116 results about "Skin sensitization" patented technology

The invention provides a viscose large biological fiber with an anti-allergy function and a preparation method thereof, and belongs to the field of viscose fibers. The preparation method of the viscose large biological fiber with the anti-allergy function comprises the following steps: preparing a molecular nest, preparing modified gel, coating and forming, preparing a spinning solution, and spinning and forming. According to the preparation method of the viscose large biological fiber with the anti-allergy function, the problem that the activity and the stability of adopted plant active ingredients are reduced due to the fact that the adopted plant active ingredients are affected by process environments, solvent ingredients and the like can be solved; meanwhile, the release characteristic of the plant active ingredients in the viscose fibers can be regulated and controlled according to needs, so that the plant active ingredients are released in a large dose within a short time or slowly released in a small dose within a long time, and then emergent repair or long-acting allergy relief of skin allergy areas is achieved.

The present invention relates to a bio-based and biodegradable superabsorbent polymer (SAP) comprising sodium alginate, modified cellulose, at least one activation agent, and at least one crosslinking agent. The SAP exhibits a high bio-based content of up to 93% and fulfills industrial composting standards such as EN 13432. The crosslinking reactions are performed under mild conditions, including ambient temperatures and neutral to alkaline pH, eliminating the need for high thermal energy. The resulting SAP granules demonstrate excellent liquid absorption performance, rapid swelling, high retention, and no observed toxicity or skin sensitization. The invention provides a sustainable alternative to petroleum-based SAPs for use in hygiene products, agriculture, and other disposable applications.

The invention discloses a thermal spring water composition for relieving itching and soothing skin and a preparation method of the thermal spring water composition, and belongs to the technical field of itching relieving and soothing. Chitosan has good film-forming property, after chitosan, mung bean protein and the like form a compound, after the compound is smeared on the surface of skin, a layer of relatively stable protective film with certain air permeability can be constructed, skin allergy and inflammatory reaction can be reduced, a relatively wet microenvironment is formed on the surface of the skin, and the skin care effect is improved. The moisture loss of the skin is reduced, and the moisture balance of the skin is favorably kept, so that uncomfortable symptoms such as dry and tight skin are relieved, and the skin is further promoted to be relieved; after the centella asiatica polysaccharide is subjected to carboxymethylation modification, the water solubility and the biological activity of the centella asiatica polysaccharide are remarkably improved, and the carboxymethylated centella asiatica polysaccharide and the mung bean protein-chitosan compound have a synergistic effect, so that the barrier function of skin can be enhanced, the metabolism of skin cells can be regulated, and the skin can be effectively protected. The repair and regeneration of damaged skin cells are promoted.

The invention discloses a collateral-dredging and pain-relieving gel plaster and a preparation method thereof. The collateral dredging and pain relieving ointment is prepared from the following raw materials in percentage by mass: camphor, borneol, menthol, absolute ethyl alcohol, collateral dredging and pain relieving volatile oil, a surfactant, collateral dredging and pain relieving extract, tartaric acid, purified water, partially neutralized sodium polyacrylate, a cross-linking agent, an adhesive, glycerol, EDTA-2Na (Ethylene Diamine Tetraacetic Acid) and a filling agent. The plaster disclosed by the invention is high in application comfort, breathable, free from aching feeling after being uncovered, free from residue on skin and not sticky when being in contact with sweat; the use of an organic solvent is basically avoided in the production process; the matrix contains components such as water and glycerol, has the effects of moistening the skin and promoting skin hydration, and is free of irritation and sensitization to the skin; repeated uncovering and pasting can be achieved, and the viscosity influence is small.

A method of predictively assessing skin sensitization of a personal care product formulation includes calculating a confidence upper limit at a desired confidence level from a plurality of physical tests for skin sensitization of each of the ingredients in the personal care product formulation to define a calculated skin sensitization value for the respective ingredient; applying at least one safety factor to at least one of the calculated skin sensitization values of the ingredient to define an adjusted skin sensitization value for the respective ingredient; combining the adjusted skin sensitization values of the ingredients to define the total sensitization of the personal care product formulation; and comparing the total sensitization to the target product sensitization of the personal care product formulation. Such personal care product formulations do not require further testing and can be applied to the skin by a user. Predictive systems and methods of preparing personal care products are also disclosed.

