American goldenrod herb total flavone extract and its preparing method and use

Abstract

The present invention relates to American goldenrod herb total flavone extract and its preparation process and use. The American goldenrod herb total flavone extract contains quercetin, quercetin-3-O-beta-D-heteroside, kaempferol-3-O-alpha-L-rhamnoside, chlorogenic acid, etc. capable of preventing and treating senile dementia, various inflammatory respiratory diseases, esophagus cancer, etc. The preparation process is simple, high extracting rate, and the extract has high pharmacological effect, stable property, low toxicity and controllable quality.

Description

technical field [0001] The invention relates to the technical fields of medicine, food and beverage, in particular to a traditional Chinese medicine extract and its preparation method and application, more specifically to a total flavonoid extract of the traditional Chinese medicine Solidago americana and its preparation method and application. Background technique [0002] (1) Research overview of Solidago americana [0003] 1 Overview [0004] Solidago americana, also known as solidago canadensis, is the whole plant or root of solidago canadensis, a plant of the genus Solidago in the family Asteraceae. Solidago americana was first recorded in the "Plant Names and Facts" mountain grasses, and it is mainly distributed in East China, Central South, Shaanxi, Taiwan and other places. [0005] Solidago is a genus in the family Compositae. There are about 120 species of Solidago genus in the world, and 4 species are distributed in China, namely Solidago decurrens Lour., Solida...

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Problems solved by technology

[0079] Tetrahydroaminoacridine is the first cholinesterase inhibitor approved by the FDA and clinically used to treat Alzheimer's disease, but regulations still need to be improved

[0086] The disadvantage of tacrine is that it has a great impact on liver function and transaminase index, which restricts the development of the market, and its sales growth is far behind other AD drugs

And because the vast majority of patients with esophageal cancer are already in the advanced stage when they are diagnosed, not only the local lesions have been extensively infiltrated, but also the distant spread of subclinical lesions or lymph node metastasis have been found. Autopsy found that many cases that were considered to be locally early died at the time of death. More than half of them have distant metastasis, more than 70% have extensive lymph node invasion, and less than 1 / 3 of the cases can be curatively resected. The 5-year survival rate of conventional radiotherapy is only 13%. The main cause of failure accounts for more than 80%. It can be seen that the treatment of esophageal cancer is far from enough by surgery and radiotherapy alone.

[0223] Through literature search, etc., so far, no relevant reports on the total flavonoids extract of Solidago americana and its preparation method and use have been found.

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