84results about How to "Reduce degeneration" patented technology

Airway disorders in a horse are relieved by electrical stimulation of the airway tissue. Particular disorders and techniques include electrical stimulation to relieve laryngeal hemiplegia. A pacemaker processor generates an electrical treatment signal to be applied to upper airway tissue of the horse for treating the upper airway disorder. One or more stimulation electrodes interfaces with the upper airway tissue for delivering the treatment signal to the upper airway tissue.

In one embodiment, a spinal orthosis includes a shoulder unit comprising a left shoulder portion and a right shoulder portion, a retracting device, a first connector connected to the left shoulder portion at a first end of the first connector and connected to the retracting device at a second end of the first connector, a second connector connected to the right shoulder portion at a first end of the second connector and connected to the retracting device at a second end of the second connector, and a lumbosacral belt attached to the retracting device, the lumbosacral belt being able to be secured to a body.

Compounds that reduce serum retinol, serum RBP, and / or serum retinol-RBP levels may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.

A neuroprotective pharmacological method in cerebral ischemic insult comprising administration of L- or DL-threo-DOPS or a pharmaceutically acceptable acid addition salt thereof to a patient. Threo-DOPS directly acts on neurons to exert an effect to protect against neuronal death due to brain ischemia, an antilethal effect, and an anti-edema effect due to excessive polarization of neuronal membrane potential caused by an increase in Na-K-ATPase activity. renaline.

The invention discloses a medical planted osteochondral prosthesis system which comprises a metal base and an articular surface, wherein the metal base adopts a metal with mechanical intensity; the articular surface adopts an ultra-high molecular weight polyethylene or ceramic alloy with a low friction coefficient. After being planted, the medical planted osteochondral prosthesis system disclosed by the invention can take an effect of replacing osteochondral coloboma, plays functions of the articular cartilage, can delay abrasion of the articular surface and degeneration of the proximate articular surface, delays or prevents osteoarthritis, can replace the functions of the normal articular cartilage, rebuilds a strong subchondral bone support and achieves effects of delaying or stopping articular degeneration and alleviating symptoms. The medical planted osteochondral prosthesis system has a simple structure and is safe and convenient to use.

The antioxidant eye drops is a topical ophthalmic formulation that contains four nutraceuticals (namely, astaxanthin, resveratrol, pyruvate and epigallocatechin gallate (EGCG)) having antioxidant, anti-inflammatory, and chelating activity in a carbomer gel carrier. The active ingredients can reduce oxidative stress through free radical scavenging and chelating activity. The carrier is composed of a solution of deionized water containing about 0.4% Carbopol 980 NF, 5.7% sorbitol. 0.01% cetrimide, 0.01% EDTA, and sodium chloride and sodium hydroxide in adequate amounts to adjust both the viscosity and the pH of the topical carrier to pH 7.0-7.4. Use of the formulation may delay the development of cataracts, reduce retinal degeneration, and maintain normal tear flow in dry eye due to the antioxidant, anti-inflammatory, and chelating activity of the active ingredients.

The invention relates to a preparation method and application of cartilage targeting double-drug-loaded nano-microspheres with the optical thermal response characteristic. According to thecartilage targeting double-drug-loaded nano-microspheres with the optical thermal response characteristic, small-particle-size mesoporous polydopamine is used as a matrix, the matrix is sequentially subjected toa cyclic reaction with FeCl3. 6H2O and H3BTC, and the surface of the mesoporous polydopamine is modified to form a metal organic framework. After the synthesized MPDA-MOF (referred to as MPM hereinafter) nano-microspheres react with EDC and NHS solution, carboxyl groups on the surface of MOF are activated, and by connection with amino groups in type II collagen targeting peptide (WYRGRL), composite nano-microspheres (MPMW) of which surfaces are loaded with a cartilage targeting peptide are formed. Double factors of bilirubin (Br) and rapamycin (Rap) are correspondingly loaded in pore passagesof an MOF shell layer and the mesoporous polydopamine, and finally, the RB@MPMW is obtained. The nano-microspheres have the advantages of high optical thermal response characteristic, good biocompatibility, active cartilage targeting, delay on in-vivo cartilage degeneration and the like, and can be used for the targeted therapy of osteoarthritis cartilage degeneration.