The invention belongs to the technical field of cosmetics, and particularly relates to whitening and freckle-removing essence oil and a preparation method thereof. According to the invention, adamantane formyl is introduced into an alpha-arbutin benzene ring to obtain the adamantane formyl modified alpha-arbutin derivative, so that the compatibility of alpha-arbutin and base oil is enhanced; the alpha-arbutin is prevented from being converted into hydroquinone by utilizing the large steric effect of adamantane formyl, so that the safety of the whitening and freckle-removing essence oil is improved; the tranexamic acid is wrapped by the ceramide nano-emulsion, so that the skin allergy risk caused by ingestion of the tranexamic acid is reduced; the ceramide nano-emulsion and tranexamic acid act together to repair skin collagenous fibers, block melanin transfer and inhibit melanin synthesis; trilinolein and glabridin are catalyzed by lipase to form a compound, so that the molecular compatibility and photo-thermal stability of glabridin are enhanced; glycerin promotes transdermal absorption of glabridin and enhances the efficacy of the whitening and freckle-removing essence oil.

The utility model provides a novel medical application adhesive tape which comprises a base layer and further comprises an adhesive layer with one side adhered to the base layer and release paper separably adhered to the other side of the adhesive layer, a plurality of transverse tearing lines and longitudinal tearing lines are arranged on the release paper, and base layer tearing lines corresponding to the longitudinal tearing lines are arranged on the base layer. A plurality of air holes are formed in the base layer in an array mode, the base layer is coated with the adhesive layer in a latticed mode, the adhesive layer is arranged to avoid the air holes, the base layer is coated with the adhesive layer in a rectangular latticed mode, and the air holes are formed in the base layer in a rectangular array mode. The novel medical application adhesive tape provided by the utility model not only is safe and reliable to paste wounds at different parts, has a better using effect, but also has better air permeability, and relieves uncomfortable symptoms such as skin allergy, redness, itching and the like which are easily caused by long-time use.

The invention discloses a signal acquisition system of a self-adaptive film electrode patch for heart diseases, and relates to the technical field of medical instruments, the signal acquisition system comprises a flexible substrate, a nano electrode wire, an electrode patch and a circuit module; a bonding layer is arranged on the bottom surface of the flexible substrate, an anti-allergic medicine is distributed in the bonding layer, and the flexible substrate is used for being attached to the skin surface through the bonding layer; the plurality of nano electrode wires are distributed on the bonding layer of the flexible substrate, one ends of the plurality of nano electrode wires are respectively arranged at the detection points, the other ends of the plurality of electrode wires are connected with the circuit module, and the circuit module is used for outputting electric signals collected by the electrode paste; the electrode patch comprises a flexible conductive base layer and a contact layer, a printed circuit is arranged on one side of the flexible conductive base layer, the contact layer is attached to the printed circuit, the other side of the flexible conductive base layer is used for being bonded to a flexible substrate and located at a detection point, and the flexible conductive base layer is conducted with the nano electrode wire; the collection system is simple to operate, and solves the problems that an existing lead wire is easy to wind, the surgical field is affected, and skin allergy is caused by patch. The method has high use value and popularization value.

The invention discloses essence with uniformly distributed oil drops and a preparation process thereof, and relates to the field of cosmetics, the essence comprises a water phase component and an oil phase component, the water phase component comprises 50-99 parts by weight of purified water, 2-30 parts by weight of a moisturizing factor, 0.001-0.2 part by weight of a chelating agent, 0.001-5 parts by weight of a thickening agent, and 0.5-2 parts by weight of a preservative; the oil phase component comprises 1-15 parts by weight of a grease component; the essence is in a transparent state, oil drops are uniformly distributed, and no emulsifier is added, so that the problems of skin allergy, irritation and the like possibly caused by the emulsifier are avoided, the product is more suitable for being used by sensitive skin, the original characteristics of water and oil are reserved, and purer use experience is brought to consumers; the whole product is in a transparent state, oil drops are in a suspended state, and the product can be sprayed and smeared and has unique sense of science and technology and visual attraction.

