1152results about How to "Anti-tumor" patented technology

The invention provides sulfamate serving as an indoleamine-2, 3-dioxygenase inhibitor and a preparation method and application thereof. The structure of the inhibitor is shown in the general formula I, wherein definitions of X, R1, R2, R3, R4, R5 and n are shown in the description and the claim. The invention further discloses the preparation method of the inhibitor. The compound shown in the general formula I can serve as the indoleamine-2, 3-dioxygenase inhibitor and is used for preparing medicine for preventing and / or treating indoleamine-2, 3-dioxygenase mediated diseases. The general formula I is shown in the description.

The invention discloses a sea cucumber polypeptide functional food and a preparation method thereof which not only remarkably improves the content of polypeptide, but also has no chemical residues; the contents of salt and arsenic are low; the food is healthier and safer to eat; simultaneously the food is simply operated, easily controlled, is effective and saves energies. The key technical scheme includes: selecting a compound protease of Protamex and needing not to adjust the pH value of materials; carrying out processes of desalting and arsenic removing on an enzymolysis liquid; more than 80 percent of the molecular weight of the product is between 100 to 6000Dalt; wherein, the small polypeptide of 100 to 2100Dalt is more than 70 percent; the product components and the content weight percentages are as follows: 50 to 60 percent of polypeptide, 5 to 10 percent of free amino acids, 2.5 to 7.5 percent of mucoitin as well as containing the inherent nutrition components of a plurality of minerals and vitamins of the sea cucumber. The product has the effects of resisting knub, reducing blood pressure, preventing cardio-cerebrovascular diseases, resisting fatigue, delaying senescence, improving the immunity. The food can be used as a healthy food to eat and can also be used as a food and a medicine additive.

The invention discloses polygonatum sibiricum lycium barbarum tablet candy and a making method thereof. The polygonatum sibiricum lycium barbarum tablet candy is made of the following raw materials in parts by weight: 1.8-2.2 parts of xylitol, 18-22 parts of polygonatum sibiricum powder, 17-19 parts of lycium barbarum powder, 11-13 parts of poria cocos powder, 12-14 parts of Chinese yam powder, 11-13 parts of date powder, 10-12 parts of walnut powder, 9-11 parts of maca powder, 0.8-1.2 parts of maltodextrin and 0.8-1.2 parts of magnesium stearate. The invention further discloses the making method of the polygonatum sibiricum lycium barbarum tablet candy. The tablet candy is improvement and conditioning function on specific and non-specific immunity functions, and has the functions of preventing tumor, preventing oxidation, reducing the blood pressure, reducing cholesterol, invigorating stomach, enriching blood, moistening lung, reposing, nourishing the kidney and the like.

The invention relates to a novel indoleamine-2,3-dioxygenase (IDO) inhibitor, as well as a preparation method and an application thereof. The inhibitor is compounds of a formula I or pharmaceutically-acceptable salt, solvate, polymorph, enantiomer or racemic mixture thereof, wherein R1 or R2 is independently selected from H, C1-C5 alkyl, halogen and a substituent of a formula II and either of R1 and R2 is the substituent of the formula II; R3 is an aryl group; and n is equal to 0, 1, 2 or 3. Compared with the know IDO inhibitors, the novel IDO inhibitor has significant inhibitory effect on IDO and can be used for treatment of diseases having IDO-mediated tryptophan metabolic pathway pathological features, such as tumors, cancers, Alzheimer's disease, autoimmune diseases, cataract, psychological disorders, depression and / or anxiety. The preparation method of the novel IDO inhibitor has the advantages of being convenient in operation, having mild reaction conditions and reducing solvent consumption and pollution, thereby facilitating industrial production.

