Tiotropium bromide olodaterol spray containing surfactant

Pending Publication Date: 2020-03-13
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the disadvantages of the latter relative to the former are: 1. Higher cost (due to internal pressure vessels, valve systems and special production equipment)
2 The propellant has a cooling effect, and repeated use on the injured skin wound can cause unsuitable irritation.
3 The propellant has ce

Method used

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  • Tiotropium bromide olodaterol spray containing surfactant
  • Tiotropium bromide olodaterol spray containing surfactant
  • Tiotropium bromide olodaterol spray containing surfactant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Preparation method: uniformly mix tiotropium bromide or tiotropium bromide monohydrate, olodaterol medicinal salt with water whose pH value is adjusted with hydrochloric acid, and adjust the surface tension of the overall solution with an aqueous solution of an inhalable surfactant to the table below.

[0034] Pharmaceutical preparation of 100ml:

[0035]

[0036]

Embodiment 2

[0038] Preparation method: mix tiotropium bromide or tiotropium bromide monohydrate, olodaterol medicinal salt, antibacterial agent and water with hydrochloric acid to adjust the pH value, and use surfactant to adjust the surface tension of the aqueous solution to a lower surface.

[0039] Pharmaceutical preparation of 100ml:

[0040]

[0041]

[0042]

Embodiment 3

[0044] Preparation method: mix tiotropium bromide or tiotropium bromide monohydrate, olodaterol medicinal salt, antibacterial agent and water with hydrochloric acid to adjust the pH value, and use surfactant to adjust the surface tension of the aqueous solution to a lower surface.

[0045] Pharmaceutical preparation of 100ml:

[0046]

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PUM

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Abstract

The invention relates to a medicine tiotropium bromide olodaterol spray for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, trachitis and the like. An inhalable surfactant enables the spray particle size, spray time and spray speed of the composition to be more suitable by adjusting the surface tension of the tiotropium bromide olodaterol spray pharmaceutical composition without propellants.

Description

Technical field: [0001] The present invention relates to the drug tiotropium bromide olodaterol spray for treating respiratory diseases, especially asthma, chronic obstructive pneumonia, bronchitis etc. The surface tension of the Datro spray pharmaceutical composition makes the spray particle size, spray time and spray speed of the composition more suitable. Background technique: [0002] Asthma is a chronic airway inflammation characterized by reversible airway obstruction and increased airway responsiveness. Airway obstruction is caused by two factors: increased secretions caused by bronchial mucosal inflammation, mucosal edema, and smooth muscle spasm stimulated by inflammation; while asthma Increased airway reactivity is also a result of damage to the bronchial epithelium due to airway inflammation. It is recognized that only by controlling the inflammation of the airway mucosa can the ultimate goal of reducing airway hyperresponsiveness and relieving asthma symptoms be...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K47/24A61K47/10A61K31/46A61K31/538A61P11/06A61P11/00
CPCA61K9/0078A61K9/12A61K47/24A61K47/10A61K31/46A61K31/538A61P11/06A61P11/00
Inventor 张杰孙亮
Owner TIANJIN JINYAO GRP
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