122 results about "Respiratory tract disorders" patented technology

The invention discloses a traditional Chinese medicine composition for treating respiratory tract haze disoperation and a preparation method, the composition comprises the following bulk drugs by weight: 10-30 g of balloonflower root, 1-15g of Zhejiang fritillaria bulb, 1-15g of grosvenor momordica fruit and 1-15g of licorice. The traditional Chinese medicine composition has the efficacy of dispersing lung Qi, lifting airway self-cleaning capability and eliminating harmful substances, in vitro and clinical verifies that the traditional Chinese medicine composition has the accurate curative effect for preventing and treating respiratory tract haze disoperation without toxic and side-effect. The above materials are ground to crude powder and packed in a tea bag, and brewed by boiled water, or water is used for immersing the bulk drugs for 20 minutes, the water decoction is carried out for 15 minutes, the above materials are filtered for drinking as tea, and auxiliary materials and a corrigent are cooperated, an oral liquid, a syrup, a capsule, a particulate agent, a tablet and effervescence particles which can be accepted on pharmacy are prepared directly or indirectly through conventional procedures, and the traditional Chinese medicine composition can be clinically used for treating or preventing the respiratory tract diseases caused by the haze disoperation.

Compounds of formula (I) and pharmaceutically acceptable salts thereof:wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

An inhalation device, assembly or system can include a kit and a pharmaceutical composition. The device can be adapted for administering therapeutic aerosols to pediatric patients, including neonates, infants or toddlers. The device can further include a vibrating mesh aerosol generator that can be insertable into a flow channel of the inhalation device through a lateral opening, and a valved face mask. The device can be connectable to a gas source through which a gas, such as oxygen, can be received into the flow channel at a low flow rate.

This invention relates to a sealed container containing a powder formulation comprising a dehydroepiandrosterone, its analogue(s) or salt(s) by itself or with a pharmaceutically or veterinarily acceptable carrier or diluent, and having a particle size of about 0.1 μm to about 100 μm. The formulation can be used to treat or prevent asthma, chronic obstructive pulmonary disease, lung inflammation, and other respiratory diseases or conditions. The formulation may be prepared by jet milling, and may be delivered through the respiratory tract or other routes using a nebulizer. The sealed container is provided in a device and / or a therapeutic kit.

The invention discloses a Tibetan medicine for treating chronic bronchitis and a preparation method thereof. The Tibetan medicine is composed of an active ingredient or the active ingredient and pharmaceutically acceptable additives, wherein the active ingredient is prepared from the following raw materials in a certain weight ratio: travertine, solms-laubachia pulcherrima, azalea, hypecoum erectum, sea buckthorn cream, alzheimer artemisia, sandwort, tinospora sinensis merr, eriophyton wallichii benth, radix phlomii and Tibetan lithospermum. The Tibetan medicine can be prepared into any common oral preparation. The Tibetan medicine provided by the invention has the functions of clearing away heat and toxic materials, eliminating swelling, stopping cough, activating qi and eliminating phlegm, and the Tibetan medicine is used for treating such respiratory diseases as acute and chronic bronchitis with infection.

The present invention provides the use of IFN-β, an agent that increases the expression of IFN-β, or a polynucleotide which is capable of expressing IFN-β or said agent for the manufacture of a medicament for the treatment of rhinovirus-induced exacerbation of a respiratory disease selected from asthma and chronic obstructive pulmonary disease, wherein said treatment is by airway delivery of said medicament, e.g. by use of an aerosol nebuliser. Also provided is IFN-λ for the same purpose.

