37 results about "Obstructive pneumonia" patented technology

The invention discloses an atomized inhalant for treating respiratory system diseases. The atomized inhalant mainly prepared from, by mass, 1%-2% of 1,8-cineole, 1%-4% of solubilizers and 20%-90% of water. The inhalant is used through the steps that a medicine solution is atomized into small particles, and the small particles are inhaled into the nose, the throat, the respiratory tract and the lung, so that the medicine is deposited on the lesions to treat the diseases. The atomized inhalant for treating the respiratory system diseases treats patients who suffer from acute and chronic faucitis, rhinitis, asthma, obstructive (spastic) bronchitis, chronic bronchitis, bronchiectasia, mucoviscidosis, cysticfibrosis and chronic obstructive pneumonia and need to humidify the tracheae and dilute the sputum. The inhalant has the advantages that the effect is achieved quickly, the medicine using amount is little, use is convenient, and the safety is high.

The invention relates to the components and applications of a compound oral preparation containing antibacterial drugs. When a trace amount of an antibacterial drug is compounded with a drug for treating asthma and chronic obstructive pneumonia, a good effect will be generated. The curative effect is more prominent, when an antibacterial drug is compounded with a leukotriene acceptor antagonist to form an oral compound preparation.

The invention discloses a preparation method and application of a bulbus fritillariae cirrhosae extract. The method comprises the following steps: pulverizing bulbus fritillariae cirrhosae, soaking the bulbus fritillariae cirrhosae in an alcoholic solution overnight, carrying out continuous reflux extraction at 60-90 DEG C, collecting an extracted concentrated solution, removing a solvent to obtain a concentrated extract, and carrying out reduced-pressure vacuum drying to obtain the bulbus fritillariae cirrhosae extract. Alkaloids in the bulbus fritillariae cirrhosae extract comprise sipeimine, peiminine, peimine, edpetiline, peimine, peimisine, sinpeinine A, yibeinoside A and ebeiedinone. The bulbus fritillariae cirrhosae extract disclosed by the invention can be used as a medicine for treating chronic respiratory system diseases, including chronic obstructive pneumonia, chronic pharyngitis and pulmonary fibrosis, and can activate MAPKs and Nrf2 signal channels.

The invention relates to an inhalation preparation containing cephalosporin antibiotic and applications thereof. The cephalosporin antibiotic is made into an inhalation dosage form, and thus the preparation can treat pulmonary bacterial infection with less dosage and has a certain curative effect on asthma and chronic obstructive pneumonia.

The invention relates to a compound inhalation preparation containing cephalosporin antibiotic and glucocorticoid and applications thereof. The cephalosporin antibiotic is made into an inhalation dosage form, so that the preparation can treat pulmonary bacterial infection with less dosage form and has a certain curative effect on asthma and chronic obstructive pneumonia at the same time.

The invention relates to the components and applications of a compound inhalation preparation containing an antifungal drug. When a trace amount of an antifungal drug is compounded with a drug for treating asthma and chronic obstructive pneumonia, a good curative effect will be generated; and the curative effect is more prominent, when the antifungal drug is compounded with glucocorticoid and an anti-cholinergic agent.

The invention relates to a medicine tiotropium bromide olodaterol spray for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, trachitis and the like. An inhalable surfactant enables the spray particle size, spray time and spray speed of the composition to be more suitable by adjusting the surface tension of the tiotropium bromide olodaterol spray pharmaceutical composition without propellants.

The invention relates to a compound inhalation preparation containing penicillin antibiotic and glucocorticoid and applications thereof. The preparation is capable of treating pulmonary bacterial infection with less dosage and has a certain curative effect on asthma and chronic obstructive pneumonia. The preparation is made into an dry powder inhalation dosage form, after a long period of preservation, the content of allergic matters namely penicilloic acid and penicillenic acid is not increased, so that the happening rate of allergy is largely reduced, when the preparation is used to treat asthma caused by non-microbial infection and chronic obstructive pneumonia.