The invention provides selenium-enriched konjac rice and a processing method thereof. The selenium-enriched konjac rice is prepared from the following raw materials in percentage by weight: 30-60% of selenium-enriched konjac, 10-30% of rice powder and 20-30% of mung bean powder, wherein the selenium-enriched konjac is selenium-enriched konjac powder or selenium-enriched konjac glucomannan or a mixture of the selenium-enriched konjac powder and the selenium-enriched konjac glucomannan. The production method comprises the steps of mixing the selenium-enriched konjac, the rice powder and the mung bean powder, adding water, stirring the mixture to ensure the moisture content of the mixture to reach 40-45%, extruding the mixture into strips in a screw extruder, granulating, polishing and drying in a fluidized bed until the safe moisture content is 2% and packaging, thus obtaining the selenium-enriched konjac rice. The selenium-enriched konjac rice and the processing method thereof have the following beneficial effects: the selenium-enriched konjac is adopted as the main material and the mung bean is adopted as the auxiliary material to produce the selenium-enriched konjac rice product, so that the product not only has the functions of lowering blood sugar level and blood lipid, resisting tumors, improving immunities, clearing heat and eliminating toxic materials, but also does not have offensive odor or harsh taste of the konjac and has good taste.

The invention relates to health-preserving fungal tea and application thereof. The health-preserving fungal tea is prepared from the raw materials by weight fraction: 10 to 50 percent of edible or medicinal fungal fruit body and 50 to 90 percent of tea. The invention provides health-preserving fungal tea with simple and scientific matching and application thereof in anticancer aspect, so that the nutritive value and pharmacological action of single product are greatly improved. Through scientific matching, the actions of the active substances of the edible or medicinal fungal fruit body and tea are multiplied, so that the nutritive value and pharmacological action are greatly improved. By scientific matching, the fungal tea has unique mouthfeel and flavor, can serve as tea or tea bag to be directly soaked for drinking, can also be prepared into fungal tea beverage, oral liquid, polysaccharide capsule, tablets and the like, and has the efficacies of conditioning yin-yang balance of the functions of five internal organs, improving organism immunity, improving fatigue state, conditioning endocrine dyscrasia, improving blood pressure, blood sugar and blood fat, strengthening body, expelling toxin and protecting liver, preventing disease and radiation, reducing weight and fat, resisting tumor and aging and the like.

The present invention relates to American goldenrod herb total flavone extract and its preparation process and use. The American goldenrod herb total flavone extract contains quercetin, quercetin-3-O-beta-D-heteroside, kaempferol-3-O-alpha-L-rhamnoside, chlorogenic acid, etc. capable of preventing and treating senile dementia, various inflammatory respiratory diseases, esophagus cancer, etc. The preparation process is simple, high extracting rate, and the extract has high pharmacological effect, stable property, low toxicity and controllable quality.

The invention discloses a teabag with cordyceps sinensis and mulberry leaves, and a preparation method thereof. The health-care teabag is prepared by taking artificially cultured cordyceps sinensis and mulberry leaves as main components, adding an appropriate quantity of kudzuvine roots, aloes, honeysuckle flowers, chrysanthemums, liquorice and ilex latifolia to the main components and fully utilizing the respective functional nutrient components of the materials for organic collocation. The teabag has the advantages that the teabag can effectively improve the blood circulation of cerebral and peripheral vessels through frequent drinking, has good efficacy in treating hyperlipidemia and hypertension, lowering cholesterol, resisting tumors and aging and enhancing organism immunity, and is a health-care drink suitable for people at different ages.

The invention provides a healthy food capable of postponing aging of women, which is prepared from plant extract with estrogen-like effect, Spirulina, collagen powder and plant polyphenol. The healthy food has the functions on caring skin, strengthening body, improving bone density, lowering blood lipid, improving appetite, preventing cancer, resisting fatigue, improving immunity, and can excite young activity and prevent and postpone aging of middle and aged females.

The invention discloses a method for separating and preparing a gelsemium alkaloid monomer from gelsemium by adopting high-speed counter current chromatography, which pertains to the separation method of medicinal plant monomers. The invention takes total alkaloids of gelsemium as a raw material and a high-speed counter current chromatograph as a separating device and the method comprises that a solvent system which is composed of stationary phase and mobile phase is prepared; the high-speed counter current chromatograph is filled with the stationary phase and then the mobile phase is pumped in and balanced; and then sampling is conducted by a sample valve; target components are collected according to the map of a detector or in combination of the detection methods of high efficiency liquid chromatography and thin layer chromatography, and distilled under reduced pressure and then recrystallized to obtain the gelsemium alkaloid monomer with high purity. By adjusting the specific proportional parameters of the solvent system, single or multiple target gelsemium alkaloid monomers can be separated by one step or step by step. The method is convenient and efficient, large in preparation amount, less in sample loss, good in separation effect and high in controllability and applicable to automatic production and the obtained gelsemium alkaloid monomer from separation has diverse pharmacological activities and application prospect to be prepared into medicines.

