, 0.01 to 5 parts of an antipollution agent A, 0.01 to 30 parts of an antipollution agent B, 0.01 to 30 parts of an antioxidant and 0.1 to 3 parts of a chelating agent. By adopting the antipollution composition provided in the invention, the harm of pollutants for the skin can be protected in multiple ways, the antipollution agent A forms a physical barrier film on the skin, the adsorption of the pollutants on the skin can be reduced, the skin can be regenerated, the detoxification capacity can be improved, and the skin allergic symptom can be alleviated.

The invention relates to an Aliya skin aging-resisting stock solution. The composition is prepared from vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin A, vitamin D, vitamin E, N-amino acid, apple vinegar, sodium hyaluronate, hydrolyzed gelatin and deionized water. The Aliya skin aging-resisting stock solution provided by the invention can improve the skin microcirculation, increase the skin metabolism rate, keep the skin tenderness, delay the skin aging, lubricate the skin, moisturize the skin for a long time, improve the skin luster and elasticity, effectively prevent and control age pigments, freckles and pigmentation, effectively promote cell regeneration, reduce wrinkle formation, effectively prevent folliculitis, skin allergy and cosmetic allergy, prevent the sunshine, and prevent the skin from being injured by ultraviolet rays.

The invention belongs to medical evaluation and detection technology field. It concerns in particular to the construction method of animal model for skin allergy therapeutic drug screen and skin allergy mechanism study. The skin allergic mouse model is built by injecting anti DNP IgE monoclonal antibody to BALB/c mouse caudal vein and provoking the action by making 2,4 dinitroflurobenzene as antigen. The model can imitate the skin allergy dynamic reaction whole process favorably, therefore, it can be used for the screening of skin allergy treating drug and study of skin allergy pathogenesis and drug action mechanism.

The invention relates to a hot-melt and pressure sensitive plaster matrigel. The hot-melt and pressure sensitive plaster matrigel is prepared by the following raw materials by weight: 5-25 parts of a thermoplastic elastomer SIS, 5-25 parts of a thermoplastic elastomer SBS, 5-20 parts of a thermoplastic elastomer SEPS, 5-30 parts of a C5 petroleum resin, 5-30 parts of a C5/C9 co-polymerized petroleum resin, 10-30 parts of a rosin resin, 10-30 parts of a naphthenic oil KNH4010 and 1-2 parts of an antioxidant BHT264. The hot-melt and pressure sensitive plaster matrigel is prepared a method of passing through nitrogen and then fusing with stirring. The plaster matrigel prepared by the method has the advantages of good initial adhesion, large release force, good ageing-resistant performance and high cohesive strength. Compared with a nonpolar material, the plaster matrigel has relatively good combined performance and is helpful for coating. When the plaster matrigel is in use, skins are not allergic to the plaster matrigel, and drug loading capacity is large; and no residue is left after the matrigel is peeled off.