A pad for protecting animals transported in vehicles includes a cushioned base portion arranged to be laid flat onto a support surface of the vehicle such that the first portion has a top surface. The pad can also have a cushioned rear portion arranged to be positioned adjacent to the base portion at an angle to the base portion such that the second portion has a front surface. The top and front surfaces are preferably covered by a vinyl covered fabric composite material. The base and rear portions can be contiguously connected along a fold line.

A method of preparing isolated body tissue (10) for cryogenic storage, the method comprising a step of actively infusing the body tissue (10) with a cryoprotectant (20). Additionally, a kit for preparing umbilical cord tissue (10) for cryogenic storage, comprising a cryoprotectant (20) and infusion means (22) for actively infusing the umbilical cord tissue (10) with the cryoprotectant (20).

The invention provides an oral liquid for treating osteoporosis, which is prepared from the following raw materials in weight ratio: 12 to 15 portions of epimedium, 15 to 20 portions of prepared rehmannia rhizome, 15 to 20 portions of Astragalus membranaceus, 15 to 20 portions of eucommia barks, 20 to 30 portions of Psoralea corylifolia, 20 to 30 portions of Davallia mariesii and proper water. The invention uses six traditional Chinese medicines, namely the epimedium, the prepared rehmannia rhizome, the Astragalus membranaceus, the eucommia barks, the Psoralea corylifolia, and the Davallia mariesii, for treating osteoporosis. The oral liquid mainly has the functions of invigorating the liver and the kidney, strengthening the muscles and bones and promoting blood circulation and stopping pain.

A memory alloy artificial cervical intervertebral disc comprises an artificial intervertebral disc body and a support plate sleeved with the artificial intervertebral disc body, wherein the artificial intervertebral disc body has conicity; drop preventing reverse stings are distributed on the upper and lower surfaces of the artificial intervertebral disc body; fixed branches are arranged at the two sides of the upper and lower surfaces; and drop preventing pawls are respectively arranged at the two ends at the inner side of each fixed branch. The intervertebral disc has simple process and shape, is easy to deform and insert, is stable in installation after complex, is convenient to use in operation, is secure and reliable in fixation, maintains the cervical vertebra motion range, reduces adjacent vertebral body complications, not only shortens the operation time and simplifies the operation, but also dispenses with bone removal and grafting, reduces more pains of the patient, maintains or increases the motion range of the vertebral articulations with lesions to some extent, avoids load of the adjacent vertebral articulations from increasing after fusion and fixation of the vertebral articulations with lesions, slows down degeneration of the adjacent vertebral articulations and realizes the aims of maintaining the movement functions and delaying and reducing secondary degeneration of the adjacent segments.

The invention provides an artificial vertebra. The artificial vertebra comprises an upper connector, a lower connector and a supporting portion. The supporting portion is connected with the upper connector and the lower connector and comprises a body and an adjustment portion, adjustability in connection between the adjustment portion and the body enables length adjustability of the supporting portion, and the body and the adjustment portion are connected with the upper connector and the lower connector respectively. The upper connector and the lower connector of the artificial vertebra are used for being connected with two vertically adjacent vertebrae in a human skeleton, and due to length adjustability of the supporting portion, the artificial vertebra can adapt to different users to highly fit original vertebrae. In addition, since the distance between the upper connector and the lower connector is adjustable, the artificial vertebra can be connected with vertebrae of a human body more accurately, connection failure caused by stress concentration at a fixed position is avoided, and reliability and fitting degree in connection of the artificial vertebra and the human body can be improved.

The invention discloses a vertebral pedicle screw, comprising a screw tail and a screw body, a spherical mortar cup is arranged on the screw tail, a spherical mortar body is arranged at the rear end of the screw body, the mortar body is arranged in the mortar cup and is matched with the mortar cup in a sliding way, and a limit part for limiting the screw body is arranged at the front end of the screw tail; by adopting the vertebral pedicle screw, a patient has better physiological function, and regression of the corresponding intervertebral disk of an operation section and the adjacent intervertebral disk is reduced to the maximum extent, so as to improve the short-term and long-term operative effect; in addition, the vertebral pedicle screw has low manufacturing cost and strong popularity.