The invention relates to a chitosan-based hepatic-targeted nano-particle drug delivery system which takes a derivative of glycyrrhetinic acid-modified chitosan as a carrier material and is prepared byembedding an anti-cancer drug, the particle size of nano-particles is 50nm-300nm, and the drug-loading rate is 5-40%; and the carrier material is glycyrrhetinic acid-sulfate chitosan or glycyrrhetinic acid-carboxymethyl chitosan, and the embedded anti-cancer drug is doxorubicin, paclitaxel or hydroxycamptothecin. The chitosan-based hepatic-targeted nano-particle drug delivery system has the beneficial effects that the chitosan and the derivative thereof are non-toxic and have good biocompatibility and anti-tumor effect, the hepatic targeting tendency of glycyrrhetinic acid and excellent biological performance of the chitosan derivative are combined and a novel hepatic-targeted drug delivery system,is developed and prepared; and the hepatic-targeted nano-particle drug delivery system has drug sustained-release function and hepatic targeting property and can reduce the using amount of the drug and the administration times, reduce the toxicity or the side effects of the drug and improvethe efficacy by being used in the treatment of liver diseases, thereby having good application prospects.

The invention provides a high-fiber instant asparagus ultramicro-powder beverage and a preparation method thereof. The asparagus ultramicro-powder beverage contains 60% to 75% of asparagus ultramicro-powders, 15% to 20% of stabilizers and 5% to 25% of flavorings. The product is prepared by the following steps: subjecting asparagus processing leftovers to vacuum freeze-drying treatment and micronization, adding stabilizers and flavorings, and mixing thoroughly; and the product is soluble in both cold and hot water. The high-fiber instant asparagus ultramicro-powder beverage is rich in dietary fiber, saponins and flavonoids and has hypolipidemic and anti-tumor functions. The method adopts the vacuum freeze-drying treatment and micronization techniques to retain the effective components of asparagus to the greatest extent and improves dissolution and digestion / absorption of nutrients of the product. The beverage and the preparation method have reasonable designs and abundant raw materials, are favorable to asparagus waste utilization, and increase the economic benefits of asparagus industry.

The present invention discloses a method for keeping the freshness of belt fish by a way that a biological fresh-keeping agent is combined with a gas-adjusting package. The biological fresh-keeping agent is composed of chitosan, tea polyphenol, glacial acetic acid and water, wherein the weight percentages of the chitosan, the tea polyphenol and the glacial acetic acid occupied the biological fresh-keeping agent is respectively 0.5% to 1.5%, 0.2% to 0.6% and 0.5% to 1.5%, and the rest is the water. Gas filled in the gas-adjusting package is composed of CO2, O2 and N2, and the volume proportioning proportion is 50% to 80% CO2, 10% to 20% O2 and 10% to 30% N2.The method for keeping the freshness of belt fish has not side effect for human bodies, and the biological fresh-keeping agent has certain cancer-preventing cancer-resisting healthcare efficiency. The present invention has the advantages of simple operation, low cost, safety and environment protection, and can obviously prolong the shelf period of fresh belt fish.

The invention discloses freeze-dried compound berry superfine powder and a production method thereof. The freeze-dried compound berry superfine powder is produced from the following berries in percent by weight: 40-45 percent of raspberry, 25-30 percent of blueberry, 6-8 percent of mulberry, 10-14 percent of sea-buckthorn, 4-6 percent of medlar and 5-7 percent of Lonicera caerulea. The method comprises the following specific steps: weighing and cleaning the berries, and draining for standby; mixing the drained berries under the condition of normal pressure and the temperature of 80 DEG C below zero, freezing for 1-3 hours, and rapidly freezing the fruits; keeping the frozen mixed berries in an environment with the pressure of 50-100Pa for 3-4 hours, controlling additional heating, and returning the temperature to 0 DEG C within 4-5 hours; raising the temperature from 0 DEG C to 45 DEG C within 6-8 hours, wherein the pressure is kept to be 20-50Pa; grinding the berries into the granularity of 5000-10000 meshes at the temperature of 0 DEG C by adopting nitrogen protection; preparing the ground superfine powder into tablets. The berries are reasonably proportioned, so that a health care effect is achieved, the functional ingredients in the product are enriched, the taste characteristics of the product are improved, the product is fresh to drink, contributes to human body absorption and is conveniently prepared into the tablets, and the active substances are well kept.

