148 results about "Adrenoceptor agonist" patented technology

Methods and compositions for the treatment of conditions including ocular, stress-associated, and neurodegenerative conditions in a mammal using a composition which directly or indirectly stimulates alpha 2 adrenoreceptor agonist activity with a minimum of sedation or other side effects.

The present invention is directed to the treatment of skin erythema as exhibited in rosacea and other conditions characterized by increased erythema (redness) of the skin. These conditions exhibit dilation of blood vessels due to a cutaneous vascular hyper-reactivity. In particular, the present invention is directed to a novel composition and method for the treatment of skin erythema using α₁-adrenergic receptor (α₁-adrenoceptor) agonists incorporated into cosmetic, pharmacological or dermatological compositions for topical application to the skin.

The invention provides novel β₂ adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β₂ adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

Combination therapies of an alpha-2 adrenergic receptor agonist and an alpha-2 adrenergic receptor antagonist at a concentration effective to potentiate but not antagonize a therapeutic effect of the alpha-2 adrenergic receptor agonist are provided. Also provided are methods for use of these combination therapies in potentiating the therapeutic effects of alpha-2 adrenergic receptor agonists, inhibiting development of acute and/or chronic tolerance to alpha-2 adrenergic receptor agonists and treating conditions treatable by alpha-2 adrenergic receptor agonist therapy in a subject. In addition, a method for reversing alpha-2 adrenergic receptor agonist tolerance and/or restoring therapeutic effect of an alpha-2 adrenergic receptor agonist in a subject via administration of an alpha-2 adrenergic receptor antagonist at a concentration effective to potentiate, but not antagonize, the therapeutic effect of the alpha-2 adrenergic receptor agonist is provided.

This invention describes the use of beta-3-adrenoceptor agonists for the treatment of disorders associated with the prostate. These include disorders like those occurring in a prostatitis, where attributable to inflammatory processes or chronic irritation, or disorders like those associated with benign changes of the prostate. The invention is particularly suitable for the treatment of benign prostatic hyperplasia (BPH).

This invention describes a new combination for the treatment of functional bladder disorders which comprises an alpha antagonist and/or 5-alpha-reductase inhibitor and a beta-3-adrenoceptor agonist.

The invention discloses a Beta 2-adrenergic receptor stimulant detection method based on microfluidic chip; the detection system adopts laser detection; the detection system takes the microfluidic chip (1) as the core, and the microfluidic chip (1) is sequentially compounded through three-layer structure, including: the upper fluid pathway layer (101), a middle elastic film layer (102) and a lower pneumatic control layer (103); the relationship of the three parts includes that: the upper fluid pathway layer (101) and the lower pneumatic control layer (103) are tightly connected with the elastic film layer (102) through surface tension respectively between the two layers and the elastic film layer. The invention has the advantages of short detection time, low LOD, good repeatability, easy operation, less sample dosage and integration, also has great foreseeable scientific value and economic value.

A pharmaceutical composition useful in the treatment of functional bladder disorders comprising an antimuscarinic agent and a beta-3-adrenoceptor agonist is described.

In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the α2C adrenergic receptor agonists using such compounds or pharmaceutical compositions.

The invention discloses an immune colloidal gold detection card for phenylethanolamine A and a preparation method thereof, and relates to the technical field of detection of beta-epinephrine receptor stimulants. A test paper in a shell of a detection card consists of a polyvinyl chloride (PVC) rubber plate, a sample cushion, a colloidal gold combined cushion, a coating membrane and a water sucking cushion, wherein a colloidal gold membrane is a glass cellulose membrane containing a phenylethanolamine A monoclonal antibody; the coating membrane is a nitrocellulose membrane; a line T and a line C are arranged on the coating membrane; the line T coating is provided with a phenylethanolamine A protein conjugate; and the line C is coated with a goat-anti-mouse IgG antibody. The immune colloidal gold detection card is effectively used for rapidly detecting the phenylethanolamine A, so that the detection is convenient and quick, and the detection result is accurate.

The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.

This invention involves involves the use of compounds having the following structure:wherein:(a) R is unsubstituted C1-C3 alkanyl or alkenyl; and(b) R' is selected from hydrogen; unsubstituted C1-C3 alkanyl or alkenyl; unsubstituted C1-C3 alkylthio or alkoxy; hydroxy; thiol; cyano; and halo;for preventing or treating of disorders modulated by alpha-2 adrenoceptors.The subject invention also involves novel compounds and compositions.

The invention relates to combinations of an aminosugar and a beta-2-adrenoceptor agonist, such as salbutamol, for the treatment of diseases associated with hypersensivity and inflamation, in particular hypersensivity skin diseases. The aminosugar is preferably a monosaccharide derivative.