The invention relates to a PRDX2 antibody colloidal gold detection test strip for rapidly screening patients with chronic obstructive pneumonia in situ. The test strip PVC comprises a PVC bottom plateas well as a sample pad, a gold labeled pad, a chromatographic membrane and a sample absorption pad which are sequentially in lap joint with the PVC bottom plate; the sample pad comprises an adsorption layer, a filtering layer and a sample layer; the sample absorption pad comprises absorbent paper; and the lower surface of the absorbent paper is provided with a porous solid material layer. The PRDX2 antibody colloidal gold detection test strip for rapidly screening patients with chronic obstructive pneumonia in situ of the invention has the advantages of strong specificity and high sensitivity. According to the PRDX2 antibody colloidal gold detection test strip of the invention, widely applied and high-efficiency antigen-antibody binding reactions are adopted to perform detection, and therefore, the level of proteins in a blood sample can be accurately detected; and a high-quality monoclonal antigen and an antibody are combined so as to realize capture, so that the sensitivity of thenucleic acid detection test strip is greatly improved.

The invention relates to the technical field of medicaments, and particularly relates to an application of cobra venom in preparation of a medicament for treating chronic obstructive pulmonary disease. The cobra venom has an obvious treatment effect on chronic obstructive pneumonia induced by repeatedly contacting LPS (lipopolysaccharide) for a long term, and can effectively improve the pathological injury of lung tissues. The Chinese cobra venom not only can reduce the lung coefficient of a chronic obstructive pneumonia mouse, but also can effectively protect the lung tissues. The cobra venom not only can inhibit the degradation of IkB-alpha in the lung tissues of a sick mouse, but also can lower the expression of TGF-beta1. The cobra venom not only can reduce the TNF-alpha level, but also can reduce the level of an inflammatory factor IL-1.

The invention discloses an injection for treating diseases of a respiratory system. The injection is mainly prepared from 1,8-cineole. The injection is used for treating the diseases of the respiratory system such as acute and chronic faucitis, rhinitis, asthma, obstructive (spastic) bronchitis, acute and chronic bronchitis, bronchiectasis, mucoviscidosis, cysticfibrosis and chronic obstructive pneumonia. The injection has the advantages of becoming effective rapidly, being small in dosage and high in safety, and the like.

The invention discloses applications of 9-methyl-3,6-diacetylcarbazole in treating or preventing respiratory inflammatory diseases. The 9-methyl-3,6-diacetylcarbazole is used for the prevention and / oralleviation and / or adjuvant treatment and / or treatment of asthma and chronic obstructive pneumonia. The 9-methyl-3,6-diacetylcarbazole has a significant specific inhibitory effect on PI3Kgamma.

The invention relates to a compound inhalation preparation containing penicillin antibiotic and applications thereof. The preparation in an inhalation dosage form is capable of treating pulmonary bacterial infection with less dosage and has a certain curative effect on asthma and chronic obstructive pneumonia. The preparation is made into an dry powder inhalation dosage form, after a long period of preservation, the content of allergic matters namely penicilloic acid and penicillenic acid is not increased, so that the happening rate of allergy is largely reduced, when the preparation is used to treat asthma caused by non-microbial infection and chronic obstructive pneumonia.

The invention relates to a medicine tiotropium bromide spray for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, trachitis and the like. An inhalable surfactant enables the spray particle size, spray time and spray speed of the composition to be more suitable by adjusting the surface tension of the tiotropium bromide aerosol pharmaceutical composition without propellants.

The invention relates to a medicine tiotropium bromide spray for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, trachitis and the like. An inhalable surfactant enables the spray particle size, spray time and spray speed of the composition to be more suitable by adjusting the surface tension of a spray pharmaceutical composition of M1, M2 and / or M3 receptor anticholinergic drugs without propellants.