The invention discloses a fly maggot extractive containing the principal components of water-soluble proteins, and the water-soluble proteins contained in the fly maggot extractive have the mass percentage of 50-70 percent and the molecular weight of 2-16 KDa. The fly maggot extractive not only has obvious inhibiting effect on human promyelocytic leukemia HL-60 cells, human erythroleukemia K562 cells, human liver cancers SMMC-7721, mouse leukemia P388 cells, human lung adenocarcinoma A549 cells, human nasopharyngeal darcinoma CNE cells, human prostatic carcinoma PC3 cells, human cervical carcinoma HeLa in vitro, but also has outstanding inhibiting effect on mouse S180 sarcomas and mouse Heps liver cancer solid tumors, and also has the effect on enhancing the humoral immunity of organisms. The invention also discloses a preparation method of the fly maggot extractive. The preparation method is easy and convenient for operation and control and low in cost and is suitable for industrialized production.

The present invention relates to sea cucumber intestine extract composite soft capsules and a preparation method thereof. The preparation method comprises: adopting sea cucumber intestine produced through fresh sea cucumber processing as a raw material, carrying out slurry grinding, carrying out a heating treatment, cooling, adding two enzymes such as neutral protease and flavor enzyme, and controlling the enzymes to carry out enzymolysis; carrying out centrifugation twice on the enzymolysis solution, adopting a nano-filtration separation technology to carry out a desalting treatment on the collected supernatant, and drying the obtained sea cucumber intestine solution to obtain the sea cucumber intestine powder; and compounding the sea cucumber intestine powder, traditional Chinese medicine extracts such as a medlar extract, a milkvetch root extract, an American ginseng extract, a siraitia grosvenorii extract, a rhodiola rosea extract and a common yam rhizome extract, and auxiliary materials such as soybean oil and beeswax to obtain the sea cucumber intestine extract composite soft capsules. According to the present invention, the preparation method has characteristics of reasonable process and strong operability; and the prepared sea cucumber intestine extract composite soft capsules have characteristics of scientific component and reasonable matching, and further have effects of fatigue resistance, aging resistance, blood fat lowering, anti-tumor, skin benefiting, beautifying, and immunity improving.

The invention discloses a processing technology for instant mushroom strips, which is realized through the following technical scheme: selecting mushroom stems as raw materials; putting the mushroom stems in clean water for soaking, and after being drained, pouring the mushroom stems into a jacketed kettle for boiling; fishing out and draining the mushroom stems; pouring the mushroom stems into a vacuum kneading machine, simultaneously adding auxiliary materials and evenly mixing, and vacuum-pumping and kneading the mushroom stems to be with tastes; frying the mushroom with tastes by using a frying pan till no fluid flows out when a hand is used for pinching the mushroom stems, and taking the mushroom stems out of the frying pan; putting the mushroom stems in a baking house for baking; after being baked, processing the mushroom stems into strips, sheets or threads; and packing and sterilizing to obtain the product. The invention uses the mushroom stems as the raw materials of the instant mushroom strips. The produced instant mushroom strips contain dietary fiber, lentinan, various vitamins and minerals needed by the body, can promote the metabolism of the body and have the functions of resisting viruses and cancers and improving body immunity.

