18 results about "Abnormal blood vessels" patented technology

The invention provides an application of USP7 (ubiquitin-specific protease 7) as a target spot in preparation of drugs for treating vascular abnormal leakage diseases, and relates to the technical field of biomedicine, USP7 (ubiquitin-specific protease 7) as a deubiquitination enzyme not only regulates tumor, nerve and immune related diseases, but also is closely related to vascular endothelial cell functions. In the vascular homeostasis, the USP7 can maintain the integrity of a vascular barrier and inhibit pathological leakage by stabilizing endothelial connexin such as VE-cadherin and beta-catenin; under the inflammation or hypoxia condition, through deubiquitination of HIF-1alpha or NF-kappa B pathway components (such as I kappa B alpha), vascular endothelial cell activation can be promoted, VEGF signal-driven abnormal angiogenesis or release of inflammatory factors can be aggravated, and diabetic retinopathy, tumor vascular hyperplasia and sepsis-related vascular leakage can be participated. According to the application, verification experiments prove that USP7 has a certain protection effect on vascular permeability, and a treatment strategy is provided for vascular abnormal leakage diseases clinically.

This invention relates to a method for segmenting and analyzing angiographic images of ischemic cerebrovascular diseases. It detects abnormal grayscale transitions, structural breaks, and artifact delay signals in angiographic images, extracts negative prior points indicating suspected ischemic areas, aggregates them to form prior abnormal regions, introduces a symmetric perturbation testing mechanism to determine potential occluded or abnormal vascular segments, and dynamically adjusts the segmentation threshold of the region. A local interference window is established within the determined region, and the frequency and rhythmic features of density stripes are extracted. Through the scaling strategy of the convolution kernel, discontinuous vascular segments caused by non-steady-state pulse changes are compensated for segmentation. Texture difference and frequency domain response offset are calculated. If the offset is within a preset physiological tolerance range, an interpolation completion mechanism is triggered to generate a reliable completion layer for subsequent calibration reference. By analyzing the multipath divergence degree of the vascular branch endpoints and the path offset changes in the image sequence, the previously segmented paths are dynamically adjusted and their continuity is calibrated.

This invention provides an antibody fusion protein comprising a binding construct that targets and is capable of binding to Ang-2, IL-6 receptors, and at least one VEGF family member; or an antigen-binding fragment or domain of the antibody fusion protein. The antibody fusion protein comprises an antibody or binding peptide against Ang-2, an antibody against IL-6R, and multiple extracellular domains of the VEGF receptor as binding components. The antibody fusion protein is suitable for treating or controlling ocular or systemic diseases, symptoms, or conditions caused by abnormal angiogenesis, increased vascular leakage, or inflammation.

The invention discloses a special AI auxiliary device for fundus blood vessel anomaly detection, which comprises a base, a system terminal, a stand column, a lifting assembly, an anti-blink assembly, a sliding assembly, a cleaning assembly and a pressure assembly, and is characterized in that the system terminal is fixedly mounted on the base. Through an anti-blink assembly, after two curved groove blocks slide to the two ends of a hyperbolic rod respectively, a patient attaches the eyebrow bone to a gap in the hyperbolic rod, wears an elastic strap on the head, attaches an air support to the jaw through a lifting assembly, and then screws a second lead screw to enable a trapezoidal block to slide backwards, at the moment, the cambered surface of the support block descends along the inclined surface of the trapezoidal block, and the air support is fixed to the upper portion of the hyperbolic rod. When the head of a patient descends along with the air support, the double curved bars keep the eyelids at the eyebrow bones still, the downward movement of the head and the fixation of the double curved bars form relative displacement, so that the upper eyelids are stably pulled up, the eyelids are kept at the eye opening amplitude, the upper eyelids are prevented from naturally drooping or reflexively closing, and imaging missing or blurring caused by blinking and eyelid drooping is avoided; and the AI detection data is ensured to be complete and effective.

The application provides a blood vessel center line correction method and device, a storage medium and equipment. The method is applied to the technical field of blood vessel center line extraction. The method obtains an abnormal blood vessel mask area in a target blood vessel based on a blood vessel reconstruction view of the target blood vessel, performs abnormal type determination based on morphological features of the abnormal blood vessel mask area, and then corrects the abnormal center line of the abnormal blood vessel mask area based on a corresponding correction strategy. After the initial center line extraction of the blood vessel, the method increases the blood vessel abnormality determination process, assigns different correction strategies to different abnormal types, and corrects the abnormal center line caused by the blood vessel abnormality in a targeted manner, thereby improving the efficiency of the center line correction and the accuracy of the center line extraction.

