8 results about "Chinese cobra" patented technology

The application discloses an antibody or antigen binding fragment against Agkistrodon acutus venom and application thereof. The antibody or antigen binding fragment against Agkistrodon acutus venom comprises three heavy chain complementarity determining regions which can specifically bind to Agkistrodon acutus venom and the amino acid sequences of which are shown in SEQ ID NO: 4, SEQ ID NO: 6 and SEQ ID NO: 8; and three light chain complementarity determining regions which the amino acid sequences of which are shown in SEQ ID NO: 12, SEQ ID NO: 14 and SEQ ID NO: 16. The antibody or antigen binding fragment against Agkistrodon acutus venom can specifically bind to Agkistrodon acutus venom and does not bind to Vipera venom, Vipera russelli venom, Naja naja atra venom and Bungarus candidus venom, and can be used for detection of Agkistrodon acutus venom. The monoclonal antibody of the application has neutralizing and protective effects on Agkistrodon acutus venom, and has important significance for assisting clinical treatment, reducing complications and improving survival rate of patients.

The invention discloses a broken sugar dietary therapy formula based on zaocys dhumnade or cobra and a preparation method, and relates to the technical field of health preservation. The method comprises the following steps: S1, raw material pretreatment: treating sandworms: taking 1.5 kg of dry sandworms, removing sandbags, washing, and baking at 170 DEG C for 4 hours for later use; 135kg of zaocys dhumnade meat and 60kg of chicken are taken, washed and diced; taking 35kg of soybeans and 20kg of hericium erinaceus, washing and soaking for 2 hours; 2 kg of ginseng and 2 kg of dendrobe are taken and washed; 25 kg of dried scallops are taken and washed; s2, performing boiling and performing filling; aluminum cans are filled with the soup bases through an automatic filling machine (258 g per can), and the aluminum cans are sealed immediately; and S4, outer packaging: putting the sterilized tank body and the self-heating bag into an outer bowl, sealing with a film, and boxing. According to the invention, through the setting of a sugar-breaking dietary therapy method, the problems that the existing sugar-breaking or diet intervention product focuses on nutrient control and lacks systematic collaborative design and scientific proportioning for functional components (such as medicinal and edible active components) are solved.

The invention discloses an electrochemical sensor based on TdT enzyme and CbAgo synergistic mediation and application of the electrochemical sensor in cobra venom protein detection, and belongs to the technical field of electrochemical biosensors. Through magnetic bead enrichment, CbAgo protein cleavage and TdT extension reaction, and construction of a TdT enzyme and CbAgo protein synergistically mediated protein-nucleic acid conversion technology, a detection target is converted from cobra venom protein into a nucleic acid product, then the nucleic acid product is utilized to activate a Cas12a system to cut a probe P combined with a gold electrode, finally, the probe P is converted into an electrochemical signal, and the electrochemical signal is detected. The efficient and accurate detection of the cobra venom protein is realized. The electrochemical biosensor disclosed by the invention is high in sensitivity and good in specificity, and has extremely high application value in the aspects of accurate identification and quantitative analysis of cobra venom protein.

The application discloses an electrochemical sensor based on TdT enzyme and CbAgo synergistically mediated and application thereof in detection of cobra venom protein, and belongs to the technical field of electrochemical biosensors.The application constructs a protein-nucleic acid conversion technology mediated by TdT enzyme and CbAgo protein through magnetic bead enrichment, CbAgo protein cleavage and TdT extension reaction, converts the detection target from cobra venom protein into a nucleic acid product, and then utilizes the nucleic acid product to activate a Cas12a system to cleave a probe P combined on a gold electrode, and finally converts into an electrochemical signal, so that efficient and accurate detection of the cobra venom protein is realized.The electrochemical biosensor has high sensitivity and good specificity, and has extremely high application value in accurate identification and quantitative analysis of the cobra venom protein.

1. Name of the designed product: fish bait (cobra). 2. Use of the designed product: fish bait for fishing. 3. Design points of the designed product: in shape. 4. Picture or photo best indicating the design points: perspective view.

This invention belongs to the field of biotechnology and discloses a detectable and therapeutic antibody against the venom of the Chinese cobra and its uses. This invention provides an antibody or its antigen-binding fragment that can target and recognize different key toxin components or antigenic epitopes in venom, exhibiting excellent diagnostic specificity and therapeutic and preventative capabilities. Utilizing the high specificity of this antibody or its antigen-binding fragment in recognizing snake venom antigens, it can be developed into a rapid detection kit (such as a lateral flow immunochromatographic test strip) for rapid identification of the biting snake species and detection of the presence of specific snake venom in the environment or sample, providing crucial technical support for precise treatment and on-site diagnosis. It can also be used directly as a neutralizing agent for emergency treatment after snakebite. Through injection, the antibody can specifically neutralize the snake venom toxins entering the body, blocking its toxic effects and providing a novel and specific treatment method for clinical care.

The invention discloses a traditional Chinese medicine composition for treating scleroderma, which is prepared from the following traditional Chinese medicines in parts by weight: 60-100 parts of agkistrodon halys, 60-100 parts of cobra and 30-50 parts of dragon's blood. In the formula, the agkistrodon halys and the cobra have the effects of dispelling wind, dredging collaterals and resisting rheumatism, the dragon's blood has the effects of removing blood stasis and relieving pain, the formula conforms to the treatment principle of scleroderma for promoting blood circulation, removing blood stasis, dispelling wind and dredging collaterals, and research in recent years shows that the snake medicine still has the effect of regulating the immune function. Clinical experiment research shows that the treatment effect of the Soukang capsule taken by a scleroderma patient is compared with the treatment effect of a patient taking penicillamine in the same period, and the effectiveness and the safety of the Soukang capsule in treating systemic scleroderma are proved, so that the medicine disclosed by the invention has a remarkable effect of treating the scleroderma and has a good application value.

The invention relates to the technical field of biological medicines, in particular to application of cobra neurotoxin or a preparation thereof to preparation of a medicine for treating psoriasis, and the cobra neurotoxin or the preparation thereof has a beautifying effect when used for treating skin diseases. The snake venom neurotoxin is cobra neurotoxin which is selected from Chinese cobra neurotoxin (cobratoxin) (CTX) and / or Thailand cobra neurotoxin (cobratoxin). Through an imiquimod-induced psoriasis model, the snake venom neurotoxin disclosed by the invention has the effects of relieving and treating psoriasis and has a beautifying effect, and can effectively improve skin lesion of mouse psoriasis and repair skin to achieve the beautifying effect; the treatment effect of certain anti-cytokine monoclonal antibodies can also be enhanced. The invention provides a new application and a new thought of the snake venom neurotoxin, brings a new hope for patients with psoriasis, and can also provide a new skin beautifying medicinal preparation.