The invention discloses a method for separating and preparing a gelsemium alkaloid monomer from gelsemium by adopting high-speed counter current chromatography, which pertains to the separation method of medicinal plant monomers. The invention takes total alkaloids of gelsemium as a raw material and a high-speed counter current chromatograph as a separating device and the method comprises that a solvent system which is composed of stationary phase and mobile phase is prepared; the high-speed counter current chromatograph is filled with the stationary phase and then the mobile phase is pumped in and balanced; and then sampling is conducted by a sample valve; target components are collected according to the map of a detector or in combination of the detection methods of high efficiency liquid chromatography and thin layer chromatography, and distilled under reduced pressure and then recrystallized to obtain the gelsemium alkaloid monomer with high purity. By adjusting the specific proportional parameters of the solvent system, single or multiple target gelsemium alkaloid monomers can be separated by one step or step by step. The method is convenient and efficient, large in preparation amount, less in sample loss, good in separation effect and high in controllability and applicable to automatic production and the obtained gelsemium alkaloid monomer from separation has diverse pharmacological activities and application prospect to be prepared into medicines.

The invention discloses paeonia suffruticosa vinegar which contains active ingredients extracted from paeonia suffruticosa, wherein the active ingredients comprise paeonin, paeonol, astragalin, flavonoid, organic acid, amino acid, mineral substances, vitamins and other nutrition ingredients. The paeonia suffruticosa vinegar is mild in tart taste, slightly sweet, pleasant in fragrance and rich in nutrition, can be directly drunk, and is taken as a natural green nutritious health-care product. The paeonia suffruticosa vinegar has the functions of reducing blood fat, softening blood vessels, reducing blood pressure, removing free radicals such as O-2 and.OH in human bodies, resisting oxidation and ageing, adjusting immunity, moisturizing skin and nourishing face as well as helping digestion and dispelling the effects of alcohol. The invention also discloses a preparation method of the paeonia suffruticos vinegar.

The invention discloses a manufacturing method for bamboo salt. Sea salt is added with bamboo juice and bamboo root, water is added after the mixed materials are mixed, boiling is carried out with clean water or spraying is carried out by high-pressure steam, thus obtaining bamboo juice solution; the bamboo juice solution is mixed with the sea salt, then is put on a refractory jar, then sealing is carried out with yellow mud, pine wood as fuel is heated to 700-750 DEG C, a defined amount of colophony is used for slowly heating up the temperature to 1300-1500 DEG C, tuckahoe powder or ginger are added after being cooled and ground, then bamboo segments are added. The pine wood is baked to 700-750 DEG C, and then is cooled, the bamboo salt is obtained after repeated times of baking and cooling. The product of the invention has the efficacy of calming the nerves, refreshing spirit and invigorating brain, and contains rich minerals and trace elements, thus being richer in nutriments and being a healthy food of new generation.

The invention provides a refreshing agent and method for inhibiting blackening of prawns. The refreshing agent comprises ergothioneine, kelp polyphenols, laminarin, and glacial acetic acid. The refreshing method comprises the following steps: extracting kelp polyphenols and laminarin; then adding ergothioneine, the extracted kelp polyphenols and the extracted laminarin to deionized water; uniformly agitating; and then adding glacial acetic acid to obtain the refreshing agent, wherein the prepared refreshing agent comprises 0.2 to 0.9% of ergothioneine in mass percent concentration, 0.3 to 0.9% of kelp polyphenols in mass percent concentration, 0.3 to 1% of laminarin in mass percent concentration, and 0.6 to 1% of glacial acetic acid in mass percent concentration. The refreshing agent is used for refreshing prawns. The refreshing method has the advantages of being few in steps and convenient in operation; the refreshing agent can remain the original color and luster of the prawns, shows a good blackening inhibiting effect and great antibacterial effect, keeps the prawns fresh, and also can prolong the shelf life of prawn products.

The invention provides a brewing formula and brewing process of heavy-flavor baijiu. The brewing formula comprises, by weight, 30-50 parts of sorghum, 10-20 parts of mung beans, 10-20 parts of rice, 5-15 parts of wheat, 3-8 parts of buckwheat, 5-14 parts of sticky rice and 3-8 parts of corn. The brewing process includes the steps of material preparation according to the formula, pretreatment for crushing, mixing and decocting raw materials, diastatic fermentation of steamed raw materials and distillation conducted on fermented grains and baijiu taking. The brewing process is simple, brewing time is short, all brewing parameters are easy to control, and operability is high. The brewed baijiu is heavy in fragrance, soft and sweet and coordinate in fragrance; after the baijiu is drunk, the stomach is not impaired, headache is not caused, and a drinker is not prone to drunkenness.