The invention discloses a straptop with skin moistening efficacy, which comprises a straptop suit, a brassiere wiping cover, shoulder strap buckles and a suit assembly, the brassiere wiping cover is arranged at the mounting position of the straptop suit, the shoulder strap buckles are arranged at the fixed position of the brassiere wiping cover, and the straptop suit and the brassiere wiping cover are arranged at the spinning position of the suit assembly. The rubber pad and the skin-friendly fabric can be wrapped in the tube top cover, the anti-pilling effect is achieved, when the tube top is cleaned, the rubber pad and the skin-friendly fabric can bear the rotating speed of a washing machine roller, the phenomenon that a tube top pad in the tube top falls off or is rubbed to pilling is avoided, meanwhile, the fitting comfort of the tube top is improved, and the service life of the tube top is prolonged. When the strapless suit and the brassiere wiping device are movably sleeved on the chest of the trying-on person through the shoulder strap buckles, the brassiere wiping device is attached to the strapless suit through the hook-and-loop fasteners, and the brassiere wiping device and the gauze brassiere wrap the chest of the trying-on person. And the brassiere wiping cover and the gauze brassiere are movably mounted on the tube top suit through the shoulder strap buckles.

This invention relates to the field of hydrogel electrode patch technology, and more particularly to a microstructured hydrogel patch and its preparation method, comprising a base layer, a conductive layer, and a hydrogel electrode layer stacked sequentially. The skin-contact surface of the hydrogel electrode layer is arrayed with micro-protrusions, each micro-protrusion having a micro-flared adsorption portion at its end, and an inward-curving portion at the end of the adsorption portion. A mesh-like breathing channel is provided between the micro-protrusions, and a breathable channel is axially opened on each micro-protrusion. A microporous one-way breathing valve communicating with the breathing and breathable channels is provided on the base layer. During preparation, the micro-protrusions and their end structures are formed using a mold, and the breathable channels are constructed. This invention enhances the adhesion between the patch and the skin through the micro-flared adsorption portion and the inward-curving portion, and combined with the breathable structure, improves breathability and wearing comfort, avoids skin allergies, and provides stable signal acquisition, making it suitable for long-term physiological signal monitoring.

The invention relates to the technical field of essence, and particularly discloses mild low-sensitivity essence of a child nursing product. The mild low-sensitivity essence of the child care product is prepared by compounding isopropyl myristate, ambrotone, o-tert-butyl cyclohexyl acetate, coconut aldehyde, virginia cedar oil, ethyl linalool, cyclamen aldehyde and convallaryl alcohol. The essence has the advantages that the essence is milder, and skin allergy of children is not easily caused.

The utility model discloses a navel patch, which comprises a navel patch body, an adhesive tape, a first adhesive tape and a second adhesive tape, and is characterized in that the navel patch body is provided with opposite inner and outer sides; the medicine core is arranged in the navel patch body, the medicine core is provided with a protruding part, the protruding part protrudes out of the inner side of the navel patch body, and the protruding part is attached to the navel of a user; and the protective cover is buckled on the navel patch body and covers the convex part of the medicine core. According to the utility model, the warm compress and the medicine core are integrally combined, so that the volatilization of the medicine effect is improved, and the product effect is improved; the protective cover prevents the medicine core from being squeezed in the transportation process and dirt caused in the packaging process, the medicine core is fixed by the breathable protective film, the protective film plays a role in fixing the medicine core and preventing the medicine core from moving, the problem that the medicine core is difficult to clean due to the fact that the medicine core falls into the navel hole is solved, and the breathable holes can effectively keep skin breathable and avoid skin allergy.

According to the titanium alloy, the spectacle frame and the 3D printing method of the titanium alloy, titanium alloy powder serves as a raw material, SLM printing forming is adopted, and the titanium alloy comprises metal I and metal II; the content of the metal I is 5-20%, the content of the metal II is 5-15%, and the balance is titanium and unremovable impurities; wherein the metal I is one or more of Cr, Pt, Zr and Mo, and the metal II is one or more of Ta, Nb, No, Re, Rh, Sc, Ho, Co and Ir. And toxic metals such as nickel, iron, aluminum and the like are not contained, so that skin allergy is not easily caused, and the manufacturing time and cost are saved.

The invention discloses an application of a composition of isoliquiritigenin (glycoside), licochalcone and ethnic groups thereof in personal care products, and relates to the technical field of daily chemicals, and the composition is an anti-allergy soothing composition prepared based on a natural plant licorice extract isoliquiritigenin or a glycoside compound isoliquiritigenin thereof, licochalcone A and ethnic groups of licochalcone B, C, D, E and G. The traditional Chinese medicine composition has multiple functions of resisting allergy, relieving, resisting bacteria, diminishing inflammation, improving skin itch and stabbing pain and the like, does not contain hormones and antibiotics, has no toxic or side effect, is mild in effect and non-irritant to skin, can be used for treating skin allergy, red and swollen skin, itch and stabbing pain caused by various reasons, is applied to cosmetics and skin care products, such as gel, cream, masks and facial cleansers, and can be used for treating skin allergy, red and swollen skin, pruritus and stabbing pain caused by various reasons. The skin care product is mild to human bodies, safe and non-irritant, is suitable for sensitive skin, is suitable for people of all ages to use, has strong market competitiveness, and has relatively high economic and social benefits and the like.

