The invention discloses a bone disease treatment plaster. The bone disease treatment plaster comprises Smilax hypoglauca Benth, Hedyotis diffusa, Zanthoxylum nitidum, Cynanchum amplexicaule (Sieb. et Zucc.) Hemsl., Herba Patriniae, Pseudobulbus Cremastrae seu Pleiones, Cornu Bubali, Cordyceps sinensis, barbed skullcap herb, fresh dendrobium, Polygonum multiflorum, geckos, Santalum album L., Dioscorea nipponica Makino, rheum officinale, toad venom, geckos, American ginseng, Salvia miltiorrhiza, Adenophora stricta, Radix Scrophulariae, Sophora flavescens, Radix Pseudostellariae, Corn Cervi Pantotrichum, sea horses, starfishes, sea urchins, Folium Cordylines Fruticosae, Rhizoma Paridis, Rhodiola rosea, Crocus sativus, Radix Astragali, Human Placenta, pangolins, long-noded pit viper, Agkistrodon acutus, Zaocys Dhumnades, Changbai Mountain Mythic Fungus, dragon's blood, panax notoginseng, black maca, Cistanche deserticola, Radix Morindae officinalis, polygonatum rhizome, Semen plantaginis, semen cuscutae, centipedes, lumbricus, musk, rhizoma gastrodiae and whole scorpions. The bone disease treatment plaster aims at macroscopic regulation, and realizes integral conditioning and treatment through regulating the self tissue ability of a complex and open huge system and depending on the self rehabilitation ability of patients.