The invention discloses an atomized inhalant for treating respiratory system diseases. The atomized inhalant mainly prepared from, by mass, 1%-2% of 1,8-cineole, 1%-4% of solubilizers and 20%-90% of water. The inhalant is used through the steps that a medicine solution is atomized into small particles, and the small particles are inhaled into the nose, the throat, the respiratory tract and the lung, so that the medicine is deposited on the lesions to treat the diseases. The atomized inhalant for treating the respiratory system diseases treats patients who suffer from acute and chronic faucitis, rhinitis, asthma, obstructive (spastic) bronchitis, chronic bronchitis, bronchiectasia, mucoviscidosis, cysticfibrosis and chronic obstructive pneumonia and need to humidify the tracheae and dilute the sputum. The inhalant has the advantages that the effect is achieved quickly, the medicine using amount is little, use is convenient, and the safety is high.

This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1 )antagonist; and a pharmaceuticalcomposition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.

The present invention relates to formulations containing extracts of Vaccinium myrtillus or other species rich in anthocyanosides, Punica granatum, Echinacea, and optionally Krameria triandra. Said formulations are useful in the treatment of disorders of the mouth and its adnexa, the throat and respiratory tract, and in the treatment of influenza.

The invention discloses meat sauce as well as a preparation method and application, and belongs to the technical field of food. Components of the meat sauce comprise large minced meat, fermented soyabeans, vegetable oil, soybean paste or broad bean sauce, oyster sauce, dark soy sauce, yellow wine, white vinegar, crystal sugar, white sesame seeds, peanut seeds, a spicy material (1), a spicy material (2), a spicy material (3), green onions, garlic, gingers and thin soup. The meat sauce disclosed by the invention is reasonable in nutrient arrangement, and the phenomenon of malnutrition caused byeating excessive meat sauce is avoided; due to reasonable selection of used materials and consumption of the soya beans and the spicy materials (1), (2) and (3), the meat sauce is warm in nature, haseffects of dispersing wind and relieving exterior syndrome, clearing heat and relieving fidgetiness, dissolving thrombosis, detoxicating, regulating the meridians, soothing the liver and regulating Qi, warming the stomach and dispelling cold, invigorating the stomach and promoting the digestion, eliminating delays and resolving phlegm, and moistening dryness of intestines to stop diarrhea, and isa protective agent for bronchitis or other respiratory tract disorders; the protective agent is natural and has an aromatic flavor, can increase a sense of appetite and has a natural and anti-corrosion effect; and moreover, symptoms such as excessive internal heat and hypogeusia caused by eating the meat sauce are avoided, so that an effect of food therapeutic health with dinner is achieved.

The invention discloses an amino acid drink which comprises the following components in percentage by mass: 0.2-2% of compound amino acid, wherein the compound amino acid consists of the following components in parts by mass: 7-9 parts of asparaginic acid, 6-8 parts of threonine, 2-4 parts of serine, 5-7 parts of glutamic acid, 7-9 parts of glycine, 7-9 parts of alanine, 1-2 parts of cystine, 4-6 parts of valine, 1-2 parts of methionine, 1-2 parts of isoleucine, 7-10 parts of leucine, 1-2 parts of tyrosine, 3-5 parts of phenylalanine, 4-6 parts of histidine, 5-7 parts of lysine, 3-5 parts of arginine and 3-5 parts of proline. The 17 amino acids are reasonably matched according to the diet structure of Chinese people, so that the 17 amino acids can be sufficiently absorbed by human bodies, the immunity of human bodies can be improved, the nutrition absorption property can be improved, sleep can be promoted, functions of intestines, stomachs and livers can be improved, diabetes and respiratory tract diseases can be treated, and heal of fracture wounds can be promoted.

Compounds expressed by the following general formula (1), [wherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1) to (1-5)]. The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.

The present invention provides the use of IFN-β, an agent that increases the expression of IFN-β, or a polynucleotide which is capable of expressing IFN-β or said agent for the manufacture of a medicament for the treatment of rhinovirus-induced exacerbation of a respiratory disease selected from asthma and chronic obstructive pulmonary disease, wherein said treatment is by airway delivery of said medicament, e.g. by use of an aerosol nebuliser. Also provided is IFN-λ for the same purpose.

