83results about How to "Reduce degeneration" patented technology

Airway disorders in a horse are relieved by electrical stimulation of the airway tissue. Particular disorders and techniques include electrical stimulation to relieve laryngeal hemiplegia. A pacemaker processor generates an electrical treatment signal to be applied to upper airway tissue of the horse for treating the upper airway disorder. One or more stimulation electrodes interfaces with the upper airway tissue for delivering the treatment signal to the upper airway tissue.

A neuroprotective pharmacological method in cerebral ischemic insult comprising administration of L- or DL-threo-DOPS or a pharmaceutically acceptable acid addition salt thereof to a patient. Threo-DOPS directly acts on neurons to exert an effect to protect against neuronal death due to brain ischemia, an antilethal effect, and an anti-edema effect due to excessive polarization of neuronal membrane potential caused by an increase in Na-K-ATPase activity. renaline.

The invention discloses a medical planted osteochondral prosthesis system which comprises a metal base and an articular surface, wherein the metal base adopts a metal with mechanical intensity; the articular surface adopts an ultra-high molecular weight polyethylene or ceramic alloy with a low friction coefficient. After being planted, the medical planted osteochondral prosthesis system disclosed by the invention can take an effect of replacing osteochondral coloboma, plays functions of the articular cartilage, can delay abrasion of the articular surface and degeneration of the proximate articular surface, delays or prevents osteoarthritis, can replace the functions of the normal articular cartilage, rebuilds a strong subchondral bone support and achieves effects of delaying or stopping articular degeneration and alleviating symptoms. The medical planted osteochondral prosthesis system has a simple structure and is safe and convenient to use.

A pad for protecting animals transported in vehicles includes a cushioned base portion arranged to be laid flat onto a support surface of the vehicle such that the first portion has a top surface. The pad can also have a cushioned rear portion arranged to be positioned adjacent to the base portion at an angle to the base portion such that the second portion has a front surface. The top and front surfaces are preferably covered by a vinyl covered fabric composite material. The base and rear portions can be contiguously connected along a fold line.

A memory alloy artificial cervical intervertebral disc comprises an artificial intervertebral disc body and a support plate sleeved with the artificial intervertebral disc body, wherein the artificial intervertebral disc body has conicity; drop preventing reverse stings are distributed on the upper and lower surfaces of the artificial intervertebral disc body; fixed branches are arranged at the two sides of the upper and lower surfaces; and drop preventing pawls are respectively arranged at the two ends at the inner side of each fixed branch. The intervertebral disc has simple process and shape, is easy to deform and insert, is stable in installation after complex, is convenient to use in operation, is secure and reliable in fixation, maintains the cervical vertebra motion range, reduces adjacent vertebral body complications, not only shortens the operation time and simplifies the operation, but also dispenses with bone removal and grafting, reduces more pains of the patient, maintains or increases the motion range of the vertebral articulations with lesions to some extent, avoids load of the adjacent vertebral articulations from increasing after fusion and fixation of the vertebral articulations with lesions, slows down degeneration of the adjacent vertebral articulations and realizes the aims of maintaining the movement functions and delaying and reducing secondary degeneration of the adjacent segments.

The invention discloses a vertebral pedicle screw, comprising a screw tail and a screw body, a spherical mortar cup is arranged on the screw tail, a spherical mortar body is arranged at the rear end of the screw body, the mortar body is arranged in the mortar cup and is matched with the mortar cup in a sliding way, and a limit part for limiting the screw body is arranged at the front end of the screw tail; by adopting the vertebral pedicle screw, a patient has better physiological function, and regression of the corresponding intervertebral disk of an operation section and the adjacent intervertebral disk is reduced to the maximum extent, so as to improve the short-term and long-term operative effect; in addition, the vertebral pedicle screw has low manufacturing cost and strong popularity.

Erythropoietin (Epo), a member of the cytokine superfamily, is a pluripotent molecule that is involved in a number of signal transduction pathways that include the stimulation of the production of red blood cells and the protection of the central nervous system from acute injury and ischemia. The invention is the discovery of Epo and the Epo receptor in the peripheral nervous system where it can act as a neuroprotective agent. The invention is also a method of use for the treatment of neuropathic pain and to increase the rate of healing from nerve injury comprising administration of Epo.

The invention belongs to the technical field of new applications of drugs, and particularly relates to an application of aspirin in preparation of drugs for treating IVDD (intervertebral disc degeneration). An intervertebral disc degeneration model is constructed by applying LPS (lipopolysaccharide)-induced oxidative stress, the therapeutic effect of aspirin on IVDD is observed, and the therapeutic effect of Aspirin on IVDD is evaluated by observing oxidative stress and various indexes of IVDD. Western blot demonstrates the brief mechanism of Aspirin in reducing oxidative stress and alleviating IVDD. IVDD is caused by oxidative stress in intervertebral disc nucleus pulposus tissue, Aspirin delays IVDD by inhibiting the oxidative stress in the nucleus pulposus tissue and further reducing decomposition of cell matrix and type II collagen, so that a new approach is provided for prevention and treatment of IVDD.