An in-depth study is performed on selaginella pulvinata extractives in the present invention, and it is found that the selaginella pulvinata extractives have a significant anti-inflammatory activity. Multiple column chromatography separation technologies and a semi-preparation high-performance liquid chromatography separation method are used to extract and separate a class of compounds (DZJB1-6) with a 9,9-diphenyl-1-(phenylethynyl)-9H-fluorene new skeleton structure, named as selaginpulvilinsA-F (structural formula (I)). The six compounds extracted and separated from selaginella pulvinata are subjected to structural modification, and then a series of compounds are obtained. These compounds can significantly inhibit the activity of type-4 phosphodiesterase (PDE4), and can be used for preparing PDE4 inhibitors, and treating asthma, chronic obstructive pneumonia, inflammations, and the like. According to the present invention, a new structure is provided for the development of PDE4 inhibitors.

The invention relates to a drug ipratropium bromide spray for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, trachitis and the like. An inhalable surfactant can makethe spray particle size, the spray time and the spray speed of the composition more suitable by adjusting the surface tension of the ipratropium bromide spray pharmaceutical composition without a propellant.

The invention relates to a medicinal tiotropium bromide olodaterol spray for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, trachitis and the like, wherein edetate isused for changing the surface tension of a medicinal composition which does not contain propellants and consists of tiotropium bromide or a hydrate thereof, olodaterol medicinal salt and water.

The invention belongs to the field of natural medicines, and in particular relates to a prescription of Tibetan Siwei Qingfei Mixture, which is the original medicine composed of rhododendron lanceolata, gentian flower, barberry bark and corydalis dwarf and an extract thereof. The research of the present invention has found that the combination of Rhododendron lanceolata, gentian flower, barberry bark and Corydalis dwarf can achieve synergy, effectively improve the anti-inflammatory effect, and improve the therapeutic effect of chronic obstructive pneumonia. In addition, It can also improve the repair function of lung injury.

The invention discloses a lung sound stethoscope for chronic obstructive pneumonia. The lung sound stethoscope comprises a sound transmission tube and a receiving part connected with the sound transmission tube, wherein two sound transmission rods which are arranged in a mutually bifurcated manner are arranged at the top of the sound transmission tube, a receiver part is arranged above each soundtransmission rod, and each receiver part comprises a first shell and an earplug arranged in the first shell, two jacks are arranged on the two sides of each earplug, and an earplug quick-change deviceis also arranged on each first shell. According to the invention, the earplugs can be rapidly replaced, and the sound transmission effect is prevented from being reduced due to earplug abrasion.

The invention relates to a formula composition containing phycocyanin peptide and application of the formula composition in improvement of chronic obstructive pneumonia, and belongs to the field of functional formula food. The composition is prepared from the following components in parts by weight: 22.6 to 42.6 g of phycocyanin peptide, 10 to 30 g of fat, 27 to 47 g of carbohydrate, 1.0 to 2.0 g of vitamin, 1.1 to 4.1 g of mineral substances and 0.1 to 0.5 g of auxiliary materials. The formula food is balanced in nutrition, can supplement high-quality nitrogen (protein) for patients with chronic obstructive pulmonary diseases, can effectively improve symptoms of chronic obstructive pulmonary diseases and inflammatory response of organisms, and improves lung functions.

The invention discloses the application of FGF10 in preparing reagents for diagnosing lung injury. The present invention is the first discovery that FGF10, especially the combination of FGF10, YKL-40 protein and AFP-L3, can be used as a diagnostic marker for the diagnosis of lung injury, especially chronic obstructive pneumonia, and can effectively improve the detection specificity of chronic obstructive pneumonia.

The invention relates to a drug ipratropium bromide for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, bronchitis and the like, the drug is the inhalable aerosol without a propellant, and the invention also relates to a preparation method of the drug.

The invention relates to a drug tiotropium bromide for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, bronchitis and the like, the drug is an inhalable aerosol, and the invention also relates to a preparation method of the drug.