Erythropoietin (Epo), a member of the cytokine superfamily, is a pluripotent molecule that is involved in a number of signal transduction pathways that include the stimulation of the production of red blood cells and the protection of the central nervous system from acute injury and ischemia. The invention is the discovery of Epo and the Epo receptor in the peripheral nervous system where it can act as a neuroprotective agent. The invention is also a method of use for the treatment of neuropathic pain and to increase the rate of healing from nerve injury comprising administration of Epo.

The invention provides a method for preparing an hBMSCs / hyaline cartilage particle / calcium alginate gel compound. According to the method, the hBMSCs / hyaline cartilage particle / calcium alginate gel compound is prepared by using hyaline cartilage particles having a size of 0.125mm<3> after inducing culture is carried out on hBMSCs and is used for repairing defects on the cartilage surface, a strong subchondral bone support can be reconstructed, a complete and smooth articular cartilage surface can be recovered, the trabecular space of the subchondral bone can be filled, and seamless connection can be formed with adjacent defects. Due to the existence of the hyaline cartilage particles, partial normal-simulated cartilage extracellular matrix and partial normal cartilage cells can be formed in the repaired tissue, so that the reconstruction process can be accelerated, the repaired tissue strength on the surface can be enhanced, double effects can be achieved by adopting hBMSCs, and abrasion of the joint surface and regression near the joint surface can be retarded.

The invention provides a nonmetallic implant screw locking structure which is simple in structure, novel in design, simple to produce and very convenient to clinically operate. The nonmetallic implantscrew locking structure is applicable to traumatic bone plates, spinal fusion cages, spinal fixing plates, cervical posterior single-opening door plates, cervical posterior plates, lumbar anterior plates, lumbosacral plates and other nonmetallic implants, and good economic and social benefits can be created gradually.

The invention discloses a bionic type hydraulic artificial vertebral body design for spinal physiological function reconstruction. The bionic type hydraulic artificial vertebral body comprises a main cylindrical artificial vertebral body with a core structure, wherein the inner part of the core structure contains pistons (13 and 14) and hydraulic bags (10 and 11). An upper end plate (24) and a lower end plate (25), which are matched with semielliptical (spherical) motion shafts (21 and 22) in structure, are arranged at two ends of each piston. The end plates of the artificial vertebral body are normal adjacent vertebral end plate flats (cemented fixation) or fixed stings (31 and 32) with metal millipores and biological material coating millipores (biological type fixation), and the rear edge of the vertebral body can be further fixedly arranged at a pedicle of vertebral arch through card slots (40 and 41) of the fixed structure of a pedicle of vertebral arch staple bolt (45). The vertebral body design can be further shrunk as a hydraulic artificial intervertebral disc design (60).

The invention belongs to the technical field of new applications of drugs, and particularly relates to an application of aspirin in preparation of drugs for treating IVDD (intervertebral disc degeneration). An intervertebral disc degeneration model is constructed by applying LPS (lipopolysaccharide)-induced oxidative stress, the therapeutic effect of aspirin on IVDD is observed, and the therapeutic effect of Aspirin on IVDD is evaluated by observing oxidative stress and various indexes of IVDD. Western blot demonstrates the brief mechanism of Aspirin in reducing oxidative stress and alleviating IVDD. IVDD is caused by oxidative stress in intervertebral disc nucleus pulposus tissue, Aspirin delays IVDD by inhibiting the oxidative stress in the nucleus pulposus tissue and further reducing decomposition of cell matrix and type II collagen, so that a new approach is provided for prevention and treatment of IVDD.

The invention discloses an externally used medicament for treating bone fracture which is prepared from raw materials of native copper, drynaria, dipsacus root, Garter snake, wood louse, frankincense, mulberry bark, mimosa-tree bark and Cinnamomum cassia by a predetermined weight proportions.