The invention discloses an aconite extract injection for treating osteoarthritis as well as a preparation method and application of the aconite extract injection, and belongs to the technical field of traditional Chinese medicine production. The preparation method comprises the steps: weighing radix aconiti and radix aconiti kusnezoffii as raw materials, adding uniformly mixed medicine powder into an alcohol solution, performing sealed soaking, transferring into a high-pressure reaction kettle, performing pressurized extraction, performing depressurization, performing filtering, separating medicine liquid from a filter residue, adding 8-10 volume times of water into the filter residue, performing uniform mixing, transferring into the high-pressure reaction kettle, performing pressurized extraction, concentrating the two medicine liquids until no alcohol odor exists, performing filtering, adding absolute alcohol to allow the alcohol content to reach 75%, performing standing overnight, performing filtering, concentrating the medicine liquid until no alcohol odor exists, performing dilution with injection water to be 10 times, and performing encapsulation and sterilization to obtain the aconite extract injection. The aconite extract injection has the significant influence on MMP-3, ADAMTS, IL-1 beta, IL-18, TNF-alpha and the like, and is confirmed to have a protective effect on chondrocyte damage caused by arthritis.

Provided are compositions and methods for the treatment of Krabbe and other neurodegenerative diseases, including storage diseases such as GM1 gangliosidosis, Niemann-Pick disease, Tay-Sachs disease, Sandhoff disease, metachromatic leukodystrophy, Canavan disease, Pelizaeus-Merzbacher disease, and storage conditions facilitated by aging of lysosomal functions, which are associated with psychosine (and/or other storage material)-mediated axonal degeneration. Compositions and methods employ (1) one or more inhibitor of a phos-photransferase activity of one or more kinase(s) such as, for example, CDK5, P38, jnk, src, CK2, PKC, GSK3α and β; (2) one or more inhibitor of a phosphotransferase activity of one or more phosphatase(s) such as, for example, the Ser/Thr protein phosphatase PP1 and Tyr protein phosphatase PP2; one or more inhibitor of a caspase/calpain activity of one or more caspases such as caspase 3 and calpains such as calpain 1 and 2; and (4) one or more inhibitor of a sodium/calcium exchange protein such as, for example, NCX1. Inhibitors include small molecules, including the GSK3β inhibitor L803 and the NCX1 inhibitor flecainide, and siRNA molecules that downmodulate cellular levels of one or more mRNA, including siRNA that are capable of downmodulating the cellular expression of PP1. Inhibitors disclosed can cross the blood-brain barrier and, thus, are available to the central nervous system (CNS) and effective in reducing psychosine-mediated axonal degeneration.

The invention discloses sustained release aspirin liposome hydrogel and a preparation method as well as application of the sustained release aspirin liposome hydrogel in preparing a medicine for treating recurrent lumbar disc herniation after discectomy. The sustained release aspirin liposome hydrogel comprises aspirin, lipidosome and gelatin methylacryloyl hydrogel; the effect and a possible mechanism of treating intervertebral disc degeneration caused by fiber ring defect by the sustained release aspirin liposome hydrogel are proved through observation of structural characteristics and mechanical characteristics of the sustained release aspirin liposome hydrogel and tests of the influence of an in vitro material on the inflammation of nucleus pulposus cells and in vivo rabbit fiber ring defect modeling; ASP-Lip+GelMA is proved to show excellent performance in the aspect of filling rabbit partial fiber ring defect part, maintaining the mechanical stability and controlling local inflammation and provides a new treatment prospect for preventing the recurrent lumbar disc herniation after partial discectomy.

In one embodiment, a spinal orthosis includes a shoulder unit comprising a left shoulder portion and a right shoulder portion, a retracting device, a first connector connected to the left shoulder portion at a first end of the first connector and connected to the retracting device at a second end of the first connector, a second connector connected to the right shoulder portion at a first end of the second connector and connected to the retracting device at a second end of the second connector, and a lumbosacral belt attached to the retracting device, the lumbosacral belt being able to be secured to a body.

The invention discloses a traditional Chinese medicinal composition with a hair cultivating function. The traditional Chinese medicinal composition with the hair cultivating function is mainly prepared from 1 to 10 parts of radix et rhizoma ginseng, 1 to 10 parts of herba gynostemmatis pentaphylli, 1 to 10 parts of cacumen platycladi, 1 to 10 parts of semen sesami nigri, 1 to 10 parts of radix polygoni multiflori, 1 to 10 parts of folium mori, 1 to 10 parts of Chinese angelica, 1 to 10 parts of radix rehmanniae, 1 to 10 parts of fructus ligustri lucidi and 1 to 10 parts of radix stemona tuberosae. When the traditional Chinese medicinal composition is used for nursing hair, the nutrients of the hair can be increased; the blood circulation and the immunity of a head skin are improved; the formation of the apoptosis and the retrogression of horn of a hair follicle in a growth period is reduced; the hair is promoted to grow and develop; the hair follicle is promoted to grow; the growth period of the hair is prolonged.

The present invention provides a method whereby a drug can be conveniently injected into the living body, without sticking a needle, from a device that is not in contact with the living body, and a device therefor. Specifically provided is a method for injecting a peptide drug such as insulin, and a device therefor. No special consumables are needed except the drug solution or suspension. The method and device comprise injecting a drug into the living body by electrospraying a solution or suspension of the drug from a nozzle to which high voltage is applied and which is not in contact with the living body.