The invention provides a silk fibroin composition for injection and a preparation method thereof, and belongs to the technical field of medical cosmetology. The silk fibroin composition is prepared from the following components in percentage by mass: 0.1 to 0.7 weight percent of hyaluronic acid or salt thereof, 0.1 to 10 weight percent of silk fibroin and the balance of phosphate buffer solution. The silk fibroin composition is used for water-light injection, can promote collagen production and inhibit collagen fibrosis, does not have adverse reactions such as skin allergy, hardening and the like, and has the effects of quickly improving the dry state of skin, fading fine wrinkles or wrinkles, replenishing water, preserving moisture and tightening the skin.

A depilatory emulsion containing paclitaxel is made from the following raw materials: 10% to 20% of oil, 8% to 12% of humectant, 4% to 6% of auxiliary emulsifier, 4% to 6% of emulsifier, 8% to 12% of paclitaxel solution, 0.5% to 1.0% of preservative, 0.01% to 0.05% of mineral, 0.05% to 0.10% of fragrance essential oil, and water for balance. This depilatory emulsion is designed to allow the paclitaxel and other active depilatory components to be absorbed by hair follicles while preventing absorption into dermis, thereby achieving advantages of an effective depilation, safety, absence of odor, reduced risk of skin allergy, and suitability for continuous use. A preparation method of this depilatory emulsion employs stepwise cooling and gradual emulsification to ensure that all components are fully dispersed and uniformly distributed, forming a stable emulsion system, which has advantages of simple steps and good emulsion stability.

The invention provides a traditional Chinese medicine grinding and mixing device for treating child food skin allergy, and relates to the technical field of traditional Chinese medicine grinding and mixing devices, the traditional Chinese medicine grinding and mixing device comprises a grinding cavity, a sealing cover is arranged at the top end of the grinding cavity, and a discharging bin is arranged at the bottom end of the grinding cavity. According to the vacuum grinding device, traditional Chinese medicinal materials can be ground in a vacuum state by adopting the design of the vacuum closed grinding cavity, oxidation and pollution of the traditional Chinese medicinal materials in the grinding process are avoided, and therefore the purity of the traditional Chinese medicinal materials is kept, and meanwhile the grinding process can be observed in real time through the transparent observation window; in order to ensure that the medicines are not influenced by the external environment in the mixing process, the device also adopts a closed mixing cavity, so that the medicines are prevented from being polluted in the mixing process, and after grinding and mixing are completed, the device automatically exhausts and seals the medicines, so that the medicines are prevented from being affected with damp and deteriorated in the storage and use processes, and the purity and safety of traditional Chinese medicine preparation are improved; and the convenience of the medicine preparation process is also improved.

The utility model discloses a cooling patch for a skin surface, and relates to the technical field of patches. The cooling patch for the skin surface comprises elastic cloth, an adhesive, a refrigerating layer and a medicine layer, the adhesive is arranged on the inner side of the elastic cloth and arranged along the edge of the elastic cloth, the refrigerating layer is arranged on the inner side of the elastic cloth, the outer ring of the refrigerating layer abuts against the inner ring of the adhesive, and the medicine layer is arranged on the inner side of the refrigerating layer. According to the cooling patch for the skin surface, the cooling layer and the medicine layer are arranged, the effects of diminishing inflammation, relieving fever and easing pain can be achieved, meanwhile, the adhesive is arranged along the edge of the elastic cloth, the interference problem between the adhesive and the medicine layer is effectively avoided, the cooling patch for the skin surface does not need to be replaced for many times, and the cost is reduced. The problem of skin allergy is reduced.