The invention discloses an application of FGF10 in preparation of a lung injury diagnosis reagent. What is found for the first time is that the combination of FGF10, especially FGF10, YKL-40 protein and AFP-L3, can be used as a diagnostic marker for diagnosing lung injury, especially chronic obstructive pneumonia, and the detection specificity of chronic obstructive pneumonia can be effectively improved.

The invention belongs to the field of extraction technology of Ilex fringeii, discloses a kind of preparation method and use of Ilex fringeii total alkaloids, the method is:Take Ilex fringeii dried bulb and crush, sieve, 60 80% ethanol solution reflux extraction, filter, concentrate to dry paste;Use 1 3% HCl solution to dissolve, filter, filtrate is repeated on cation exchange resin;Sequentially eluted with deionized water and 50 70% NaCl ethanol solution, collect ethanol eluent and concentrate to dry paste;Add absolute ethanol, adjust pH to weak alkaline rear hot reflux extraction, filter the extract and be concentrated under reduced pressure to no alcohol taste;Add 1 3% HCl to dissolve completely, adjust pH to 8 9, repeatedly load over macroporous resin;Sequentially eluted with deionized water, ethanol solution of different volume concentrations;Collect target eluent decompression concentration, dry and obtain Ilex fringeii total alkaloid extract.Ilex fringeii total alkaloids of the present invention can be used for developing medicines for the treatment of chronic respiratory diseases, including: chronic obstructive pneumonia, chronic pharyngitis, pulmonary fibrosis.

The composition of Chinese medicine for curing chronic obstructive preumonia comprises 16 Chinese medicinal materials of bushy knotweed root, stir-fried peach kernel, sappan wood, notoginseng, carthamus flower, myrrh and others. Said Chinese medicine adopts the measures of removing blood stasis, discharging repletion heat and dispersing lung swelling to cure chronic obstructive pneumonia.

The invention relates to an annular gene-oriented paper micro-fluidic chip detection card for rapidly screening chronic obstructive pneumonia at an early stage and a test strip of the detection card.The detection card comprises an upper clamping cover and a lower clamping cover; the upper clamping cover is arranged on the lower clamping cover; a test strip groove is formed in the inner surface ofthe lower clamping cover; a test strip is arranged in the test strip groove; the test strip comprises a PVC bottom plate as well as a sample pad, a gold labeled pad, a nitrocellulose membrane and a sample absorption pad which are sequentially in lap joint with the PVC bottom plate. The test strip disclosed by the invention has the advantages of strong specificity and high sensitivity. According to the detection card and the test strip of the invention, widely applied and high-efficiency base complementation and compound binding reactions are adopted to perform detection, and therefore, the level of proteins in a blood sample can be accurately detected; and a high-quality gene probe and a compound are combined so as to realize capture, so that the sensitivity of the nucleic acid detectiontest strip is greatly improved.

The invention discloses applications of 9-methyl-3,6-diacetylcarbazole in treating or preventing respiratory inflammatory diseases. The 9-methyl-3,6-diacetylcarbazole is used for the prevention and / oralleviation and / or adjuvant treatment and / or treatment of asthma and chronic obstructive pneumonia. The 9-methyl-3,6-diacetylcarbazole has a significant specific inhibitory effect on PI3Kgamma.

The invention discloses a soft capsule for treating diseases of a respiratory system. The soft capsule is mainly prepared from 1,8-cineole, and the contained substance can contain vegetable oil with a certain ratio. The soft capsule is used for treating the diseases of the respiratory system such as acute and chronic faucitis, rhinitis, asthma, obstructive (spastic) bronchitis, acute and chronic bronchitis, bronchiectasis, mucoviscidosis, cysticfibrosis and chronic obstructive pneumonia. The soft capsule has the advantages of being obvious in curative effect, convenient to use, high in safety and the like.