The invention relates to an anti-aging and life-increasing beverage with effect of restoring youthful energy. the beverage is made from the following traditional Chinese medicines in proportions by weight: ginseng, honeysuckle flower, Cynomorium, Chinese date, spine date seeds, semen boitae, honey, hawthorn fruit, dark plum, dogwood, medlar, mulberry fruit, longan, Chinese magnoliavine fruit, radix astragali, Eucommia barks, herba cistanche, Chinese dodder seeds, dangshen, raspberry fruit and five-leaf Gynostemma herbs. The anti-aging and life-increasing beverage with the effect of restoring youthful energy is free of chemicals, sugar or additives, is a pure natural drink, and integrates the effects of enhancing physical fitness, protecting against aging, restoring youthful energy, preventing and treating diseases and improving health.

The invention discloses an aconite extract injection for treating osteoarthritis as well as a preparation method and application of the aconite extract injection, and belongs to the technical field of traditional Chinese medicine production. The preparation method comprises the steps: weighing radix aconiti and radix aconiti kusnezoffii as raw materials, adding uniformly mixed medicine powder into an alcohol solution, performing sealed soaking, transferring into a high-pressure reaction kettle, performing pressurized extraction, performing depressurization, performing filtering, separating medicine liquid from a filter residue, adding 8-10 volume times of water into the filter residue, performing uniform mixing, transferring into the high-pressure reaction kettle, performing pressurized extraction, concentrating the two medicine liquids until no alcohol odor exists, performing filtering, adding absolute alcohol to allow the alcohol content to reach 75%, performing standing overnight, performing filtering, concentrating the medicine liquid until no alcohol odor exists, performing dilution with injection water to be 10 times, and performing encapsulation and sterilization to obtain the aconite extract injection. The aconite extract injection has the significant influence on MMP-3, ADAMTS, IL-1 beta, IL-18, TNF-alpha and the like, and is confirmed to have a protective effect on chondrocyte damage caused by arthritis.

Provided are compositions and methods for the treatment of Krabbe and other neurodegenerative diseases, including storage diseases such as GM1 gangliosidosis, Niemann-Pick disease, Tay-Sachs disease, Sandhoff disease, metachromatic leukodystrophy, Canavan disease, Pelizaeus-Merzbacher disease, and storage conditions facilitated by aging of lysosomal functions, which are associated with psychosine (and / or other storage material)-mediated axonal degeneration. Compositions and methods employ (1) one or more inhibitor of a phos-photransferase activity of one or more kinase(s) such as, for example, CDK5, P38, jnk, src, CK2, PKC, GSK3α and β; (2) one or more inhibitor of a phosphotransferase activity of one or more phosphatase(s) such as, for example, the Ser / Thr protein phosphatase PP1 and Tyr protein phosphatase PP2; one or more inhibitor of a caspase / calpain activity of one or more caspases such as caspase 3 and calpains such as calpain 1 and 2; and (4) one or more inhibitor of a sodium / calcium exchange protein such as, for example, NCX1. Inhibitors include small molecules, including the GSK3β inhibitor L803 and the NCX1 inhibitor flecainide, and siRNA molecules that downmodulate cellular levels of one or more mRNA, including siRNA that are capable of downmodulating the cellular expression of PP1. Inhibitors disclosed can cross the blood-brain barrier and, thus, are available to the central nervous system (CNS) and effective in reducing psychosine-mediated axonal degeneration.

The invention discloses sustained release aspirin liposome hydrogel and a preparation method as well as application of the sustained release aspirin liposome hydrogel in preparing a medicine for treating recurrent lumbar disc herniation after discectomy. The sustained release aspirin liposome hydrogel comprises aspirin, lipidosome and gelatin methylacryloyl hydrogel; the effect and a possible mechanism of treating intervertebral disc degeneration caused by fiber ring defect by the sustained release aspirin liposome hydrogel are proved through observation of structural characteristics and mechanical characteristics of the sustained release aspirin liposome hydrogel and tests of the influence of an in vitro material on the inflammation of nucleus pulposus cells and in vivo rabbit fiber ring defect modeling; ASP-Lip+GelMA is proved to show excellent performance in the aspect of filling rabbit partial fiber ring defect part, maintaining the mechanical stability and controlling local inflammation and provides a new treatment prospect for preventing the recurrent lumbar disc herniation after partial discectomy.