The invention discloses indigowoad root indigo antibacterial solid soap and a preparation method thereof. The indigowoad root indigo antibacterial solid soap is prepared from the following components in parts by mass: 5-30 parts of indigowoad root powder, 1000-1100 parts of soap base and 36-40 parts of coconut oil. The invention relates to the technical field of daily chemicals. According to the indigo indigo antibacterial solid soap and the preparation method thereof, high-purity indigo indigo powder is specially extracted, and a low-temperature cold soap making method is adopted, so that decomposition of indigo indigo and indirubin under high temperature and strong alkali is greatly avoided, and high efficiency of antibacterial and anti-inflammatory biological activity is ensured; impurities in crude indigo naturalis are removed, the risk of skin allergy and friction is reduced, the compounded soap base also makes the soap foam fine and smooth, and the skin is moist and not tight after the soap is used.

The application provides a kind of image positioning sticker marking method based on iodine-gallium complex chelate, through chelation reaction to prepare excellent stability iodine-gallium complex developer, non-woven fabric substrate is modified by chitosan coating, combined with screen printing process to prepare high-precision positioning sticker, and establish standardized clinical marking process. The method uses iodine-gallium double element synergistic development mechanism, so that the CT value of the marking area is 350-400HU, the contrast of the surrounding tissue is improved by 40%, the development clarity retention rate is more than 92% after 48 hours of sticking, the positioning error is stable within 0.3mm, solves the pain points of traditional marking easy diffusion and poor adhesion. The application has excellent biocompatibility, the skin allergy rate is only 0.8%, the single patient positioning operation time is shortened to 5-10 minutes, the production cost is reduced by 40%, can be widely used in precise medical positioning scenes such as tumor radiotherapy and interventional surgery, has significant clinical popularization value.

The utility model belongs to the technical field of medical supplies, and particularly relates to a gypsum sock which comprises a gypsum sock body, the gypsum sock body is composed of an outer layer and an inner layer, a first protection pad, a second protection pad, a third protection pad, a supporting air bag, a pressure reduction pad and a supporting protruding strip are arranged between the outer layer and the inner layer, an air nozzle is arranged on the supporting air bag, and a pressure reduction pad is arranged on the pressure reduction pad. Due to the fact that the gypsum sock body is made of the pure cotton material which is moisture-absorbing, breathable and elastic, the comfort level of a patient when the gypsum sock is worn and used can be increased, and the phenomenon that the healthy skin of the patient makes direct contact with gypsum, and the skin allergy or the itching feeling or the dermabrasion phenomenon is likely to occur is prevented; due to the arrangement of the protection pads, the supporting air bags and the pressure reduction pads, the pressure can be relieved, and the risk that the limbs of the patient are pressed for a long time under gypsum fixation, and the skin is prone to pressure injury is avoided.

This invention belongs to the field of essential oil preparation technology, specifically relating to a method for preparing hypoallergenic agarwood essential oil and its application. The method involves desensitizing the raw agarwood essential oil obtained by supercritical carbon dioxide extraction. The desensitization process involves heating at low temperature followed by dissolution with water to remove the sensitizing components. The agarwood essential oil prepared by this method can reduce skin sensitization and irritation while retaining the main active ingredients of the agarwood essential oil.

The present application relates to the technical field of computational theoretical chemistry, and particularly relates to a preparation and optimization method of a long-acting moisture-permeable anti-allergic electrocardio electrode, which comprises the following steps: setting electrode-skin interface stability target parameters; calculating the binding energy strength of each candidate polymer material and the skin stratum corneum, and screening the candidate polymer material meeting the allergic reaction probability threshold; constructing a microporous structure model according to the chemical molecular structure of the candidate polymer material, adjusting the micropore gradient distribution parameters until the simulated sweat diffusion rate reaches the sweat diffusion rate threshold; performing dynamic impedance simulation, and when the detection does not reach the impedance decay rate threshold, re-triggering the adjustment of the micropore gradient distribution parameters; and generating and outputting the physical structure parameter set of the electrocardio electrode based on the micropore gradient distribution parameters and the microporous structure model. Through the present application, the problems of insufficient moisture permeability, electrical signal attenuation and skin allergy risk caused by the conflict between sweat diffusion and interface impedance during the material selection and preparation of the existing electrocardio electrode are effectively solved.

The present invention provides an instant soothing and calming composition and its application, wherein the instant soothing and calming composition comprises Sensysoothe, NEWAPLE, PLANT 21N and XYREPIOR. The present invention creatively finds that the four ingredients of Sensysoothe, NEWAPLE, PLANT 21N and XYREPIOR have synergistic effects in moisturizing, enhancing skin barrier, soothing and calming, can quickly soothe skin allergy problems, and can significantly increase the moisture content of skin keratin, reduce transepidermal water loss, enhance skin barrier, and effectively reduce adverse skin conditions such as redness, stinging, itching, burning, etc. caused by acute allergies.