The present invention relates to a method of medicine administration for respiratory tract and an apparatus for continuous medicine administration for respiratory tract. The present invention mainly utilize a respiratory tract medicine-administrated apparatus, which includes a medicine-storing chamber, which may be attached with an opening for filling in medicine, a medicine-administrated mechanism, which is connected to the medicine-storing chamber, and a medicine-exiting port, which is connected to the medicine-administrated mechanism. The medicine-administrated mechanism includes a pusher, an air intake, and a medicine-mixing chamber. In the most front end of the medicine-exiting port, there is an arrangement of nose-inserting portion of medicine-inhaling hole with opening shape. The interior of medicine-storing chamber may be filled with powder-like medicine, and a pusher with handgrip is inserted into one side portion of the medicine-storing chamber. The medicine-mixing chamber is connected to the pusher's trough. On the upper portion of the medicine-mixing chamber, there is an arrangement of air intake for introducing air. Wherein, the medicine storing chamber is already added with powder-like medicine, and the medicine is also dropped into the medicine-retrieving portion of the pusher, after the pusher is pushed back, the medicine will drop into the medicine-mixing chamber for proceeding mixing. By inserting the nose-inserting portion into the nostril and inhaled, the medicine is mixed with air, inhaled into the nostril through the medicine-inhaling hole, entering into human body, and adhered to the mucous membrane of the respiratory tract for effectively developing the effect of the medicine. With the respiratory tract medicine-administrated method of the present invention, the medicine will be directly inhaled into the respiratory tract and adhered onto the mucous membrane to optimize the treatment for the diseases of respiratory tract.

The invention relates to a traditional Chinese medicine patch for the prevention and early-stage curing of bronchial asthma, and the treatment of a plurality of respiratory diseases and megrims, characterized in that the traditional Chinese medicine patch comprises, based on the weight percentage, 57 to 70 % of peach seed, 12 to 25 % of cape jasmine, 6 to 8 % of almond, and 5 to 10% of pepper. The invention has the advantages that the traditional Chinese medicine patch is mainly used for treating bronchial asthma, can cure the bronchial asthma of children at the age of below 12, and can be used in the outbreaking or catabatic period. The traditional Chinese medicine patch has the efficacy of diminishing inflammation, invigorating blood circulation, removing blood stasis, clearing away cold, relieving cough and calming panting. The traditional Chinese medicine patch can promote the synthesis of the alveolar surfactant, protect the pulmonary function to improve the lesion tissues, and can stimulate the proliferation of blood vessel endothelial cells to restore the endangium. The traditional Chinese medicine patch has the antiallergic effect, can inhibit the antiserum reaction of allergic antibody of the skin, reduce the pigment seepage and alleviate the airway obstruction. The traditional Chinese medicine patch can enhance the proliferation and conversion of T lymphocyte of spleen of a body, and improve the autoimmunity.

The invention relates to an epidemic prevention respirator (mask) and an application method thereof. Harmful substances such as germs and particles in ambient air can be prevented from being inhaled by wearing the respirator, and particularly, respiratory diseases can be prevented. The respirator is composed of a mouth-nose mask device, a breathable air source device and an air guide pipeline, wherein the air guide pipeline connects the mouth-nose mask device and the breathable air source device; external air can only be introduced to the mouth-nose mask device from the air guide pipeline in aone-way mode through the air source device; air pumping equipment is arranged in the air source device for wearers to inhale easily; a plurality of sterilization and disinfection components and a filtering component are arranged in the air source device; an electronic temperature adjusting facility is arranged inside to maintain the long-term delivery of refreshing air; body temperature measuringand uploading components are arranged on the respirator and can monitor the body temperature characteristics of people in an administrative area via wireless network; and the mouth-nose mask device can open a movable window for the replacement of a melt-blown cloth, so that the mouth-nose mask device is convenient to sterilize. The epidemic prevention respirator is wide in application and high inpracticability, and also has the characteristics of being simple in production process, easy to industrialize and convenient to use.