The invention relates to the technical field of biological medicine, in particular to ureido indolone compounds and a preparation method and application thereof. Compared with the prior art, the ureido indolone compound provided by the invention has the advantages that the activity of VEGFR, PDGFR and / or FGFR can be effectively inhibited, signal transduction of VEGF, PDGF and / or FGF is blocked, and systemic neovascularization (abnormal vascular hyperplasia) related diseases are treated.

The present invention discloses compounds according to Formula I:wherein R1, R2a, W, X1, X2, Y and Z are as defined herein.The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and / or treatment of inflammatory diseases, autoinflammatory diseases, autoimmune diseases, proliferative diseases, fibrotic diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation, diseases involving impairment of bone turnover, diseases associated with hypersecretion of IL-6, diseases associated with hypersecretion of TNFα, interferons, IL-12 and / or IL-23, respiratory diseases, endocrine and / or metabolic diseases, cardiovascular diseases, dermatological diseases, and / or abnormal angiogenesis associated diseases by administering the compound of the invention.

The invention relates to the technical field of preparation of targeted nanoparticles and gel materials, and discloses a nanoparticle hydrogel spray containing targeted NRP1 as well as a preparation method and application of the nanoparticle hydrogel spray, the nanoparticle is of a core-shell structure, polydopamine is taken as a carrier material, the core is obtained by connecting Tat-C-RP7 and PDA-NPs through a Schiff base reaction, and the shell is ZIF8. The preparation method of the hydrogel spray comprises the following steps: step 1, synthesis of nanoparticles: synthesizing PDA-TCR7-ZIF8-NPs by a three-step method; and step 2, preparation of hydrogel spray: resuspending the PDA-TCR7-ZIF8-NPs in a beta-sodium glycerophosphate solution, and uniformly mixing and stirring the PDA-TCR7-ZIF8-CS (at) GP hydrogel solution with a chitosan solution under an ice-water bath condition, so as to obtain a PDA-TCR7-ZIF8-CS (at) GP hydrogel solution. The nano hydrogel can accurately target NRP1, and can reduce the scar area by 60% and the skin thickness from 1.8 mm to 1.1 mm in animal experiments aiming at the key vascular abnormality generation and fibrosis mechanism for scar formation, and can improve the scar color and flatness.

The invention relates to temperature-sensitive hydrogel and a preparation method thereof, and belongs to the technical field of temperature-sensitive hydrogel. The preparation method of the thermo-sensitive hydrogel comprises the following steps: carrying out hydroxyl protection on hydroxybutyl chitosan, carrying out hydroxylation modification on amino sites, grafting a chain transfer agent by using the modified hydroxyl, carrying out graft copolymerization on a wet adhesive functional monomer with a phenolic hydroxyl protective agent by using the chain transfer agent, and finally removing a hydrophobic end group of the chain transfer agent to obtain the thermo-sensitive hydrogel. The temperature-sensitive hydrogel with excellent adhesiveness, injectability and temperature-sensitive characteristic is obtained by adding the hydrogel, the phenolic hydroxyl protective agent and the hydroxyl protective agent, the material can effectively block abnormal blood vessels after being injected into a human body, and due to the good wet-state adhesion performance and embolism performance, the temperature-sensitive hydrogel can be used for blocking the abnormal blood vessels. The probability that residual fragments are formed due to blood flow impact in the blood vessel embolism process and the probability that blood vessels are re-opened due to blood flow impact after embolism can be effectively reduced.

The present invention achieves: a compound having lysine demethylase 3A inhibitory activity; a lysine demethylase 3A inhibitor containing the compound; and a therapeutic or prophylactic agent for abnormal angiogenesis containing the lysine demethylase 3A inhibitor. An azide-alkyne conjugate having a specific structure is used as an active ingredient of the lysine demethylase 3A inhibitor, or the therapeutic or prophylactic agent for abnormal angiogenesis.

Systems and methods are disclosed herein for providing guidance and feedback during an operation during a vascular intervention by Doppler ultrasound during the operation on one or more distal peripheral vessels affected by the vascular intervention. In accordance with various exemplary embodiments, Doppler ultrasound is performed during operation to detect flow characteristic changes and / or abnormal vascular flow characteristics of the interventional-affected peripheral vascular system, such as detection of adverse vascular events. The detected blood flow characteristic changes are communicated during operation to guide and / or assist in clinical decisions, and / or are used to automatically send control signals to interrupt or adjust treatment. In other embodiments, guidance and / or feedback during the operation is automatically provided during the neuromodulation operation via Doppler ultrasound of one or more peripheral vessels whose blood flow is modulated by the neuromodulation operation, and the neuromodulation device may be optionally controlled based on detected changes in blood flow.