The invention discloses a probiotic composition with an anti-tumor function as well as a preparation method and application thereof. The probiotic composition comprises the following components in mass percent: 60-70% of probiotic dry powder, 20-30% of astragalus root extract powder and 10-20% of asparagus extract powder. Probiotics and traditional Chinese medicines belong to two types of internationally recognized probiotic substances, and the probiotics and the traditional Chinese medicines are similar in mechanism of action and can perfectly complement each other in a concrete use process so as to jointly exert advantages. According to the probiotic composition disclosed by the invention, the probiotics and the traditional Chinese medicines are perfectly combined, and proliferation of the probiotics is promoted by virtue of the probiotic proliferation action of the traditional Chinese medicines so as to enhance the immune function of organisms and inhibit the proliferation of tumor cells, thereby achieving an anti-tumor effect.

The present invention discloses one kind of functional polysaccharide and polypeptide blue berry beverage. During preparing blue berry beverage, mycose, silk polypeptide powder and other nutritious reinforcing agent containing special function factor are added to make the beverage possess functions of preventing and treating diabetes, promoting intelligence growth, strengthening body's immunity, etc. The functional polysaccharide and polypeptide blue berry beverage is bluish, and has unique flavor.

The invention discloses an angelica keiskei health-care chewable tablet, which comprises angelica keiskei powder, starch, sucralose, stevioside, vitamin C, ganoderma lucidum spore, lactose and magnesium stearate. The chewable tablet has the advantages of strong flavor, high purity, comprehensive nutrition, delicious sour and sweet tastes, multiple health-care functions, convenience for taking andcarrying and simple preparation process. According to the invention, the food series of angelica keiskei are enriched, the converting way of the angelica keiskei resource is increased, and an important technical reference value and a wide market development prospect are achieved.

The invention relates to gargle with the drinking safety, comprising the following components by weight percent: 0.1-0.5 percent of tea polyphenols, 0.05-0.3 percent of magnolol, 0.05-0.3 percent of paeonol, 0.01-0.1 percent of phytic acid dodecasodium salt, 0.5-3 percent of glycyrrhizic acid, 1-5 percent of ethanol, 0.05-0.5 percent of mentha haplocalyx, 0.001-0.01 percent of essence, 0.05-0.2 percent of propylgallate, 0.01-0.1 percent of sodium cyclamate, 0.05-0.5 percent of macromolecule suspending agent, 0.3-2 percent of surface active agent and the balance of water. A preparation method of the gargle comprises the following steps of: adding tea polyphenols, magnolol, paeonol, propylgallate, mentha haplocalyx and essence into the ethanol according to the content and components, stirring for dissolving to obtain solution A; adding the phytic acid dodecasodium salt, glycyrrhizic acid, sodium cyclamate, macromolecule suspending agent and surface active agent into water, stirring for dissolving to obtain solution B; slowly adding the solution A into the solution B while stirring, and evenly stirring the mixture solution to obtain the gargle. The gargle has clear appearance, is slightly sweet in the mouth feel and ensures fresh breath after use.

The invention provides a preparation for treating viral myocarditis, wherein the medicinal reactivity of cinnamic aldehyde for antiviral, immunity adjustment, cardiac rhythm stabilization and blood vessel amplificatus, the cinnamic aldehyde can be prepared into cinnamic aldehyde slow release tablet, cinnamic aldehyde slow release capsule and cinnamic aldehyde injection for treating viral myocarditis. The invention has the advantages of stabilized medicinal content, high biological availability, small amount of administration, high curative effect, and low toxicity.

The invention relates to a method for preparing novel valved vessels. The method is characterized in that the novel valved vessel comprises a blood vessel pipe, valves and a connection; the valves areconnected to the blood vessel pipe through the connection. This method not only ensures the internal and external fixation of blood vessels, but also ensures the natural state of blood vessels whichare not folded and twisted, and is beneficial to surgical anastomosis, anti-calcification, anti-aging, and significantly improve the long-term results.