Compounds of formula (I) described herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and / or treatment of diseases of the respiratory tract characterized by airway obstruction.

The invention discloses a medical atomizing treatment device. According to the medical atomizing treatment device disclosed by the invention, graduations are arranged on the side surface of a drug cup, and a piston is arranged in the drug cup and is sequentially connected with a telescopic rod and a rotating plug; and the position of the piston can be adjusted by the rotating plug and the telescopic rod. The position of the piston is adjusted according to the drug consumption, and a patient only needs to fill the drug cup every time without observing the liquid surface once again, so that theproblem that an old person charges drugs difficultly is solved. A two stage atomizing flow including rotational flow atomizing and spray head atomizing is set to prepare large granule fog drops, so that the treatment of upper respiratory diseases is realized; a three stage atomizing flow including rotational flow atomizing, collision atomizing and spray head atomizing is set to prepare microparticle fog drops, so that the treatment of lower respiratory diseases is realized; the three stage atomizing flow is adopted, so that the particle dimension of the fog drops can be effectively reduced, and microparticle fog drops can be prepared; and according to the type of the diseases, two atomizing flows can be chosen, the and targeting performance of disease treatment is clear. The medical atomizing treatment device disclosed by the invention has the characteristics of being quantitative in drug charging, simple and convenient in drug injection, friendly to the old people, clear in targetingperformance, and good in atomizing effects, the microparticle fog drops can be prepared, and the preparation manner of the fog drops can be chosen.

The invention belongs to the technical field of veterinary medicines, and specifically relates to a preparation method for compound tilmicosin enteric-coated granules. The preparation method sequentially comprises the steps of: preparing materials, mixing the materials, granulating, preparing a coating solution, coating and the like, wherein the raw materials of the granules are tilmicosin, colistin, gatifloxacin, a sweetening agent, a flavouring agent, bromhexine hydrochloride, oral glucose, corn starch, saccharose powder, dextrin, talcum powder and starch slurry; the raw materials of the coating solution are HPMC, Tween-80, polyethylene glycol 6000, talcum powder and ethanol. The method disclosed by the invention enables the tilmicosin effective ingredient not to be broken in gastric acid, and to safely arrive at intestinal tracts to be absorbed; the obtained compound tilmicosin enteric-coated granules are capable of preventing and treating respiratory diseases such as mycoplasma diseases, pleuropneumonia and swine plague, capable of reducing the occurrences of bacterial diseases such as diarrhoea and salmonellosis, and capable of increasing the feed conversion.

Disclosed is a respiratory system protecting mask. The respiratory system protecting mask is a nose-and-mouth covering bowl. The nose-and-mouth covering bowl is provided with an electric heating net, a medicament atomizer, a mini-type anion generator, an oxygen inhalation joint, a medicine gauze frame combination and the like which are arranged in a cylindrical surface type air inhaling passage. Under action of the respiratory system protecting mask filled with medicines, air inhaled in a human body contains various effective medicine atmosphere with a certain physicochemical function and constantly directly acts on a principal part, namely a mucosal surface of an organ wall of the body respiratory system. The mucosal surface of an organ wall is weakest, most susceptible and hard to cure according to conventional method. Thus a dedusting and sterilizing function is achieved to improve curative effect and antitoxic and disease prevention capacity of people to environment, prevent some respiratory diseases and improve living quality. With wide application of the auxiliary health protection device with high use frequency and standby degree, the respiratory system protecting mask serves as an antitoxic mask in emergency to win evacuating time, so that survival chance of victims in accidental fire scene can be increased.

A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and / or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising a β2-agonist bronchodilator for the treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases.