The present disclosure relates to crystalline monoapadisylate and/or heminapadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, and pharmaceutically acceptable solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the crystalline monoapadisylate and/or heminapadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, and to methods of treatment comprising these pharmaceutical compositions.

This invention relates to the use of beta-3-adrenoceptor agonists for the prevention and treatment of kidney damage and/or functional bladder complaints, particularly bladder complaints of neurogenic origin as the result of spinal cord injury.

The invention discloses a potentiometric sensing electrode for testing an adrenergic agonist and a sensor thereof. The sensing electrode comprises an electrode cable, a platinum electrode, an insulating sleeve, an electrode cap, a molecular imprinting membrane and a potential electrode solution; the platinum electrode is arranged in the insulating sleeve, and the electrode cable is drawn out from the upper end portion of the insulating sleeve; an end cap of the electrode cap is in an annular hollow structure, and an inner circle area on the inner side of the end cap is covered with the molecular imprinting membrane provided with a molecular imprinting pore structure; the outer side on the lower end portion of the insulating sleeve is closely sleeved with the electrode cap to fix the molecular imprinting membrane between the electrode cap and the insulating sleeve; and the potential electrode solution immersing at least the lower end of the platinum electrode is poured in the insulating sleeve. According to the potentiometric sensing electrode for detecting the adrenergic agonist and the sensor thereof, the potentiometric sensing electrode uses the molecular imprinting membrane with high peculiarity as a receptor of an electrochemical sensor and has the advantages that the test sensitivity is high, the operation is simple, the sensing electrode is convenient to carry, and the like, and field tests of adrenergic agonists are achieved.

The invention discloses a zilpaterol immune colloidal gold detection card and a preparation method thereof, and relates to the beta-epinephrine receptor agonist detection technical field. A test strip in an outer shell of the detection card is composed of a PVC rubber plate, a sample pad, a colloidal gold combined pad, a coating film and a water-absorbing pad; a colloidal gold film is a glass cellulose film containing a zilpaterol monoclonal antibody, and the coating film is a nitrocellulose film; a T line and a C line are arranged on the nitrocellulose film, the T line is coated with a zilpaterol-protein conjugate, and the C line is coated with a sheep anti-mouse IgG antibody. The detection card is effectively used for rapid detection of zilpaterol, is convenient and fast, and has accurate results.

Dry powder formulations for inhalation comprising a combination of an anticholinergic, a long-acting beta₂-adrenoceptor agonist, and a corticosteroid are useful for the prevention and/or treatment of inflammatory and/or obstructive airways diseases.

A compound of formula (I) or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof wherein R¹ is a group chosen from —CH₂OH and —NHC(O)H; R² is a hydrogen atom or R¹ together with R² form the group —NH—C(O)—CH═CH—, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R¹ and the carbon atom is bound to the carbon atom in the phenyl ring holding R²; R³ is chosen from a hydrogen atom, a halogen atom and groups chosen from —SO—R⁵, —SO₂—R⁵, —NH—CO—NH₂, —CO—NH₂, hydantoino, C_1-4alkyl, C_1-4alkoxy and —SO₂NR⁵R⁶; R⁴ is chosen from a hydrogen atom, a halogen atom and a C_1-4 alkyl group; R⁵ is chosen from a C_1-4 alkyl group and a C_3-8 cycloalkyl group; R⁶ is independently chosen from a hydrogen atom and a C_1-4 alkyl group; n, p and q are independently 0, 1, 2, 3 or 4; m and s are independently 0, 1, 2 or 3; and r is 0, 1 or 2 with the provisos that at least one of m and r is not 0, the sum n+m+p+q+r+s is 7, 8, 9, 10, 11, 12 or 13, and the sum q+r+s is 2, 3, 4, 5 or 6.

The invention discloses an electrochemical immunosensor capable of detecting various beta-adrenergic receptor stimulants (short for beta-stimulants). The sensor comprises a base electrode, a graphene/chitosan complex membrane and multi-determinant antigens of beta-stimulants, wherein the graphenee/chitosan complex membrane is modified on the surface of the base electrode, and the multi-determinant antigens of the beta-stimulants are fixed on the surface of the graphene/chitosan complex membrane. The multi-determinant antigens fixed on the surface of the sensor are salbutamol-ractopamine-BSA or salbutamol-ractopamine-OVA. The invention also provides an electrochemical immunodetection method for various beta-stimulant residues. The electrochemical immunosensor can be used for detecting six beta-stimulants including clenbuterol, salbutamol, ractopamine, terbutaline, mabuterol and tulobutezol through carrying out cross immune reaction on the beta-stimulants based on wide-spectrum specific antibodies of the beta-stimulants by taking K3[Fe(CN)6] as a probe.