The present invention discloses compounds according to Formula (I) wherein X1, X2, Y, R1, L1, R 2, R 3, Cy and the subscript n are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and / or treatment of inflammatory diseases, autoinflammatory diseases, autoimmune diseases, proliferative diseases, fibrotic diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformation, diseases involving impairment of bone turnover, diseases associated with hypersecretion of IL-6, diseases associated with hypersecretion of TNFα, interferons, IL-12, IL-17 and / or IL-23, respiratory diseases, endocrine diseases, metabolic diseases, cardiovascular diseases, dermatological diseases, and / or abnormal angiogenesis associated diseases by administering a compound of the invention.

This application discloses a multispecific fusion protein comprising a binding construct that targets and is capable of binding to at least one of DLL4 and VEGF family members; or an antigen-binding fragment or domain thereof. This application also discloses a multispecific fusion protein comprising an antibody against DLL4 or an antigen-binding fragment thereof, multiple extracellular domains of the VEGF receptor or an antibody against at least one VEGF family member or an antigen-binding fragment thereof, and an antibody or binding peptide against Ang-2. The multispecific fusion protein can be used to treat or control ocular or systemic diseases, conditions, or disorders caused by abnormal angiogenesis, increased vascular leakage, inflammation, fibrosis, or combinations thereof.

The invention provides a blood vessel deformity degree evaluation method based on confocal endoscope imaging hemodynamic parameters, and relates to the technical field of artificial intelligence medical treatment, the method comprises two stages: imaging stable stage screening: collecting a blood vessel examination video through a confocal laser microendoscope; screening out image stable fragments in the blood vessel examination video according to dynamic change and velocity dynamics characteristics of red blood cells in the blood vessel; and malformation blood vessel evaluation: performing video frame extraction processing on the image stable segment to obtain multiple frames of images, analyzing the blood vessel malformation condition in each frame of image in combination with haemodynamic parameters and blood vessel morphology, labeling the blood vessel malformation segment, quantifying the malformation degree of the blood vessel malformation segment, and evaluating the blood vessel malformation. According to the method provided by the invention, the blood vessel abnormality is evaluated by combining the hemodynamic parameters and the blood vessel morphology, and the efficiency and accuracy of blood vessel abnormality detection can be effectively improved.

The invention relates to the technical field of biological medicine, in particular to a quinoline indolone compound and a preparation method and application thereof. The quinoline indolone compound has the advantages that the quinoline indolone compound provided by the invention can be used for treating diseases caused by abnormal vascular hyperplasia.

The invention discloses a skull CT (Computed Tomography) plain scanning image processing method, a skull CT plain scanning image processing platform and a storage medium. Comprising the following steps: acquiring and preprocessing a skull CT plain-scan image scanned by hospital image equipment for a target object to obtain a to-be-processed CT plain-scan image; inputting the CT plain scanning image to be processed into a pre-trained segmentation model, and outputting the midline position of the brain, each brain region in the left brain image and the right brain image, and cerebrospinal fluid regions existing in each brain region; calculating the brain purified water uptake amount of each brain region and the volume of the cerebrospinal fluid region to obtain the brain purified water uptake amount of each brain region in the left brain image and the right brain image and the volume of the cerebrospinal fluid region in the left brain image and the right brain image; and according to the midline position, the brain purified water intake and the volume, marking an abnormal region and an abnormal blood vessel in the CT plain scanning image to be processed, and outputting a marked image. According to the invention, the image processing platform automatically processes the skull CT plain scan image, marks the abnormal area and the responsible blood vessel, and outputs the marked image.

Systems and methods are disclosed for providing intraprocedural guidance and feedback during a vascular intervention via intraprocedural Doppler ultrasound performed on one more distal peripheral vessels impacted by the vascular intervention. According to various example embodiments, intraprocedural Doppler ultrasound is performed to detect the changes in flow characteristics and / or anomalous vascular flow signatures of the peripheral vasculature impacted by the intervention, such as the detection of an adverse vascular event. The detected changes in flow characteristics are intraprocedurally communicated to guide and / or assist clinical decision making, and / or employed to autonomously send control signals to interrupt or modify treatment. In other embodiments, intraprocedural guidance and / or feedback is autonomously provided during a neuromodulation procedure via Doppler ultrasound performed on one more peripheral vessels for which blood flow is modulated by the neuromodulation procedure, with the neuromodulation device optionally being controlled according to the detected changes in blood flow.

This invention provides a recombinant human Fc fusion protein useful for treating or controlling ocular diseases, conditions, or disorders that have an etiology of abnormal angiogenesis. [Solution] The recombinant human Fc fusion protein comprises an Ig-like domain of a first human VEGF receptor, a different Ig-like domain of a second human VEGF receptor, at least yet another Ig-like domain of a third human VEGF receptor, and the Fc portion of human IgG1.