The utility model relates to an infusion film for a remaining needle, and aims to solve the problems of the traditional film in the aspects of stability, air permeability, observation convenience, material waste and the like. The sticking film consists of a main sticking film and an extended sticking strip which are fixedly connected into a whole. An observation window groove is formed in the main pasting film, so that medical staff can directly observe the puncture part of a patient under the condition that the pasting film is not removed. The edge of the observation window groove is subjected to smooth treatment so as to reduce irritation to the skin of a patient. Both the main pasting film and the extension pasting strip are made of medical-grade non-woven fabrics or polyurethane materials with low sensitivity and good air permeability, so that the comfort level of a patient is improved, and the risk of skin allergy is reduced. Through the design of the pasting film, the stability is enhanced, the air permeability is improved, the effects of observation convenience and material saving are achieved, and safer, more comfortable and more efficient nursing service is provided for a patient.

The invention discloses a natural Chinese herbal medicine printing paste formula which is prepared from the following raw materials in parts by weight: 20-30 parts of Chinese herbal medicine powder, 30-50 parts of vegetable glue, 10-15 parts of animal glue, 5-10 parts of chitosan, 2-3 parts of citric acid, 3-5 parts of sodium chloride and the balance of water. The invention has the beneficial effects that the raw materials of the formula of the printing paste in the technical scheme are selected from natural, non-toxic and screened paste suitable for human skin to prepare the washable natural Chinese herbal medicine printing paste, and by applying the printing paste, the problem of skin allergy is effectively avoided, and meanwhile, the washable performance of a fabric is also improved; the printing ink is widely applicable to printing of various treatment and health care textiles in contact with skin.

The utility model relates to the technical field of medicine patches, and discloses an acupuncture point patch convenient to paste and tear, which comprises a positioning frame, a detachable frame is sleeved on the outer surface of the positioning frame, a handrail is inserted in the detachable frame, a tear film is arranged in the detachable frame, and the positioning frame, the detachable frame, the handrail and the tear film are arranged in the detachable frame. The acupuncture point patch is reasonable in structure, medicine in the fixing ring is heated by the heating layer through the breathable layer in the using process, the medicine is volatilized, the breathable layer enables the medicine to be volatilized and breathable, skin allergy caused by stuffiness at the application position due to the fact that the acupuncture point patch is not breathable is reduced, the connecting buckle is in butt joint with the snap fastener, the breathable layer is fixed, and the acupuncture point patch is convenient to use. The problem of displacement of the breathable layer in the using process is solved, the hollowed-out breathable plate is in butt joint and pasted through the pasting layer, the cleaning cloth is folded to be folded into the hollowed-out breathable plate, the cleaning cloth is folded to wipe the pasting position of the cleaning cloth, and the problem that the skin is allergic due to the fact that wiping is not in place is solved.

This information processing device comprises a processor, wherein the processor uses a plurality of determination models pertaining to different events among a plurality of events including an important event in an expression pathway of skin sensitization of a chemical substance and including an expression itself of skin sensitization, outputs a determination result of presence / absence of skin sensitization of the chemical substance from each of the determination models, and performs final determination of presence / absence of skin sensitization of the chemical substance on the basis of a plurality of determination results output from each of the determination models.

The invention discloses a skincare stem cell exosome separation and extraction method, and relates to the technical field of biological medicine, the skincare stem cell exosome separation and extraction method comprises the following steps: S1, culture of mixed stem cells: unfreezing urine-derived stem cells and pilose antler stem cells, resuspending in an improved DMEM culture medium, and carrying out mixed culture to prepare a mixed culture solution; epidermal growth factors, cholera toxin, penicillin, streptomycin, transferrin, IL-2 and IL-15 are added into the improved DMEM culture medium; s2, pretreatment of the mixed culture solution: performing centrifugal treatment on the mixed culture solution, and separating to obtain a precipitate and a supernatant, the precipitate being mixed stem cells. The urine-derived stem cells and the pilose antler stem cells are subjected to mixed culture and matched with the improved culture medium containing IL-2, IL-15 and other components, so that the yield and biological activity of the exosome are remarkably improved, high purity and low impurity protein residue of the exosome are achieved by means of a complete purification process of multi-step centrifugation, ultrafiltration concentration and filter membrane filtration, and the yield of the exosome is improved. The skin allergy stimulation risk is effectively reduced.