In one embodiment, a spinal orthosis includes a shoulder unit comprising a left shoulder portion and a right shoulder portion, a retracting device, a first connector connected to the left shoulder portion at a first end of the first connector and connected to the retracting device at a second end of the first connector, a second connector connected to the right shoulder portion at a first end of the second connector and connected to the retracting device at a second end of the second connector, and a lumbosacral belt attached to the retracting device, the lumbosacral belt being able to be secured to a body.

The invention discloses a tenon-and-mortise type artificial vertebrae, which comprises an upper connecting body, a lower connecting body and at least one support body, wherein the upper connecting body and the lower connecting body are in a center symmetry state; the at least one support body is arranged between the two connecting bodies; the connecting bodies and the support body, and the adjacent support bodies are in tenon-and-mortise connection. The invention provides an artificial vertebrae of a tenon-and-mortise structure; the stability is high; different quantity of support components can be selected according to requirements of different users; the proper length is formed; better matching is realized with the original vertebrae bone; the connection failure due to stress concentration in a fixed position is avoided; the matching degree of the artificial vertebrae and the human body and the reliability are improved; the load on the human body vertebrae bone can be reduced; the occurrence of complications of human body vertebrae section regression and the like can be reduced.

The invention discloses a traditional Chinese medicinal composition with a hair cultivating function. The traditional Chinese medicinal composition with the hair cultivating function is mainly prepared from 1 to 10 parts of radix et rhizoma ginseng, 1 to 10 parts of herba gynostemmatis pentaphylli, 1 to 10 parts of cacumen platycladi, 1 to 10 parts of semen sesami nigri, 1 to 10 parts of radix polygoni multiflori, 1 to 10 parts of folium mori, 1 to 10 parts of Chinese angelica, 1 to 10 parts of radix rehmanniae, 1 to 10 parts of fructus ligustri lucidi and 1 to 10 parts of radix stemona tuberosae. When the traditional Chinese medicinal composition is used for nursing hair, the nutrients of the hair can be increased; the blood circulation and the immunity of a head skin are improved; the formation of the apoptosis and the retrogression of horn of a hair follicle in a growth period is reduced; the hair is promoted to grow and develop; the hair follicle is promoted to grow; the growth period of the hair is prolonged.

The invention discloses healthy food and drug composition for improving cartilage metabolic disorder diseases, and relates to the technical field of drugs. The healthy food and drug composition is prepared from the following components: polypeptide glucosamine chondroitin, calcium L-threonate, ethanol extract and glucosamine sulfate, wherein main components of the polypeptide glucosamine chondroitin comprise glucosamine sulfate, chondroitin sulfate, soybean peptide powder, radix puerariae powder, calcium carbonate, microcrystalline cellulose and magnesium stearate, and glucosamine sulfate is prepared from chitin as a raw material. The healthy food and drug composition for improving the cartilage metabolic disorder diseases not only can realize the effects of common inflammation diminishingand pain relieving and has no side effects, but also can further improve drug absorption by human cartilage on the basis of human immunity improvement, so that the problem of low drug absorption ratecaused by cartilage metabolic disorder can be solved to a certain extent, and a good physiotherapy effect on the human cartilage can be realized.

A memory alloy artificial cervical intervertebral disc comprises an artificial intervertebral disc body and a support plate sleeved with the artificial intervertebral disc body, wherein the artificial intervertebral disc body has conicity; drop preventing reverse stings are distributed on the upper and lower surfaces of the artificial intervertebral disc body; fixed branches are arranged at the two sides of the upper and lower surfaces; and drop preventing pawls are respectively arranged at the two ends at the inner side of each fixed branch. The intervertebral disc has simple process and shape, is easy to deform and insert, is stable in installation after complex, is convenient to use in operation, is secure and reliable in fixation, maintains the cervical vertebra motion range, reduces adjacent vertebral body complications, not only shortens the operation time and simplifies the operation, but also dispenses with bone removal and grafting, reduces more pains of the patient, maintains or increases the motion range of the vertebral articulations with lesions to some extent, avoids load of the adjacent vertebral articulations from increasing after fusion and fixation of the vertebral articulations with lesions, slows down degeneration of the adjacent vertebral articulations and realizes the aims of maintaining the movement functions and delaying and reducing secondary degeneration of the adjacent segments.