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Preparation method for compound tilmicosin enteric-coated granules

A technology for tilmicosin and granules, which is applied in the field of preparation of compound tilmicosin enteric-coated granules, can solve the problems of low bioavailability, poor curative effect, and discomfort for group administration of pigs, and achieves improved palatability, The effect of increasing feed compensation

Active Publication Date: 2015-05-06
ZHENGZHOU DOURIN VETERINARY TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, injection administration is not suitable for group administration of pigs, so it is mainly administered orally, and tilmicosin is unstable in gastric acid, and its bioavailability is low, so the curative effect of drug mixing is usually not good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method of compound tilmicosin enteric-coated granules, comprising the following steps:

[0032] (1) Su granules are prepared according to the following weight ratio: 20 parts of tilmicosin, 20 parts of colistin, 50 parts of gatifloxacin, 10 parts of sweetener, 5 parts of flavoring agent, 6 parts of bromhexine hydrochloride, Oral glucose 55 servings 、 190 parts of corn starch, 100 parts of sucrose powder, 40 parts of dextrin, 3 parts of talcum powder, 85 parts of starch slurry;

[0033] (2) Mixing: Take the prepared tilmicosin, colistin, gatifloxacin, sweetener, flavoring agent and mix evenly, then add bromhexine hydrochloride, oral glucose and mix evenly, then add talcum powder, corn Mix starch, sucrose powder, and dextrin evenly, and pass through a 70-mesh sieve;

[0034] (3) Granulation: add the prepared soft material made of starch slurry for 12 minutes, pass through a 15-mesh sieve to granulate, then dry at 63°C, control the water content at 1-3wt%, ...

Embodiment 2

[0040] A preparation method of compound tilmicosin enteric-coated granules, comprising the following steps:

[0041] (1) Su granules are prepared according to the following weight ratio: 16 parts of tilmicosin, 16 parts of colistin, 45 parts of gatifloxacin, 8 parts of sweetener, 4 parts of flavoring agent, 5 parts of bromhexine hydrochloride, Oral glucose 50 servings 、 170 parts of corn starch, 90 parts of sucrose powder, 35 parts of dextrin, 2 parts of talcum powder, 70 parts of starch slurry;

[0042](2) Mixing: Take the prepared tilmicosin, colistin, gatifloxacin, sweetener, flavoring agent and mix evenly, then add bromhexine hydrochloride, oral glucose and mix evenly, then add talcum powder, corn Mix starch, sucrose powder, and dextrin evenly, and pass through a 80-mesh sieve;

[0043] (3) Granulation: add the prepared soft material made of starch slurry for 10 minutes, pass through a 14-mesh sieve to granulate, and then dry at 60°C, control the water content at 1-3wt%,...

Embodiment 3

[0049] A preparation method of compound tilmicosin enteric-coated granules, comprising the following steps:

[0050] (1) Su granules are prepared according to the following weight ratio: 24 parts of tilmicosin, 24 parts of colistin, 55 parts of gatifloxacin, 12 parts of sweetener, 6 parts of flavoring agent, 8 parts of bromhexine hydrochloride, Oral glucose 60 servings 、 210 parts of corn starch, 110 parts of sucrose powder, 45 parts of dextrin, 4 parts of talcum powder, 100 parts of starch slurry;

[0051] (2) Mixing: Take the prepared tilmicosin, colistin, gatifloxacin, sweetener, flavoring agent and mix evenly, then add bromhexine hydrochloride, oral glucose and mix evenly, then add talcum powder, corn Mix starch, sucrose powder, and dextrin evenly, and pass through a 60-mesh sieve;

[0052] (3) Granulation: add the prepared soft material made of starch slurry for 15 minutes, pass through a 16-mesh sieve to granulate, then dry at 65°C, control the water content at 1-3wt%,...

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Abstract

The invention belongs to the technical field of veterinary medicines, and specifically relates to a preparation method for compound tilmicosin enteric-coated granules. The preparation method sequentially comprises the steps of: preparing materials, mixing the materials, granulating, preparing a coating solution, coating and the like, wherein the raw materials of the granules are tilmicosin, colistin, gatifloxacin, a sweetening agent, a flavouring agent, bromhexine hydrochloride, oral glucose, corn starch, saccharose powder, dextrin, talcum powder and starch slurry; the raw materials of the coating solution are HPMC, Tween-80, polyethylene glycol 6000, talcum powder and ethanol. The method disclosed by the invention enables the tilmicosin effective ingredient not to be broken in gastric acid, and to safely arrive at intestinal tracts to be absorbed; the obtained compound tilmicosin enteric-coated granules are capable of preventing and treating respiratory diseases such as mycoplasma diseases, pleuropneumonia and swine plague, capable of reducing the occurrences of bacterial diseases such as diarrhoea and salmonellosis, and capable of increasing the feed conversion.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a preparation method of compound tilmicosin enteric-coated granules. Background technique [0002] Tilmicosin is a semi-synthesized macrolide antibiotic for livestock and poultry from a hydrolyzate of tylosin, and its phosphate is used in medicine. Pharmacokinetics: Oral administration and subcutaneous injection are quickly absorbed, but not completely. After taking it, the apparent distribution solvent is large, and the drug concentration in the lung tissue is high; it has good tissue penetration, can quickly and completely enter the breast from the blood, the drug concentration in the milk is high, the maintenance time is long, and the half-life in the milk is long. Up to 1 to 2 days. Pharmacological effects: It has inhibitory effect on Gram-positive bacteria, some Gram-negative bacteria, mycoplasma, spirochete, etc.; it has stronger antibacterial acti...

Claims

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Application Information

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IPC IPC(8): A61K31/706A61K9/16A61P31/04A61P11/00A61K31/496A61K31/137
Inventor 胡功政王燕李德明张志祥
Owner ZHENGZHOU DOURIN VETERINARY TECH
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