The invention discloses an odor rehabilitation training device for respiratory diseases and a matched traditional Chinese medicine bag. The odor rehabilitation training device comprises a device body,a telescopic pipe and a breathing apparatus, wherein an air inlet hole and a main air outlet hole are formed in a shell; a traditional Chinese medicine chamber, a filtering chamber, a second chamberand an air storage chamber are formed in the shell; the traditional Chinese medicine chamber comprises a traditional Chinese medicine bag applied to odor treatment of the respiratory diseases; filtercotton and a heating system are arranged in the filtering chamber; the heating system comprises an outer surface layer and carbon fibers; an air pump and a circuit board are arranged in the air storage chamber; an air vent and a controller are arranged on the circuit board; and the main air outlet hole is connected with the breathing apparatus by virtue of the telescopic pipe. The traditional Chinese medicine bag contains siberian cocklebur, menthol, radix angelicae, flos magnolia and centipeda minima; or ephedra, menthol, camphor, clove, centipeda minima and grassleaf sweelflag rhizome. According to the device disclosed by the invention, odor of the traditional Chinese medicine bag is introduced into the respiratory tract, so that the respiratory diseases such as headache, nasal obstruction, sneezing and running nose, wheezing and tightness in chest, ungratifying coughing of phlegm, dry cough with little phlegm and the like can be prevented and treated. Moreover, the traditional Chinese medicine bag is small in size, low in cost and convenient to carry.

The invention belongs to the technical field of pharmacy, particularly discloses a benzylpiperazine urea TRPV1 antagonistic and MOR agonistic double-target drug as well as a preparation method and application thereof, and particularly relates to a compound in a general formula (I) and pharmaceutically acceptable salts thereof, and the drug can be used for preventing and / or treating diseases related to TRPV1 and / or MOR activity, such as pain, inflammation, immune dysfunction, neurological and psychiatric disorders, respiratory diseases, urinary and reproductive disorders. the invention also relates to a preparation method of the compounds and a pharmaceutical preparation containing the compounds.

The invention provides application of a compound Haqing injection in preparation of an atomization and rectal administration preparation, and a preparation method thereof. The preparation can be a drug combination of the compound Haqing injection and one or more of ambroxol, budesonide, terbutaline, dexamethasone and salbutamol, is mainly used for atomization and rectal administration, and has an obvious curative effect on treatment of respiratory diseases such as upper respiratory infection, capillary bronchus and bronchitis.

The invention belongs to the technical field of medicine, and relates to a method for treating the phthisis and the respiratory disease by inhaling atomized purple garlic liquid, in particular to a method for treating the phthisis through the extracting solution of purple garlic (the purple garlic liquid) and an atomizer. The purple garlic liquid is extracted at the low temperature and is atomized by the atomizer into ultramicro particles with the diameter being about 0.2 micron, the atomized liquid can fully and evenly adhere to the pulmonary alveoli and the inner walls of the bronchi through the deep breathing and medicine feeding treatment, and due to the fact that the diameter of the atomized liquid is small, the atomized liquid permeates evenly and can reach the focal zone to carry out sterilization and take part in the lung blood microcirculation, and the active ingredient allisatin of the garlic liquid is conveyed along with the blood to kill and restrain bacteria. The method solves the problems that current common oral administration anti-phthisis western medicines are large in side effect and bad in medicine resistance and curative effect and injure the liver and kidneys. The method can be applied to the pneumology department to treat bronchitis, asthma, flu, sphagitis, rhinitis, nasosinusitis and other respiratory diseases besides the phthisis and pneumonia in the pulmonary medicine. The purple garlic liquid is a very good natural medicine, and the method is very good.

The present invention relates to a method and compounds of Formula (1) and / or (2) or their pharmaceutically acceptable inorganic or organic salt thereof, and their compositions for treating respiratory conditions including post viral / bacterial infections, acute / chronic bronchitis, COPD, cystic fibrosis, and inflammatory conditions. It has been found by the applicants that the compounds of Formula (1) and / or (2) or their pharmaceutically acceptable inorganic or organic salt thereof could speed up the recovery of the viability of damaged respiratory tract cells by restoring sialylglyco-conjugates on their surface.