Tiotropium bromide olodaterol spray containing surfactant
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Embodiment 1
[0033] Preparation method: uniformly mix tiotropium bromide or tiotropium bromide monohydrate, olodaterol medicinal salt with water whose pH value is adjusted with hydrochloric acid, and adjust the surface tension of the overall solution with an aqueous solution of an inhalable surfactant to the table below.
[0034] Pharmaceutical preparation of 100ml:
[0035]
[0036]
Embodiment 2
[0038] Preparation method: mix tiotropium bromide or tiotropium bromide monohydrate, olodaterol medicinal salt, antibacterial agent and water with hydrochloric acid to adjust the pH value, and use surfactant to adjust the surface tension of the aqueous solution to a lower surface.
[0039] Pharmaceutical preparation of 100ml:
[0040]
[0041]
[0042]
Embodiment 3
[0044] Preparation method: mix tiotropium bromide or tiotropium bromide monohydrate, olodaterol medicinal salt, antibacterial agent and water with hydrochloric acid to adjust the pH value, and use surfactant to adjust the surface tension of the aqueous solution to a lower surface.
[0045] Pharmaceutical preparation of 100ml:
[0046]
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